LitAutoScreener: Development and Validation of an Automated Literature Screening Tool in Evidence-Based Medicine Driven by Large Language Models.

The traditional manual literature screening approach is limited by its time-consuming nature and high labor costs. A pressing issue is how to leverage large language models to enhance the efficiency and quality of evidence-based evaluations of drug efficacy and safety. This study utilized a manually curated reference literature database-comprising vaccine, hypoglycemic agent, and antidepressant evaluation studies-previously developed by our team through conventional systematic review methods.

STAGE: A compact and versatile TnpB-based genome editing toolkit for .

are naturally endowed with the capacity to produce a wide array of natural products with biomedical and biotechnological value. They have garnered great interest in synthetic biology applications given the abundance of uncharacterized biosynthetic gene clusters (BGCs). However, progress has been hindered by the limited availability of genetic tools for manipulating these bacteria.

Metal-Polyphenol Network Coated Bilirubin Nanoparticles for the Alleviation of Periodontitis via Mild Photothermal Therapy and Immunomodulatory Therapy.

At present, the development of nanoplatforms that integrate infection control, inflammation resolution, and tissue repair for the treatment of periodontitis remains an enormous challenge. Based on the intricate pathogenesis of periodontitis and the advantages of mild photothermal therapy (PTT) and nanotherapy, a multifunctional photothermal nanoplatform (designated BR@C3G-Cu) was rationally developed by coating bilirubin nanoparticles (BR NPs) with copper ion coordinated cyanidin-3--glucoside metal-polyphenol networks (MPNs) in this study. The synergistic consequences of the photothermal conversion properties and metal-dependent functionality of this MPNs contributed to the effective and persistent elimination of periodontal pathogens under safe and mild conditions, meeting the heterogeneous antibacterial requirements of periodontitis.

Impact of a mobile health intervention on health management among children with phenylketonuria based on a multi-theory model of the behavior change wheel theory and family health theory: protocol for a randomized controlled trial.

Background: Phenylketonuria (PKU) is a hereditary metabolic disorder caused by mutations in the phenylalanine hydroxylase () gene, leading to the accumulation of phenylalanine (Phe) in the blood. Without timely treatment, PKU patients may develop irreversible intellectual and neurocognitive deficits. The primary treatment for PKU is a strict low-Phe diet, which must be initiated in early life to achieve better outcomes.

Microneedles Loaded with Nitric-Oxide Driven Nanomotors Improve Force-Induced Efferocytosis Impairment and Sterile Inflammation by Revitalizing Macrophage Energy Metabolism.

Mechanical force initiates sterile inflammation, a process implicated in diverse physiological and pathological processes. The timely clearance of apoptotic cells by macrophages via efferocytosis is crucial for the proper resolution of sterile inflammation and for averting excessive tissue damage. Despite this, the specific role and underlying mechanisms of mechanical force on macrophage efferocytosis remain obscure.

Three-Dimensional Evaluation of Condylar Position and Joint Spaces Following Orthodontic Treatment With Quadruple Premolar Extractions.

This study aimed to assess the alterations in the temporomandibular joint among adult patients undergoing orthodontic treatment involving the extraction of four premolars. A cohort of 44 adults, with a mean age of 24.2 years, underwent orthodontic therapy that included quadruple premolar extractions.

Connecting past and present.

A neural signature of serial dependence has been found, which mirrors the attractive bias of visual information seen in behavioral experiments.

SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation.

Excessive scar formation such as hypertrophic scars and keloids, resulting from trauma or surgical procedures, present a widespread concern for causing disfigurement, discomfort, and functional limitations. Macrophages play pivotal roles in maintaining tissue homeostasis, orchestrating tissue development, repair, and immune responses, and its transition of function and phenotype plays a critical role in regulating the balance between inflammation and tissue regeneration, which is central to cutaneous scar formation. Recent evidence suggests the involvement of Sonic Hedgehog (SHH) in the induction of anti-inflammatory M2-like macrophage phenotypes within tumor microenvironments.

Chitobiose exhibited a lipid-lowering effect in ob/ob mice via butyric acid enrolled liver-gut crosstalk.

Chitobiose (COS) efficiently lowers lipids in vivo and facilitates butyric acid enrichment during human fecal fermentation. However, whether COS can interact with butyric acid to generate a hypolipidemic effect remains unclear. This study examined the hypolipidemic mechanism of COS involving butyric acid, which could alleviate non-alcoholic fatty liver disease (NAFLD).

Lipotoxicity: The missing link between diabetes and periodontitis?

Lipotoxicity refers to the accumulation of lipids in tissues other than adipose tissue (body fat). It is one of the major pathophysiological mechanisms responsible for the progression of diabetes complications such as non-alcoholic fatty liver disease and diabetic nephropathy. Accumulating evidence indicates that lipotoxicity also contributes significantly to the toxic effects of diabetes on periodontitis.

Validation of a physiological type 2 diabetes model in human periodontal ligament stem cells.

Objectives: Type 2 diabetes (T2DM), a recognized risk factor for periodontitis, is characterized by insulin resistance. However, the molecular mechanisms concerning the role of insulin resistance in linking T2DM and periodontitis remain poorly elucidated due to the absence of an appropriate T2DM cell model. We aimed to explore an appropriate model of T2DM in human periodontal ligament stem cells (hPDLSCs) and uncover the involved mechanisms.

Synthesis and Antiphytopathogenic Activity of Novel Oxazolidine-2,4-diones Bearing Phenoxypyridine Moiety.

In the present study, we conducted optimization of pyramoxadone and synthesized a series of novel oxazolidinediones. Antifungal assays showed that these compounds exhibited moderate to excellent antifungal activity against various pathogens. Further SAR analysis revealed that the introduction of substituents to the benzene ring of the phenoxy group or the inclusion of bulky groups, such as -butyl, on the aniline moiety, had a detrimental effect on the activity.

Application of Decellularized Adipose Matrix as a Bioscaffold in Different Tissue Engineering.

With the development of tissue engineering, the application of decellularized adipose matrix as scaffold material in tissue engineering has been intensively explored due to its wide source and excellent potential in tissue regeneration. Decellularized adipose matrix is a promising candidate for adipose tissue regeneration, while modification of decellularized adipose matrix scaffold can also allow it to transcend the limitations of adipose tissue source properties and applied to other tissue engineering fields, including cartilage and bone tissue engineering, neural tissue engineering, and skin tissue engineering. In this review, we summarized the development of the applications of decellularized adipose matrix in different tissue engineering and present future perspectives.

Structural Construction of Au-Pd Nanocomposite for Alkali-Free Oxidation of Benzyl Alcohol.

A bimetallic Au-Pd system is an alternative candidate to catalyze primary alcohol oxidation and is of crucial importance for the sustainable chemical industry. However, understanding the bimetallic system in terms of the nanostructure is still challenging. Herein, we adopt the in situ colloid immobilization to obtain a series of bimetallic AuPd/CNT samples supported by carbon nanotubes (CNTs).

Pyroptosis in periodontitis: From the intricate interaction with apoptosis, NETosis, and necroptosis to the therapeutic prospects.

Periodontitis is highly prevalent worldwide. It is characterized by periodontal attachment and alveolar bone destruction, which not only leads to tooth loss but also results in the exacerbation of systematic diseases. As such, periodontitis has a significant negative impact on the daily lives of patients.

BaHgGaS: A Zero-Dimensional Quaternary Sulfide Featuring a Unique [HgGaS] String and Exhibiting a High Photocurrent Response.

The discovery of new types of metal sulfides is attractive because of their rich structures and diverse physical properties. Here, a novel quaternary sulfide, BaHgGaS (BHGS), is obtained by a solid-state reaction at 1123 K. It crystallizes in the monoclinic space group 2/, and its zero-dimensional structure features two seesaw-like HgS units and four GaS tetrahedra, constructing a unique [HgGaS] string.

Regulation of Dietary Protein Solubility Improves Ruminal Nitrogen Metabolism In Vitro: Role of Bacteria-Protozoa Interactions.

Precision dietary interventions (e.g., altering proportions of dietary protein fractions) has significant implications for the efficiency of nutrient use in ruminants, as well as lowering their environmental footprint, specifically nitrogen (N) emissions.

Eu P S : The First Rare-Earth Chalcogenophosphate Exhibiting Large Second-Harmonic Generation Response and High Laser-Induced Damage Threshold.

Metal chalcogenophosphates are receiving increasing interest, specifically as promising infrared nonlinear optical (NLO) candidates. Here, a rare-earth chalcogenophosphate Eu P S crystallizing in the monoclinic noncentrosymmetric space group Pn was synthesized using a high-temperature solid-state method. Its structure features isolated [P S ] dimer, and two types of EuS bicapped triangular prisms.

Boosting the catalytic behavior and stability of a gold catalyst with structure regulated by ceria.

In this work, a series of colloidal gold nanoparticles with controllable sizes were anchored on carbon nanotubes (CNT) for the aerobic oxidation of benzyl alcohol. The intrinsic influence of Au particles on the catalytic behavior was unraveled based on different nanoscale-gold systems. The Au/CNT-A sample with smaller Au sizes deserved a faster reaction rate, mainly resulting from the higher dispersion degree (23.

Statistical Analysis of Spatial Network Characteristics in Relation to COVID-19 Transmission Risks in US Counties.

Since the pandemic of COVID-19 began in January 2020, the world has witnessed drastic social-economic changes. To harness the virus spread, several studies have been done to study contributing factors that are pertinent to COVID-19 transmission risks. However, little has been done to investigate how human activities on the spatial network are correlated to the virus transmission and spread.