A magnetic porous carbon material achieving rapid and convenient separation of volatile cinnamaldehyde in cinnamon.

Rapid and convenient enrichment and detection of volatile cinnamaldehyde (Cin) from a common herbal medicine, cinnamon, was achieved through a reliable MSPE-HPLC-DAD approach. The magnetic porous carbon material (Carbon-FeC/lignin) used for MSPE was prepared as follows. First, the metal organic framework (MIL-101-NH (Fe)) was synthesized using the solvothermal method.

Selenium regulated the responses of soil bacterial communities to short-term elevated atmospheric CO stress.

Recent studies highlight essential metallic micronutrients (e.g., zinc, nickel, copper, iron, manganese) in influencing soil microbial structure and functions.

Toxoplasma gondii PPM3H regulates the parasite virulence and modulates host immune and inflammatory responses in mice.

Toxoplasma gondii is an obligate intracellular parasite that causes severe illness in infants infected during pregnancy and in immunocompromised individuals. This parasite manipulates host cells through effector proteins that promote its survival and replication. While the phosphatases in the PP2C family have been shown to regulate host immune responses and contribute to the virulence and pathogenicity of various pathogens, the specific biological functions of PPM3H in T.

Twisted Bilayer Materials as a Promising Platform for Solid-State Qubits.

Qubits are the fundamental units in quantum computing, quantum communication, and sensing. In current platforms, such as cold atoms, superconducting circuits, point defects, and semiconductor quantum dots, each qubit requires individual preparation, making identical replication a challenging task. Constructing and maintaining stable, scalable qubits remains a formidable challenge.

Nitric oxide induces apoptosis of human primary melanocytes by regulating calcium homeostasis via VDAC1.

Vitiligo is an autoimmune skin disease that originates from damage and loss of melanocytes (MCs). Studies have identified abnormal nitric oxide (NO) metabolism in vitiligo patients, but the mechanisms by which NO contributes to MC loss remain unclear. Skin samples from patients with vitiligo and healthy controls were collected to evaluate the expression of three nitric oxide synthases (NOS) isoforms.

Cellular composition of tissue-resident monocyte-lineage cells reveal functional heterogeneity during inflammatory arthritis.

Tissue-resident monocyte-lineage cell (TRMC) are an extravascular population distinct from circulating monocytes and synovial macrophages and are critical for the development of inflammatory arthritis. However, the precise identities and origins of TRMC subpopulations remain unclear. Here, we characterize the ontogeny of TRMC, which are comprised of bone-marrow (BM)-derived and an embryonic, long-lived population.

Inhibition of FOXM1 Synergizes with BH3 Mimetics Venetoclax and Sonrotoclax in Killing Multiple Myeloma Cells through Repressing MYC Pathway.

Relapsed and refractory multiple myeloma (RRMM) remains the leading cause of MM mortality. FOXM1 is strongly associated with RRMM, making it a compelling therapeutic target. Through three low-throughput screenings, we have identified nine FDA-approved drugs, including the BH3 mimetic Venetoclax, that synergize with FOXM1 inhibitor NB73 in killing MM cells.

Comparative analysis of mitochondrial and chloroplast genomes of from contrasting island habitats.

Introduction: , a vulnerable species widely distributed in tropical and subtropical areas, has been recognized as a model plant for studying island conservation biology due to its fragmented habitat, slow growth, and ecological sensitivity. However, its organelle genome evolution and population divergence across different island environments remain poorly understood.

Method: In this study, we assembled and annotated the complete chloroplast (cp) and mitochondrial (mt) genomes of two geographically distinct individuals of from Hainan Island, China: a coastal area (SY) and a mountainous forest area (DF).

Comparative efficacy of Ba-Duan-Jin and pregabalin in the treatment of fibromyalgia: An RCT with an exploratory analysis based on fMRI.

A clinical study used pregabalin as a control to test the effectiveness and safety of Ba-Duan-Jin for fibromyalgia (FM) and explore the relation with brain function. This was a 12-week, prospective, randomized, single-blind trial with 36-week follow-up. A total of 104 FM patients were randomly assigned to Ba-Duan-Jin or pregabalin group.

A Comparative Analysis Dissecting the Immune Landscape of Vitiligo and Melanoma from a single-cell Perspective: Two Sides of the Same Coin?

Background: Vitiligo and melanoma, while sharing overlapping immune responses and cellular environments, represent distinct dermatological conditions. A comprehensive comparison of the immune microenvironments in vitiligo and melanoma through detailed single-cell analysis has not yet been thoroughly defined.

Methods: Integrated single-cell RNA sequencing (scRNA-seq) data were obtained from healthy controls, vitiligo and melanoma patients.

Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors.

Introduction: Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment of refractory hematological malignancies, yet significant challenges persist in extending its success to solid tumors. This review aims to provide a comprehensive overview of the current landscape and future perspectives of CAR-T therapy in both hematological malignancies and solid tumors.

Methods: A thorough literature search was conducted to identify relevant preclinical and clinical studies, as well as review articles, focusing on CAR-T therapy in various hematological malignancies and solid tumors.

Two Neuroanatomical Subtypes in Fibromyalgia Patients: Distinct Morphological Patterns and Treatment Outcomes.

Objectives: To better investigate neurobiological heterogeneity in fibromyalgia for its symptom diversity and individual differences.

Methods: We collected structural MRI data and clinical characteristics of Chinese female fibromyalgia patients and healthy controls matched by age and educational level, then invited qualified patients to undergo either Ba-Duan-Jin or pregabalin intervention for 12 weeks randomly. Structural MRI was analyzed by CAT12 software, and the regional volume of gray matter (GMV) was calculated according to the Brainnetome atlas.

Explorations of a novel effector CcAA9-20333 from Colletotrichum coccodes: the potential roles played in host immunity.

The AA9 LMPO protein, CcAA9-20333, acts as a secretory effector by inhibiting N. benthamiana cell death via its enzymatic activity and contributes to the virulence of C. coccodes.

LGRPv2: A high-value platform for the advancement of Fabaceae genomics.

Fabaceae, as one of the most diverse angiosperm families, plays a crucial role in maintaining global ecosystems and advancing human civilization. With the rapid accumulation of legume genomes, we developed LGRPv2 (https://fabaceae.cgrpoee.

POSS-based hybrid biomaterials for tissue engineering and regenerative medicine.

Polyhedral oligomeric silsesquioxanes (POSS), as an organic-inorganic hybrid nanomaterial, have shown broad application prospects in biomedical field due to their unique rigid nano core structure and abundant modifiable functional groups. These characteristics make it an ideal platform for preparing POSS-based hybrid biomaterials (POSSHB) with controllable mechanical properties and tunable degradability. This article systematically elaborates on the preparation method, structural characteristics, and basic properties of POSSHB; The latest research progress of this type of material in the fields of bone and cartilage regeneration, wound repair, cardiovascular tissue engineering, nerve repair, dental restoration, ophthalmic treatment, and skeletal muscle regeneration is summarized, and the key role of POSSHB in tissue regeneration is deeply explored; Finally, future development directions and prospects are proposed in response to the limitations of current research.

Investigating the role of calcium ions in modulating the physicochemical and gel properties of myofibrillar protein-soybean protein isolate binary composites.

This study investigated the role of Ca in modulating the physicochemical and gelation properties of myofibrillar protein (MP)-soybean protein isolate (SPI) binary systems, which were constructed with varying additions of SPI. Structural analysis revealed that Ca neutralized surface charges, reduced electrostatic repulsion, and promoted hydrogen bonding (primary interaction) and ionic bridges between MP and SPI, leading to enhanced gel network formation. At 50 % SPI content, the composite gel exhibited optimal water-holding capacity (87.

CARM1-Mediated MAP2K4 Methylation Potentiates the Oncogenic Functions of MAP2K4 and Constitutes a Targetable Dependency in Triple-Negative Breast Cancer.

Unlabelled: The arginine methyltransferase coactivator-associated arginine methyltransferase 1 (CARM1) is amplified/overexpressed in a variety of cancers, including triple-negative breast cancer (TNBC), spurring the interest of developing CARM1 inhibitors (CARM1i). In this study, we discovered that CARM1i treatment leads to elevated CARM1 levels as well as activation of AKT, which could result in long-term treatment resistance in breast cancer cells. CARM1 methylated MAP2K4 at arginine 58 in TNBC, and methylated-MAP2K4 localized to the nucleus and potentiated the proliferation- and metastasis-promoting functions of MAP2K4 via activation of JNK signaling.

Vina-CUDA: An Efficient Program with in-Depth Utilization of GPU to Accelerate Molecular Docking.

As a mainstream technology in modern drug discovery, molecular docking methodologies enable precise and efficient identification of lead compounds within large chemical repositories to improve drug development efficiency and reduce costs. The exponential growth of chemical databases has substantially expanded drug discovery resources while improving the identification rates of true positives in lead compounds. However, this rapid expansion poses significant challenges for existing docking tools to efficiently screen lead compounds from these massive chemical libraries.

PD-L1 antibody-modified plant-derived nanovesicles carrying a STING agonist for the combinational immunotherapy of melanoma.

Combination therapies for melanoma face challenges due to asynchronous drug delivery and associated toxicity, underscoring the need for advanced delivery systems. While immune checkpoint inhibitors (ICIs) enhance T cell activity, optimal cytotoxic responses require efficient antigen presentation by mature dendritic cells (DCs), which are often functionally impaired in the tumor microenvironment. Thus, effective treatment requires coordinated T cell activation, DC-mediated priming, and direct tumor suppression.

Analysis of the complete mitogenomes of three high economic value tea plants (Tea-oil Camellia) provide insights into evolution and phylogeny relationship.

Introduction: Tea-oil Camellia species play a crucial economic and ecological role worldwide, yet their mitochondrial genomes remain largely unexplored.

Methods: In this study, we assembled and analyzed the complete mitochondrial genomes of and , revealing multi-branch structures that deviate from the typical circular mitochondrial genome observed in most plants. The assembled mitogenomes span 953,690 bp () and 923,117 bp (), containing 74 and 76 annotated mitochondrial genes, respectively.

Accelerated ultrashort echo time quantitative magnetization transfer (UTE-qMT) imaging of macromolecular fraction (MMF) in cortical bone based on a self-attention convolutional neural network.

Purpose: To combine ultrashort echo time quantitative magnetization transfer (UTE-qMT) imaging with a self-attention convolutional neural network (SAT-Net) for accelerated mapping of macromolecular fraction (MMF) in cortical bone.

Materials And Methods: This institutional review board-approved study involved 31 young female subjects (young control, <45 years) and 50 postmenopausal subjects (6 normal (old control), 14 with osteopenia (osteopenia group), and 30 with osteoporosis (OP group)). After written informed consent was obtained from each subject, 15 UTE-qMT images of the tibial midshaft were acquired with three saturation powers (500°, 1000°, and 1500°) and five frequency offsets (2, 5, 10, 20, and 50 kHz) for each power to estimate the baseline MMF using a two-pool model.

Pyrolysis oil to power: Carbon nanomaterials as photosensitizers for high-performance Dye-Sensitized Solar Cells.

Pyrolysis oil, a byproduct of biomass pyrolysis, has faced significant challenges due to its high acidity, complex composition, and low heating value, limiting its direct application. This study presents an innovative approach to valorize cornstalk-derived pyrolysis oil by transforming it into advanced carbon-based nanomaterials for Dye-Sensitized Solar cells (DSSCs). Through atmospheric distillation, pyrolysis oil was converted into bio-oil-derived char, featuring a hybrid structure of graphitic (sp) and disordered (sp) domains enriched with oxygen and nitrogen functionalities.

Shexiang Baoxin Pill alleviates atherosclerosis by inhibiting macrophage-mediated inflammation via suppressing KMT5A mediated Irf7 transcription.

Ethnopharmacological Relevance: Shexiang Baoxin Pill (SBP) is a traditional compound formulation composed of seven Chinese medicinal ingredients. Although SBP has shown promising clinical outcomes in the treatment of cardiovascular diseases, its role and underlying mechanisms in alleviating atherosclerosis remain insufficiently studied.

Aim Of The Study: This study aims to investigate the effects and mechanisms of SBP in epigenetic modulating macrophage inflammatory responses to mitigate atherosclerosis.

Multiplex one-step RT-qPCR assays for simultaneous detection of BRV, BCoV, K99 and .

Introduction: Bovine rotavirus (BRV), bovine coronavirus (BCoV), K99 ( K99), and () are the most common pathogens involved in calf production. These pathogens can cause calf diarrhea, leading to significant economic losses in the cattle farming industry. These four pathogens have similar clinical symptoms, making them difficult to distinguish.