First observation of biochar aerosol generation from raindrop impact on biochar-amended soils.

This study presents the first experimental evidence of biochar (BC) aerosol generation via raindrop impact on amended soils, combining controlled rainfall simulations with year-long field monitoring of atmospheric particulates from a BC-treated plot (2.0 wt%). Microscopic and isotopic analyses confirmed BC incorporation in total suspended particles (TSP), accounting for 15.

A copper-based single-atom material effectively controls plant diseases with nearly zero soil residue and low phytotoxicity.

A growing population necessitates the development of sustainable agriculture, which requires achieving atom economy in pesticide delivery, fertilization, and so on. To this end, we focus on single-atom materials (SAMs) to enhance atom utilization within agricultural systems. In this study, we report a novel pesticide for plants, a single-atom copper (Cu) formulation, by employing a precipitation-equilibrium-driven (K-driven) method to anchor Cu onto a calcium carbonate (CaCO) carrier.

Online Neural-to-Movement Mapping Transfer for Task Switching and Retention in Brain-Machine Interfaces.

Current brain-machine interfaces (BMIs) often rely on decoders trained for single tasks, limiting their flexibility in real-world applications. We propose an online learning framework that enables the transfer of neural-to-movement (knowledge) across tasks, supporting both task switching and memory retention. In our framework, neural activity is projected into a dynamical jPCA space to effectively dissociate into variant and invariant components.

Evaluation of serum alkaline phosphatase and lactate dehydrogenase as predictive biomarkers for the prognosis of male breast cancer.

Breast cancer has become one of the most common malignant tumors in women, and the incidence rate is increasing annually in men. This study focused on exploring the prognostic significance of the combined detection of serum ALP and LDH in patients with breast cancer. We enrolled 80 individuals with male breast cancer (MBC), female breast cancers (FBCs) were randomly matched via propensity score matching (PSM).

The JNK-JAK/STAT Signaling Axis Mediates Lead Exposure-Induced Gut Dysbiosis in Drosophila melanogaster.

Lead (Pb) is a pervasive environmental pollutant that poses significant risks to both microbial communities and host physiology. However, the bidirectional interactions between Pb and insect gut microbiota, as well as the underlying mechanisms by which Pb disturbs microbiota homeostasis, remain poorly understood. Using Drosophila melanogaster as a model, this study investigates how Pb exposure affects the gut microbial ecosystem and how intestinal bacteria, in turn, influence Pb metabolism in the host.

Influence of implant macrodesign and insertion load during implant placement on primary stability in artificial bone.

Background: Implant placement is a critical step for achieving primary stability. During this process, a compressive force, referred to as an "insertion load," is applied through a handpiece or manual driver. However, the influence of the insertion load has not been quantitatively investigated.

An increase in wind erosion dominated by wind speed changes over the Tibetan Plateau from 1982 to 2020.

Soil wind erosion is a primary cause of land degradation, which exerts profound adverse impacts on agricultural productivity. Because of limited observations, the long-term variability of wind erosion and its potential causes remain largely unknown for high-elevation areas, e.g.

Cortical structural signatures for early identification of bipolar disorder from depressive episode.

Objective: This study aims to explore specific biomarkers for the early identification of bipolar disorder (BD) by assessing cortical morphological features.

Methods: This study comprised 185 BD patients, 203 unipolar depression (UD) patients, and 257 healthy controls (HC). In addition, through follow-up, a cohort of 86 patients initially diagnosed with major depressive disorder (MDD) who later transitioned to BD were identified as having initial depressive episode BD (IDE-BD).

Glycaemic responses to metformin monotherapy by SNP clusters in patients with type 2 diabetes.

Aims: This study retrospectively investigates the association between polygenic risk scores (PRS) derived from SNP clusters and glycaemic response to metformin in patients with newly diagnosed T2D.

Materials And Methods: Utilizing a dataset from the Taiwan Precision Medicine Initiative, we evaluated alterations in fasting glucose (FBG) and glycated haemoglobin (HbA1c) in individuals newly diagnosed with T2D who underwent metformin monotherapy for a duration of 6 months. Glycaemic responses between those in the bottom 20% of PRS (Q1) and the top 20% of PRS (Q5) for each of the SNP clusters and for the combination of two clusters were analysed.

Does Sulfasalazine Still Have Therapeutic Value in the Treatment of Axial Spondyloarthritis? A Real-World Cohort Study From China.

Objective: The efficacy of sulfasalazine (SSZ) in axial spondyloarthritis (ax-SpA) patients meeting both 2009 ax-SpA and 2011 peripheral SpA (p-SpA) criteria is unclear. This study aimed to assess SSZ's clinical efficacy in pure ax-SpA and overlapping ax-SpA patients and to identify factors influencing peripheral symptom development.

Methods: SpA patients from 2016 to 2023 at the First Medical Center of People's Liberation Army General Hospital were categorized into pure ax-SpA and ax-SpA with peripheral features.

The effect of emotion on false memories of events under a unified misinformation interference paradigm.

This research examines how emotions influence the creation of false memories regarding events. Utilizing the misinformation interference framework, it investigates how the emotional characteristics of materials, as well as emotional states during both the encoding and retrieval stages, affect false memory formation. The study consists of three experiments, each designed with a 3 (emotional nature of target events: positive, neutral, negative) × 2 (information type: control information, misleading information) mixed approach.

The potential and therapeutic advances of the integrin family in neurological disorders.

Neurological disorders encompass a diverse and heterogeneous group of medical conditions, including cerebrovascular diseases (e.g., stroke), neurodegenerative diseases (e.

A Review of On-Surface Synthesis and Characterization of Macrocycles.

Macrocyclic organic nanostructures have emerged as crucial components of functional supramolecular materials owing to their unique structural and chemical features, such as their distinctive "infinite" cyclic topology and tunable topology-dependent properties, attracting significant recent attention. However, the controlled synthesis of macrocyclic compounds with well-defined compositions and geometries remains a formidable challenge. On-surface synthesis, capable of constructing nanostructures with atomic precision on various substrates, has become a frontier technique for exploring novel macrocyclic architectures.

Molecularly engineered sisal fibers with programmable interfaces for efficient separation of complex emulsions and multipollutants.

Purifying surfactant-stabilized oily wastewater remains significant challenge, as conventional demulsifiers frequently fail to disrupt complex emulsions stabilized by multiple surfactant types. Herein, we developed an innovative molecular engineering strategy that constructs phytic acid-crosslinked β-cyclodextrin (PA-cl-β-CD) networks on sisal fibers (SFs) through a facile one-step process, creating an eco-friendly separation material (SFs@PA-cl-β-CD) with dynamically tunable surface wettability and interfacial properties. This biomass-based material exhibits remarkable versatility, achieving universal high separation efficiency (>99 %) for diverse oil-in-water emulsions regardless of surfactant types (cationic, anionic, or nonionic) through molecularly programmable surface wettability control.

Exploring fecal microbiota signatures associated with immune response and antibiotic impact in NSCLC: insights from metagenomic and machine learning approaches.

Background: Substantial interstudy heterogeneity in cancer immunotherapy-associated biomarkers has hindered their clinical applicability. To address this challenge, we performed a comprehensive integration of publicly available global metagenomic datasets. By leveraging metagenomic profiling and machine learning approaches, this study aimed to elucidate gut microbial signatures associated with immune response in lung cancer (LC) and to evaluate the modulatory effects of antibiotic exposure.

Gut-Brain Dialogues in Fruit Fly (Drosophila melanogaster): How Peptide Hormones Bridge Metabolism, Longevity, and Behavioral Adaptation.

Background: Gut-peptide hormones are crucial regulators of various physiological processes, including metabolism, digestion, behavior, and homeostasis. In Drosophila melanogaster, a widely used model organism, a diverse range of gut-peptide hormones governs gut-brain communication, influencing food intake, energy balance, circadian rhythms, stress responses, and aging.

Objective: This review summarizes recent studies on gut-peptide hormones in D.

Signal pathways in the treatment of Rheumatoid Arthritis with traditional Chinese medicine.

Ethnopharmacological Relevance: Rheumatoid arthritis (RA) is a chronic autoimmune disorder of unknown etiology that severely impairs patients' quality of life and may ultimately result in functional disability and increased mortality. Traditional Chinese medicine (TCM) possesses extensive clinical experience and has demonstrated favorable outcomes in managing RA. At present, it has been found that TCM compound and effective active ingredients can effectively treat RA, and its mechanism of action needs further study.

A predictive nomogram for intramyocardial hemorrhage in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention based on coronary angiography-derived index of microcirculatory resistance.

Background: Intramyocardial hemorrhage (IMH) after ST-segment elevation myocardial infarction (STEMI) reperfusion increases the risk of major adverse cardiovascular events (MACE). We aimed to integrate a coronary angiography-derived index of microcirculatory resistance (caIMR) with clinical features in a nomogram model for predicting IMH in patients with STEMI following primary percutaneous coronary intervention (PCI).

Methods: A retrospective study included 309 STEMI patients admitted at Xuzhou Medical University for primary PCI from 2022 to 2023 in training and validation cohorts.

CircPhc3 promotes the repair of intestinal mucosa after burn injury through the TRIM28-mediated hnRNPK SUMOylation stability modification mechanism.

This paper investigates the mechanism of action of circPhc3 in the repair of intestinal mucosa in mice with severe burn injuries. The expression of circPhc3 is decreased in the intestinal mucosal tissue of these mice, and its overexpression may aid in the reconstruction of the damaged mucosa. The effects of circPhc3 on cell proliferation and migration were studied in MC38 cells, with an initial assessment of its repair function in mouse intestinal mucosa.

Multi-biosensing hairband for emergency health assessment.

Blood analysis is regarded as the gold standard for monitoring analytes in clinical diagnostics. However, the time-consuming and site-limited nature often delays medical interventions that are crucial for patients in emergency scenarios. Herein, a weavable multi-biosensor array is developed through coaxial wet spinning for real-time multiplex detection of sweat biomarkers (pH, Na, K, and Ca) and body temperature.

Marital Dynamics and Daily Memory Among Aging Same-Sex and Different-Sex Couples.

Objectives: In older adulthood, a spouse is often the closest relationship and a key source of support for health. While prior research emphasizes the importance of marital dynamics for cognition, it predominantly focuses on different-sex couples. This leaves a critical gap in understanding how these processes might differ for aging same-sex couples.

Dissecting the Genetic Correlations and Causal Effects of Gut Microbiota on Pan-Cancer Phenotype: Driven by Common Dietary Preferences.

Previous studies have found that the gut microbiota are associated with various types of cancer. However, the effects under the pan-cancer phenotype and whether they are driven by dietary preferences remain unclear. Here, we aim to comprehensively examine the genetic correlations and causal effects between gut microbiota and pan-cancer using linkage disequilibrium score (LDSC) regression and Mendelian randomization (MR).

Recent Patents of Stent Grafts for Intravascular Aortic Repair.

Introduction: Endovascular aortic repair involves the placement of stents through minimally invasive methods to seal rupture sites near the aortic inflow tract, thereby preventing blood entry into the false lumen and promoting thrombosis, which reduces the risk of aortic rupture. Endovascular stents typically consist of a metal framework and a flexible membrane graft designed to reopen obstructed aortic segments and maintain blood flow through the true lumen. Consequently, stents are widely used to treat aortic expansion diseases and aortic occlusive stenosis.

The effectiveness and safety of specific dietary supplements in modulating uric acid levels, oxidative stress, and lipid metabolism in patients: a network meta-analysis of 13 interventions.

Background: Hyperuricemia and gout have garnered increasing attention as significant health concerns in recent years, often associated with damage to multiple bodily systems. Consequently, the reduction of uric acid levels has become particularly crucial. The utilization of dietary supplements presents potential adjunctive treatment options for individuals with gout.