The Fritillaria alkaloid peiminine acts as a chemosensitizer to potentiate oxaliplatin efficacy against gastric cancer.

Background: Fritillaria walujewii Regel (Xinjiang Bei-Mu), an authentic ("Dao-di") medicinal herb documented in Chinese pharmacopoeias, is traditionally used to treat respiratory disorders. Its principal steroidal alkaloid, peiminine (PMI), demonstrates significant anticancer activity. Oxaliplatin (Oxa), a first-line chemotherapeutic cornerstone for gastric cancer (GC), is limited clinically by intrinsic chemoresistance.

Barriers and enablers of HPV vaccination among caregivers of school-age girls in resource-limited regions of Western Sichuan, China: a mixed-methods study.

Background: The HPV infection rate in Sichuan exceeds the national average. The provincial government has initiated vaccination programs, with a particular focus on impoverished areas such as the Ganzi, Aba, and Liangshan prefectures, where both the HPV disease burden is elevated and vaccination uptake remains suboptimal. This study aimed to investigate HPV vaccination among adolescent girls in these prefectures, evaluate caregivers' knowledge and attitudes, identify factors influencing their willingness to vaccinate their daughters, and examine existing policies to provide evidence-based recommendations for improving vaccination strategies.

40 Hz Audiovisual Stimulation Improves Sustained Attention and Related Brain Oscillations.

Gamma oscillations (30-100 Hz) have long been theorized to play a key role in sensory processing and attention by coordinating neural firing across distributed neurons. Gamma oscillations can be generated internally by neural circuits during attention or exogenously by stimuli that turn on and off at gamma frequencies. However, it remains unknown if driving gamma activity via exogenous sensory stimulation affects attention.

Olfactory training improves cognition and modifies brain networks in type 2 diabetes patients with mild cognitive impairment: A 16-week randomised controlled trial.

Aims: Type 2 diabetes (T2D) related cognitive impairment links to comorbid and modifiable olfactory dysfunction; however, the efficacy of olfactory training (OT) to mitigate cognitive decline specifically in these patients with mild cognitive impairment (MCI) remains unestablished. This study aimed to determine whether OT alleviates cognitive decline in this population.

Materials And Methods: In this 16-week, open-label trial, 60 T2D participants with MCI were randomly assigned (1:1) to OT or routine care (control).

The defensin-like protein OsCDT5 reduces Cd accumulation in rice (Oryza sativa L.).

Rice (Oryza sativa L.) is one of the most important food crops worldwide, with a strong capacity for Cd accumulation. Cd accumulation in rice is regulated by multiple genes.

Healthcare Utilization and Cost in the Two Years Before Neuromodulation Implantation Among Medicaid Enrollees with Drug-Resistant Epilepsy.

Background: Current treatment guidelines recommend consideration of neurostimulators and other alternative treatments to antiseizure medications in patients with drug-resistant epilepsy (DRE). This study assessed patterns of utilization and cost of healthcare services and prescription pharmacotherapies during the 2-year period before neurostimulator implantation among Medicaid enrollees with DRE.

Methods: This retrospective, observational cohort study used healthcare claims and enrollment data obtained from the US Centers for Medicare and Medicaid Services.

Preclinical evaluation of antitumor activity and toxicity of TROP2-specific CAR-T cells for treatment of triple-negative breast cancer.

Background: Triple-negative breast cancer (TNBC) represents a subtype of breast cancer with poorest prognosis due to limited effective targeted therapies. Chimeric antigen receptor T cell (CAR-T) therapy has shown remarkable efficacy in treating hematological cancers, but its application in TNBC requires further development. One major obstacle is the lack of suitable tumor-specific target in TNBC.

Increased 68Ga-FAPI Uptake of Ureteric Fibroepithelial Polyp and Costal Cyst Mimicking Malignancy With Bone Metastasis.

A 70-year-old man presented with progressive dysuria. 18F-FDG PET/CT showed no abnormal metabolic activity. 68Ga-FAPI PET/CT revealed intense 68Ga-FAPI in the lower left ureter and the left rib, mimicking malignancy with bone metastasis.

Chronic Waterborne Exposure to Polystyrene Microplastics Induces Kupffer Cell Polarization Imbalance and Hepatic Lipid Accumulation.

Microplastics (MPs), particles under 5 mm, are widespread environmental contaminants. Polystyrene (PS), used in many household items, degrades into polystyrene MPs (PS-MPs), which accumulate in the environment. Chronic exposure to waterborne PS-MPs was found to disrupt hepatic lipid metabolism in C57BL/6N mice through inflammatory Kupffer cell polarization and IL-17/NF-κB signaling pathways.

TM9SF1 as a Novel Prognostic Biomarker for Sepsis Severity and Mortality: A Longitudinal Study.

Background: Sepsis is a prevalent and detrimental condition in intensive care units (ICUs) and a leading cause of mortality. The present study evaluated the role and clinical importance of Transmembrane 9 superfamily member 1 (TM9SF1) as a potential indicator for the early detection of sepsis severity and prognosis.

Methods: This study included 118 patients with septic shock and 107 patients with sepsis, all of whom underwent follow-up assessments.

Comparative analysis of CDR3 length-dependent patterns in VHHs.

Introduction: VHHs, or nanobodies, are distinguished by their compact size, high stability, and unique ability to selectively target specific epitopes. The CDR3 region in VHHs, which plays a crucial role in antigen binding, exhibits significant diversity and varies among species.

Method: This study systematically examined CDR3 length dependent patterns by analyzing NGS sequences from the PBMCs of Alpacas, Llamas and Bactrians, in conjunction with VHH structure data from the public database.

Screening Candidates for Conversion Therapy in Unresectable Hepatocellular Carcinoma Patients After Tyrosine Kinase Inhibitor Plus PD-1/PD-L1 Antibody Therapy: A Multicenter Retrospective Study.

Background: Conversion therapies after immune checkpoint inhibitors (ICIs) plus tyrosine-kinase inhibitors (TKIs) provide curative surgery chance and prolong survival for unresectable hepatocellular carcinoma (uHCC). However, only some patients have the opportunity to receive conversion therapies. To this end, we aimed to develop and validate a machine-learning model to identify patients who may have the chance to undergo conversion therapy.

The Mkx- TGF-β pathway induced the development of the myodural bridge complex in SD rats.

Objective: The myodural bridge complex (MDBC) is a tendon-like structure highly conserved during vertebrate evolution, suggesting it plays an important physiological role. Substantial evidence indicates that the MDBC may contribute to cerebrospinal fluid (CSF) circulation by generating mechanical force. Studying its developmental process may offer new insights into CSF dynamics and lead to improved strategies for diagnosing and treating neurodegenerative diseases.

Enhanced non-radical activation of peroxymonosulfate by the P-doped CoO nanoparticles confined in SiO aerogel.

P-doped strategy exhibits remarkable advantages in the field of environmental catalytic materials due to its excellent charge modulation ability and enhanced chemical stability. Although the current SiO-based aerogel materials have outstanding high specific surface area properties, their lack of stability and poor electrical conductivity limit their application potential. Herein, the SiO aerogel confined material with P-doped CoO nanoparticles (P-Co@SiO2 aerogel) was constructed for the removal of tetracycline (TC) from water by the activation of peroxymonosulfate (PMS).

Effect of Blue Covarine Toothpastes on Tooth Colour: A Randomised Crossover Study.

Objective: To measure the effect of toothpastes containing blue covarine on tooth whiteness and yellowness.

Methods: This was a randomised, double-blind, 4-period, crossover design study conducted at a Chinese clinical research facility. Sixty-six participants with 2 natural upper central incisors (UCIs) with Vita tooth shade in range 2M2 to 3M3, without visible damage, gum recession, restorations or extrinsic/intrinsic stain, were allocated to evaluate 4 test toothpastes in random order using Williams square approach.

Selenium regulated the responses of soil bacterial communities to short-term elevated atmospheric CO stress.

Recent studies highlight essential metallic micronutrients (e.g., zinc, nickel, copper, iron, manganese) in influencing soil microbial structure and functions.

E3 ligase RAD18 targets phosphorylated IRF3 to terminate IFNB1 transcription.

The transcription factor interferon regulatory factor 3 (IRF3) initiates type I interferon transcription, which is required for host defense. Here, we identify RAD18 as a central E3 ubiquitin ligase that selectively targets phosphorylated IRF3 (p-IRF3) for autophagic degradation. RAD18 specifically promotes the dissociation of p-IRF3 from the IFNB promoter and in turn terminates its transcriptional activity.

Protective Efficacy of Subunit Vaccine Expressing Rv0976c Against Tuberculosis.

Objectives: The construction of subunit vaccines based on antigens that can induce strong cellular immunity is a widely accepted strategy to develop new tuberculosis vaccines. This study screens immunogens with potential for subunit vaccine development from seven candidate antigens and then verifies their vaccine efficacy.

Design: C57BL/6 mice were immunized subcutaneously with purified PPE19, PPE50, FadD21, Rv1505c, Rv1506c, Rv2035, and Rv0976c proteins formulated with Freund's adjuvant to evaluate both the antigen-specific Th1 cellular immune responses and IgG level.

End-of-Season Influenza Vaccine Effectiveness Against Laboratory-Confirmed Influenza in Outpatient Settings, Beijing, China: A Test-Negative Design.

This study aimed to estimate the end-of-season influenza vaccine effectiveness (VE) for the 2024/25 season in Beijing, China. We used a test-negative design (TND) to assess influenza VE among outpatients with influenza-like illness (ILI) enrolled through the influenza virological surveillance in sentinel hospitals in Beijing from week 44, 2024 to week 14, 2025. Cases were ILI patients who tested positive for influenza; controls were those who tested negative.

Root-Zone Temperature Drives Coordinated Photosynthesis, Root Architecture, and Metabolism Responses in (Trucz.) Baill.

Soil warming due to climate change has a significant potential impact on crop yield and quality. (Trucz.) Baill, a multipurpose plant disseminated in the highly climate-sensitive region of Northeast Asia, is affected by soil warming, which limits the supply and quality of raw materials.

Analysis of the Differences in Rhizosphere Microbial Communities and Pathogen Adaptability in Chili Root Rot Disease Between Continuous Cropping and Rotation Cropping Systems.

In chili cultivation, obstacles to continuous cropping significantly compromise crop yield and soil health, whereas crop rotation can enhance the microbial environment of the soil and reduce disease incidence. However, its effects on the diversity of rhizosphere soil microbial communities are not clear. In this study, we analyzed the composition and characteristics of rhizosphere soil microbial communities under chili continuous cropping (CC) and chili-cotton crop rotation (CR) using high-throughput sequencing technology.

Polysaccharides Alleviate Aflatoxin B1-Induced Liver Damage and Immune Disorders by Inhibiting the ROS-Mediated Mitochondrial Apoptosis Pathway.

polysaccharide (DSPS) is the main natural compound extracted from the traditional Chinese herb . Although DSPS is well-known for its antioxidant and anti-inflammatory properties, its impact on aflatoxin B1 (AFB1)-induced damage has not been explored. This study aims to investigate the potential protective mechanisms of DSPS against AFB1-induced liver damage and immune disorders.

Report on the relevance of perovskite module outdoor ageing performance and indoor UV degradation trend.

Perovskite solar cells have made remarkable progress in laboratory-scale efficiency, positioning them as a promising next-generation photovoltaic technology. However, their long-term operational stability under real-world conditions remains a critical barrier to commercial deployment. This study presents a three-year outdoor field investigation of a micro power station composed of 20 perovskite sub-modules (FACsPbI-based, each measuring 30 cm × 40 cm), deployed in subtropical eastern China and fabricated using scalable, industry-compatible processes.

Effect Evaluation and Mechanism Study of Polyether Surfactant-Assisted Supercritical Carbon Dioxide-Oil Miscibility Based on the Visible Vanish of Interface Measurement Method.

Research on reducing the minimum miscible pressure (MMP) of CO and oil is imperative for the advancement of CO flooding, which can effectively enhance the recovery of low-permeability reservoirs and enable CO geological storage. However, the conventional methods of determining the MMP (e.g.

Insulin resistance in school-age children: comparison surrogate diagnostic markers.

Background: This study aimed to identify surrogate markers suitable for evaluating insulin resistance in children and adolescents with overweight and obesity.

Methods: Forty-nine reported surrogate markers of insulin resistance were selected, including 14 insulin-based markers and 35 non-insulin-based markers. The markers were analyzed in 800 children aged 7-12 years.