Rational Design of Purely Inorganic Self-Healing Colloidal Hydrogels To Enable "Green" 3D Printing of Bioglass-Based Bone Substitutes.

3D printing of ceramics or glass typically requires sacrificial organic plasticizers and high-temperature sintering, which is time- and cost-consuming, potentially cytotoxic, and may compromise the bioactivity and functionality of the inorganic components. We herein developed purely inorganic self-healing colloidal gels, consisting of electrostatically attractive silica-based hard nanospheres, to enable 3D printing of highly strong inorganic constructs via additive-free and low temperature sintering (LTS) processing. Through cross-scale analysis of the structural and mechanical features, we quantitatively described the constitutive relationship of attractive colloidal gels based on the integration of colloidal assembly theory with experimental characterizations.

A single-cell transcriptomic landscape characterizes the endocrine system aging in the mouse.

The endocrine system is crucial for maintaining overall homeostasis. However, its cellular signatures have not been elucidated during aging. Here, we conducted the first-ever single-cell transcriptomic profiles from eight endocrine organs in young and aged mice, revealing the activation of cell-type-specific aging pathways, such as loss of proteostasis, genomic instability and reactive oxygen species (ROS).

Genome-wide identification and characterization of the Brassinazole-resistant gene family and associated responses to osmotic stress in .

Background: The Brassinazole-resistant (BZR) family of transcription factors acts as key regulators in brassinosteroid (BR) signaling, influencing plant growth, development, biotic and abiotic stresses. However, systematic analysis of the genes in oat has not been conducted. Moreover, little is known about their functions in osmotic stress, which is a major abiotic stress affecting oat production.

Marrying Perona Malik diffusion with Mamba for efficient pediatric echocardiographic left ventricular segmentation.

Segmenting echocardiographic images is a crucial step in assessing heart function, as clinical indicators can be obtained by precisely delineating the left ventricle. The success of subsequent heart analyses depends entirely on the precision of this segmentation. However, echocardiography is characterized by ambiguity and heavy background noise interference, making accurate segmentation more challenging.

Impact of slanted lateral rectus recession on pediatric patients with convergence insufficiency intermittent exotropia.

Background: Convergence insufficiency intermittent exotropia (CIX(T)) is a common type of strabismus in children, characterized by greater ocular deviation at near fixation compared to distance fixation. This study aimed to explore impact of slanted lateral rectus recession (S-LRc) compared to conventional lateral rectus recession (LR) on pediatric patients with CIX(T).

Methods: This retrospective study enrolled pediatric patients with CIX(T) at Shanxi Aier Eye Hospital between June 2022 and December 2024.

Ecological Pest Control in Alpine Ecosystems: Monitoring Asteraceae Phytophages and Developing Integrated Management Protocols in the Three River Source Region.

spp., a key grass species for the ecological restoration of alpine degraded grasslands on the Qinghai-Tibet Plateau, often suffers from pest damage during its flowering and seed maturation stages, severely limiting the effectiveness of ecological restoration and the sustainable utilization of germplasm resources. This study focused on nine widely distributed species of in the Three River Source Region of Qinghai Province, systematically investigated the structure of arthropod communities and the spatiotemporal dynamics of pests, and developed an integrated pest management (IPM) strategy.

Discovery and functional validation of a novel lotus root-derived peptide (EWGHLGL) alleviating oxidative stress in vitro and in vivo.

Lotus root (Nelumbo nucifera) is a nutrient-rich source of bioactive peptides. This study extracted lotus root juice and identified a novel antioxidant peptide, EWGHLGL, using LC-MS/MS and computational methods including molecular docking and molecular dynamics simulations. Molecular docking revealed its strong binding affinity to myeloperoxidase (MPO; -9.

Enalapril mitigates senescence and aging-related phenotypes in human cells and mice via pSmad1/5/9-driven antioxidative genes.

Aging increases the risk of a myriad of chronic diseases, which are expensive and difficult to treat owing to their various risk factors. Repurposing existing medications has accelerated the development of therapies aimed at slowing aging. In this study, using IMR90 cells and aged mice, we revealed that enalapril, a drug widely prescribed for hypertension, can improve both cellular senescence and individual health.

FDA Approval Summary: Datopotamab deruxtecan-dlnk for treatment of patients with unresectable or metastatic, HR-positive, HER2-negative breast cancer.

On January 17, 2025, the FDA approved datopotamab deruxtecan-dlnk (DATROWAY, Dato-DXd), a Trop-2-directed antibody and topoisomerase inhibitor conjugate, for the treatment of adults with unresectable or metastatic, hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer who have received prior endocrine-based therapy and chemotherapy for unresectable or metastatic disease. Approval was based on results from TROPION-Breast01 (TB01), a multicenter, randomized, open-label trial comparing Dato-DXd to investigator's choice of chemotherapy (ICC). The trial was designed with dual primary endpoints: progression-free survival (PFS) assessed by blinded independent central review (BICR) according to Response Evaluation Criteria in Solid Tumors (RECIST) v1.

Topology-Optimized 3D Metalloporphyrin Covalent Organic Framework for Photocatalytic CO Fixation.

Three-dimensional (3D) covalent organic frameworks (COFs) represent promising photocatalytic platforms with accessible active sites, yet their development faces challenges in terms of structural diversity and synthetic complexity. Herein, a robust 3D metalloporphyrin COF with topology and 2-fold interpenetration is achieved by using high-connectivity metalloporphyrin, and different metal centers within the porphyrin units of 3D COFs lead to intriguing structural variations. Particularly, the 3D cobalt-porphyrin-based COF achieves efficient photocatalytic CO-to-CO conversion with a rate of 21 251.

Seed-Source Precipitation Drives Drought Acclimatization of : Implications for Seed Germination and Seedling Growth in the HeHuang Valley.

is a key dominant species in the desert regions of northern China. The selection of appropriate seed source and the determination of optimal seed harvesting times are critical for the development and utilization of its germplasm resources. In this study, nine habitats with varying precipitation levels were identified in the HeHuang Valley.

Adaptation invariant concentration discrimination in an insect olfactory system.

Neural responses evoked by a stimulus reduce upon repetition. While this adaptation allows the sensory system to attend to novel cues, does information about the recurring stimulus, particularly its intensity, get compromised? We explored this issue in the locust olfactory system. We found that locusts' innate behavioral response to odorants varied with repetition and stimulus intensity.

Fixation for metaphyseal-diaphyseal junction noncomminuted fracture of the distal humerus in children: K-wire or ESIN, how to decide?

Background: The metaphyseal-diaphyseal junction (MDJ) fracture of the distal humerus has posed significant difficulty clinically, as the increased height of the distal fragmant makes it hard for Kirschner wires to reach the proximal fragment. Our previous study provided suggestions for the choice of fixation in metaphyseal-diaphyseal junction (MDJ) fracture of the distal humerus according to the location of the fracture line based on biomechanical analysis. This study went on to testify an advanced suggestions in clinical patients.

Multivalent mpox protein nanoparticle vaccines confer cross-protection against orthopoxvirus infection.

The outbreak of mpox since 2022 has driven the development of mpox virus (MPXV)-specific, subunit-based, next-generation vaccines, instead of the currently used live-attenuated vaccinia virus (VACV) vaccines. Here, we describe a self-assembling protein nanoparticle against MPXV using lumazine synthase to present viral surface proteins. Multivalent nanoparticles elicited broader and stronger immune responses against MPXV and provided superior heterologous protection in rodent models against lethal VACV challenges compared to monovalent formulations.

C-14 oxygenated quassinoids with control effect against larvae of Diaphorina citri Kuwayama from fruits of Picrasma quassioides.

Background: Diaphorina citri is one of the most severe pests affecting citrus production worldwide. Our previous research identified a series of quassinoids that exhibit insecticidal activity against D. citri adults.

Design and fabrication of 4 double input NAND gate chip with excellent electrical and physical performances.

In order to improve the performances of 4 two-input NAND so that it can be better used in the aerospace application field and in harsh environments, 4 two-input NAND gate chips were designed and successfully fabricated in this paper, based on 1.2 [Formula: see text]m P-well SPDM CMOS technological processes. The N transistors were fabricated in P-well and connected to GND via [Formula: see text]-well.

Antidepressant in treating myocardial infarction complicated with depression via 5-HT/inflammation from heart to brain.

Objective: Exploring the potential mechanism by which inflammation and 5-HT linking myocardial infarction (MI) and depression, and to evaluate therapeutic effect of fluoxetine and SN50.

Methods: Patients with coronary artery disease (CAD) were recruited; depressive symptoms were evaluated, inflammatory factors were detected, and the effects of selective serotonin reuptake inhibitors (SSRIs) for CAD patients with depression were recorded. Furthermore, fluoxetine and SN50 were administrated separately for treatment in MI mice, SERT knockout mice, and H9C2 cell experiments.

The role of synthetic lethality in overcoming cancer therapy resistance: Emerging paradigm and recent advances.

Cancer therapy resistance remains a major barrier to successful treatment, often leading to reduced clinical efficacy or cancer relapse. Synthetic lethality (SL) has emerged as a promising strategy to exploit genetic vulnerabilities in cancer cells, allowing for more selective and less toxic therapies. By leveraging the genetic or non-genetic adaptations that cancer cells develop under therapeutic pressure, SL-based therapies provide a more precise and less toxic treatment approach.

Cancer-associated fibroblasts in hypopharyngeal squamous cell carcinoma: Clinical significance, prognostic impact, and correlation with microvessel density.

Cancer-associated fibroblasts (CAFs) play pivotal roles in facilitating tumor growth, recurrence, and metastasis. Nevertheless, studies examining the clinicopathological significance of CAFs and microvessel density (MVD) in hypopharyngeal squamous cell carcinoma (HPSCC), as well as their implications for prognosis, are scarce. Tissue samples from 96 HPSCC patients were subjected to immunohistochemistry (IHC) for CAF markers (including FAP and α-SMA) and MVD (characterized by the CD31 marker).

Genomic insights into the divergence between hulled and hulless oats.

Common oat, one of the most important crops worldwide, comprises hulled and hulless types with substantial agronomic differences. However, their evolutionary history and the genomic basis of phenotypic variations remain unclear. Herein, we report a 10.

Effect of intraoperative mitomycin C application at different concentrations on corneal densitometry after SmartSurf transepithelial photorefractive keratectomy.

Purpose: This study aimed to investigate corneal densitometry (CD), visual, and refractive outcomes after transepithelial photorefractive keratectomy (TPRK) using smart pulse technology (SPT), known as the SmartSurface procedure, in patients treated with or without mitomycin C (MMC) at concentrations of 0.01% and 0.02%.

Nanostructured GelMA colloidal gels as bioinks for freeform multi-mode 3D printing: better replacement for the classical GelMA polymeric inks.

Methacrylated gelatin (GelMA) hydrogels have been well-recognized as a widely-used natural polymer for biofabrications due to the adaptability for multiple crosslinking schemes, desirable biocompatibility and biodegradability, and ease of chemical functionalization. With regard to 3D bioprinting, however, GelMA has shown unsatisfactory printing stability and accuracy due to slow sol-gel transition, suboptimal mechanical strength, and strict temperature control for printing. We herein developed an innovative dual-crosslinkable colloidal inks composed of self-assembled GelMA nanospheres with 80 % self-healing efficiency, which outperform the traditional GelMA polymeric inks in terms of enhanced printability and fidelity, broader printing temperature range, adjustable mechanical strength ranging from brain analogue 2.

PVBF: A framework for mitigating parameter variation imbalance in online continual learning.

Online continual learning (OCL), which enables AI systems to adaptively learn from non-stationary data streams, is commonly achieved using experience replay (ER)-based methods that retain knowledge by replaying stored past during training. However, these methods face challenges of prediction bias, stemming from deviations in parameter update directions during task transitions. This paper identifies parameter variation imbalance as a critical factor contributing to prediction bias in ER-based OCL.

[mTOR promotes oxLDL-induced vascular smooth muscle cell ferroptosis by inhibiting autophagy].

Objective To explore the role and mechanism of mammalian target of rapamycin (mTOR) in oxidized low-density lipoprotein (oxLDL)-induced ferroptosis in vascular smooth muscle cells (VSMCs). Methods A model of oxLDL-induced VSMC ferroptosis was established. VSMCs were co-treated with either the mTOR inhibitor rapamycin or the autophagy inducer carbonyl cyanide m-chlorophenylhydrazone (CCCP), followed by detection of autophagy and ferroptosis-related indexes.

Cardiac magnetic resonance follow-up of myocardial function in patients with chronic total occlusion of the coronary arteries: a retrospective cohort study.

Background: The impact of percutaneous coronary intervention (PCI) for chronic total occlusion (CTO) on myocardial function remains controversial. This study aims to evaluate changes in myocardial function following CTO-PCI using cardiac magnetic resonance (CMR) imaging and to identify the patient subgroups that derive the greatest benefit from CTO artery recanalization.

Methods: We retrospectively screened 652 patients diagnosed with single-vessel CTO through coronary angiography at Beijing Anzhen Hospital between December 2014 and July 2023.