Fabrication of ZIF/SiO hybrid particles to prepare cotton-based antibacterial and anti-biofilm composites with high durability.

As living standards continue to rise, the demand for advanced cotton textiles that fulfill enhanced functional requirements has grown significantly. Therefore, the development of multifunctional antibacterial/hydrophobic cotton fabrics holds considerable practical value. In this study, a zeolitic imidazolate framework (ZIF-8) based hybrid material, ZIF/SiO-LDS (Long-chain derivative of silane), was synthesized via a co-precipitation method using silica, zinc nitrate hexahydrate, 3-aminopropyltriethoxysilane (KH-550), 2-methylimidazole and hexadecyltrimethylsilane (HDTMS).

Drug-induced liver injury prediction based on graph convolutional networks and toxicogenomics.

Drug-induced liver injury is a leading cause of high attrition rates for both candidate drugs and marketed medications. Previous in silico models may not effectively utilize biological drug property information and often lack robust model validation. In this study, we developed a graph convolutional network embedded with a biological graph learning (BioGL) module-named BioGL-GCN(Biological Graph Learning-Graph Convolutional Network)-for drug-induced liver injury prediction using toxicogenomic profiles.

Compound-specific stable carbon and bromine isotope analysis tracking transformation mechanisms of organobrominated contaminants: a review of principles, methodologies and applications.

Organobrominated contaminants, such as brominated flame retardants (BFRs), pose significant environmental risks due to their persistence, toxicity, and complex transformation pathways. Compound-specific stable isotope analysis (CSIA) of carbon (C) and bromine (Br) has emerged as a powerful tool to elucidate degradation mechanisms, particularly debromination processes that are critical to understanding environmental fate. This review synthesizes principles, methodologies, and applications of CSIA-C/Br for tracking the transformation of organobrominated pollutants, emphasizing advances in overcoming analytical challenges.

Structure Makes a Difference: IFT Complex in Ciliary Function and Ciliopathy.

Cilia, evolutionarily conserved organelles on eukaryotic cell surfaces, depend on the intraflagellar transport (IFT) system for their assembly, maintenance, and signaling. The IFT system orchestrates bidirectional trafficking of structural components and signaling molecules through coordinated actions of protein complexes and molecular motors. IFT complexes assemble into anterograde trains at the ciliary base and undergo structural remodeling at the ciliary tip to form retrograde trains, with bidirectional motility regulated by modifications on the trains per se and the microtubule tracks.

Quantitative study of vestibular endolymphatic hydrops in Meniere's disease based on Three-Dimensional real Inversion Recovery (3D-real IR) sequence.

Objective: To establish objective criteria for grading vestibular endolymphatic hydrops (EH) in Meniere's disease (MD) using 3D-real IR MRI, and investigate its clinical correlations.

Methods: Retrospective analysis of 155 MD patients (189 ears) included clinical data, audiovestibular assessments, and gadolinium-enhanced MRI. Vestibule volume (VV) and the volume of vestibular endolymph (EndV) were outlined on 3D-real IR sequence images, and the volume of vestibular endolymph was calculated by the vestibular endolymphatic ratio (ELR) to evaluate the degree of EH, analyze the correlation between the degree of EH and specific clinical features, hearing and vestibular function, and determine the optimal ELR value to differentiate each degree of effusion by using receiver operating characteristic (ROC) curve analysis.

Forecasting Northward Range Expansion of Switchgrass in China via Multi-Scenario MaxEnt Simulations.

Global warming is accelerating the poleward and upward shifts in climatically suitable ranges of species. (switchgrass) is recognized for its dual value in China's dual-carbon strategy: mitigating food-energy land competition and restoring marginal ecosystems. However, the accuracy of habitat projections is constrained by three limitations: reliance on North American provenance data, uncalibrated model parameters, and insufficient scenario coverage.

[Effects and mechanisms of Yuxuebi Tablets combined with ibuprofen in treating chronic musculoskeletal pain through "integrated regulation of inflammation and pain-related oxylipins"].

This study adopted a three-dimensional "effect-dose-mechanism" evaluation system to screen the optimal regimen of Yuxuebi Tablets(YXB) combined with ibuprofen(IBU) for chronic musculoskeletal pain(CMP) intervention and elucidate its pharmacological mechanism, so as to provide a scientific basis for the clinical application of the regimen. The experiments were conducted using 8-week-old ICR mice, which were randomly divided into sham operation(sham) group, model(CFA) group, IBU group, YXB group, stasis paralysis tablets combined with ibuprofen low-dose group(IBU-L-YXB), stasis paralysis combined with ibuprofen high-dose group(IBU-H-YXB), stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen discontinuation on the 10th day of administration(IBU-10-YXB), and stasis paralysis tablets combined with ibuprofen high-dose with ibuprofen halving on the 10th day of administration(IBU-1/2-YXB) group. An animal model was established using the CFA plantar injection method.

Prostaglandins: Key players in immunomodulation of the nervous system.

As a class of bioactive substances that play important roles in a variety of physiological and pathological processes, prostaglandins have attracted increasing research attention. Published studies have identified the molecular characteristics of prostaglandins in peripheral organs, the enzymes involved in prostaglandin biosynthesis, and prostaglandin receptors. Some studies have also explored the characteristics of prostaglandins and their functions in the central nervous system.

A flexible microneedle sensor for long-term, enzyme-free glucose monitoring with high sensitivity and stability.

Background: Blood glucose monitoring is of paramount importance for patients with diabetes. However, conventional glucose meters exhibit limited accuracy and present challenges for prolonged use, primarily due to the high consumption of glucose oxidase (GOD) and their sensitivity to temperature and environmental factors. phenylboronic acid (PBA), benefiting from its reversible reaction with glucose and superior stability, holds potential as a promising medium for long-term glucose monitoring.

Purine metabolism in tumorigenesis and its clinical implications.

Metabolic reprogramming constitutes a hallmark of malignant neoplasms. Purine metabolism emerges as a pivotal regulator in cellular metabolic networks through multiple mechanisms, including dysregulation of de novo biosynthesis/salvage pathway coordination, adenosine-mediated immunosuppressive microenvironment formation, and collective contributions to tumorigenesis and malignant progression. During metastatic progression, purine metabolism reinforces tumor cell plasticity through mitochondrial energy regulation and modulation of cell cycle checkpoints (eg, G1/S transition).

Bundle recommendation methods considering rating data differences for online retailers.

Bundling has emerged as a pivotal marketing strategy for online retailers, offering mutual benefits to both merchants and consumers in the rapidly expanding e-commerce landscape. Among various types of user behavior data, user-generated product ratings serve as a critical indicator of individual preferences and satisfaction levels. This research proposes a novel bundle recommendation framework that leverages rating disparities to capture nuanced user preferences and unmet demands.

Combining machine learning algorithms to construct a new method for inferring dental age of children with missing teeth in southern China.

Age inference is a key focus of forensic work, and traditional dental age inference methods require individuals to have a complete dental arch. However, congenital or acquired tooth loss may lead to random tooth loss in individuals, resulting in bias in age prediction. To address this issue, we validated and modified Bedek's tooth age inference method (a method for inferring the age of a population with missing teeth) for the first time in the Chinese population of children with complete dentition, congenital tooth loss, and acquired tooth loss, and constructed two new machine learning based tooth age inference methods (unilateral mandible and bilateral mandible tooth age estimation models) in this population.

Innovative Photon-Engineered Fluorescent Tri-Layer Polymeric Coatings for Sub-Ambient Colored Radiative Cooling.

Colored radiative cooling (CRC) materials provide a sustainable solution to thermal management, mitigating global warming while maintaining aesthetic appeal. Nevertheless, conventional CRC materials exhibit reduced cooling efficiency due to their significant sunlight absorption and degraded optical performance in dusty outdoor environments. Developing self-cleaning CRC materials with high cooling performance and vibrant color remains challenging.

Targeting HDAC8 sensitizes tyrosine kinase inhibitors in the elimination of B-cell acute lymphoblastic leukemia cells through degradation of HIF-1α.

Tyrosine kinase inhibitors (TKIs) only partially inhibit the growth of Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia (Ph B-ALL) cells, and often lead to rapid relapse. Therefore, it is essential to elucidate the mechanisms of resistance and develop novel treatment strategies. Histone deacetylases (HDACs) are often dysregulated in hematological malignancies, and many HDAC inhibitors have shown potent antitumor activities.

Risk factor identification mechanism for coronary artery disease based on multiple cross-filtering and binary cuckoo search.

Coronary artery disease (CAD) is a major public health concern, necessitating accurate risk factor identification. However, existing methods often suffer from feature preference bias and insufficient multidimensional evaluation, limiting their reliability. To address this, we propose a novel two-stage mechanism integrating multiple cross-filtering and binary cuckoo search (BCS).

Exploring the relationship between secondhand smoke exposure in different indoor environments and depression symptoms among non-smoking adults: A cross-sectional study from NHANES.

Introduction: The existing evidence regarding the relationship between secondhand smoke (SHS) exposure and depression symptoms in non-smoking adults remains inconclusive. This cross-sectional study aims to further investigate this relationship using data from the National Health and Nutrition Examination Survey (NHANES).

Methods: SHS exposure was assessed through self-reported passive exposure to indoor tobacco products, such as those encountered at work or in vehicles.

The predictive value of TyG index in patients with vertebrobasilar system thrombectomy.

Introduction: The triglyceride-glucose (TyG) index, a robust surrogate marker of metabolic dysregulation reflecting both insulin resistance and lipid-glucose homeostasis, has emerged as a significant predictor of cerebrovascular outcomes. Given the critical role of metabolic-nutritional status in post-stroke recovery, we supposed that the TyG index may predict the prognosis of ischemic stroke patients who underwent thrombectomy in the posterior circulation.

Methods: We studied 60 patients with cerebral infarction who underwent emergency posterior circulation interventional thrombectomy at a comprehensive stroke center from January 2018 to July 2024.

Mechanistic insights into the T6SS of multi-drug-resistant and its role in competition and pathogenesis.

, an opportunistic pathogen, often encodes Type VI Secretion System (T6SS) genes. However, the specific functions of T6SS, particularly in the context of clinical strains, remain poorly understood. In this study, we characterize a multi-drug-resistant strain, AH54, which possesses a complete and functional T6SS, composed of a structural cluster and two homologous auxiliary clusters (Aux1 and Aux2).

SLC38A4 as a prognostic biomarker and correlated with immune infiltration in colorectal liver metastasis.

Background: Colorectal liver metastasis (CRLM) is the most frequent form of metastasis and the main reason for deaths associated with colorectal cancer. However, prognostic biomarkers originating from CRLM tissue remain limited. Additionally, the impact of the metabolism-associated gene SLC38A4 on patients with CRLM remains elusive.

Distribution for platelet antibody in patients with immune-mediated platelet transfusion refractoriness.

Objectives: HLA Class I, HPA (Human platelet antigen), CD36 allo/isoantibodies, and platelet glycoprotein autoantibodies are the primary causes of immune-mediated platelet transfusion refractoriness (iPTR). Detecting these antibodies and selecting antigen-negative platelets for transfusion effectively manages iPTR, but large-scale data on platelet antibody distribution in the Chinese population are scarce.

Methods: From Jan 2021 to Dec 2023, 2073 patients with suspected iPTR underwent platelet cross-matching via solid-phase red blood cell adherence.

Population structure and adaptive signals in the white-backed planthopper, Sogatella furcifera inferred from genome-wide analysis.

Background: The white-backed planthopper (WBPH), Sogatella furcifera (Horváth) (Homoptera: Delphacidae), is a highly migratory insect pest that poses a significant threat to rice production in East and Southeast Asia. Although considerable advances have been made in understanding its migration sources and dispersal patterns with the advent of newer molecular tools, genomic-level insights into these processes, as well as its environmental adaptation mechanisms, remain limited.

Results: This study conducted whole-genome resequencing of 289 WBPH individuals from China and Southeast Asian countries, including Myanmar, Laos and Vietnam, to investigate population structure, gene flow and selective signals.

Identifying latent classes of longitudinal change in picture naming in a population-based sample.

Although cognitive changes may not become apparent until after age 65, many factors associated with late-life decline are already well-established in midlife. In particular, deficits in picture naming have been associated with early and accelerated cognitive change. A measure of picture vocabulary, requiring participants to name drawings of objects, was collected in 4 waves (each separated by 2 years) of the Understanding America Study, a nationally representative internet panel (mean follow-up = 5.

N-butylphthalide (NBP) and ligustrazine (TMP) triazole hybrids target the KEAP1-NRF2 pathway to inhibit ferroptosis and exert brain neuroprotectivity.

Ischemic stroke is a life-threatening disease, its pathological progression involves multiple factors, including oxidative stress, apoptosis, and ferroptosis. Our previous study demonstrated that hybridizing N-butylphthalide (NBP) with ligustrazine (TMP) yielded promising anti-ischemic compounds. In this study, we further introduced a triazole structure into NBP-TMP hybrids and synthesized 20 novel compounds.

Plasma SIRT7 as a novel biomarker for coronary artery disease and rehospitalization risk in hypertensive patients: a cross-sectional and longitudinal study.

The exact role of SIRT7 in hypertensive patients with coronary artery disease (CAD) remains elusive. This study aimed to explore plasma SIRT7 levels and their clinical significance in this population. From July 2022 to June 2024, 222 hypertensive patients (106 with isolated hypertension and 116 with hypertension plus CAD) were enrolled.