Diatom-inspired hierarchical carbon catalysts advance sustainable water decontamination via electron transfer-driven peroxide activation.

Catalysts for heterogeneous advanced oxidation processes (AOPs) in water remediation face environmental sustainability challenges, due to the intensive production of catalysts and limited stability of catalysts while maintaining high efficiency. Herein, we design a biomimetic carbon catalyst (BCC) inspired by the diatom frustule valve structure, achieving high environmental sustainability while maintaining superior water decontamination performance by a non-radical direct electron transfer (DET) pathway through activating peracetic acid (PAA). Utilizing a hydrogen-bonding strategy, BCC features pillared layered hierarchical pores with an ultrahigh specific surface area of 2710.

Persistent burden and health inequalities of disease in women of childbearing age attributable to Intimate Partner Violence, 1990-2021.

Aims: Intimate Partner Violence (IPV) presents a significant global public health issue, particularly affecting women of childbearing age (WBCA). The COVID-19 pandemic has exacerbated the IPV globally. This study aimed to assess the global burden and health inequalities attributable to IPV among WBCA from 1990 to 2021.

Target volume delineation of the neck for radiotherapy in nasopharyngeal carcinoma: CSTRO, CACA, CSCO, HNCIG, ESTRO, and ASTRO guidelines and contouring atlas.

The Chinese Society for Therapeutic Radiology Oncology, the Chinese Anti-Cancer Association, the Chinese Society of Clinical Oncology, the Head and Neck Cancer International Group, the European Society for Radiotherapy and Oncology, and the American Society for Radiation Oncology collaboratively developed evidence-based guidelines and a comprehensive contouring atlas for neck target volume delineation in nasopharyngeal carcinoma. These guidelines address five key challenges in modern radiotherapy practice: margin design of clinical target volume; nodal target volume delineation after induction chemotherapy; delineation of equivocal nodes evident on imaging; low-risk clinical target volume delineation based on regional stepwise extension patterns; and modifications for anatomical boundaries of lymphatic areas. Developed through a rigorous systematic review and expert appraisal process by a panel of 50 international, multidisciplinary members from 17 countries and regions, these guidelines incorporate the latest advances in nasopharyngeal carcinoma diagnosis and treatment.

Primary target volume delineation for radiotherapy in nasopharyngeal carcinoma: CSTRO, CACA, CSCO, HNCIG, ESTRO, and ASTRO guidelines and contouring atlas.

The Chinese Society for Therapeutic Radiology Oncology, the Chinese Anti-Cancer Association, the Chinese Society of Clinical Oncology, Head and Neck Cancer International Group, the European Society for Radiotherapy and Oncology, and the American Society for Radiation Oncology jointly developed evidence-based guidelines and a contouring atlas for primary target volume delineation for radiotherapy in nasopharyngeal carcinoma. The guidelines systematically address three crucial challenges: margin design of clinical target volumes; target volume delineation after induction chemotherapy; and low-risk clinical target volume delineation based on local stepwise extension patterns. Based on a comprehensive systematic review and critical appraisal by an international multidisciplinary panel of 50 nasopharyngeal carcinoma specialists from 17 countries and regions, these guidelines are in keeping with advances in nasopharyngeal carcinoma diagnosis and treatment, embodying contemporary treatment concepts, and elaborating on the differences in practice.

A Non-Newtonian Sol Electrolyte with Shear-Thinning Effect for Stable Zn Metal Anodes.

Aqueous Zn metal batteries (AZMBs) emerge as promising candidates for large-scale energy storage due to their cost-effectiveness and safety, yet challenges like dendrite growth, hydrogen evolution, and poor cycling stability persist. Herein, a homogeneous non-Newtonian electrolyte (NNE) with shear-thinning property is designed to address these challenges. The NNE is prepared by incorporating a thickening polyquaternary ammonium salt, forming a super-viscous sol electrolyte while maintaining high ionic conductivity (52.

Modulating covalency competition and neutral microenvironment in cobalt spinel catalysts enables sustainable peracetic acid activation and ultrafast antibiotics degradation.

Conventional cobalt spinel oxides, widely employed in advanced oxidation processes, suffer from limited catalytic activity due to competitive overlap of O 2p orbitals between tetrahedral (Co) and octahedral cobalt (Co). Furthermore, their narrow pH activity window near neutrality severely restricts environmental applicability. To address these limits, the theories of covalency competition and microenvironment modulation are introduced to simulate the catalytic process and propose optimization strategies.

China Expert consensus on the application of metagenomic next-generation sequencing for the etiological diagnosis of infections in hematological disorders (2024).

Infections are frequent complications in patients with hematological disorders, and pathogen diagnosis remains challenging. Metagenomic next-generation sequencing (mNGS) is an unbiased high-throughput technology that has been widely applied in the diagnosis of infectious diseases. However, to date, there are no established international guidelines or expert consensuses regarding the use of mNGS to diagnose infections in patients with hematologic disorders.

Aptamer-Functionalized Redox-Responsive Mesoporous Organosilica-Coated Selenium Nanoparticles for Targeted Therapy of Triple-Negative Breast Cancer Cells.

Selenium nanoparticles (SeNPs) exhibit tumor-suppressive capabilities via reactive oxygen species (ROS)-mediated mitochondrial dysfunction, yet their biomedical application remains constrained by poor targeting specificity and aqueous instability. Herein, we engineered glutathione-responsive therapeutic nanoparticles by encapsulating SeNPs within mesoporous organosilica (MON) isolation layers to ensure aqueous stability, while conjugating LXL-1 aptamers for targeted delivery to triple-negative MDA-MB-231 breast cancer cells. In vitro assessments across breast cell lines (MDA-MB-231 vs MCF-10A/MCF-7) revealed a 5.

Treatment response-adapted risk index model for survival prediction and adjuvant chemotherapy selection in nonmetastatic nasopharyngeal carcinoma.

Dynamic response to therapy is strongly associated with cancer outcomes. We aim to develop the response-adapted individualized risk index (RAIRI) as an individual prognostic approach and predictive biomarker for adjuvant chemotherapy (AC) benefit in nasopharyngeal carcinoma (NPC) based on pretreatment clinical characteristics, longitudinal cell-free Epstein-Barr virus DNA, and MRI-based tumor regression measurements collected during treatment. Using Bayesian joint model, we developed and validated RAIRI, a dynamic and multidimensional model, with 2148 patients in training, internal validation, external validation, and RCT cohorts (ClinicalTrials.

Ion transport-triggered rapid flexible hydrovoltaic sensing.

The hydrovoltaic effect, based on interactions at the solid-liquid interface, offers a promising route for ion sensing. However, it is hampered by long response times, typically several minutes, due to slow ion diffusion equilibrium in nanochannels. Here, we demonstrate a rapid, flexible hydrovoltaic ion sensing strategy enabled by fast ion transport.

Phytochrome-interacting factors 3 (AbPIF3) synergistically regulates anthocyanin, carotenoids and chlorophyll biosynthesis in the chimeric leaves of Ananas comosus var. bracteatus.

Ananas comosus var. bracteatus, known for its ornamental chimeric leaves, exhibits a colorful pattern due to a combination of central photosynthetic tissue (CP) and marginal albino tissue (MA). The leaves turn red during spring and autumn, driven by changes in pigments biosynthesis.

Ellagic acid on milk production performance, blood and milk hormones, antioxidant capacity and fecal microbial communities in lactating Yili mares.

Ellagic acid (EA), a natural polyphenol, exerts potent antioxidant and anti-inflammatory effects in humans and other animals, while contributing to intestinal microbiota homeostasis. This study investigated the impact of EA supplementation on milk production, hormone secretion, antioxidant activity, and gut microbiota in lactating Yili mares. Eighteen lactating Yili mares with an average body weight of 400.

Avian Influenza Surveillance Among Migratory Birds, Poultry, and Humans Around Nansi Lake, China, 2021-2024.

Avian influenza A viruses (AIVs) pose a significant pandemic threat due to their cross-species transmission potential. However, AIV surveillance at the critical "migratory birds-poultry-exposed population" interface remains limited. Between 2021 and 2024, we implemented a prospective One Health surveillance program around Nansi Lake, monitoring AIVs in migratory birds, poultry, and environmental samples, as well as serological investigations against representative AIVs among migratory birds or poultry-exposed subjects.

Association Between Exercise Behavior Stages and Obesity Transition in Children and Adolescents: A Nationwide Follow-Up Study.

To examine the association between stages of exercise behavior change, as defined by the transtheoretical model (TTM), and obesity progression among Chinese children and adolescents, with attention to gender and urban-rural differences. A total of 5006 Chinese children and adolescents aged 9-18 years were assessed in 2019 and followed up in 2020. Participants were categorized into five TTM stages: precontemplation, contemplation, preparation, action, and maintenance.

Environmental Effects on Bacterial Community Assembly in Arid and Semi-Arid Grasslands.

Studying the effects of environmental factors on microbial community assemblies is crucial for understanding microbial biodiversity and ecosystem processes. Although numerous studies have explored the spatial patterns of microbial communities in surface soils, bacterial community distributions in subsurface layers remain poorly understood. We investigated multiple community metrics of soil bacteria in arid and semi-arid grasslands in China, and the V4 region of 16S rDNA was analyzed using soil property measurements, fluorescent PCR, and high-throughput sequencing techniques.

Toxoplasma gondii PPM3H regulates the parasite virulence and modulates host immune and inflammatory responses in mice.

Toxoplasma gondii is an obligate intracellular parasite that causes severe illness in infants infected during pregnancy and in immunocompromised individuals. This parasite manipulates host cells through effector proteins that promote its survival and replication. While the phosphatases in the PP2C family have been shown to regulate host immune responses and contribute to the virulence and pathogenicity of various pathogens, the specific biological functions of PPM3H in T.

MRI-based Middle Neck Involvement in Stage N1-N2 Nasopharyngeal Carcinoma: A Marker for Risk Stratification.

Background The prognostic implications of middle neck involvement, defined as cervical lymph node metastasis between the caudal border of the hyoid bone and the cricoid cartilage, remain unclear in nasopharyngeal carcinoma (NPC). Purpose To investigate the prognostic significance of middle neck involvement in patients with N1 or N2 NPC. Materials and Methods This retrospective analysis included patients with N1 or N2 NPC without distant metastasis treated between April 2009 and December 2017.

Evaluation of Modified CC Stabilization using LARS Artificial Ligament in Unstable Distal Clavicle Fracture.

Unstable distal clavicle fractures are clinically common, and there is no consensus regarding gold-standard treatment. The purpose of this study was to report on a new surgical technique for the treatment of unstable distal clavicle fracture with modified coracoclavicular (CC) stabilization using a ligament augmentation and reconstruction system (LARS) of an artificial ligament, and to compare the clinical and radiographic outcomes with hook-plate fixation.Thirty patients with unstable distal clavicle fractures were treated with modified coracoclavicular (CC) stabilization using either a ligament augmentation and reconstruction system (LARS) or open reduction internal fixation with a hook plate.

Roles and features of smart control and sensing applications for sleep quality improvement: a scoping review.

Objectives: This scoping review synthesises evidence on the measures and characteristics of the components of combined smart control and sensing technologies, and their impact on sleep quality.

Design: Scoping review following Joanna Briggs Institute (JBI) methodology and reports using the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews (PRISMA-ScR).

Data Sources: A comprehensive literature search was conducted in PubMed, Web of Science, EMBASE, Ovid, China National Knowledge Infrastructure, Wanfang Data and VIP Information from the inception of the databases to November 2024 following the PRISMA-ScR statement and updated in June 2025.

CO-promoted polyethylene hydrogenolysis with renewable formic acid as hydrogen donor.

Hydrogenolysis has emerged as a promising strategy for the chemical recycling of plastic waste, yet its reliance on high-pressure hydrogen poses significant challenges. Biomass- or CO-derived formic acid (FA) is a renewable hydrogen carrier with the advantages of low toxicity and ease of storage and transport. Here, we use FA to replace high-pressure hydrogen to convert polyethylene (PE) into fuels and chemicals with only 4.

Toripalimab Combination Therapy Without Concurrent Cisplatin for Nasopharyngeal Carcinoma: The DIAMOND Randomized Clinical Trial.

Importance: With the programmed cell death protein 1 (PD-1) blockade toripalimab, omitting highly toxic concurrent cisplatin may be feasible for nasopharyngeal carcinoma (NPC) without compromising survival.

Objective: To evaluate the efficacy and safety of toripalimab incorporated into induction chemotherapy and radiotherapy, without concurrent cisplatin, for locoregionally advanced NPC.

Design, Setting, And Participants: Open-label, multicenter, randomized phase 3 clinical trial conducted from August 2021 to July 2022 at 13 hospitals in China, enrolling 532 patients with T4N1M0 or T1-4N2-3M0 NPC; 400 (75.

In vitro probiotic characteristics and whole-genome sequence analysis of lactic acid bacteria isolated from monkey faeces.

This study aimed to isolate lactic acid bacteria from monkey faeces and evaluate their safety and probiotic properties through a combination of in vitro assays and complete genomic sequencing. The results revealed that two strains (LDHa and LSHe) exhibited promising probiotic attributes: no hemolytic activity, remarkable antibacterial activity against intestinal pathogens, high bile salt tolerance (77.46% survival rate for LDHa at 0.

Prediction Model and Assessment of Work-Related Musculoskeletal Disorders Among Nurses in Tertiary Hospitals in China: A Cross-Sectional Study.

Work-related musculoskeletal disorders (WMSDs) significantly impact the health and work efficiency of nurses. This study aimed to investigate factors influencing WMSD risk among nurses, including protective measures, physical activity, and biomechanical factors. This cross-sectional study surveyed 3500 nurses from tertiary hospitals to assess musculoskeletal disorder risk factors, yielding 3380 valid responses.

The surface nutrients in China's coastal waters in the winter of 2025.

Nutrients are the material basis of marine ecosystems, and understanding their levels and structures is of great significance for fully understanding marine ecosystems. Based on a survey of surface water in China's coastal waters in January 2025, this study explored the spatial heterogeneity and controlling factors of nutrient distribution in different areas of China's coastal waters. The results showed that there are significant regional variations in nutrient levels and structures, with the East China Sea exhibiting the highest concentrations of NO-N, PO-P, and SiO-Si, while the South China Sea showing the lowest levels and a distinct nitrogen-deficient signature.