Association between maternal sexually transmitted diseases and birth defects in the United States: A nationwide population-based study.

Purpose: We estimated the association between maternal sexually transmitted diseases (STDs) and the risk of specific birth defects among live singleton births in the United States (US).

Methods: We conducted a population-based study using data from birth certificates for 14,602,822 live singleton births occurring from 2016 to 2019 in the US. We used logistic regression to estimate the associations between three maternal STDs (chlamydia, gonorrhea, and syphilis) and the risk of four specific birth defects (gastroschisis, cleft lip with or without cleft palate, spina bifida, and hypospadias), adjusting for socio-demographic and pregnancy-related factors.

Sleep duration and mental health in middle-aged and older adults: a study on gender differences.

Background: As the global population ages, mental health issues among middle-aged and older adults have become an important public health concern. Although the impact of sleep disorders on mental health is widely recognised, the specific mechanisms underlying the gender differences in mental health among middle-aged and older adults due to differences in sleep duration remain unclear. This study aims to explore the impact of sleep duration on mental health differences between middle-aged and older adults of different genders, providing key mechanistic evidence for understanding gender inequality in mental health among middle-aged and older adults.

Effect of short-term exposure to fine particulate matter components on respiratory mortality - evidence from a study of inland cities in China.

There is a lack of research on the association between fine particulate matter (PM) fractions and respiratory disease mortality. Therefore, this study aims to investigate how short-term exposure to fine particulate matter components affects the mortality risk of patients with respiratory diseases.We collected data on the number of respiratory deaths and fine particulate matter components, including sulfate (SO), nitrate (NO), ammonium (NH), organic matters (OM), and black carbon (BC), in Hefei, Anhui Province, between 2017 and 2020.

LitAutoScreener: Development and Validation of an Automated Literature Screening Tool in Evidence-Based Medicine Driven by Large Language Models.

The traditional manual literature screening approach is limited by its time-consuming nature and high labor costs. A pressing issue is how to leverage large language models to enhance the efficiency and quality of evidence-based evaluations of drug efficacy and safety. This study utilized a manually curated reference literature database-comprising vaccine, hypoglycemic agent, and antidepressant evaluation studies-previously developed by our team through conventional systematic review methods.

Investigation into Antibiotic Resistance Profiles of Among Chronic Rhinosinusitis Patients and Multifaceted Analysis of Factors Influencing Methicillin-Resistant Infection.

Objective: This study aimed to comprehensively investigate the antibiotic resistance characteristics of in chronic rhinosinusitis (CRS) patients and to identify key determinants influencing the development of methicillin-resistant Staphylococcus aureus (MRSA) infections.

Methods: A retrospective analysis was conducted on 180 CRS patients admitted to our hospital between February 2022 and July 2024. Nasal secretion samples were collected upon admission for strain isolation, and antibiotic susceptibility testing was performed using an automated microbiology system.

Sci-tech analysis and related research on three glass beads unearthed from M686 in the Qin cemetery of Warring States Period in Hejia, Zhouling.

This study presents a systematic analysis of three glass beads excavated from Tomb M686 in the Qin Cemetery of Warring States Period (475 BC-207 BC) in Hejia,Zhouling. The aim is to reveal their material characteristics and weathering mechanisms. Using super-depth-of-field 3D video microscopy system (OM), X-ray fluorescence spectroscopy (XRF), and micro-Raman spectroscopy (Raman), all three glass beads were identified as the unique lead-barium silicate glass system of ancient China.

Phenotypic heterogeneity in adenomyosis: internal and external subtypes.

Purpose: To investigate and compare the clinical characteristics and risk factors between intrinsic and extrinsic adenomyosis (AM), as well as the differences in their perioperative management and findings in the two subtypes.

Methods: This observational study included women who were diagnosed with either intrinsic or extrinsic AM based on magnetic resonance imaging (MRI) and who underwent a hysterectomy with a subsequent pathological examination. Demographic characteristics, clinical features, treatment outcomes and associated factors were evaluated.

A Multi-marker model based on serum IL-10 predicts response to conversion immunochemotherapy in gastric cancer patients: a retrospective cohort study.

Background: Conversion immunochemotherapy may enable curative surgery in patients with initially unresectable locally advanced gastric cancer, but its response rate remains low. Little evidence has shown how to easily predict therapeutic efficacy from hematological biomarkers, apart from tissue biomarkers. This study aimed to identify predictive factors for treatment response from hematological biomarkers and propose strategies for non-responsive patients.

Affective-cognitive circuits in postoperative appetite reduction: an adaptive neuroimmune response to surgical stress.

Postoperative reduction in appetite perception, conceptualized as an interplay between emotion, perception, and cognition, may lead to adverse nutritional outcomes. However, an increasing body of research suggests that it may serve as an adaptive mechanism to inhibit inflammatory responses and regulate metabolic burden. This review comprehensively summarizes the multifaceted mechanisms underlying postoperative changes in appetite perception, particularly from the perspectives of immune regulation, inflammatory suppression, and metabolic reprogramming.

Indole Propionic Acid Regulates Gut Immunity: Mechanisms of Metabolite-Driven Immunomodulation and Barrier Integrity.

Indole propionic acid (IPA) is a functional indole derivative produced exclusively by intestinal flora through tryptophan metabolism. Numerous studies have shown that IPA has a variety of beneficial biological functions, including anti-inflammatory and antioxidant effects, immunomodulation, intestinal barrier protection, regulation of intestinal flora composition, and neuroprotection. IPA, as an intestinal microbial metabolite, actively participates in the establishment of intestinal immune homeostasis and positively influences the prevention and control of intestinal diseases, thereby playing an indispensable role in regulating host health.

Evolutionary Conservation and Immunoregulatory Function of LOXL3 Gene in Lamprey.

Lysyl oxidase (LOX) family enzymes play a pivotal role in extracellular matrix (ECM) remodeling and tissue homeostasis, and have evolved diverse functions in vertebrate immunity and metabolism. However, the evolutionary trajectory of these multifunctional roles-particularly in jawless vertebrates-remains obscure. Here, we investigate LOXL3 in the lamprey (Lethenteron reissneri), a jawless vertebrate that retains ancestral features of early vertebrate evolution.

CuSO protects hepatocytes from lipotoxicity by promoting autophagic degradation of lipid droplets to attenuate oxidative stress.

Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) is a prevalent chronic liver condition that often progresses to Metabolic Dysfunction-Associated Steatohepatitis (MASH), ultimately leading to liver fibrosis and hepatocellular carcinoma (HCC). Consequently, the early diagnosis and treatment of MASLD are particularly crucial. Currently, the pathogenic mechanisms underlying MASLD remain incompletely understood, and there is no optimal therapy available for this condition.

Medications for adults with type 2 diabetes: a living systematic review and network meta-analysis.

Objective: To provide up-to-date evidence on key benefits, harms, and uncertainties regarding medications for adults with type 2 diabetes.

Design: Living systematic review and network meta-analysis (NMA), using frequentist random effects and GRADE (grading of recommendations, assessment, development and evaluation) approaches. Updates are planned at least two times a year.

X-UNet:A novel global context-aware collaborative fusion U-shaped network with progressive feature fusion of codec for medical image segmentation.

Due to the inductive bias of convolutions, CNNs perform hierarchical feature extraction efficiently in the field of medical image segmentation. However, the local correlation assumption of inductive bias limits the ability of convolutions to focus on global information, which has led to the performance of Transformer-based methods surpassing that of CNNs in some segmentation tasks in recent years. Although combining with Transformers can solve this problem, it also introduces computational complexity and considerable parameters.

An efficient approach for the extraction of glycoproteins from American ginseng by natural deep eutectic solvent.

Glycoproteins have not been reported in the previous studies of American ginseng. This study focuses on developing an efficient method for the extraction of glycoproteins from American ginseng (GAG). Three choline chloride (ChCl)-based natural deep eutectic solvents (NADES) and three extraction techniques including microwave-, ultrasound-, and heating and stirring-assisted extraction were evaluated in the study.

Treatment Patterns and Triple Therapy Utilization in Chinese Patients with Chronic Obstructive Pulmonary Disease: An Analysis of Real-World Data from the Yinzhou Database.

Purpose: Triple therapy of chronic obstructive pulmonary disease (COPD), consisting of inhaled corticosteroid (ICS), long-acting β2-agonist (LABA) and long-acting muscarinic antagonist (LAMA) has shown benefits in patients with COPD. However, little is known about the use of triple therapy in Chinese patients. This study aims to describe the treatment patterns and the utilization of triple therapy in COPD patients based on real-world data from China.

The exacerbating effects of stable pulmonary tuberculosis on the deterioration of inflammatory response, coagulation function, and pulmonary function in COPD: A propensity score-matched retrospective study.

Chronic obstructive pulmonary disease (COPD) and tuberculosis pose significant public health challenges, particularly in tuberculosis-endemic developing regions where their co-prevalence may exacerbate the disease burden of chronic airflow obstruction. This study aimed to investigate the impact of stable pulmonary tuberculosis on inflammatory status, coagulation function, and pulmonary function in COPD patients during acute exacerbations.We conducted a retrospective analysis of 68 COPD patients with acute exacerbation and stable pulmonary tuberculosis (observation group) admitted between December 2019 and December 2023.

Pharmacoepidemiologic Research Based on Common Data Models: Systematic Review and Bibliometric Analysis.

Background: The adoption of common data models (CDMs) has transformed pharmacoepidemiologic research by enabling standardized data formatting and shared analytical tools across institutions. These models facilitate large-scale, multicenter studies and support timely real-world evidence generation. However, no comprehensive global evaluation of CDM applications in pharmacoepidemiology has been conducted.

Impacts of COPD exacerbation history on mortality and severe cardiovascular events among patients with COPD in China: a retrospective cohort study.

Background: Chronic Obstructive Pulmonary Disease (COPD) exacerbations are associated with increased mortality and cardiovascular events. However, there is limited evidence on the relationship between COPD exacerbations and mortality and cardiovascular outcomes in China.

Methods: This retrospective cohort study included Chinese patients with COPD aged ≥ 40 years from the Yinzhou regional electronic health records database.

Antihypertensive medications and cancer risk: Evidence from 0.27 million patients with newly diagnosed hypertension.

Background: Whether specific antihypertensive treatments increase cancer risk in patients with hypertension is still controversial. We aimed to estimate the associations of different antihypertensive treatments with cancer risk in real-world settings.

Methods: A longitudinal cohort study was designed in a population of 1.

Evaluation of the accuracy of dynamic navigation versus robot-assisted dental implant placement in models with one missing tooth or multiple missing teeth with a free-end: an in vitro study.

Objectives: To assess and compare the accuracy of robot-assisted and dynamic navigation systems for dental implant placement in models with either a single missing tooth or multiple consecutive missing teeth at the distal extension.

Methods: Thirty-two models and 86 implants were utilized. Implant placement was randomly assigned using either a robot-assisted or dynamic navigation system.

Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone.

Objective: To analyze the clinical symptom improvement and recurrence rate of chronic suppurative otitis media (CSOM) patients treated with a combination therapy regimen (combination of ofloxacin and dexamethasone).

Methods: Based on the treatment regimen, patients were divided into two groups: the control group was treated with dexamethasone, while the treatment group received a combination of ofloxacin and dexamethasone. The clinical symptom improvement, hearing evaluation, pathogen clearance rate, inflammatory marker detection, adverse reactions, recurrence rate and recurrence rate post-treatment were compared between the two groups.

A Short, All-Oral Regimen for Pre-Extensively Drug-Resistant Tuberculosis: A Multicenter Open-label Single-arm Study.

Background: Pre-extensively drug-resistant tuberculosis (pre-XDR-TB) remains a critical public health threat due to limited treatment options and significant disease burden. Existing regimens have shown high success rates but are often inaccessible globally, necessitating alternative options.

Methods: This study was an open-label, multicenter, single-arm study conducted in China to evaluate the efficacy and safety of a 6- to 9-month oral regimen.