Pulmonary Embolism With Serpentine Thrombus Straddling a Patent Foramen Ovale.

Background: A thrombus straddling patent foramen ovale (PFO) is rare. We present a case of timely diagnosis and surgical management of a life-threatening straddling thrombus in a PFO and pulmonary embolism, utilizing advanced imaging techniques and emergency thrombectomy.

Case Summary: We used multimodality imaging (transthoracic echocardiography, transesophageal echocardiography, computed tomography angiography) to confirm and assess a straddling thrombus in the PFO and pulmonary artery, identifying key findings such as a snake-like thrombus crossing the PFO and pulmonary thromboembolism, and performed emergency surgical thrombectomy to remove the thrombus, prevent embolism, and reduce mortality risk.

Green synthesis of zinc oxide nanoparticles using Cnidium monnieri fruit extract: Prescription optimization, Characterization and antifungal activity.

Currently, the drugs employed to treat superficial fungal infections are encountering challenges, particularly the rise of drug resistance. Numerous studies have suggested that zinc oxide nanoparticles (ZnO NPs) show promise in the realm of antifungal treatment. Green synthesis makes the preparation of ZnO NPs more environmentally friendly and economical.

In situ generation of Copper sulfide within Poly(lactic-co-glycolic acid): A strategy for Safer photothermal therapy in Triple-Negative breast cancer.

Copper sulfide nanoparticles (CuS NPs) have garnered significant attention in photothermal therapy (PTT) owing to their facile synthesis, biodegradability, stability, and excellent photothermal conversion efficiency. Nonetheless, their potential toxic effects have restricted their application. This research focuses on the encapsulation of CuS NPs with the biocompatible polymer poly(lactic-co-glycolic acid) (PLGA) to enhance their biocompatibility, thereby improving the efficacy and safety of PTT in the treatment of triple-negative breast cancer (TNBC).

Corrigendum: Biosynthesis, characterization, and antifungal activity of plant-mediated silver nanoparticles using fruit extract.

[This corrects the article DOI: 10.3389/fmicb.2023.

Biosynthesis, characterization, and antifungal activity of plant-mediated silver nanoparticles using fruit extract.

The present study describes a novel method for green synthesis of silver nanoparticles using (CM-AgNPs). fruit is an excellent anti tinea drug that can be used externally to treat superficial fungal infections in the human body. The aqueous ethanolic extract of fruit was prepared and employed in the synthesis of stable silver nanoparticles via biological reduction method.

A comparative study on the preparation and evaluation of solubilizing systems for silymarin.

Silymarin (SM) exhibits clinical efficacy in treating liver injuries, cirrhosis, and chronic hepatitis. However, its limited water solubility and low bioavailability hinder its therapeutic potential. The primary objective of this study was to compare the in vitro and in vivo characteristics of the four distinct SM solubilization systems, namely SM solid dispersion (SM-SD), SM phospholipid complex (SM-PC), SM sulfobutyl ether-β-cyclodextrin inclusion complex (SM-SBE-β-CDIC) and SM self-microemulsifying drug delivery system (SM-SMEDDS) to provide further insights into their potential for enhancing the solubility and bioavailability of SM.

Synergy of Paired Brønsted-Lewis Acid Sites on Defects of Zr-MIL-140A for Methanol Dehydration.

As a common defect-capping ligand in metal-organic frameworks (MOFs), the hydroxyl group normally exhibits Brønsted acidity or basicity, but the presence of inherent hydroxyl groups in the MOF structure makes it a great challenge to identify the exact role of defect-capping hydroxyl groups in catalysis. Herein, we used hydroxyl-free MIL-140A as the platform to generate terminal hydroxyl groups on defect sites a continuous post-synthetic treatment. The structure and acidity of MIL-140A were properly characterized.

Preparation and curing behaviour of microencapsulated curing agents for cold-mixed epoxy asphalt.

This study aimed to improve control over the curing behaviour of cold-mixed epoxy asphalt by using a microencapsulated curing agent (2-PZ@PC). Prepared through solvent evaporation, the 2-PZ@PC microcapsules had 2-phenylimidazole as the core material and polycarbonate as the shell material. The research examined the impact of core-shell mass ratio on microcapsule morphology and composition.

Population pharmacokinetics and dosing optimization of unbound teicoplanin in Chinese adult patients.

To develop a population pharmacokinetic (PopPK) model describing unbound teicoplanin concentrations in Chinese adult patients and perform Monte Carlo simulations to optimize the dosing regimens. The raw data for PopPK analysis in this study were collected from Chinese adult patients. A PopPK model of unbound teicoplanin was developed and Monte Carlo simulations were used to optimize the dosing regimens.

Population pharmacokinetics and model-informed precision dosing of lamivudine in Chinese HIV-infected patients with mild and moderate impaired renal function.

Background: Lamivudine is a first-line medication used for human immunodeficiency virus (HIV) treatment. To date, the population pharmacokinetics of lamivudine in Chinese HIV-infected adults have not been assessed. This study aimed to develop a population pharmacokinetic model for oral lamivudine in Chinese HIV-infected adults and to determine the optimal lamivudine dosage regimens.

Investigation of the soft carbon microstructure in silicon/carbon anodes for superior lithium storage.

It is essential to consider the controllable microstructure of soft carbon and its enhancement effect on the electrochemical performance of silicon (Si) active materials. In this study, a series of Si@mesocarbon microbead (Si@MCMB) composites were prepared using mesophase pitch as the soft carbon source to coat nano-Si. The results showed that the ordered carbon layer stacking of soft carbon increased slightly with increasing heat treatment temperature in the range of 800-1400 °C.

Correction to: Preparation and Evaluation of Cubic Nanoparticles for Improved Transdermal Delivery of Propranolol Hydrochloride.

Xin Zhou is a co-corresponding author of this published article and the affiliation should read "Xin Zhou".

Preparation and Evaluation of Cubic Nanoparticles for Improved Transdermal Delivery of Propranolol Hydrochloride.

Transdermal drug delivery of propranolol hydrochloride (PRH) is promising for the treatment of infantile hemangioma (IH). Clinically used PRH hydrogel fails to reach the deep IH for complete recovery. In this study, the PRH-loaded cubic nanoparticles (CNPs) were prepared to promote the transdermal effect of PRH.

Light-triggered OVA release based on CuS@poly(lactide-co-glycolide acid) nanoparticles for synergistic photothermal-immunotherapy of tumor.

The immunotherapy played a vital role in the treatment of metastatic tumor. To further enhance the effect of the immunotherapy, the combination of photothermal effect can not only eradicate the tumor cells by hyperthermia, but also improved the antigen release in vivo to achieve enhanced immune responses. In this study, a core-shell structured nanocomplex was developed by loading of ovalbumin (OVA) and copper sulfide nanoparticles (CuS-NPs) into the poly(lactide-co-glycolide acid) nanoparticles (PLGA-NPs).

Cationic nanoemulsions with prolonged retention time as promising carriers for ophthalmic delivery of tacrolimus.

Tacrolimus, also known as FK506, is a first-line drug for the topical treatment of immune-mediated inflammatory anterior ocular diseases (IIAODs). However, due to its limited water solubility, hydrophobic nature and relatively high molecular weight, topical application of FK506 features poor bioavailability. Numbers of formulations have been attempted to enhance the erratic bioavailability of FK506 through various techniques.

Quantifying Land Use/Land Cover and Landscape Pattern Changes and Impacts on Ecosystem Services.

Based on satellite remote sensing image, GIS and Fragstats, this study modeled and calculated the dynamic changes of land use, land cover and landscape patterns in Guizhou Province, China, and calculated the changes of ecosystem service values (ESVs). The impacts of the evolution of landscape patterns on the ESVs were analyzed, and reasonable policy recommendations were made. The findings are as follows: (1) In the past two decades, the area of cropland and grassland has decreased; the area of water bodies, urban and rural, industrial and mining, and residential areas has increased; the area of forestland has increased first and then decreased.

Preparation and comparison of tacrolimus-loaded solid dispersion and self-microemulsifying drug delivery system by in vitro/in vivo evaluation.

This study aimed to compare the dissolution and the intestinal absorption of tacrolimus in self-microemulsifying drug delivery system (SMEDDS) and solid dispersion (SD). Poloxamer 188 SD was prepared by the combination of the solvent evaporation method and the freeze drying method. Hydroxypropyl methylcellulose (HPMC) SD was prepared by the solvent evaporation method combined with the vacuum drying method.

Effect of CYP3A4 and CYP3A5 Genetic Polymorphisms on the Pharmacokinetics of Sirolimus in Healthy Chinese Volunteers.

Background: Sirolimus is a promising immunosuppressive drug for preventing the rejection of organ transplants. However, inter-individual variability in sirolimus pharmacokinetics causes adverse drug reactions, compromising therapeutic efficacy. Sirolimus is primarily metabolized by cytochrome CYP3A4 and CYP3A5.

[Effect of propranolol gel on infantile hemangiomas].

Objective: To evaluate the efficacy and security of propranolol gel in treatment of Infantile hemangiomas.

Methods: 51 consecutive infants with hemangiomas from October 2010 to September 2011 in Department of General Surgery Fuzhou General Hospital of Nanjing Military Command were treated with propranolol hydrochloride 3% gel. Changes in hemangioma size, texture, color, tumor blood flow peak were recorded.