Assessment of liver stiffness measurement-related markers in predicting liver-related events in viral cirrhosis with clinically significant portal hypertension.

Background: Clinically significant portal hypertension (CSPH) is a crucial prognostic determinant for liver-related events (LREs) in patients with compensated viral cirrhosis. Liver stiffness measurement (LSM)-related markers may help to predict the risk of LREs.

Aim: To evaluate the value of LSM and its composite biomarkers [LSM-platelet ratio (LPR), LSM-albumin ratio (LAR)] in predicting LREs.

The protein arginine methyltransferase PRMT1 ameliorates cerebral ischemia-reperfusion injury by suppressing RIPK1-mediated necroptosis and apoptosis.

Receptor-interacting protein kinase 1 (RIPK1) plays an essential role in regulating the necroptosis and apoptosis in cerebral ischemia-reperfusion (I/R) injury. However, the regulation of RIPK1 kinase activity after cerebral I/R injury remains largely unknown. In this study, we found the downregulation of protein arginine methyltransferase 1 (PRMT1) was induced by cerebral I/R injury, which negatively correlated with the activation of RIPK1.

UBE2C promotes pancreatic tumorigenesis by KRAS stabilization via APC/C-mediated WDR76 degradation.

Bioinformatics-based association study revealed a strong positive correlation between UBE2C, an E2 ubiquitin-conjugating enzyme, and pancreatic cancer and patient survival. However, whether and how UBE2C plays a causal role in pancreatic tumorigenesis remains elusive. Here, we report that UBE2C functions as a promoter in this process.

Sulfur-Mediated Microenvironment Modulation of High-Density Fe-N Sites for High-Efficiency Oxygen Reduction and Cryotolerant Quasi-Solid-State Zinc-Air Batteries.

Single-atom catalysts (SACs) featuring Fe-N active sites hold significant potential for the oxygen reduction reaction (ORR). However, achieving high-density Fe-N active sites while precisely modulating their microenvironment to enhance ORR activity remains a formidable challenge. Here, an S-mediated strategy is presented for the preparation of Fe single-atom-loaded S,N-doped carbon (FeNSC).

A redox switch in p21-CDK feedback during G2 phase controls the proliferation-cell cycle exit decision.

Reactive oxygen species (ROS) influence cell proliferation and fate decisions by oxidizing cysteine residues (S-sulfenylation) of proteins, but specific targets and underlying regulatory mechanisms remain poorly defined. Here, we employ redox proteomics to identify cell-cycle-coordinated S-sulfenylation events and investigate their functional role in proliferation control. Although ROS levels rise during cell cycle progression, the overall oxidation of the proteome remains constant, with dynamic S-sulfenylation restricted to a subset of cysteines.

Discovery of Novel Pyrazole-4-carboxamide Derivatives with Thioether Moiety as Potential SDHI Agents for Crop Protection.

In the ongoing search for more potent succinate dehydrogenase inhibitors (SDHIs) for agricultural applications, 30 pyrazole-4-carboxamide derivatives bearing a thioether group were designed and synthesized via bioisosteric replacement and scaffold-hopping based on the structure of two SDHIs lead compounds in our previous work. The antifungal efficacy of these target compounds was evaluated against five major plant pathogenic fungi, and the results indicated that the majority of the synthesized compounds exhibited strong antifungal activities, particularly against and . Among these, compound emerged as the most promising candidate, displaying exceptional antifungal potency against (EC = 0.

Hierarchically structured hydrogel exhibiting spatiotemporal release profiles: Enabling digital remote diagnosis and personalized therapeutics.

Wound therapy has long been a complex challenge within the medical field. The parameters at the wound area change constantly, presenting a significant challenge in monitoring wound conditions for guiding drug release and enabling real-time therapy. Herein, a hierarchically structured hydrogel, composed of a supramolecular hydrogel with bactericidal activity and a polymer hydrogel promoting wound healing, was designed and fabricated using physical crosslinking method.

Distinct Gut Microbial Signatures and Diminished Anti-Inflammatory Effect of Short-Chain Fatty Acids in Schizophrenia With Immune Activation.

Background And Hypothesis: A subset of patients with schizophrenia (SCZ) exhibit subclinical immune activation. However, the gut microbial features of this subgroup and their interplay with the immune function remain poorly understood. This study aimed to identify the gut microbiome signature of immune-activated SCZ and elucidate the role of short-chain fatty acids (SCFAs) in the gut-immune crosstalk.

NIR-II Photothermal Conversion in Spin Crossover Metal-organic Frameworks.

The synthesis of multifunctional materials that exhibit two or more distinct physicochemical properties is critical for the development of advanced smart materials. To date, the research regarding the near-infrared II (NIR-II) photothermal properties of spin crossover (SCO) materials remains scarce. Here, we synthesized an inverse-Hofmann-type cationic framework, [Fe{Ag(CN)}(TTF(py))] (1, TTF(py) = tetra(4-pyridyl)tetrathiafulvalene), which exhibits hysteretic SCO behavior.

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5.

Okanin is a natural product with few known biological activities. Its anti-cancer effects and the underlying mechanisms are investigated. It is found that okanin inhibits cancer cell growth (25-50 µm) with minimal effects on non-cancerous colorectal cells except at much higher doses (i.

Parthanatos: A redox-dependent cell death pathway in cardiovascular disease and myocardial aging.

Parthanatos, a form of programmed cell death that is heavily dependent on redox imbalance, is gaining attention for its important role in cardiovascular disease (CVD) and myocardial aging. Its core mechanism involves hyperactivation of poly (ADP-ribose) polymerase-1 (PARP1), triggered primarily by oxidative stress-induced DNA damage. This hyperactivation initiates a detrimental cascade: excessive consumption of NAD+ and ATP leads to cellular energy crisis, while the resultant accumulation of poly (ADP-ribose) (PAR) polymers facilitates the nuclear translocation of apoptosis-inducing factor (AIF), culminating in large-scale DNA fragmentation and cell demise.

Ce(III)-Doped Mixed-Valence Metal-Organic Frameworks Boosting Ligand-To-Metal Charge Transfer for Photooxidation of a Mustard-Gas Simulant.

Due to the high toxicity and potential threats to society, extensive efforts are devoted to developing catalysts for efficient photodegradation of mustard gas. Metal-organic frameworks (MOFs) are considered as promising candidates for photooxidation, but the limited charge separation efficiency of the pristine MOFs restricts their further applications. Herein, through a one-pot synthesis strategy, Ce(III) ions are incorporated in a Ti-based porphyrin MOF (DGIST-1), leading to a mixed-valence MOF with enhanced charge transfer efficiency.

Programmed Intermittent Bolus versus Continuous Infusion for Regional Analgesia Following Thoracoscopic Surgery: A Systematic Review and Meta-Analysis.

Background: Continuous regional analgesia techniques have emerged as a more effective alternative for postoperative analgesia, but the clinical efficacy of infusion modes in thoracoscopic surgery remains controversial. This systematic review and meta-analysis to compare the efficacy of programmed intermittent bolus infusion (PIBI) with continuous infusion (CI) for regional analgesia in patients undergoing thoracoscopic surgery.

Methods: We searched PubMed, Embase, Web of Science, and the Cochrane Library for relevant research from inception to March 2025.

Effect of digital mindfulness on perceived stress and anxious emotion among college students.

Background: Perceived stress and anxiety are common psychological issues among college students. Traditional mindfulness interventions effectively ameliorate these psychological issues, while digital mindfulness interventions-an emerging approach-are gaining increasing attention owing to their convenience and accessibility.

Purpose: This study aimed to assess the effectiveness of digital mindfulness in reducing perceived stress and anxiety among college students and to explore its potential effects on mindfulness.

Oral ruthenium-based PAD4 inhibitor modulates immunogenic cell death and neutrophil extracellular traps in triple-negative breast cancer.

Triple-negative breast cancer (TNBC) is a highly aggressive breast cancer subtype characterized by a poor prognosis and resistance to conventional therapies. Peptidylarginine deiminase 4 (PAD4), which catalyzes the conversion of arginine to citrulline, facilitating neutrophil extracellular trap (NET) formation and promoting tumor immune evasion, has been identified as a promising target for TNBC treatment. However, current PAD4 inhibitors have low bioavailability and inadequate stability.

Integrated spatial transcriptome and metabolism study reveals metabolic heterogeneity in human bladder cancer.

Bladder cancer (BC) is a malignancy that originates from the cells lining the bladder and is one of the most common cancers of the urinary system, capable of occurring in any part of the bladder. However, the molecular mechanisms underlying the malignant transformation of BC have not been systematically studied. This study integrated cutting-edge techniques of spatial transcriptomics (ST) and spatial metabolomics (SM) to capture the transcriptomic and metabolomic landscapes of both BC and adjacent normal tissues.

The effect of emotion on false memories of events under a unified misinformation interference paradigm.

This research examines how emotions influence the creation of false memories regarding events. Utilizing the misinformation interference framework, it investigates how the emotional characteristics of materials, as well as emotional states during both the encoding and retrieval stages, affect false memory formation. The study consists of three experiments, each designed with a 3 (emotional nature of target events: positive, neutral, negative) × 2 (information type: control information, misleading information) mixed approach.

Gaultheria leucocarpa inhibits Aβ fibrillization and enhances mitophagy-mediated degradation of pathogenic proteins.

Alzheimer's disease (AD) pathology involves amyloid-beta (Aβ) accumulation and neuronal toxicity, highlighting the need for therapeutic strategies that can both inhibit Aβ aggregation and promote pathogenic protein clearance. In this study, we identified Gaultheria leucocarpa as a medicinal plant with promising neuroprotective potential. Thioflavin T (ThT) fluorescence screening revealed that extracts from G.

A silk fibroin/chitosan hydrogel with ferulic acid derivatives: Promoting diabetic wound healing through immune modulation and angiogenesis.

The impaired wound healing observed in diabetes is closely associated with immune system imbalance, in which the dysregulation of positive feedback mechanisms disrupts normal tissue repair processes. This study addresses the limited bioavailability of the natural anti-inflammatory compound ferulic acid (FA) by developing a novel derivative, FA-1a, via a phenylboronic acid modification strategy. Leveraging the reversible covalent interaction between chitosan (CS) and phenylboronic acid, the FA-1a-CS complex was successfully synthesized and subsequently incorporated into a silk fibroin (SF) dual-network hydrogel to create a multifunctional FA-1a-CS/SF composite hydrogel.

Design and fabrication of 4 double input NAND gate chip with excellent electrical and physical performances.

In order to improve the performances of 4 two-input NAND so that it can be better used in the aerospace application field and in harsh environments, 4 two-input NAND gate chips were designed and successfully fabricated in this paper, based on 1.2 [Formula: see text]m P-well SPDM CMOS technological processes. The N transistors were fabricated in P-well and connected to GND via [Formula: see text]-well.

Asthma Detection Research Based on Voice Signal Processing and Machine Learning.

To analyze voice signals and identify asthma patients using voice signal analysis and machine learning techniques, we collected clear, low-noise fixed-pattern voice signals from 50 asthma patients and 50 healthy controls to build an analysis database. The research conducted multi-dimensional voice signal analysis based on MATLAB and selected voice feature indicators with significant differences between asthma patients and healthy controls. After dimensionality reduction analysis on differential phonetic features, the processed features were incorporated into subsequent SVM and RF modeling and classification research.

Efficacy of carrimycin against complex and .

complex (MAC) is one of the principal pathogenic strains among nontuberculous . Current antibiotics have poor microbiological responses, and repurposed antibiotics are a way to meet clinical needs. Herein, the anti-MAC activity of carrimycin (CAM), a new macrolide, was evaluated vitro and .

Placental chorioangiomatosis: a case report and literature review.

The placenta is a highly specialized temporary organ during pregnancy. As the hinge of material exchange between mother and fetus, it plays a crucial role in maintaining the fetus's intrauterine life and growth period of fetus. Placental lesions or dysfunction can cause pregnancy diseases.

Role of Iron Metabolic Disturbances and Inflammatory Iron Biomarkers in Liver Transplant Prognosis.

Iron metabolism plays a pivotal role in liver transplantation, significantly impacting outcomes for both donors and recipients. The liver, central to iron homeostasis, is often impaired in chronic liver diseases leading to metabolic disorders that exacerbate liver damage. Liver transplantation (LT) is a critical treatment for end-stage liver diseases, with iron status in both donors and recipients influencing post-transplant outcomes.

Aducanumab binds high molecular weight soluble Aβ oligomers and restores intracellular calcium levels.

Background: Alzheimer's disease (AD) is characterized by amyloid-beta (Aβ) accumulation, leading to the formation of neurotoxic soluble oligomers (AβOs) that impair calcium homeostasis in neurons and astrocytes. Aducanumab, a fully human monoclonal antibody targeting aggregated Aβ, has been approved for AD treatment due to its ability to reduce amyloid plaque burden. However, its specificity toward different AβO species and its functional impact on calcium homeostasis remain unclear.