Astrocytic Mettl14 depletion enhances cognitive function by attenuating astrogliosis via the DUSP1/MAPK pathway in APP/PS1 mice: targeting neuroinflammation in Alzheimer's disease.

Alzheimer's disease (AD), a leading cause of dementia, represents a critical unmet global medical need. While the precise mechanisms underlying AD pathogenesis remain elusive, increasing evidence underscores the pivotal role of neuroinflammation in driving cognitive impairment. N6-methyladenosine (m6A), an epigenetic modification regulating RNA metabolism, has been found to be dysregulated in AD.

Soy isoflavones improve sympathetic nervous system-driven non-alcoholic fatty liver disease through estrogen-like effects.

This study investigated the advantages of gerbils as a sympathetic nervous system (SNS)-driven model for non-alcoholic fatty liver disease (NAFLD) and evaluated the therapeutic potential of soy isoflavones (SIFs). Gerbils exhibited unique SNS characteristics, with an adrenal gland-to-kidney weight ratio 2-3 times higher than that of C57BL/6 mice and Wistar rats, demonstrating elevated levels of adrenaline (AE) and noradrenaline (NE) as well as more pronounced anxiety-like behaviors, indicating enhanced SNS activity. Additionally, gerbils possessed liver lipid metabolism and storage capacities similar to humans, along with a simple genetic background, allowing them to more accurately reflect the pathogenesis of NAFLD.

Developing a prognostic model of glutamine metabolism-related genes associated with clinical features and immune status in melanoma.

Introduction: Melanoma exhibited a poor prognosis due to its aggression and heterogeneity. The effect of glutamate metabolism promoting tumor progression on cutaneous melanoma remains unknown. Herein, glutamine metabolism-related genes (GRGs) were identified followed by constructing a prognostic model for melanoma via bioinformatics analysis.

Predicting 28-day mortality for patients with acute anterior circulation large vessel occlusion stroke following endovascular treatment in neurology intensive care units.

Background: The clinical utility of the National Institutes of Health Stroke Scale, Glasgow Coma Scale, and modified Rankin Scale scores in predicting prognosis is well established. However, whether the Acute Physiology and Chronic Health Evaluation System II (APACHE II) score can predict mortality in patients with large vessel occlusion stroke (LVOS) admitted to the neurology intensive care unit (NICU) following endovascular treatment (EVT) remains unclear. This study aims to evaluate the ability of the APACHE II score to predict mortality in post-EVT LVOS patients admitted to the NICU.

Synergistic enhancement of chitosan-diatomite composite in microalgae flocculation: Mechanistic insights into extracellular polymeric substances-mediated harvesting.

Chitosan is a promising bioflocculant for harvesting microalgae, its practical implementation is constrained by high dosage demands (typically >1 g/L) and suboptimal settling kinetics. And the microalgae harvesting process is susceptible to the significant influence of extracellular polymeric substances (EPS), the mechanism of which is still unclear. This study synthesized amino-functionalized chitosan-diatomite composites (APTES-CTS/DTE) and revealed the action mechanism of EPS in the flocculation of microalgae.

Incidence and Risk Factors for Progression of Acute Kidney Injury to Chronic Kidney Disease After Liver Transplantation: A Retrospective Cohort Study.

Acute kidney injury (AKI) following liver transplantation has the potential to progress to chronic kidney disease (CKD), which can result in extended hospital stays, elevated healthcare costs, and increased mortality rates. This retrospective cohort study seeks to examine the prognosis of AKI progression to CKD post-liver transplantation and to identify its independent risk factors. A cohort of 443 patients who developed AKI post-liver transplantation was analyzed, with participants categorized into a CKD group and a non-CKD group.

Female light capture is shaped by juvenile hormone-mediated post-mating behavior in the diamondback moth.

Background: Post-mating behavioral changes are crucial for optimizing female reproductive success in insects, frequently resulting in shifts in both physiology and behavior. In moths, light traps typically capture more mated females than unmated ones; however, the mechanisms driving this discrepancy remain unclear.

Results: In this study, we examined how mating status influences female light capture in the diamondback moth (DBM; Plutella xylostella).

Diminishing returns of task-oriented interaction in digitally-mediated dynamic teams: evidence from amateur sports organizing.

Although extant research has emphasized task-oriented processes in teams, its focus on dynamic teams in digital environments remains limited, particularly regarding non-linear effects. Integrating attention capacity theory and activation theory, this study proposes a curvilinear (inverted-U) relationship between task-oriented interaction and team organizing efficiency in digitally-mediated teams. Analyzing 455 spontaneous sports teams from an open-boundary organizational platform revealed support for the proposed curvilinear relationship, with team identification moderating the effect.

Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake.

The regulation of cellular metabolism and growth in response to nutrient availability is crucial for cell survival and can significantly impact on lifespan. Central to this regulation is a class of transporters that sense and transport specific nutrients and transduce the signal downstream to control genes responsible for growth and survival. In this study, we identified SUL1, a plasma membrane transporter responsible for regulating the entry of extracellular sulfate in , as a key gene for regulating lifespan.

Moisture Microenvironment-Regulating Electro spun Membranes for Extending Litchi Shelf Life.

To address post-harvest issues of litchi, including browning, water loss, and nutrient degradation, a moisture microenvironment-regulating electro spun membrane was prepared by incorporating hydrophobic carnauba wax (CW)@nano silica (SiO) composite powder into a polyethylene terephthalate (PET) matrix via electro spinning. The dynamic water penetration equilibrium was evaluated by monitoring the water vapor absorption of the electrospun membrane within 12 h, while the effects of CW@SiO on the micro-structure, mechanical properties, hydrophobicity, and thermal stability were investigated. Results showed that the tensile strength of the PET-2.

Establishing the super-enhancer landscape in chicken adipose tissue.

Enhancers are cis-regulatory elements that control spatiotemporal gene expression patterns. Super-enhancers (SEs), which function as clustered regulatory elements, play crucial roles in establishment and maintenance of cellular identity. Accumulating evidence highlights the importance of SEs in mammalian adipogenesis and fat deposition.

Socioeconomic status and risk of gestational diabetes mellitus among pregnant women in Zunyi, China.

Background: The impact of socioeconomic status on disease is becoming increasingly apparent. However, the relationship between gestational diabetes mellitus (GDM) and socioeconomic status (SES) has been less studied and remains inconsistent. The aim of this study was to investigate the relationship between SES and GDM.

Development of a low-cost and high-throughput LC-MS method for newborn screening of thalassemia and abnormal hemoglobin disorders.

Background: Screening and pre-symptomatic diagnosis in newborns allows early treatment of thalassemia and abnormal hemoglobin (Hb) disorders in childhood. However, there remains a lack of efficient methods to screen for hemoglobinopathies in newborns. This study aimed to establish a bottom-up mass spectrometry (MS)-based method for efficient screening of hemoglobinopathies in newborns using dried blood spot (DBS) samples.

Exosomal MicroRNAs as novel diagnostic biomarkers in head and neck cancer: a systematic evaluation and meta-analysis.

Background: Head and neck cancer ranks as the sixth most common malignant tumor globally, with the majority of patients detected at advanced stages. Consequently, this study assessed the clinical diagnostic efficiency of exosomal microRNAs (miRNAs) for head and neck malignancies by meta-analysis.

Methods: The pertinent literature about exosomal miRNAs for the diagnosis of head and neck cancer was retrieved from the Chinese full-text journal database, Wanfang database, Wipu database, and the databases of PubMed, Embase, and Web of Science, spanning from the inception of the databases to April 30, 2024.

Proteomic signatures of grip strength and healthy aging among older adults: A prospective cohort study in the UK Biobank.

Background: While grip strength (GS) is recognized as a feasible predictor of various health outcomes, its association with healthy aging and the role of plasma proteins remain unclear.

Methods: We included 27,828 apparently healthy adults aged 64 years or older who were eligible to survive to age 80 as of the latest follow-up. Healthy aging was defined as survival to age 80 without developing major chronic diseases (MCDs) during the follow-up.

Glymphatic, Structural, and Cognitive Changes During Breast Cancer Chemotherapy: A Longitudinal MRI Study.

The glymphatic system maintains brain homeostasis through cerebrospinal fluid transport and waste clearance. Its potential involvement in chemotherapy-related cognitive impairment remains largely unexplored due to limited in vivo evidence. In this prospective longitudinal study, 126 female breast cancer patients underwent multiparametric brain MRI and neuropsychological assessments at three time points: baseline (bc1), after the first cycle of neoadjuvant chemotherapy (bc2), and upon completion of neoadjuvant chemotherapy (bc3).

Case Report: Simnotrelvir/Ritonavir are effective in shortening the course of prolonged SARS-CoV-2 infection during anti-CD20 maintenance therapy in patients with follicular lymphoma.

Patients with hematologic malignancy had the possibility of persistent infection with COVID-19, particularly those who received anti-CD20 monoclonal antibody therapy for lymphoma, regardless of vaccination status. We report two cases of follicular lymphoma (FL) infected with Omicron virus that could not be confirmed by routine SARS-CoV-2 tests during maintenance therapy with an anti-CD20 agent, obinutuzumab or rituximab. In addition to immunomodulatory drugs, both of them took Simnotrelvir/Ritonavir to effectively alleviate the symptoms.

Global trends, regional variations, and future projections of type 1 diabetes mellitus burden among women of reproductive age: A comprehensive analysis from 1990 to 2040.

Background And Aim: Type 1 diabetes mellitus (T1DM) is an autoimmune disease, which has a heavy disease burden and seriously affects the reproductive health of women of reproductive age. Therefore, this study assessed the disease burden of T1DM among women of reproductive age worldwide.

Methods And Results: This study extracted the incidence, prevalence, disability adjusted life years (DALYs) and deaths data of T1DM in women of reproductive age from the Global Burden of Disease (GBD) database from 1990 to 2021.

The Glutathione Peroxidase Gene Family in : Genome-Wide Identification, Classification, Gene Expression and Functional Analysis.

Glutathione peroxidase (GPX) is crucial in mediating plant responses to abiotic stresses. In this study, bioinformatics methods were used to identify the gene family in quinoa. A total of 15 genes were identified at the quinoa genome level and conducted preliminary analysis on their protein characteristics, chromosome distribution, gene structure, conserved domain structure, cis-acting elements, and expression patterns.

The safety and feasibility of telerobotic cholecystectomy via a 5G network: a prospective controlled clinical trial.

Background: Since advances in the fifth-generation (5G) communication technology have effectively facilitated the development of robotic telesurgery, the popularity of telerobotic operations has increased. The purpose of this study was to evaluate the safety and feasibility of robotic telecholecystectomy with a 5G wireless network using a new domestic robotic surgical system.

Methods: This study is a prospective controlled clinical trial.

Human gut microbiota-derived antimicrobials against Salmonella Typhi: diversity, mechanisms, and therapeutic potential.

Salmonella enterica serovar Typhi (S. Typhi) is a strictly human-restricted Gram-negative pathogen and the causative agent of typhoid fever, a major global health concern. Current treatment relies heavily on antibiotics, however, the rapid emergence of multidrug-resistant strains has severely compromised their efficacy, underscoring the urgent need for alternative therapeutic strategies.

Phenotypic and genotypic profiles of clinical isolates of various Nocardia species to carbapenems and fluoroquinolones.

Objectives: To establish patterns of the antimicrobial susceptibility of Nocardia species to carbapenems and fluoroquinolones and analysis of phenotypic-genotypic correlations.

Methods: Isolates were identified to the species using 16S rRNA, secA1, or rpoB gene sequencing analysis. The antimicrobial susceptibility testing was performed using the broth microdilution method, and WGS was employed to analyse the presence of resistance genes and/or mutations of Nocardia species against carbapenems and fluoroquinolones.

A case-control study on the individualized use of opioid analgesics based on single-nucleotide polymorphism.

Objective: The aim of this study is to explore the relationship between gene polymorphism and the efficacy and adverse drug reactions (ADRs) of opioid analgesics, improve medication safety, and promote personalized medication.

Methods: First, the method of evidence-based medicine retrieval and evaluation was adopted to systematically summarize the opioid analgesic drug ADR and efficacy-related gene loci currently recommended by guidelines, authoritative genetic information databases, and low-bias clinical trial studies. The gene loci with strong correlation evaluation were selected as target genes for testing.

From eye to cortex: Tracing the neurocognitive dynamics of bilingual novel word acquisition.

The current study examined how native language (L1) orthographic features influence bilinguals' ability to rapidly form new representations for second-language (L2) written word forms. We assessed eye movements, neural activity, and behavioral performance in sequential bilinguals with L1-L2 orthographical pairs within (Spanish-English) and across (Mandarin Chinese-English) writing systems. Participants were trained on novel English words embedded in naturalistic sentence contexts, followed by a two-day post-training session.