A Microfluidic System for Real-Time Monitoring and In Situ Metabolite Detection of Plasma-Enhanced Wound Healing.

Although cold atmospheric plasma (CAP) has shown promise in facilitating wound repair due to its non-thermal and non-invasive properties, its dynamic effects on cellular response and metabolic regulation remain poorly characterized, and the mechanism is still unclear. In this study, we developed a microfluidic experimental system that integrates a CAP treatment module with multiparametric in situ sensing capabilities, along with precise environmental control of temperature, humidity, and CO concentration. A stratified microfluidic chip was engineered to co-culture HaCaT keratinocytes and HSF fibroblasts.

Salvinia-inspired architectures for enhancing interface stability and mass transfer in microchannels.

Mass transfer in conventional microchannels primarily relies on wall-mediated diffusion or is compromised by dynamic instability at free interfaces, which limits interphase transport efficiency. Inspired by the hierarchical trichomes of leaves, we designed composite architectures featuring spatially selective hydrophilic modification polydopamine (PDA) grafting, which enhance mass transfer while maintaining interface stability in microchannels. High-speed imaging was used to capture the dynamic evolution of interfacial morphology, revealing failure behaviours consistent with theoretical analysis.

Neutrophil-Related Genes Predict Prognosis and Contribute to Immunosuppression in Acute Myeloid Leukemia.

Introduction: Acute myeloid leukemia (AML) prognosis remains challenging due to limited biomarkers integrating tumor microenvironment (TME) dynamics. Neutrophils, key mediators of immune regulation, exhibit dual roles in cancer progression, yet their prognostic significance in AML is poorly defined. This study aimed to construct a neutrophil-related gene signature for AML risk stratification and explore its clinical and immunological implications.

Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner.

Clinical studies have suggested that increased plasma oxytocin (OT) levels are a promising biomarker for bipolar disorder (BD), and our earlier post-mortem study found increased OT activity in the hypothalamic paraventricular nucleus (OT) in BD. However, the potential contribution of the supraoptic nucleus (SON, OT), a major part of the central OT system, to BD remains unknown. We therefore systematically performed independent acute or chronic chemogenetic activation of OT, OT, or OT experiments in OT-cre mice.

BiNaTiO-Based Relaxor Ferroelectrics with Highly Polarizable Concentrated Nanodomains for High Capacitive Energy Storage under Moderate Electric Fields.

The achievement of high recoverable energy density () and efficiency (η) simultaneously in dielectric ceramics under low/moderate electric fields ('s) offers potential for use in compact microelectronics and portable devices. However, a major challenge lies in the difficulty of coexistence of high maximum polarization () and low polarization hysteresis under low/moderate 's. Here, through the modification of heterovalent ferroelectric-active ions to enhance average ionic polarizability, guarantee considerable spontaneous polarization, and disrupt long-range ferroelectric order, both the high and low polarization hysteresis were obtained in the 0.

Efficacy and safety analysis of different treatment regimens in newly diagnosed acute promyelocytic leukemia.

This retrospective study analyzed the clinical data of 151 newly diagnosed adult acute promyelocytic leukemia (APL) patients during induction therapy at Qilu Hospital of Shandong University to compare the efficacy and complications of different treatment regimens in low-to-intermediate-risk (WBC < 10 × 10⁹/L) and high-risk (WBC ≥ 10 × 10⁹/L) patients. Low-to-intermediate-risk patients were divided into three groups: ATRA + ATO dual induction (n = 18), ATRA + ATO + single-agent chemotherapy (n = 63), and ATRA + ATO + dual-agent chemotherapy (n = 18). High-risk patients were divided into two groups: ATRA + chemotherapy (n = 11) and ATRA + ATO + chemotherapy (n = 41).

Microbubbles Enhanced Oil Displacement in Deep Pores.

The presence of deep pores allows the fluid to stop in them, and the presence of deep pores can lead to incomplete displacement of surface stains, which can lead to undesirable consequences in both petroleum engineering and skin cleaning. As a new and safe cleaning method, microbubbles have been found to have good application potential in the oil displacement process. In this study, microfluidic chips were constructed to simulate deep pores of different sizes on the surface.

Optical coherence tomography angiography integrating differential phase and intensity images for imaging of a mouse retina.

Optical coherence tomography angiography (OCTA) suffers from more motion artifacts compared to optical coherence tomography, which are the primary source of image quality degradation in imaging. We propose an OCTA algorithm in this Letter that differs from motion compensation methods widely employed to reduce motion artifacts and effectively mitigates these artifacts. The algorithm integrates differential phase and intensity images based on the standard deviation of the flow signals.

Revealing unusual storage failure of single-crystal high-nickel cathodes during high-temperature and high-humidity exposure.

This work investigates an unusual storage failure in single-crystal high-nickel cathode materials under a simulated hot and humid environment. A transient passivation effect was observed during short-term exposure, followed by rapid performance deterioration and structural/chemical state transformations upon prolonged storage. The findings highlight the need for targeted ambient storage control and material modification strategies.

The Emerging Role and Mechanism of E2/E3 Hybrid Enzyme UBE2O in Human Diseases.

The ubiquitin-proteasome system (UPS) plays a pivotal role in determining protein fate, regulating signal transduction, and maintaining cellular homeostasis. Protein ubiquitination, a key post-translational modification, is orchestrated by the sequential actions of three primary enzymes, ubiquitin-activating enzyme (E1), ubiquitin-conjugating enzyme (E2), and ubiquitin protein ligase (E3), alongside the regulatory influence of deubiquitinases (DUBs) and various cofactors. The process begins with E1, which activates ubiquitin molecules.

Low-Concentration Vitrification Agent Based on Polyglutamic Acid and Nanowarming for Porcine Blood Vessel Cryopreservation.

Long-term cryopreservation of blood vessels is crucial for cardiovascular disease treatments. To avoid ice crystal-induced injuries and achieve higher recovery, viability, function, and scalability of blood vessels, ice-free vitrification technology is required. However, traditional ice-free vitrification often necessitates high concentrations of toxic cryopreservation agents (CPAs), such as VS55 at concentrations up to 8.

Crosstalk of lactate metabolism-related subtypes, establishment of a prognostic signature and immune infiltration characteristics in colon adenocarcinoma.

Colon adenocarcinoma (COAD) is a common malignant tumor of digestive tract and lactate metabolism has been linked to tumor development and progression. In this study, we sought to investigate the influence of lactate metabolism-related genes (LRGs) prognosis. We also aimed to identify distinct LRG-related clusters and develop a risk signature for assessing patient prognosis, immunological characteristics, and response to therapy.

Increased oxytocin/vasopressin ratio in bipolar disorder in a cohort of human postmortem adults.

Bipolar disorder (BD) and major depressive disorder (MDD) share some common characteristics in stress-related brain circuits, but they also exhibit distinct symptoms. Our previous postmortem research on the immunoreactivity (ir) levels of neuropeptide oxytocin (OT) in the hypothalamic paraventricular nucleus (OT) and some clinical research on plasma OT levels suggested that increased levels of OT is a potential trait marker for BD. However, dysregulation of the related neuropeptide arginine vasopressin (AVP), that often shows opposite effects for stress responses compared to OT has not been investigated in BD.

Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease.

Background: Metabolic-associated fatty liver disease (MAFLD) is characterized by lipid accumulation in hepatocytes and is closely associated with oxidative stress. Increasing clinical evidence indicates that MAFLD is linked to bone metabolic disorders, including osteoporosis. Recent studies indicate that the expression profiles of liver circular RNAs (circRNAs) are altered in MAFLD.

[Prediction method of paroxysmal atrial fibrillation based on multimodal feature fusion].

The risk prediction of paroxysmal atrial fibrillation (PAF) is a challenge in the field of biomedical engineering. This study integrated the advantages of machine learning feature engineering and end-to-end modeling of deep learning to propose a PAF risk prediction method based on multimodal feature fusion. Additionally, the study utilized four different feature selection methods and Pearson correlation analysis to determine the optimal multimodal feature set, and employed random forest for PAF risk assessment.

Wastewater quality prediction based on channel attention and TCN-BiGRU model.

Water quality prediction is crucial for water resource management, as accurate forecasting can help identify potential issues in advance and provide a scientific basis for sustainable management. To predict key water quality indicators, including chemical oxygen demand (COD), suspended solids (SS), total phosphorus (TP), pH, total nitrogen (TN), and ammonia nitrogen (NH₃-N), we propose a novel model, CA-TCN-BiGRU, which combines channel attention mechanisms with temporal convolutional networks (TCN) and bidirectional gated recurrent units (BiGRU). The model, which uses a multi-input multi-output (MIMO) architecture, is capable of simultaneously predicting multiple water quality indicators.

Ultrafast Li-Rich Transport in Composite Solid-State Electrolytes.

Solid-state lithium (Li) metal batteries (SSLMBs) have garnered considerable attention due to their potential for high energy density and intrinsic safety. However, their widespread development has been hindered by the low ionic conductivity of solid-state electrolytes. In this contribution, a novel Li-rich transport mechanism is proposed to achieve ultrafast Li-ion conduction in composite solid-state electrolytes.

Transparent and Thermally Stable Rare-Earth-Doped Luminescent Gallate Glass toward Passive Daytime Radiative Cooling Applications.

Currently, the implementation of passive daytime radiative cooling based on zero-energy cooling methodologies primarily focuses on polymers and composite materials, whereas the available literature on all-inorganic materials is relatively few. Here, we present a novel microcrystalline glass material CaGaAlO (CGAO), doped with rare-earth elements and prepared by the high-temperature melting method. This material exhibits long-term stability at 200 °C, coupled with an effective infrared radiation cooling function, demonstrating a 4.

The dynamics of red blood cells traversing slits of mechanical heart valves under high shear.

Hemolysis, including subclinical hemolysis, is a potentially severe complications of mechanical heart valves (MHVs), which leads to shortened red blood cell (RBC) lifespan and hemolytic anemia. Serious hemolysis is usually associated with structural deterioration and regurgitation. However, the shear stress in MHVs' narrow leakage slits is much lower than the shear stress threshold causing hemolysis and the mechanisms in this context remain largely unclear.

Identification of potential diagnostic biomarkers for hypertension via integrated analysis of gene expression and DNA methylation.

Objective: Hypertension refers to the elevated blood pressure (BP) in arteries, with a BP reading of 140/90 mm Hg or higher in adults. Over 40% of >25-year-old population have suffered from hypertension. Thus, this study aimed to find novel diagnostic biomarkers for hypertension.

Internet + wearable device training effects on limb function recovery and serum neurocytokine content in stroke patients.

Background: The traditional method of post-hospital intervention and guidance of stroke patients has some limitations.

Objective: To investigate the effects of Internet + wearable device training on limb function recovery and the levels of serum neurocytokines (BDNF, NT-3, and NGF) in stroke patients.

Methods: 80 stroke patients with hemiplegia were randomly selected from the Department of Neurorehabilitation, Affiliated Rehabilitation Hospital of Chongqing Medical University.

Microinvasive Intrascleral Double Continuous Suture Repair Surgery for Cyclodialysis Clefts.

Background: The traditional suturing method for cyclodialysis cleft usually requires an incision in the sclera for direct suturing, resulting in greater damage and a high risk of postoperative complications. The purpose of this work was to propose a newly intrascleral double continuous suture repair technique for the treatment of cyclodialysis clefts.

Methods: Seven patients with cyclodialysis cleft underwent microinvasive intrascleral double continuous suture repair surgery to restore the attachment of the detached ciliary body to the sclera without scleral incision.

RHOF activation of AKT/β-catenin signaling pathway drives acute myeloid leukemia progression and chemotherapy resistance.

Acute myeloid leukemia (AML) is a clonal malignancy originating from leukemia stem cells, characterized by a poor prognosis, underscoring the necessity for novel therapeutic targets and treatment methodologies. This study focuses on Ras homolog family member F, filopodia associated (RHOF), a Rho guanosine triphosphatase (GTPase) family member. We found that RHOF is overexpressed in AML, correlating with an adverse prognosis.

Interventional Removal of Travelling Microthrombi Using Targeted Magnetic Microbubble.

Microthrombus is one of the major causes of the sequelae of Corona Virus Disease 2019 (COVID-19 and leads to subsequent embolism and necrosis. Due to their small size and irregular movements, the early detection and efficient removal of microthrombi in vivo remain a great challenge. In this work, an interventional method is developed to identify and remove the traveling microthrombi using targeted-magnetic-microbubbles (TMMBs) and an interventional magnetic catheter.