Resistin-like molecule γ attacks cardiomyocyte membranes and promotes ventricular tachycardia.

Ventricular tachycardia disrupts the heart's coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrhythmias. Comparing neutrophils with macrophages, we found that resistin-like molecule γ ( or RELMγ) was the most differentially expressed gene in mouse infarcts.

Efficacy and Safety of Jingling Oral Liquid for Children With ADHD: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Objective: This study aims to verify the therapeutic efficacy and safety of a traditional Chinese medicine, Jingling Oral Liquid, in treating ADHD through a multicenter, randomized, double-blind, placebo-controlled trial (ChiCTR-IPR-17012293).

Method: Eighty-five children with ADHD underwent 8 weeks of strictly monitored treatment. Forty children (8.

Deletion of sulfate transporter SUL1 extends yeast replicative lifespan via reduced PKA signaling instead of decreased sulfate uptake.

The regulation of cellular metabolism and growth in response to nutrient availability is crucial for cell survival and can significantly impact on lifespan. Central to this regulation is a class of transporters that sense and transport specific nutrients and transduce the signal downstream to control genes responsible for growth and survival. In this study, we identified SUL1, a plasma membrane transporter responsible for regulating the entry of extracellular sulfate in , as a key gene for regulating lifespan.

A 41-Year Global All-Sky Surface Longwave Radiation Components Dataset at 5 km and hourly Resolution.

Longwave radiation (LWR) is a critical factor in surface energy balance and greenhouse effect studies, and its accurate measurement is essential for understanding climate change. However, existing remote sensing-based LWR products still have room for improvement in terms of spatiotemporal coverage, resolution, and accuracy. To address this issue, we developed the LWR Component of the global Long-term Earth System spatiotemporally Seamless Radiation budget dataset (LessRad).

Simultaneous adsorption and detection of naphthenic acids using potassium-doped carbon dots/lignin-based porous carbon composite.

Naphthenic acids (NAs) in petroleum wastewater are difficult to volatilize, degrade and persistent. In this study, we developed a potassium-doped carbon dots/lignin-based porous carbon composite (K-CDs/LPC-X) using renewable lignin as a carbon source and potassium-doped carbon dots (K-CDs) as a fluorescent probe. Lignin, a natural and sustainable biomass material, serves as a cost-effective, eco-friendly carbon precursor and forms highly porous structures during pyrolysis‌.

High-performance magnetic biochar prepared via acid and mg/Fe Co-modification for ultraefficient Pb (II) adsorption.

In this study, MgO-containing magnetic composite biochar (MBC) was prepared from activated corn stover for the efficient removal of Pb. Through the introduction of magnesium and iron ions, the surface and pore structures of the acid-treated corn stover biochar adsorbent were optimized, with its adsorption capacity being enhanced to 253.6 mg g.

The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia-reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis.

Receptor-interacting protein kinase 1 (RIPK1) plays an essential role in regulating the necroptosis and apoptosis in cerebral ischemia-reperfusion (I/R) injury. However, the regulation of RIPK1 kinase activity after cerebral I/R injury remains largely unknown. In this study, we found the downregulation of protein arginine methyltransferase 1 (PRMT1) was induced by cerebral I/R injury, which negatively correlated with the activation of RIPK1.

Exploring the genetic intersection of dried fruit intake and breast cancer risk: a multi-trait genomic analysis with epidemiological context.

Background: Epidemiological studies have suggested that dried fruit intake may be associated with a lower risk of breast cancer (BC), yet the genetic mechanisms underlying this association remain unclear. This study aimed to explore the potential genetic relationship between dried fruit intake and BC susceptibility.

Methods: We conducted a comprehensive genetic analysis using genome-wide association study (GWAS) data for dried fruit intake and BC, focusing on individuals of European ancestry.

Paracetamol Concentrations and Time-Course of Ductus Arteriosus Diameter in Extremely Preterm Neonates: A Population Pharmacokinetic-Pharmacodynamic Analysis.

Background: Patent ductus arteriosus is a common complication of extreme prematurity. Prophylactic treatment with indomethacin or ibuprofen has shown efficacy on ductus closure but without reducing mortality and morbidity. Prophylactic treatment by paracetamol could be a safer alternative.

Opposite Interactive Effects of Heat Wave and Cold Spell with Fine Particulate Matter on Pneumonia Mortality.

Exposure to extreme temperature events (ETEs) and ambient fine particulate matter (PM) has been linked to an increased risk of pneumonia mortality, but their interactive effects remain largely unknown. We investigated 50,196 pneumonia deaths from 2015 to 2022 in Jiangsu province, China, with a time-stratified case-crossover design. An individual-level exposure to heat wave, cold spell, and PM was assessed at each subject's residential address using validated grid datasets.

Gut-brain axis dysfunction mediates neurotoxicity of embryonic p-phenylenediamine exposure in zebrafish.

P-phenylenediamine antioxidants (PPDs) are widely used in the rubber industry and are increasingly recognized as environmental contaminants, raising concerns about their potential risks to wildlife and human health. Our present study investigated the neurotoxicity of embryonic exposure to a sublethal concentration (0.05 mg/L) of three PPDs (CPPD, IPPD and 77PD) in zebrafish.

Temperature-induced algae harvesting with grafted poly(N-isopropylacrylamide).

Microalgae biorefinery has a broad spectrum of applications, but the high cost of the algae harvesting process restricts the scale-up of this industry. This work developed a new method for algae harvesting by using grafted poly(N-isopropylacrylamide) (PNIPAM). PNIPAM has a temperature-induced phase change property that can be taken advantage to capture algae cells in the cultivation medium.

Preliminary Exploration of Random Flipped Classroom and Simulation Skills Training in Standardized Training for Ultrasound Medical Residents Under the Background of Hierarchical and Progressive Teaching.

Background: The random flipped classroom is developed from the standard flipped course. In the random flipped classroom, students engage with class content outside of class, and one student is selected to lead the class activity during class time. This study aimed to train ultrasound residents with the random flipped classroom combined with simulation skills training, which overcame the limitations of the standard flipped classroom, achieving a better clinical performance of ultrasound residents.

Large Field-of-View Ptychographic Reconstruction of Tilted Surfaces with Adaptive Free Path.

In atomic-resolution imaging of solids, the sample surface is frequently tilted. This tilt causes the electron beam to traverse varying distances in the vacuum prior to entering the sample at different locations. This phenomenon markedly degrades image quality, especially over large fields of view in ptychography.

Aberrant Modular Dynamics of Functional Networks in Schizophrenia and Their Relationship With Neurotransmitter and Gene Expression Profiles.

Numerous studies have emphasized the time-varying modular architecture of functional brain networks and its relevance to cognitive functions in healthy participants. However, how modular dynamics of resting-state functional networks change in schizophrenia and how these alterations relate to neurotransmitter and transcriptomic signatures have not been well elucidated. We harmonized resting-state fMRI data from a multi-site sample including 223 patients and 279 healthy controls and applied the multilayer network method to estimate the regional module switching rate (flexibility) of functional brain connectomes.

Prognostic value of LncRNA DLGAP1-AS2 in bladder cancer and its regulatory effect on tumor progression.

Background: Bladder cancer (BLCA) represents one of the most prevalent malignant neoplasms within the urinary system, and its incidence is progressively rising annually in China.

Objectives: This research investigated the clinical significance of DLGAP1-AS2, and examined its potential mechanisms in modulating the behavior of BLCA cells.

Methods: This study collected cancerous and normal tissue samples from 86 BLCA patients.

Suture Bridge Technique for Arthroscopic Repair of Posterior Cruciate Ligament Tibial Avulsion.

Arthroscopy has gradually become the routine method to treat posterior cruciate ligament tibial insertion avulsion. However, arthroscopic surgery possesses the advantages of being minimally invasive, having a good appearance, and having no need for revision surgery for internal fixation. Compared with open surgery, it is limited by disadvantages such as unstable fixation, unsatisfactory reduction, and fracture fragment displacement.

Ultrasound-Assisted Anatomic Posterior Cruciate Ligament Reconstruction With Remnant Preservation by Reference to Distal Reflection of the Posterior Capsule and Posterior Septum.

Compared with anterior cruciate ligament reconstruction, posterior cruciate ligament (PCL) reconstruction has a higher failure rate and revision rate, which is associated with multiple factors such as graft option, fixation method, postoperative rehabilitation, and management of concomitant injuries. Among them, "killer turn" is a key factor in the failure of PCL reconstruction. Although there are various techniques for PCL reconstruction, the ideal surgery remains controversial.

Biallelic loss-of-function variants of DNAH7 cause male infertility associated with asthenozoospermia in humans.

Although variants in DNAH family genes have been suggested as a main contributor to asthenozoospermia in humans, the role of DNAH7 on male fertility remains largely unexplored. In this study, loss-of-function variants in DNAH7 were identified in two unrelated infertile men with asthenozoospermia through whole exome sequencing, including compound heterozygous variants c.9702_9705del (p.

Hand gesture recognition based on an optical fiber specklegram sensor.

Gesture recognition offers considerable promise for enhancing the naturalness, intuitiveness, and efficiency of human-computer interaction. In this paper, a novel hand gesture recognition system based on a single-mode, multimode, multicore optical fiber sensing structure is presented. By leveraging deep learning to analyze fiber specklegrams and training a simplified six-layer ResNet network, accurate and efficient hand gesture recognition was realized with minimal hardware requirements and high stability.

Dynamics of multimode creeping solitons and soliton explosions in a spatiotemporal mode-locked laser.

The study of high-dimensional solitons will bring great interest and new opportunities for understanding three-dimensional nonlinear physical phenomena and the design of complex nonlinear systems. The development of spatiotemporal mode-locked (STML) lasers has enabled the exploration of high-dimensional soliton dynamics. In this study, an STML laser and a dual-channel real-time measurement system based on dispersion Fourier transform technology were constructed.

Widowhood disparities in nonaccidental mortality attributable to heat waves and ozone.

Emerging evidence suggests that heat waves and ozone (O) contribute to increased mortality risks. Since widowhood is a common event that can increase individuals' susceptibility to the environment, it is of great importance and interest to elucidate the widowhood disparity in mortality attributable to heat waves and O. We therefore conducted a case-crossover study of 1,214,763 nonaccidental deaths in Jiangsu Province, China, during 2015-2021 to investigate the independent and interactive associations of exposure to heat waves and O with mortality by widowhood status.

Synergistic effect of anthraquinone and biochar on anaerobic ammonia oxidation system initiation and functional microorganism enrichment.

This study explored the effects of anthraquinone concentration gradients (0.025-0.075 mmol/L) in combination with biochar (10 g/L) on the initiation of an anaerobic ammonia oxidation (anammox) system and the dynamics of associated functional microorganisms.