Development and Validation of a Nomogram for Prognostic Prediction in Ovarian Cancer Based on Tumor Proliferation and Immune-Related Biomarkers in Chinese Patients.

Objective: To develop a nomogram prediction model for ovarian cancer prognosis using tumor proliferation and immune-related biomarkers.

Methods: Between January 2018 and December 2023, clinical data were collected from 140 patients diagnosed with epithelial ovarian cancer (EOC). These patients were randomly allocated into a training cohort consisting of 84 patients and a validation cohort comprising 56 patients, adhering to a 6:4 ratio.

Successful Diagnosis and Treatment of Early Postpartum Choriocarcinoma.

Background: Postpartum placental choriocarcinoma is a rare gestational trophoblastic tumor, with an incidence of approximately one in 50 000. Patients often present with persistent postpartum hemorrhage, which can lead to delayed diagnosis, hematogenous metastasis, and ultimately, a poor prognosis.

Case: A 35-year-old woman was admitted to the Emergency Department 39 days after a cesarean section due to persistent heavy vaginal bleeding.

Composite dietary antioxidant index and infertility: A study based on NHANES 2013 to 2018.

The Composite Dietary Antioxidant Index (CDAI), a robust metric reflecting the antioxidant richness of one's diet, has garnered attention for its capacity to temper the progression of a plethora of chronic maladies: among them, chronic obstructive pulmonary disease, chronic kidney disease, depression, nephrolithiasis (kidney stones), and papillomavirus infections. Its established role as a guardian against such conditions notwithstanding, the association between CDAI and reproductive health, particularly infertility, has yet to be thoroughly delineated. Against this backdrop, our research endeavor aims to explore the potential correlation between CDAI scores and the prevalence of infertility, thereby contributing to the existing knowledge base on the multifaceted impacts of dietary antioxidants on human health.

Global, regional, and national burden of ovarian cancer in women aged 45 + from 1990 to 2021 and projections for 2050: a systematic analysis based on the 2021 global burden of disease study.

Purpose: Ovarian cancer is the most common cause of gynecologic cancer-related deaths. We aimed to assess the global, regional, and national burdens and trends of Ovarian Cancer in Women Aged 45 + from 1990 to 2019 and Projections for 2050, utilizing data from the most recent Global Burden of Disease (GBD) 2021 database.

Methods: Age-standardized rates of incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were analyzed using GBD 2021 data.

NFIC suppressed the epithelial ovarian cancer via modulating the balance of PTEN/TGFβ1/EGR1/BRD4 and SP1/EZH2 induced Inhibition of TBX2/MMPs signaling.

This study aims to explore the impact of NFIC and its regulated signaling factors on epithelial ovarian cancer, providing new insights for the treatment of ovarian epithelial cancer. Bioinformatics methods were applied to predict and analyze NFIC and its downstream signaling factors. In vivo experiments involved dividing 27 purchased female nude mice into three groups: NC group, NFIC-OE group, and NFIC-OE + TBX2-OE group, to observe tumor growth in each group.

The quality and reliability of short videos about premature ovarian failure on Bilibili and TikTok: Cross-sectional study.

Background: Premature ovarian failure (POF) is a condition where ovarian function ceases before age 40, leading to infertility and other health issues. As public health awareness increases, platforms like TikTok and Bilibili have become key sources for health-related content. However, the absence of peer review and regulatory oversight on short-video platforms may result in the spread of inaccurate or incomplete health information.

5-Methylcytosine methylation predicts cervical cancer prognosis, shaping immune cell infiltration.

BackgroundEpigenetics, encompassing DNA and RNA modifications, has emerged as a prominent area of research in the post-genomic era. Numerous studies have elucidated the impact of epigenetics on tumor regulation. However, the methylation patterns of 5-methylcytosine in cervical cancer as well as its role in the tumor microenvironment and immunotherapy remain poorly understood.

Association between urinary arsenic and the prevalence of endometriosis in women in the United States.

Background: Endometriosis affects up to 15% of women of reproductive age and can lead to various symptoms. More than 200 million people worldwide are at risk of higher than safe levels of arsenic exposure through drinking water. Studies investigating the relationship between arsenic and endometriosis are very limited and have yielded inconsistent results.

Association between the C-reactive protein-triglyceride-glucose index and endometriosis: a cross-sectional study using data from the national health and nutrition examination survey, 1996-2006.

Background: The C-reactive protein-triglyceride glucose index (CTI) is a promising new marker for evaluating the severity of inflammation. Endometriosis (EM) is a prevalent chronic inflammatory condition influenced by estrogen, primarily affecting women of reproductive age. However, no study has demonstrated an association between the CTI and EM.

Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data.

Background: Medroxyprogesterone acetate (MPA), a synthetic progestogen, is extensively used for the treatment of various conditions, including contraception, irregular menstruation, functional uterine bleeding, and endometriosis. However, like all pharmaceutical agents, MPA is associated with adverse drug reactions. This study aimed to evaluate the adverse events (AEs) associated with MPA in by analyzing real-world data from the U.