Lipidomics in chicken meat flavor chemistry: Current understanding, integrated omics approaches, and future perspectives.

Chicken meat flavor is a significant factor in consumer preferences and purchasing behaviors, including taste, aroma, and texture, directly impacting perceived chicken meat quality. The formation of chicken meat flavor is predominantly regulated by various biochemical processes such as lipid oxidation, Maillard reaction, and thiamine degradation. The lipids significantly impact the flavor of chicken meat.

Functional differentiation of industrial hemp rhizosphere microbiome along environmental gradients.

The southwestern, central, and northeastern regions of China are the primary cultivation areas for industrial hemp. Microorganisms within the soil-root continuum play a crucial role in plant health. However, the mechanisms by which these microbial communities respond to environmental gradients remain unclear.

[Clinical and histological evaluation of three-dimensional printing individualized titanium mesh for alveolar bone defect repair].

Objectives: To evaluate the osteogenic efficacy of three-dimensional printing individualized titanium mesh (3D-PITM) as a scaffold material in guided bone regeneration (GBR).

Methods: 1) Patients undergoing GBR for alveolar bone defects were enrolled as study subjects, and postoperative healing complications were recorded. 2) Postoperative cone beam computed tomography (CBCT) scans acquired at least 6 months post-surgery were used to calculate the percentage of actual bone formation volume.

Deciphering intrakingdom synergism in 17β-estradiol degradation through DNA-SIP coupled metagenomics: Metabolic cooperation and niche partitioning in bioaugmented soil microbiomes.

17β-Estradiol (17β-E2), a persistent endocrine-disrupting compound, threatens ecosystem health through bioaccumulation. While bioaugmentation offers promise for environmental remediation, mechanistic insights into interspecies interactions between exogenous and indigenous degraders remain underexplored. Here, a synthetic microbial consortium (EL) was constructed by combining Rhodococcus erythropolis D310-1 and Microbacterium oxydans ML-6, which reduced the 17β-E2 degradation half-life by 53.

Optimizing pureed diets via texture analysis: A study on the impact of different energy levels and ingredient ratios on nasogastric tube patency.

Objective: This study aimed to investigate the impact of different energy levels and ingredient ratios on the nasogastric tube patency of pureed diets, optimizing the formulations to meet the nutritional requirements of elderly nasogastric feeding patients while minimizing tube blockage risk.

Methods: The study followed the guidelines of the "Chinese Resident's Balanced Diet Pyramid" and formulated five different energy levels of pureed diets (900 kcal, 1200 kcal, 1500 kcal, 1800 kcal, and 2100 kcal) using natural food groups. The diets consisted of seven major food categories: cereals and tubers, vegetables, meats, milk, oil, salt, and fruits.

Liberating Exciton Transfer as a Pioneering Strategy to Construct Type I Photosensitizers for Hypoxia Deep-Seated Metastases Suppression.

Type I photosensitizers (PSs) have revolutionized traditional photodynamic therapy for hypoxia tumors by eliminating oxygen dependence. Nevertheless, the current development of Type I PSs faces formidable obstacles stemming from the paucity of universal regulatory strategies that steer molecular systems toward efficient reactive oxygen species (ROS) generation through the Type I electron transfer pathway. Herein, we propose the "liberating exciton transfer" strategy to construct a series of Type I PSs (IDMX, X = H, F, Cl, Br) with remarkable generation of superoxide radicals (O ) and hydroxyl radicals (•OH).

Palonosetron plus megestrol acetate versus palonosetron plus dexamethasone in preventing moderately emetogenic chemotherapy-induced nausea and vomiting: a randomized, multicenter, crossover trial.

Backgrounds: Evidence shows that megestrol acetate (MA) is a potential antiemetic for preventing chemotherapy-induced nausea and vomiting (CINV). No persuasive clinical trials have been performed to validate the efficacy and safety of MA. Here we designed a randomized controlled trial to assess the efficacy of palonosetron plus megestrol acetate versus palonosetron plus dexamethasone (DEX) in preventing chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy (MEC) regimens.

CO-promoted polyethylene hydrogenolysis with renewable formic acid as hydrogen donor.

Hydrogenolysis has emerged as a promising strategy for the chemical recycling of plastic waste, yet its reliance on high-pressure hydrogen poses significant challenges. Biomass- or CO-derived formic acid (FA) is a renewable hydrogen carrier with the advantages of low toxicity and ease of storage and transport. Here, we use FA to replace high-pressure hydrogen to convert polyethylene (PE) into fuels and chemicals with only 4.

Estrogen receptor 1 (ESR1) promotes Di-butyl phthalate (DBP)-induced hypospadias by regulating mitophagy through PINK1-Parkin axis to inhibit ferroptosis.

This study reveals how Di-butyl phthalate (DBP), an estrogen-mimicking environmental pollutant, induces hypospadias by inhibiting ferroptosis through ESR1 activation and PINK1-Parkin-dependent mitophagy. Utilizing a prenatal DBP-exposed fetal rat hypospadias model, we observed significant downregulation of pro-ferroptotic ACSL4 and upregulation of anti-ferroptotic GPX4/SLC7A11 in urethral tissues, alongside elevated oxidative stress markers (MDA, Fe²⁺) and reduced glutathione (GSH). In vitro experiments using rat urethral plate fibroblasts (RUPFs) demonstrated that DBP enhanced ferroptosis resistance and promoted proliferation at concentrations below 200 μM.

Role of Generative Artificial Intelligence in Assisting Systematic Review Process in Health Research: A Systematic Review.

Objectives: Artificial intelligence (AI) is widely used in healthcare for various purposes, with generative AI (GAI) increasingly being applied to systematic review (SR) processes. We aimed to summarize the evidence on the performance metrics of GAI in the SR process.

Methods: PubMed, EMBASE, Scopus, and ProQuest Dissertations & Theses Global were searched from their inception up to March 2025.

Intrinsic capacity, genetic susceptibility, and the risks of metabolic dysfunction-associated steatotic liver disease and cirrhosis.

Background: The World Health Organization (WHO) has introduced a new functional aging framework centered on intrinsic capacity (IC). This study aimed to evaluate the relationship between IC and the risk of incident metabolic dysfunction-associated steatotic liver disease (MASLD) and cirrhosis, and to assess the potential modifying effect of genetic susceptibility.

Methods: We included 393,355 participants without prior liver disease from the UK Biobank.

R5S4TRAIL ameliorates radiation-induced pulmonary fibrosis by alleviating inflammatory responses and promoting apoptosis of fibroblasts.

Background: Radiation-induced pulmonary fibrosis (RIPF) is a chronic, fatal and irreversible disease that develops after a consequence of thoracic radiation therapy and few effective treatments have been developed for this condition. Repeated inflammation and excessive accumulation of fibroblasts are features of RIPF. Thus, reducing inflammation and inducing lung fibroblast apoptosis may be an effective strategy for RIPF.

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses.

Anthropogenic activities, particularly land use change and management practices, alter the global nitrogen (N) cycle. As a central part of the global N cycle, soil N supply from net N mineralization (NNM) and net nitrification (NN) contributes to over 50% of crop N uptake. However, how global land use changes impact soil N supply and potential N loss remains elusive.

Butyrate protects against myocardial ischemia injury and cardiomyocyte pyroptosis by inhibiting MALT1-mediated Nrf2 ubiquitination and degradation.

Butyrate, a microbiota-derived short-chain fatty acid, has been implicated in myocardial protection against ischemia (MI), yet its underlying mechanisms remain incompletely understood. To address this, we generated an MI model in C57BL/6 mice through left anterior descending coronary artery (LAD) ligation. The model demonstrated characteristic myocardial injury, including increased infarct size, elevated lactate dehydrogenase (LDH) release, upregulated mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), and downregulated NF-E2-related factor 2 (Nrf2).

Creating topological exceptional point by on-chip all-dielectric metasurface.

Classified as a non-Hermitian system, topological metasurface is one of the ideal platforms for exploring a striking property, that is, the exceptional point (EP). Recently, creating and encircling EP in metasurfaces has triggered various progressive functionalities, including polarization control and optical holographic encoding. However, existing topological metasurfaces mostly rely on plasmonic materials, which introduce inevitable ohmic losses and limit their compatibility with mainstream all-dielectric meta-devices.

Current approaches to overcome the limit of TRAIL-based treatment in colorectal cancer: From fusion protein to nano-delivery platform.

Colorectal cancer (CRC), one of common malignancies, ranks second in cancer-related mortality worldwide. Despite advances in targeted therapy and immune therapy, patients with metastatic CRC have poor 5-year survival, which is approximately 14%. Multiple investigations are underway with the aim to improve outcome of this cohort.

M-Sec Overexpressed Stem Cells Growing Abundant Tunneling Nanotubes for Diverse Active Transferring.

Stem cell-based therapy holds immense potential for treating patients with intractable diseases and injuries, while its benefit is often limited by the inefficient delivery of therapeutic actives. In this study, using mRNA analysis and validation, we discovered that the M-sec protein can interact with the Ral-exocyst pathway to induce tunneling nanotubes (TNTs) in stem cells, which could represent a pathway for the direct transfer of bioactive agents to damaged cells for therapeutic purposes. With this, we constructed a genetically engineered stem cell delivery system overexpressing M-sec (MSCs), which forms abundant TNTs.

Bacterial Co-Infection Delays Hepatitis B Virus Clearance in a Chronic Replication Mouse Model by Inducing T Cell Exhaustion.

Hepatitis B virus (HBV) and bacterial infections are major global health concerns. However, the impact of bacterial co-infection on HBV clearance remains unclear. To investigate how bacterial co-infection affects HBV clearance, we used a mouse model with chronic HBV replication and Klebsiella pneumoniae co-infection.

Adjuvant therapeutic efficacy of low-dose aspirin on short-term outcomes of patients with cancer-associated venous thromboembolism.

Background: Although aspirin was reported to have primary thromboprophylactic efficacy on cancer patients, its adjuvant role in the treatment of patients with cancer-associated venous thromboembolism (VTE) has been unclear yet.

Methods: Patients with cancer-associated VTE were retrospectively analyzed and divided into aspirin group and non-aspirin group based on whether they underwent low-dose aspirin (100 mg daily) in addition to conventional anticoagulants. Propensity score matching was used to balance baseline characteristics between the aspirin group and non-aspirin group in a 1:2 ratio.

Arsenic trioxide regulates DYNAP through hsa-mir-573 and inhibits the proliferation of laryngeal cancer.

Laryngeal squamous cell carcinoma (LSCC) is a malignant tumor with limited treatment options and poor prognosis in advanced stages. Arsenic trioxide (ATO), a drug well-known for treating acute promyelocytic leukemia, has shown potential antitumor effects in several solid tumors. This study aimed to investigate the role of ATO on LSCC proliferation and its underlying molecular mechanisms.

Augmented Reality Productivity In-the-Wild: A Diary Study of Usage Patterns and Experiences of Working With AR Laptops in Real-World Settings.

Augmented Reality (AR) is increasingly positioned as a tool for knowledge work, providing beneficial affordances such as a virtually limitless display space that integrates digital information with the user's physical surroundings. However, for AR to supplant traditional screen-based devices in knowledge work, it must support prolonged usage across diverse contexts. Until now, few studies have explored the effects, opportunities, and challenges of working in AR outside a controlled laboratory setting and for an extended duration.

Molecular Characterization and Feeding-Associated Expression Dynamics of the Period Gene Family in Channel Catfish ().

Rhythms, regulated by core clock genes like the period () gene family, are crucial for maintaining physiological processes in animals. In teleost fish, including channel catfish (), these genes have evolved distinct functions. However, the evolutionary characteristics and functional roles of period genes, particularly in response to environmental cues such as feeding, remain unclear.

Synthesis of l-β-(6-azulenyl)alanine and the fluorescent actin disruptor (6-azuleno)chalasin H.

l-β-(6-Azulenyl)alanine was synthesised for the first time. Supplementation of this compound to Δ led to the biosynthesis of the unnatural (6-azuleno)chalasin H and its 1'-bromo congener that have unprecedented natural product skeletons and that are both fluorescent and highly cytotoxic, with IC of 0.18 μg mL L929 cells .