Quaternary-ammonium chitosan/Sericin-modified carbon nanotubes Photothermal coatings: A reusable and sustainable chemical-free seed disinfection strategy.

The increasing global demand for food and the adverse environmental impacts of excessive agrochemical use highlights the urgent need for sustainable and scalable seed treatment technologies. This paper reports a novel photothermal seed coating (QC@SCCNTs) with high biocompatibility, exceptional photothermal efficiency, and notable reusability, serving as an effective alternative to conventional chemical treatments. The coating consists of sericin-functionalized carboxylated carbon nanotubes (SCCNTs) electrostatically complexed with quaternary ammonium chitosan (QC), forming a composite film (QS film).

Correction: Efficient photocatalytic performance of hydrogen bonding between P25 and microcrystalline cellulose aerogel.

[This corrects the article DOI: 10.1039/D4RA07087A.].

Recent Advances in Metal-Organic Framework Nanozyme (MOFzyme)-Based Biosensors for Detecting Food Contaminants.

Ensuring food safety and freshness demands highly sensitive and reliable biosensors for food contaminant detection, where signal probes act as vital elements in this endeavor. Metal-organic framework nanozymes (MOFzymes) have emerged as signal probes owing to their highly tunable porosity, component versatility for modulating enzyme-like activity, and customizable surface modifications. This review systematically encapsulates MOFzyme-based biosensors for the identification of diverse food pollutants.

Development and Validation of a Nomogram for Prognostic Prediction in Ovarian Cancer Based on Tumor Proliferation and Immune-Related Biomarkers in Chinese Patients.

Objective: To develop a nomogram prediction model for ovarian cancer prognosis using tumor proliferation and immune-related biomarkers.

Methods: Between January 2018 and December 2023, clinical data were collected from 140 patients diagnosed with epithelial ovarian cancer (EOC). These patients were randomly allocated into a training cohort consisting of 84 patients and a validation cohort comprising 56 patients, adhering to a 6:4 ratio.

Seasonal blooms of in a temperate semi-enclosed bay: linking community succession to thermal and nutrient regimes.

is a key picocyanobacterium in coastal ecosystems, yet its seasonal bloom dynamics and environmental responses remain unclear in temperate coastal seas. Here, we integrated flow cytometry and gene analysis to investigate its bloom development and community succession in Laizhou Bay, based on 3 years of 10 seasonal surveys and a year-long monthly observation at a fixed station. blooms reached their peak in summer (up to 10 cells mL), particularly in the southern part of the bay, with high abundances in autumn as well.

Development of a yeast-based CRISPR genome editing system for feline coronavirus.

Introduction: Feline infectious peritonitis (FIP), caused by feline coronavirus (FCoV), is a highly lethal disease characterized by systemic organ infection in cats. Current challenges of FIP include the absence of definitive diagnostic criteria, effective vaccines, and targeted therapies. Developing a robust genome editing toolkit is therefore critical to unraveling FCoV replication and pathogenesis mechanisms, elucidating viral protein functions, and identifying promising diagnostic and therapeutic targets.

Assessing difficulties in regulating negative and positive emotions: The Difficulties in Emotion Regulation Scale-Expanded (DERS-X).

Negative and positive emotion regulation are important to psychological well-being. However, most individual-difference measures of emotion regulation focus primarily or exclusively on negative emotion regulation. In the present research, we sought to expand the widely used Difficulties in Emotion Regulation Scale (DERS) by including items assessing positive as well as negative emotion regulation.

Retrieval practice versus generating mnemonics: Implications for study strategy use in chemistry.

Many researchers and educators have strongly advocated for utilizing retrieval practice to improve student learning and grades. Yet, the mnemonic consequences of retrieval practice have almost exclusively been compared to rereading, which is a passive, ineffective study strategy. Across two experiments that each included 69 college student participants conducted in the 2022-2023 academic year, we tested how practice retrieving chemistry concepts impacts memory and transfer compared to generating mnemonics (and rereading).

Single-Cell Sequencing-Based Exploration of the Role of Tip Cells on Astrocytes and Macrophages After Spinal Cord Injury.

Excessive inflammation is a capital cause of scar formation and inflammation microenvironment that result in challenge of axonal regeneration after spinal cord injury (SCI). Macrophages and astrocytes play important roles in the inflammatory response. Tip cells, a critical endothelial sub-population, play pivotal roles in post-injury vascular regeneration.

11-Methoxytabersonine Induces Ferroptosis in Triple-Negative Breast Cancer via YY1-CDKL1-GPX4 Axis.

The 11-Methoxytabersonine (11-MT), a monoterpenoid-indole alkaloid isolated from the leaves of Melodinus henryi, has shown promising therapeutic potential against triple-negative breast cancer (TNBC). This study aimed to evaluate the anti-tumor efficacy of 11-MT and to elucidate its underlying molecular mechanisms in the context of TNBC. The in vitro anti-cancer effects of 11-MT were assessed using Cell Counting Kit-8 (CCK-8), colony formation assays, and flow cytometry.

StaDis: Stability distance to detecting out-of-distribution data in computational pathology.

Modern Computational pathology (CPath) models aim to alleviate the burden on pathologists. However, once deployed, these models may generate unreliable predictions when encountering data types not seen during training, potentially causing a trust crisis within the computational pathology community. Out-of-distribution (OOD) detection, acting as a safety measure before model deployment, demonstrates significant promise in ensuring the reliable use of models in real clinical application.

"Twisted" Terpolymer Donor Enabling High-Performance Intrinsically Stretchable Organic Solar Cells.

Intrinsically stretchable organic solar cells (is-OSCs) hold great potential for next-generation wearable power generators. Currently, high-efficiency polymeric donor materials are based on rigid planar conjugated backbones, which limits their mechanical robustness and creates a trade-off between photovoltaic performance and stretchability. To simultaneously improve the power conversion efficiency (PCE) and mechanical robustness of is-OSCs, we develop a series of ductile PM-BOX% terpolymers by incorporating different amounts (X = 5, 10, and 20) of 3-butyloctyl-thiophene (ThBO) units into PM6 backbone.

Postoperative Radiotherapy for Head and Neck Merkel Cell Carcinoma: Sometimes, Less Is More.

Background: Head and neck Merkel cell carcinoma (HNMCC) is a rare but aggressive malignancy characterized by high recurrence rates and an uncertain survival benefit from postoperative radiotherapy (PORT). This study aimed to develop and validate a prognostic nomogram for risk stratification and to evaluate the survival benefit of PORT across risk groups.

Methods: Patients with surgically resected, non-metastatic HNMCC were retrospectively identified.

Neutrophil-Related Genes Predict Prognosis and Contribute to Immunosuppression in Acute Myeloid Leukemia.

Introduction: Acute myeloid leukemia (AML) prognosis remains challenging due to limited biomarkers integrating tumor microenvironment (TME) dynamics. Neutrophils, key mediators of immune regulation, exhibit dual roles in cancer progression, yet their prognostic significance in AML is poorly defined. This study aimed to construct a neutrophil-related gene signature for AML risk stratification and explore its clinical and immunological implications.

Acid and weakly acidic reflux characteristics in pediatric airway malacia by pH and multiple intraluminal impedance monitoring: a retrospective cohort study.

Unlabelled: The objective of this study was to analyze the 24-h pH and multiple intraluminal impedance (pH-MII) monitoring results in pediatric patients with airway malacia, with the aim of comprehensively understanding the characteristics of gastroesophageal reflux (GER) in these patients and exploring their potential roles in the pathogenesis of airway malacia. This retrospective cohort study enrolled pediatric patients who underwent 24-h pH-MII monitoring and bronchoscopy at Maternal and Child Health Hospital of Hubei Province from January 2017 to October 2023. Among 64 pediatric patients with airway malacia, 24 (37.

Light-triggered molecular mechanotherapy of tumor using membrane-mimicking conjugated oligoelectrolytes.

A class of light-mediated mechanotherapeutic agents was developed on the basis of conjugated oligoelectrolytes (COEs), which mimic the topology of lipid membranes and intrinsically exhibit excellent biocompatibility. Low-dose white light irradiation (20 milliwatts per square centimeter for 10 minutes) substantially decreased the half-maximal inhibitory concentration of the optimized COE against A549 cancer cells from more than 256 to 0.6 micromolar.

Starch/ polyvinyl alcohol/Brazilein film with enhanced stability by using medium-chain triglycerides emulsion for real-time meat freshness monitoring.

Brazilein natural dye (BR) and various concentrations of medium-chain triglycerides emulsion (EM) were added to a starch/polyvinyl alcohol (S/PA) base film to monitor beef and shrimp freshness in a novel intelligent food packaging film. The color of the BR solution changed from yellow to dark red at pH levels ranging from 2.0 to 12.

High-Density W Single Atoms in Two-Dimensional Spinel Oxide Break the Structural Integrity for Enhanced Oxygen Evolution Catalysis.

The performance of oxygen evolution reaction (OER) catalysts heavily depends on intrinsically active and robust sites as well as high active site number, which poses challenges in catalyst design concerning composition and structure. This study presents a general oxygen-vacancy anchoring strategy for preparing oxide-based 4d/5d transition metal single-atom 2D materials as efficient and robust OER catalysts. In a typical synthesis, Keggin-structure polyoxometalate [PWO] clusters decompose into tetrahedral WO anions, which in situ adhere to the newly nucleated metal (Co, Fe, Ni) hydroxide (M(OH)) due to the latter's abundant oxygen vacancies, ensuring a uniform distribution of W single atoms.

Pembrolizumab-associated hepatobiliary disorders: a real-world pharmacovigilance study using the FDA Adverse Events Reporting System (FAERS).

The aim of this study was to evaluate hepatobiliary disorders adverse events associated with pembrolizumab by using the Food and Drug Administration Adverse Event Reporting System (FAERS).We collected FAERS data from the first quarter of 2009 to the third quarter of 2024 and used reporting odds ratio (ROR) to detect pembrolizumab-associated hepatobiliary adverse events (AEs). A signal was considered significant when the lower limit of the 95% confidence interval (CI) of the ROR exceeded 1, and≥5 AEs were reported.

Cysteine dioxygenase knockout and taurine deficiency impair mouse uterine adenogenesis by inhibiting epithelial cell proliferation and enhancing apoptosis.

Uterine glands and their secretions are essential for conceptus survival and development, with abnormalities in uterine gland morphogenesis (adenogenesis) are closely related to high rates of peri-implantation embryonic loss in humans and livestock. While uterine adenogenesis occurs postnatally in most mammals, the key regulatory factors and mechanisms governing this developmental event remains largely unexplored. Our recent study reveals that cysteine dioxygenase (CDO) is highly expressed in the uterus of adult mice, which is also rich in taurine.

Effect of the combination of remifentanil and neuromuscular blockers in pediatric endotracheal intubation: a prospective, double-blinded, randomized clinical trial.

Background: Endotracheal intubation must be performed more carefully in children than in adults, as children are likely to more serious consequences due to the buck, move, and hemodynamic changes during the procedure. The aim of this study was to explore whether increasing the use of remifentanil during anesthesia induction can further improve the effectiveness and safety of tracheal intubation in children.

Design: This double-blind clinical trial included patients who underwent elective surgery under general anesthesia for intubation at Beijing Children's Hospital.

Analysis of collaborative robot technology patent map and research on development trends.

This study conducts a systematic analysis of global patents in the field of collaborative robot technology based on applications and type of industry. The data analyzed derives from the PatSnap database covering 30,425 patents from 2006 to 2025, using explicit keywords such as "collaborative robot" to ensure specificity, with procedural filters and manual curation applied to maximize relevance and accuracy. The research focuses on patent application trends, technological hotspots, geographical distribution, as well as applicant and inventor analyses, providing a comprehensive overview of the innovation landscape and development trends in this domain.

Electrochemiluminescence and Fluorescence Dual-Mode Aptamer Sensor Based on AIEgens-Based Self-Luminous Flower-like MOF for the Detection of Acetamiprid.

High-performance self-luminous electrochemiluminescence (ECL) materials can effectively improve the sensitivity of ECL sensors. In this study, 4',4‴,4‴″,4‴‴″-(ethene-1,1,2,2-tetrayl)tetrakis([1,1'-biphenyl]-3-carboxylic acid) (HETTC) was used as the organic ligand to prepare self-luminous flower-like aggregation-induced luminescent molecules (AIEgens)-based metal-organic frameworks (MOFs) (Hf NFs) with aggregation-induced electrochemiluminescence (AIECL) and aggregation-induced emission (AIE) properties. HETTC as an organic ligand to construct Hf NFs not only increases the loading capacity of the chromophore but also gives them self-luminescence properties, enabling them to produce excellent AIECL responses even without exogenous coreactants.