PdTe Nanowires as an Efficient Multifunctional Catalyst for CO and O Electroreduction.

Discovering a multifunctional electrocatalyst that can achieve the selective electrochemical reduction of a variety of small molecules (such as CO and O, etc.) is a highly promising process. However, most reported Pd-based nanomaterials can only convert one kind of small molecule.

Specific Lung-Targeting Shortwave Infrared Luminescence Nanoprobe: Precisely Delineating Sepsis-Induced Acute Lung Injury.

Sepsis-induced acute lung injury (ALI), a life-threatening condition, necessitates a deeper molecular-level understanding to promote the development of therapeutic strategies. Although hydrogen sulfide (HS) has been implicated in sepsis-associated ALI, current detection methods and poor pulmonary targeting have limited mechanistic insights. In this study, we present a lung-targeted shortwave infrared (SWIR) nanoprobe (RENPs@PB@LIP) for noninvasive monitoring of HS in ALI though a novel mismatched resonance energy transfer (MRET) strategy.

Fabrication of thermally activated lead-zinc tailings/sodium alginate composites for high-efficiency adsorption of Cu/Cd.

Wastewater containing Cu and Cd poses a huge threat to the surrounding environment and human safety. To treat such wastewater, this study developed a novel composite adsorbent (LZT@SA) from thermally activated LZT and sodium alginate (SA). LZT was thermally activated at 850 °C (LZT).

Electrochemiluminescence and Fluorescence Dual-Mode Aptamer Sensor Based on AIEgens-Based Self-Luminous Flower-like MOF for the Detection of Acetamiprid.

High-performance self-luminous electrochemiluminescence (ECL) materials can effectively improve the sensitivity of ECL sensors. In this study, 4',4‴,4‴″,4‴‴″-(ethene-1,1,2,2-tetrayl)tetrakis([1,1'-biphenyl]-3-carboxylic acid) (HETTC) was used as the organic ligand to prepare self-luminous flower-like aggregation-induced luminescent molecules (AIEgens)-based metal-organic frameworks (MOFs) (Hf NFs) with aggregation-induced electrochemiluminescence (AIECL) and aggregation-induced emission (AIE) properties. HETTC as an organic ligand to construct Hf NFs not only increases the loading capacity of the chromophore but also gives them self-luminescence properties, enabling them to produce excellent AIECL responses even without exogenous coreactants.

Polarization- and angle-insensitive frequency-tunable metasurface absorber with multi-tailoring modes.

The active metasurface absorbers that can regulate the microwave absorption frequencies provide a possibility to construct an intelligent stealth system, which has attracted a great deal of attention. Despite significant progress, achieving dual-band dynamic absorption with a wide tuning range when the profile is extremely thin is still a challenging task. Here, we propose a dual-band tunable ultra-thin metasurface absorber with polarization- and angle-insensitivity.

Comparative long-term outcomes of first-line CDK4/6 inhibitors plus endocrine therapy versus endocrine therapy in patients with HR+/HER2-metastatic or advanced breast cancer: a meta-analysis.

Introduction: This meta-analysis was designed to compare the long-term outcomes of first-line cyclin-dependent kinase 4/6 (CDK4/6) inhibitors plus endocrine therapy (ET) versus ET in patients with HR+/HER2-metastatic or advanced breast cancer (BC).

Materials And Methods: Four databases (Medline, Embase, Web of Science, and CENTRAL) were searched for literature comparing First-line CDK4/6 inhibitors plus ET to ET in patients with HR+/HER2-metastatic or advanced breast cancer. The search was conducted from the database's establishment to April 3, 2025.

Danggui Buxue Decoction inhibits pulmonary fibrosis by alleviating TGF-β1-induced proliferation and apoptosis in EBL cells via PI3K/AKT/FOXO1 pathway.

Ethnopharmacological Relevance: Pulmonary fibrosis (PF), a major fatal complication of calf pneumonia, is classified in traditional Chinese medicine as qi stagnation and blood stasis syndrome. The classic formula Danggui Buxue Decoction (DBD) effectively treats PF by replenishing qi and blood and promoting circulation, though its precise mechanism remains unclear.

Aims: To elucidate DBD's anti-PF mechanism via apoptosis regulation using network pharmacology and in vitro studies.

A NIR dual-channel fluorescent probe for detecting viscosity and ONOO in vitro and vivo.

Aberrant viscosity and excessive levels of peroxynitrite (ONOO) in organism system often result in biological dysfunction and even diseases. Hence, it is crucial to construct near-infrared (NIR) dual-response fluorescent probes for simultaneous detection of viscosity and ONOO. Herein, we fabricated a NIR fluorescent probe (TCPB) with a large emission shift, enabling independent dual-response determination of viscosity and ONOO in living cells.

Advanced Cancer Immunotherapy via SMARCAL1 Blockade Using a Glucose-Responsive CRISPR Nanovaccine.

Cancer immunotherapy that activates the stimulator of interferon genes (STING) signaling pathway to resist tumors has recently attracted considerable attention. However, STING activation can induce opposing interferon functions that contribute to T-cell exhaustion via programmed death-ligand 1 (PD-L1). In particular, effectively using the immune system to combat tumors remains a substantial challenge due to tumor immunosuppressive factors such as SMARCAL1.

A multi-index evaluation system for tuff-asphalt mixtures exposed to long-term water damage based on the fractional grey prediction model.

Given the high susceptibility of tuff-asphalt mixtures to water damage, it is crucial to conduct a comprehensive evaluation of their post-damage performance across multiple performance metrics and integrate these indicators to assess the impact of different water-stability improvement methods on the overall performance of the mixture. This study enhances the long-term water stability of tuff asphalt mixtures by incorporating cement and anti-stripping agents, evaluating their performance under prolonged water exposure. A fractional grey prediction model (FGM) was employed to predict long-term behavior, while a comprehensive evaluation framework was developed using weighted averaging and relative scoring methods.

Synthesis and Catalytic Advances of 2D Hexagonal Noble-Metal Nanostructures.

Noble-metal nanomaterials are widely used as electrocatalysts because of their high activity and stability. And properties of materials are related to their size and morphology, endowing the morphology and size-controlled synthesis for noble-metal nanomaterials to be a hotspot in varied fields. 2D hexagonal nanostructures possess unique electronic and physical properties including high electrical conductivity, chemical stability, large specific surface area.

Utilizing Podocyte Foot Process Morphology for the Identification of Diabetic Nephropathy with or without Minimal Change Disease: Establishment of an Artificial Intelligence-Assisted Diagnostic Model.

Background: This study aimed to differentiate whether diabetic nephropathy (DN) is complicated by minimal change disease (MCD) through the differences in podocyte foot process morphology, and subsequently establish an Artificial Intelligence-Assisted (AI-assisted) Diagnostic Model through machine learning of renal tissue electron microscopy images.

Methods: Patients diagnosed with DN with nephrotic syndrome and treated in our hospital from January 2014 to December 2023 were selected. Patients were divided into the DN group and the DN with MCD group (DN+MCD group).

Ferroptosis as an Emerging Target in Diabetic Osteoporosis.

Diabetic osteoporosis (DOP), as a metabolic bone disease, leads to an increased risk of fracture in patients and imposes a huge burden on society and individuals. The microenvironment of type two diabetes mellitus (T2DM) may contribute to osteoporosis by triggering cell death in bone tissue. Ferroptosis is a novel type of regulated cell death driven by iron-dependent lipid peroxidation discovered in recent years, and the main molecular mechanism involves dysregulation of iron homeostasis, mitochondrial dysfunction, impaired antioxidant capacity, and accumulation of lipid peroxides.

Machine Learning-Enhanced Nanoparticle Design for Precision Cancer Drug Delivery.

In recent years, nanomedicine has emerged as a promising approach to deliver therapeutic agents directly to tumors. However, despite its potential, cancer nanomedicine encounters significant challenges. The synthesis of nanomedicines involves numerous parameters, and the complexity of nano-bio interactions in vivo presents further difficulties.

Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer.

Background: Resistance to immune checkpoint inhibitors remains a significant challenge in the treatment of cancer. Emerging evidence suggests that metabolic reprogramming plays a crucial role in tumor metabolism and progression. Our study strived to investigate the role and underlying mechanisms of the glutamate transporter SLC1A6 in resistance to immunotherapy of cancer.

Synthesis of 25-hydroxycholesterol from bisnoralcohol.

25-Hydroxycholesterol not only exhibits various important biological activities but also plays a crucial role in the synthesis of 25-hydroxyvitamin D. To date, researchers have proposed multiple synthetic routes for 25-hydroxycholesterol. Herein, a novel synthetic method for 25-hydroxycholesterol is described, involving a seven-step reaction that starts from economical and commercially available plant-derived bisnoralcohol, with an overall yield of up to 43.

The dual effects of iron deficiency on intervertebral disc development and on acute injury-induced disc degeneration.

Clinical studies have reported that anemic patients with lower back pain exhibit significantly more severe lumbar intervertebral disc (IVD) degeneration compared to non-anemic individuals. Given that iron deficiency (ID) is the leading cause of anemia, we hypothesized that ID may disrupt IVD metabolism-particularly extracellular matrix synthesis-thereby contributing to aberrant disc development and degeneration. To investigate this, we established an iron-deficiency anemia (IDA) rat model via an iron-deficient diet and induced IVD degeneration through needle puncture.

Efficacy and safety of neoadjuvant PD-1 inhibitors or PD-L1 inhibitors combined with chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis.

Background: The objective of this meta-analysis was to assess the effectiveness and safety of neoadjuvant PD-1/L1 inhibitors plus chemoradiotherapy(CRT) for locally advanced rectal cancer (LARC).

Materials And Methods: Databases including PubMed, Embase, Cochrane Library and Web of Science were examined for pertinent studies. Meta-analyses were conducted on pathological complete response (pCR), clinical complete response (cCR), major pathologic response (MPR), sphincter-sparing surgery (SSS), R0 resection, surgery rate, Grade≥3 adverse events (AEs), and 3-year disease-free survival (DFS).

Longitudinal scRNA-seq of retinal organoids derived from Stargardt disease patient with ABCA4 mutation.

Stargardt disease (STGD), predominantly caused by mutations in the ABCA4 gene, is a leading cause of inherited retinal degeneration. Although several lines of mice expressing disease-causing variants have been produced, mice due to the lack of macular may not be the perfect model to mimic the characteristics of STGD. To address this knowledge gap, we generated retinal organoids from patient-derived induced pluripotent stem cells (iPSCs) harboring ABCA4 mutations and performed biological validation.

Bio-inspired lotus-fiber and mussel-based multifunctional hydrogels for wound healing: super-stretchability, self-healing, adhesion and antibacterial properties.

Hydrogel-based wound dressings, which facilitate rapid wound closure and healing, are essential for effective wound management. However, the development of an ideal hydrogel that possesses excellent mechanical properties, effective self-healing capabilities, tissue adherence and antimicrobial characteristics for wound dressing presents a significant challenge in clinical settings. Inspired by lotus-fiber and mussel, we synthesized a novel multifunctional hydrogel composed of bacterial cellulose-reinforced dopamine-grafted oxidized hyaluronic acid/polyacrylamide (OHA-DA/PAM/BC).

Synthesis, anti-tumor evaluation, and mechanistic investigation of 3-indolylpyrazole phenoxyacetamide derivatives against chronic myeloid leukemia cells.

Both indole and phenol structures are important active components of drug structure. In this study, a series of novel 3-indole pyrazole derivatives incorporating phenolic moieties were rationally designed and synthesized through molecular hybridization strategy. A comprehensive evaluation of antitumor activity demonstrated that these target compounds exhibited remarkable cytotoxicity across four distinct cancer cell lines.

Different Forms of Regulated Cell Death in Type-2-Diabetes-Mellitus-Related Osteoporosis: A Focus on Mechanisms and Therapeutic Strategies.

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder with a high prevalence and challenging treatment options. It significantly affects the function of various organs, including bones, and imposes substantial social and economic costs. Chronic hyperglycemia, insulin resistance, and abnormalities in glucolipid metabolism can lead to cellular damage within the body.

Degradation of sweet corn cob polysaccharides by ultrasound-assisted HO/Vc treatment: Structural characterization and hypoglycemic effects in vitro and in vivo.

To investigate the inhibitory potential of plant-degraded polysaccharides on glycosidases and elucidate the mechanism by which they alleviate type 2 diabetes mellitus (T2DM), a degraded sweet corn cob polysaccharide (UHDSCP) was prepared using ultrasound-assisted hydrogen peroxide-ascorbic acid oxidation (HO/Vc). UHDSCP was subsequently characterized using various analytical techniques, including UV spectroscopy, Fourier transform infrared (FT-IR) spectroscopy, gel permeation chromatography (GPC), high-performance liquid chromatography (HPLC), scanning electron microscopy (SEM), and atomic force microscopy (AFM). Our findings indicated that UHDSCP has a molecular weight of 14.