Hierarchical Structures of Protein-Fiber-Infused Aminoglycan Hydrogels to Promote Myocardial Repair.

Myocardial infarction (MI) is followed by irreversible damage to the myocardium, which eventually evolves into ventricular remodeling and heart failure. An imbalanced inflammatory response after MI can exacerbate myocardial injury. Current strategies to modulate inflammation and thereby improve myocardial tissue repair are limited.

Global, regional, and national burden of peripheral artery disease: a systematic analysis of prevalence, incidence, deaths, and DALYs with projections for the next 15 years.

Background And Aims: Lower extremity peripheral artery disease (PAD) represents a major global health challenge, with significant disparities in disease burden across countries. This study aims to analyze the burden and epidemiological characteristics of PAD from 1990 to 2021, assess inequalities among nations, and project PAD burden trends over the next 15 years.

Methods And Results: Using data from the 2021 Global Burden of Disease (GBD) study, we analyzed the prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of PAD through Joinpoint regression, health inequality analysis, frontier analysis, and Bayesian age-period-cohort modeling.

Pulmonary Embolism With Serpentine Thrombus Straddling a Patent Foramen Ovale.

Background: A thrombus straddling patent foramen ovale (PFO) is rare. We present a case of timely diagnosis and surgical management of a life-threatening straddling thrombus in a PFO and pulmonary embolism, utilizing advanced imaging techniques and emergency thrombectomy.

Case Summary: We used multimodality imaging (transthoracic echocardiography, transesophageal echocardiography, computed tomography angiography) to confirm and assess a straddling thrombus in the PFO and pulmonary artery, identifying key findings such as a snake-like thrombus crossing the PFO and pulmonary thromboembolism, and performed emergency surgical thrombectomy to remove the thrombus, prevent embolism, and reduce mortality risk.

Estrogen receptor 1 (ESR1) promotes Di-butyl phthalate (DBP)-induced hypospadias by regulating mitophagy through PINK1-Parkin axis to inhibit ferroptosis.

This study reveals how Di-butyl phthalate (DBP), an estrogen-mimicking environmental pollutant, induces hypospadias by inhibiting ferroptosis through ESR1 activation and PINK1-Parkin-dependent mitophagy. Utilizing a prenatal DBP-exposed fetal rat hypospadias model, we observed significant downregulation of pro-ferroptotic ACSL4 and upregulation of anti-ferroptotic GPX4/SLC7A11 in urethral tissues, alongside elevated oxidative stress markers (MDA, Fe²⁺) and reduced glutathione (GSH). In vitro experiments using rat urethral plate fibroblasts (RUPFs) demonstrated that DBP enhanced ferroptosis resistance and promoted proliferation at concentrations below 200 μM.

CCDC86-BHLHE40-ATF3 axis promotes aerobic glycolysis and tumor development in glioma.

Glioma, an aggressively malignant brain tumor with a poor prognosis, comprises nearly 50% of all primary malignant brain tumors. Despite its significance in other cancers, the role of coiled-coil domain containing 86(CCDC86) in glioma remains largely unexplored. Our study revealed a significant up-regulation of CCDC86 expression in glioma tissues, correlating notably with patient age, tumor recurrence, and pathological grade.

Interventions for adult survivors discharged from the intensive care unit: a scoping review.

Objectives: To comprehensively map the available evidence on interventions implemented for adult survivors following discharge from the intensive care unit (ICU).

Design: A scoping review was conducted following the methodological framework proposed by Arksey and O'Malley.

Data Sources: A systematic search was done across Embase, Medline, Scopus, China National Knowledge Infrastructure, China Science and Technology Journal Database, Chinese Biomedical Database, Wanfang Data, ProQuest Dissertations and Theses, ClinicalTrials.

Triple-Branched Stent Graft for Acute Type A Aortic Dissection Complicated by Imaging Cerebral Malperfusion: A Multicentre Retrospective Study.

Background: Patients with acute type A aortic dissection (ATAAD) complicated by imaging cerebral malperfusion (ICM) have poor prognoses. In this study we aimed to evaluate the clinical efficacy of the modified triple-branched stent graft (MTBSG) in these patients.

Methods: In this retrospective comparative study we analyzed consecutive patients with ATAAD complicated by ICM between 2010 and 2019 who underwent either MTBSG implantation or conventional total arch replacement with frozen elephant trunk.

Oleanolic acid 28-O-β-D-glucopyranoside alleviates TNBS-induced ulcerative colitis in rat by regulating Nrf2/x-CT/GPX4-mediated ferroptosis.

Ethnopharmacological Relevance: Panax ginseng C.A. Meyer has been used traditionally for treating gastrointestinal disorders.

Correction: Mitochondrial genome assembly and comparative analysis of decaploid .

[This corrects the article DOI: 10.3389/fpls.2025.

MFG-E8 Accelerates Abdominal Aortic Aneurysm Formation by Enhancing ERK MAPK/NOX4 Axis-Associated Oxidative Stress.

MFG-E8 promotes oxidative stress by upregulating NOX4 and activating the MAPK pathway, which increases ROS production and affects vascular smooth muscle cell (VSMC) apoptosis, thereby driving the progression of abdominal aortic aneurysm (AAA). Resveratrol can inhibit the expression and function of MFG-E8, reduce ROS generation, and lower the incidence and severity of AAA, making it a potential therapeutic agent for AAA.

[Explanation and interpretation of blood transfusion provisions for children undergoing cardiac surgery in the national health standard "Guideline for pediatric transfusion"].

To guide clinical blood transfusion practices in pediatric patients, the National Health Commission has issued the health standard "Guideline for pediatric transfusion" (WS/T 795-2022). Children undergoing cardiac surgery are at high risk of bleeding, and the causes of perioperative anemia and coagulation disorders in neonates and children are complex and varied, often necessitating the transfusion of allogeneic blood components. This guideline provides direction and recommendations for specific measures in blood management for children undergoing cardiac surgery before, during, and after surgery.

Mitochondrial genome assembly and comparative analysis of decaploid .

Introduction: Decaploid is a new tea oil species discovered in recent years that is unique to Hainan. This species has high nutritional and medicinal value and shows strong adaptability in the growth process. Mitochondria play an important role in plant cells and have an independent genetic system.

Epigenetic adaptation of beta cells across lifespan and disease: age-related demethylation is advanced in type 2 diabetes.

Although the prevalence of type 2 diabetes (T2D) increases with age, most adults maintain normoglycemia despite rising insulin resistance, largely due to the adaptive capacity of pancreatic beta cells to meet increased metabolic demand. However, persistent insulin resistance can lead to beta cell dysfunction and T2D onset. Here, leveraging cell-type-specific methylome data from the Human Pancreas Analysis Program (HPAP), we investigate the epigenomic basis of beta cell adaptation by mapping genome-wide DNA methylation (DNAm) patterns across the human lifespan.

The effects of coffee vs. Gum chewing after cesarean on bowel functions: a systematic review and network meta-analysis.

Study Objective: This systematic review and network meta-analysis aimed to compare the effects of coffee consumption and gum chewing on postoperative bowel function recovery in patients undergoing cesarean sections.

Design: Systematic review and network meta-analysis of randomized controlled trials.

Patients: Patients undergoing cesarean section.

Anti-Icing Organogel Enables Quasi-Homogeneous Supercooling Preservation of Mouse Hearts.

Supercooling preservation holds great promise for extending the storage limits of organs. However, supercooled systems are susceptible to stochastic ice nucleation, which can cause fatal damage to the organs. In this study, an organogel interface composed of nanoscale polydimethylsiloxane and dimethyl-silicone oil is proposed, which presents a significant energy barrier for ice nucleation, comparable to that of homogeneous nucleation.

Study on freeze-thaw damage of surface and pore structure of steam cured concrete.

The study of freeze-thaw (F-T) damage of steam cured concrete (SCC) plays a positive role in promoting the development of prefabricated technology in water conservancy project construction and construction industrialization in cold areas. This study aims to investigate and provide a better understanding of the surface damage pattern and pore structure of SCC. In this paper, a 3D scanner was used to scan the surface topography of SCC under five conditions of F-T (the number of F-T was 0, 50, 100, 150, and 200 respectively), and the spatial distribution of point cloud data generated by scanning results was analyzed, and surface roughness was introduced to quantify the damage effect of F-T cycle on the surface of SCC.

Designing High-Ionic-Conductivity and Air-Stable Composite Sulfide Electrolytes via Polymer-in-Salt Binder with Surface Engineering for All-Solid-State Lithium Batteries.

Composite sulfide electrolytes (CSEs), composed of a sulfide electrolyte matrix and a small amount of polymer binder, are promising for all-solid-state lithium batteries (ASSLBs) owing to their potential to achieve both high ionic conductivity and mechanical robustness. However, current polymer-based binders are not well ionically conductive and generally have non-/low-polarity, leading to a dramatic decrease in ionic conductivity and weak interparticle bonding; furthermore, CSEs are still unstable in air. Herein, a unique polymer-in-salt binder is proposed, further engineered with an ion-conducting hydrophobic layer (IHL) on surface to design hydrophobic CSE (HCSE) to address the above challenges.

Clinically Diagnose Asthma and Monitor Its Severity Using an Ultrasensitive Chemiresistive Nitric Oxide (NO) Gas Sensor via Exhaled Breath Analysis Assisted by Pattern Recognition.

Fractional exhaled nitric oxide (FeNO) is widely recognized as a reliable biomarker for asthma. FeNO sensors can help diagnose asthma and monitor its severity. In this study, an ultrasensitive chemiresistive gas sensor, sensitive to the key breath biomarkers of asthma─nitric oxide (NO) and HS─was fabricated using Ag-decorated ZnO.

Deficiency of the RNA-binding protein RBMS1 improves myocardial fibrosis and heart failure.

Background And Aims: Previous studies have highlighted the significance of RNA-binding proteins and alternative splicing (AS) in the progression of complex diseases, but the specific involvement of AS in heart failure (HF) remains unclear. This study aimed to elucidate the role of RNA-binding motif single-stranded interacting protein 1 (RBMS1), an RNA-binding protein, in the development of HF by regulating AS and its effect on cardiac fibrosis.

Methods: The level of RBMS1 was investigated in the hearts of both HF patients and mice.

Impact of Alkali-Activated Tannery Sludge-Derived Geopolymer Gel on Cement Properties: Workability, Hydration Process, and Compressive Strength.

The utilization of tannery sludge (TS) in construction materials not only effectively reduces pollution and resource consumption associated with waste disposal, but also promotes low carbon transformation in the building materials sector, further advancing sustainable development of green construction. This study aims to investigate the impact of sludge-based geopolymer gel on cementitious material performance, revealing the evolution mechanisms of material fluidity, setting time, hydration process, and compressive strength under the coupled effects of tannery sludge and alkali activation, thereby providing a reusable technical pathway to address the resource utilization challenges of similar special solid wastes. A series of alkali-activated composite cementitious materials (AACC) were prepared in the study by partially substituting cement with alkaline activators, TS, and fly ash (FA), through adjustments in TS-FA ratios and alkali equivalent (AE) variations.

Systematic identification of SNCA as a key gene in ischemic cardiomyopathy via integrated weighted gene co-expression network analysis and experimental validation.

Ischemic cardiomyopathy (ICM) is associated with high mortality and hospitalization rates, and current treatments are suboptimal. The aim of this research was to identify novel therapeutic targets for ICM. The datasets GSE57338 and GSE5406 were obtained from the Gene Expression Omnibus (GEO) database.

Semi-Heterogeneous Graph-Perception Network With Gradient-Weighted Class Activation Mapping for Class-Incremental Industrial Fault Recognition and Root Cause Diagnosis.

Modern industrial systems often operate under complex dynamics and strict reliability constraints, demanding a timely and precise fault diagnosis with efficient root cause analysis to ensure operational safety and minimize downtime. However, the inherent uncertainties and complexities of industrial processes present significant challenges for conventional diagnostic approaches. Specifically, even minor anomalies can escalate into critical incidents, while process uncertainties frequently induce distribution shifts, leading to novel fault types that complicate fault detection and diagnosis.

Anlotinib mediates intrinsic drug resistance in hepatoblastoma through the GAD1/GABA pathway.

Background: Intrinsic resistance reduces the effectiveness of many anticancer therapies. Anlotinib, a small-molecule multi-targeted tyrosine kinase inhibitor, has shown potential in treating hepatoblastoma. This study investigates the role of γ-aminobutyric acid (GABA) in anlotinib resistance using in vivo and in vitro models.

Dual-Organelle-Targeted Fluorescent Probe for Lipid Droplets and Endoplasmic Reticulum Using Bay-Region Substituted Perylene Diimides.

In the complex cellular microenvironment, lipid droplets (LDs) and the endoplasmic reticulum (ER) are essential for maintaining cellular homeostasis. Their interactions are crucial for regulating processes such as lipid metabolism. Nevertheless, simultaneously monitoring these two organelles remains a challenging task.

Oleanane-type triterpene saponins promote extracellular vesicle secretion of human adipose-derived mesenchymal stem cells.

The application of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) holds significant promise in anti-aging cosmetics, regenerative medicine, and drug delivery systems. However, their limited production efficiency remains a critical barrier to advancing related therapies and pharmaceutical applications. In this study, a library of triterpene saponins was screened, leading to the re-discovery of an oleanane-type triterpene saponin Lucyoside H (1), along with its structural analogs, Chikusetsusaponins IVa (2), IV (3), and V (4), which were found to increase the production of EV from human adipose-derived mesenchymal stem cells (ADMSCs) at a concentration ranging from 10 to 100 µM.