The relationship between restrained eating and exercise addiction: The chain mediating role of social physique anxiety and grit.

Background: Exercise addiction often coexists with eating disorders and extreme dietary habits. It has remained unclear whether restrained eating, the most common maladaptive behavior in eating disorders, is associated with exercise addiction and whether some common psychological factors will affect their relationship. This study aimed to explore the interplay among restrained eating, exercise addiction, social physique anxiety, and grit.

[Development and practice of an interactive chromatography learning tool for beginners based on GeoGebra： a case study of plate theory].

This study developed a GeoGebra platform-based interactive pedagogical tool focusing on plate theory to address challenges associated with abstract theory transmission， unidirectional knowledge delivery， and low student engagement in chromatography teaching in instrumental analysis courses. This study introduced an innovative methodology that encompasses theoretical model reconstruction， tool development， and teaching-chain integration that addresses the limitations of existing teaching tools， including the complex operation of professional software， restricted accessibility to web-based tools， and insufficient parameter-adjustment flexibility. An improved mathematical plate-theory model was established by incorporating mobile-phase flow rate， dead time， and phase ratio parameters.

Recent Progress in Nonanolides of Natural Origin: Structures, Synthesis, Biosynthesis, and Bioactivities.

Nonanolides, a diverse group of secondary metabolites with a unique 10-membered lactone subunit, are abundant in nature. To date, nonanolides have exhibited various biological activities, including cytotoxicity, phytotoxicity, antimalarial activity, antiosteoporosis, and antimicrobial activity. Previous literature has extensively reviewed nonanolides reported from 1975 to July 2011.

Rational design of a bispecific antibody for rapid and prolonged neutrophil mobilization and proliferation.

Human granulocyte colony stimulating factor (G-CSF) and the G-protein C-X-C chemokine receptor 4 (CXCR4)/stromal cell-derived factor-1 (SDF-1) axis play pivotal roles in neutrophil mobilization, differentiation and proliferation. Bispecific antibodies represent a viable therapeutic strategy by simultaneously targeting these two granulocyte-associated receptors while providing an extended half-life. In this study, we engineered a bispecific antibody by grafting human G-CSF and a synthetic anti-CXCR4 peptide into the heavy chain complementarity-determining region 3 (CDR3) of the humanized antibody Herceptin.

[Effects of elastic modulus of the metal block on the condylar-constrained knee prosthesis tibial fixation stability].

Although metal blocks have been widely used for reconstructing uncontained tibial bone defects, the influence of their elastic modulus on the stability of tibial prosthesis fixation remains unclear. Based on this, a finite element model incorporating constrained condylar knee (CCK) prosthesis, tibia, and metal block was established. Considering the influence of the post-restraint structure of the prosthesis, the effects of variations in the elastic modulus of the block on the von Mises stress distribution in the tibia and the block, as well as on the micromotion at the bone-prosthesis fixation interface, were investigated.

Salvianolic Acid B and Ginsenoside Rg1 Combination Attenuates Cerebral Edema Accompanying Glymphatic Modulation.

Cerebral edema is characterized by fluid accumulation, and the glymphatic system (GS) plays a pivotal role in regulating fluid transport. Using the Tenecteplase system, magnesium salt of salvianolic acid B/ginsenoside Rg1 (SalB/Rg1) was injected intravenously into mice 4.5 h after middle cerebral artery occlusion and once every 24 h for the following 72 h.

L009 peptide as a novel antiangiogenic agent for corneal neovascularization via regulation of the TNFSF15-VEGF axis.

Corneal neovascularization (CNV) is a leading cause of vision impairment, with existing therapeutic options offering limited efficacy. This study presents L009, a novel antiangiogenic agent derived from the Kringle 5 domain of human plasminogen, specifically a heptapeptide, designed to treat CNV. In preclinical models, L009 demonstrated substantial efficacy by markedly inhibiting endothelial cell proliferation and migration, reducing vascular permeability, and maintaining ocular safety.

CurveMark: Detecting AI-Generated Text via Probabilistic Curvature and Dynamic Semantic Watermarking.

Large language models (LLMs) pose significant challenges to content authentication, as their sophisticated generation capabilities make distinguishing AI-produced text from human writing increasingly difficult. Current detection methods suffer from limited information capture, poor rate-distortion trade-offs, and vulnerability to adversarial perturbations. We present CurveMark, a novel dual-channel detection framework that combines probability curvature analysis with dynamic semantic watermarking, grounded in information-theoretic principles to maximize mutual information between text sources and observable features.

CAD hijacks STING to impair antitumor immunity and radiotherapy efficacy of colorectal cancer.

Radiotherapy (RT)-elicited antitumor immunity serves as a pivotal mechanism in RT-mediated tumor control. The strategic integration of RT with immunotherapies, particularly immune checkpoint blockade (ICB), is revolutionizing cancer therapeutics, demonstrating remarkable clinical potential. In this context, identifying molecular targets to potentiate radioimmunotherapy (RIT) efficacy represents a critical research priority.

Alterisocoumarins A-M: Isocoumarins with anti-inflammatory and anti-tuberculosis activities from a mangrove endophytic fungus Alternaria sp. HN-17.

Fifteen new isocoumarin derivatives 1-3, (±)-4, (±)-5, 6-10, (+)-11, (+)-12, and 13, together with eleven known analogues (-)-11, (-)-12, and 14-22 were isolated from the mangrove endophytic fungus Alternaria sp. HN-17. Their structures were unambiguously established by 1D/2D NMR and HRESIMS spectra, and electronic circular dichroism (ECD) calculations.

Zingibroside R1 Isolated From Achyranthes bidentata Blume Ameliorates LPS/D-GalN-Induced Liver Injury by Regulating Succinic Acid Metabolism via the Gut Microbiota.

Achyranthes bidentata Blume is a traditional Chinese medicine used to treat liver and kidney protection and improve liver injury; however, its active components and mechanism of action remain unclear. This study focused on the monomer compound zingibroside R1 (R1) from Achyranthes bidentata Blume, specifically studying its effects on liver injury through the modulation of succinic acid-mediated immunity and inflammation via the gut microbiota. We isolated R1 and investigated its therapeutic effects in a lipopolysaccharide (LPS)- and D-galactosamine-induced acute liver injury mouse model.

A PRF-Based Multibaseline fitting model for temperature prediction.

MRI is capable of constructing in vivo temperature profiles to provide precise thermal guidance for benign and malignant diseases and minimally invasive, rapid recovery and highly reproducible treatments for tumors and benign nodules. Despite the real-time thermal monitoring capabilities of proton resonance frequency (PRF) thermometry, this important magnetic resonance-based temperature measurement technique faces challenges in oncology energy therapy because it is susceptible to image alignment errors and magnetic induction field variations, resulting in unreliable temperature tracking. To address these issues, this study proposes a novel multibaseline fitting temperature prediction model based on proton resonance frequency.

Isovitexin and schaftoside from rice plants have antifeedant activity on brown planthoppers.

Background: Many secondary metabolites of plants have antifeedant activity against herbivorous insects and can be used as antifeedants in green plant protection. However, it is not clear whether the secondary metabolites of rice plants can act on the brown planthopper (BPHs) Nilaparvata lugens and can be used for pest control. In this study, we screened two flavonoids from rice plants that increased under N.

2″-O-rhamnosyl icariside Ⅱ from Epimedium sagittatum maxim ameliorates pulmonary fibrosis by modulating the E-cadherin-mediated oxidative-epithelial mesenchymal transition axis.

Ethnopharmacological Relevance: Epimedium sagittatum Maxim (EPI) is a prominent herb in Traditional Chinese Medicine (TCM) with a millennia-long history of therapeutic applications. In TCM theory, its actions are linked to improving blood circulation, reducing phlegm, and restoring lung qi regulation-functions that align with modern understandings of anti-fibrotic and anti-inflammatory mechanisms. 2″-O-rhamnosyl icariside Ⅱ (Ica Ⅱ), a compound isolated from EPI, has been shown to significantly reduce TGF-β1-induced injury in BEAS-2B cells.

Electroacupuncture Protects Against Post-stroke Cognitive Impairment by Promoting an IL-33/ST2 Axis-Mediated Microglia M2 Polarization.

Post-stroke cognitive impairment (PSCI) is a common and debilitating complication of stroke that significantly hinders rehabilitation. Electroacupuncture (EA), which integrates traditional acupuncture with electrical stimulation, has been widely applied in clinical practice and shown remarkable efficacy in treating PSCI. However, its underlying mechanisms remain largely unexplored.

Self-efficacy centered comprehensive interventions and effects in patients undergoing radical surgery for gastric cancer.

Objective: To assess the effects of self-efficacy theory centered comprehensive interventions on perioperative nutritional status, self-management ability, self-efficacy perception, and quality of life in patients undergoing radical surgery for gastric cancer.

Methods: Using a convenience sampling method, 213 patients who underwent radical gastrectomy for gastric cancer at a tertiary specialized hospital in Sichuan Province from October 2023 to April 2024 were selected as the research subjects for randomized controlled trial. The selected patients were randomly assigned to the experimental group with 107 cases and the control group with 106 cases.

The Nature of Oxidized Oxygen in Oxygen Redox Cathodes.

Oxygen redox cathodes (ORCs) are expected to surpass the capacity limits of conventional batteries. However, the commercialization of ORCs has suffered from severe voltage decay due to irreversible structural reconstructions, which are related to the evolution of oxidized oxygen upon charging. Several models have been proposed to elucidate the relationship between oxygen redox and cathode failures.

RIPK1 kinase drove brain microvascular endothelial cells death and blood-brain barrier disruption in neonatal Escherichia coli meningitis.

Neonatal meningitis Escherichia coli (NMEC) breaching the blood-brain barrier (BBB) is a critical event in the development of E. coli meningitis. Brain microvascular endothelial cells (BMECs), the primary structural component of the BBB, play a central role in defending against pathogen invasion.

Visible Light-Driven Soft Actuator Exhibiting Multistage Shape Morphing.

Traditional soft robots, while praised for their flexibility and biocompatibility, often face challenges with complex motion and adaptability. In this work, a visible light-driven liquid crystalline network (LCN) film with a multistage photo-responsive behavior is judiciously designed and prepared. By integrating donor-acceptor stenhouse adducts (DASAs) into LCN matrix, it is found that the DASA exhibits polymerization temperature-dependent isomerization, indicating an opportunity to fabricate complex photo-driven soft actuators and devices by simply adjusting the polymerization conditions.

Effects of Intracellular Polysaccharides and Proteins of on Water Quality, Floc Formation, and Microbial Composition in a Biofloc System.

The use of (formerly ) and its intracellular substances (ISs) to promote biofloc development has been extensively studied. To identify the key components of the ISs of that drive biofloc formation, algal-extracted polysaccharides (AEPSs) and algal-extracted proteins (AEPTs) were isolated from the ISs. In this study, we established four groups: ISs, AEPSs, AEPTs, and tap water (TW, control), to investigate the effects of AEPSs and AEPTs on biofloc formation dynamics, water quality parameters, and microbial community composition.

Identification of constitutional MLH1 methylation in MLH1-deficient colorectal cancer.

Background: Constitutional MLH1 methylation (epimutation), a poorly recognized mechanism for Lynch syndrome (LS), is usually overlooked due to current screening strategies that rely on tumor MLH1 methylation as an indication of sporadic mismatch repair-deficient (dMMR) colorectal cancer (CRC). We aimed to assess the frequency and clinicopathological characteristics of constitutional MLH1 methylation among dMMR CRC cases with tumor MLH1 methylation.

Methods: We conducted a retrospective study on two independent cohorts: a discovery cohort of 48 MLH1-deficient CRC cases (2017-2021) and a validation cohort of 159 consecutive CRC cases (2022-2024).

Machine learning to predict postdialysis fatigue in patients undergoing hemodialysis.

Background: Machine learning (ML) has been widely used to predict complications and prognosis in patients undergoing hemodialysis (HD). However, accurate and efficient models for predicting postdialysis fatigue (PDF) in this population are still needed because PDF is surprisingly prevalent.

Aims: This study aimed to explore the potential of ML models for predicting PDF in patients undergoing HD.

Sleeve gastrectomy alleviates anxiety-like behaviors in mice with high-fat diet induced obesity.

The efficacy of bariatric surgery (BS) in alleviating obesity-associated anxiety symptoms remains unclear. This study aimed to investigate the impact of BS on anxiety using an obese mouse model, elucidating the complex interplay between obesity, anxiety, and related biological factors. Sleeve gastrectomy (SG) was performed on mice rendered obese via a high-fat diet to establish a BS model.

Integration of preparative HPLC and quantitative H NMR with quantitative analysis of multi-components by single marker (QAMS) for rapid stilbene analysis in pigeonpea (Cajanus cajan (L.) Millsp.).

The quantification of stilbenes in pigeonpea (Cajanus cajan (L.) Millsp.) is critical for its development as a medicinal resource.