A robot scheduling method based on rMAPPO for H-beam riveting and welding work cell.

The H-beam riveting and welding work cell is an automated unit used for processing H-beams. By coordinating the gripping and welding robots, the work cell achieves processes such as riveting and welding stiffener plates, transforming the H-beam into a stiffened H-beam. In the context of intelligent manufacturing, there is still significant potential for improving the productivity of riveting and welding tasks in existing H-beam riveting and welding work cells.

Integrated machine learning-based RNA sequencing and single-cell analysis reveal RNA methylation regulation patterns in the immune microenvironment of Alzheimer's disease.

Alterations in RNA methylation may affect the initiation and development of Alzheimer's disease. However, the exact nature of the relationship between RNA methylation and Alzheimer's disease remains unclear. In this study, RNA methylation levels were analyzed by bulk transcriptomic and single-cell RNA sequencing.

Humanized Monoclonal Antibody Against Citrullinated Histone H3 Attenuates Myocardial Injury and Prevents Heart Failure in Rodent Models.

Excessive formation of neutrophil extracellular traps (NETs) leads to NETosis, accompanied by the release of citrullinated histone H3 (CitH3), a key mediator of septic inflammation. However, the role of CitH3 in sterile inflammation, such as acute myocardial infarction (MI) and post-MI heart failure, remains incompletely understood. We investigated the role of CitH3, a byproduct of NETosis, in myocardial ischemia/reperfusion (I/R) injury using a murine MI model.

Plasma SIRT7 as a novel biomarker for coronary artery disease and rehospitalization risk in hypertensive patients: a cross-sectional and longitudinal study.

The exact role of SIRT7 in hypertensive patients with coronary artery disease (CAD) remains elusive. This study aimed to explore plasma SIRT7 levels and their clinical significance in this population. From July 2022 to June 2024, 222 hypertensive patients (106 with isolated hypertension and 116 with hypertension plus CAD) were enrolled.

The global, regional, and national burden of Non-Hodgkin lymphoma in 204 countries and territories and 811 subnational locations, 1990-2021: an update from the Global Burden of Disease Study 2021.

Non-Hodgkin lymphoma (NHL) constitutes a significant portion of the global cancer burden and associated mortality. However, a comprehensive understanding of NHL's scale and trends remains limited, underscoring the need for evidence-based epidemiological research to inform healthcare decisions and planning effectively. Incidence, mortality, and disability-adjusted life-years (DALYs) estimates, along with 95% uncertainty intervals (UIs), were derived from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021.

Decoding Mitotic Chromosome Assembly: Three Rules Governing Condensin-Cohesin Engagement.

Mitotic chromosome formation depends on coordinated SMC complex activities, yet how condensin engages cohesin during this process remains unclear. Samejima et al. combined synchronized mitotic entry, auxin-inducible degrons, high-resolution Hi-C, live-cell imaging, quantitative proteomics, and polymer simulations to dissect condensin I, condensin II, and cohesin interplay in vertebrate cells.

Fabrication of thermally activated lead-zinc tailings/sodium alginate composites for high-efficiency adsorption of Cu/Cd.

Wastewater containing Cu and Cd poses a huge threat to the surrounding environment and human safety. To treat such wastewater, this study developed a novel composite adsorbent (LZT@SA) from thermally activated LZT and sodium alginate (SA). LZT was thermally activated at 850 °C (LZT).

Crustacean cardioactive peptide (CCAP) negatively regulates sand-diving behaviour in kuruma shrimp, Penaeus japonicus.

Kuruma shrimp (Penaeus japonicus) exhibits sand-diving behaviour. The genetic control mechanism of this behaviour is still unclear, although previous single-cell transcriptome sequencing suggests that crustacean cardioactive peptide (CCAP) may be involved. In this study, we cloned the CCAP precursor cDNA (Pj-CCAP) in kuruma shrimp.

A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis.

Citrullinated histone H3 (CitH3), released from immune cells during early sepsis, drives a vicious cycle of inflammation through excessive NETosis and pyroptosis, causing immune dysfunction and tissue damage. To regulate this process, we develop a humanized CitH3 monoclonal antibody (hCitH3-mAb) with high affinity and specificity to target this process. In murine models, hCitH3-mAb reduces cytokine production, mortality and acute lung injury (ALI) caused by LPS and Pseudomonas aeruginosa while enhancing bacteria phagocytosis in the lungs, spleen, and liver.

Differentiation of mtDNA Methylation in Tissues of Ridgetail White Prawn, .

In a previous study, we found that mitochondrial DNA methylation occurred in the muscle tissue of under starvation stress. To explore whether this phenomenon also existed in other tissues, we used the bisulfite method (BSP) to detect the methylation of the mitochondrial genome in the intestinal tissues, hepatopancreas, gills, eye stalks, muscles, heart, and other tissues before and after starvation. In situ hybridization and qPCR techniques were used to analyze the expression of DNMT1 and DNMT3b involved in methylation regulation in different tissues.

An Olsalazine-Loaded Hollow Mesoporous Prussian Blue/Polydopamine Nanozyme Alleviates Anxiety/Depression-like Behavior and Enhances Brain Neural Activity in Colitis Mice.

Individuals diagnosed with inflammatory bowel disease (IBD) exhibit a markedly elevated prevalence of psychiatric disorders, particularly anxiety and depression. However, the underlying mechanisms contributing to the development of these psychiatric conditions in IBD patients remain poorly understood, and no effective therapeutic strategy has been definitively established. Recent advancements in nanotechnology-based interventions offer promising potential for restoring gut homeostasis, which may mitigate inflammation and oxidative stress associated with IBD.

Study on the correlation between total cerebral small vessel disease score and lacunar infarction.

Objective: To investigate the relationship between the total cerebral small vessel disease (CSVD) burden and the occurrence of first-ever and recurrent lacunar infarction (LI).

Methods: This study included 271 patients with first-ever acute cerebral infarction hospitalized in the Department of Neurology, Affiliated Hospital of Qingdao University, between January 2019 and January 2024. The total CSVD score was calculated based on imaging findings.

Modulating gut microbiota with SCFAs and high-fiber diets to mitigate PM-induced hypertension in mice.

Exposure to PM is recognized to significantly impact the development of cardiovascular diseases, particularly hypertension, which has been recently attributed to an abnormal microenvironment characterized by disordered gut microbiota. Despite this recognition, the impacts of modulating gut microbiota with short chain fatty acids (SCFAs) and high-fiber diets (HF) on mitigating PM-induced hypertension remain unclear. Our study demonstrates that mice supplemented with SCFAs or a HF exhibit reduced blood pressure, improved vascular remodeling, and alleviated gastrointestinal tract damages compared to those exposed to PM alone.

Correction: Adverse events associated with amlodipine: a pharmacovigilance study using the FDA adverse event reporting system.

[This corrects the article DOI: 10.3389/fcvm.2025.

Linking species distribution and chemistry to support the management of Saposhnikovia divaricata under global change.

Saposhnikovia divaricata is a Level III nationally protected wild medicinal plant in China. Due to its high medicinal and economic value, its wild populations have been severely depleted in recent years. This study used the MaxEnt and Biomod2 models to identify the limiting factors, main environmental factors, and the impact of future climate change on the distribution of S.

Ion-Conductive Polyphosphasiloxane Networks: Constructing Robust Solid Electrolyte Interphase for SiO Anode.

Silicon (Si) is famous for its high theoretical specific capacity, natural abundance, and low reduction potential. However, enormous volume change, fast capacity decay, and poor ionic conductivity hamper the practical utilization of Si-based anodes. Until now, strategies to improve cycling performance by tailoring solid electrolyte interphase (SEI) have remained less effective, especially in high-Si content anodes.

Effects of wild-type and mutant TDP-43 on cognitive function and hippocampal neurons in mice.

This study investigates the effects of wild-type (wt) TDP-43 and mutant TDP-43 on cognitive function in C57BL/6J mice and hippocampal neurons (HT22 cells), focusing on the roles of progranulin (PGRN) and Caspase-3 in this process. C57BL/6J mice were injected with lentivirus (TDP-43 wt, TDP-43, or control) into the hippocampus. Cognitive function was evaluated using the novel object recognition and Y-maze tests.

The association between alexithymia and internet addiction disorder in a large sample of Chinese undergraduates: the role of sexual assault experiences.

Objective: While a positive association between alexithymia and Internet Addiction Disorder (IAD) has been established, previous studies are often limited by small sample sizes, lack of representative populations, and insufficient attention to intra-group differences, such as the impact of experiences like sexual assault.

Method: Anonymous questionnaires assessing alexithymia and IAD were distributed to approximately 11,000 university students across six institutions in Southwest China, resulting in 7,890 valid responses. In addition to measures of alexithymia and IAD, data were also collected on experiences of sexual assault, psychological distress, and a range of sociodemographic variables.

γ-glutamyl transpeptidase-catalyzed polymer-enzyme-drug conjugate enhances penetration and suppression in oral squamous cell carcinoma via transdermal application.

Over the past century, the treatment of superficial malignant tumors has largely remained within systemic therapies. The major drawback of systemic administration lies in its limited killing effects specifically to superficial tumors while causing potentially severe damage to other organs. Currently, transdermal drug administration for superficial tumors is still minimal, primarily constrained by the poor permeability and specificity in tumorous/precancerous tissue.

Powering Up the Brain: Intercellular Mitochondrial Quality Control and Its Implication in Stroke.

Mitochondria are critical for neuronal survival and function, and their dysregulation is closely related to the incidence and prevalence of various neurological disorders, including stroke. Mitochondrial quality control (MQC) is vital for maintaining mitochondrial integrity, particularly in neurons. Under ischemic conditions, neurons evolve a range of adaptive strategies to preserve mitochondria function dynamically, either by generating functional mitochondria or by eliminating dysfunctional ones via autophagy, both of which play key roles in keeping neuronal survival under the conditions of stroke.

Cancer Immunotherapy Based on the Bidirectional Reprogramming of the Tumor Microenvironment by a "Brakes Off/ Step on the Accelerator" Core-Shell Manganese Phosphate/siPD-L1 Modulator.

The insufficient infiltration and functional inhibition of CD8 T cells due to tumor microenvironment (TME) are considered enormous obstacles to anti-tumor immunotherapy. Herein, a pH-responsive core-shell manganese phosphate nanomodulator co-loading siPD-L1 and Mn into nanoparticles coated with hyaluronic acid was prepared, which was aimed at the bidirectional reprogramming the tumor microenvironment: (1) "Brakes off," restoring CD8 T cells function by siPD-L1 knockdowning PD-L1 expression of tumor cells; (2) "Step on the accelerator," promoting CD8 T cells infiltration in tumors tissue based on the multidimensional immune effects of Mn (immunogenic cell death induced the enhancing cGAS-STING pathway, the proliferation and maturation of relative immune cells). Additionally, this strategy could induce macrophage polarization and inhibit the regulatory T cells in tumor site.

Virome diversity in small mammals from south China: Insights into virus evolution, transmission, and ecology.

Mammals are critical reservoirs of human infectious diseases and the spillover of viruses is related to climate conditions. We conducted meta-transcriptomic sequencing of 226 mammals (bats, rodents, hedgehogs, and shrews) representing 20 species collected across eight cities in south China between 2018 and 2024. Samples included internal organs, oropharyngeal and anal swabs, and feces.

The association of exposure to multiple metals with the risk of idiopathic oligoasthenoteratozoospermia: The mediating role of sperm chromatin.

Background: The sperm DNA fragmentation index (DFI) is a crucial marker of single- or double-stranded DNA breaks, whereas the sperm high DNA stainability (HDS) indicates immature sperm nuclei accompanied with aberrant protein expression or altered protamine-to-histone ratios. Thus, sperm DFI and HDS constitute non-classical semen parameters that may serve as surrogate indicators of male fertility beyond what classical semen parameters (sperm motility, concentration and morphology) can offer. However, few epidemiological studies have investigated the impact of metal exposure on high sperm DFI and sperm HDS risk, especially their potential mediating roles in the association between metal exposure and risk of idiopathic oligo-asthenoteratozoospermia (iOAT).

Opioid analgesics for sedation-based gastrointestinal endoscopy.

Gastrointestinal endoscopy is a common examination for digestive system. The stimulation of endoscope often causes cough, nausea and vomiting, increased heart rate and blood pressure, arrhythmia, and even cardiovascular and cerebrovascular accidents, thus makes people fear of this procedure. Sedation or anesthesia can effectively improve the safety, comfort and quality of gastrointestinal endoscopy.