Discovery of Novel Pyrazole-4-carboxamide Derivatives with Thioether Moiety as Potential SDHI Agents for Crop Protection.

In the ongoing search for more potent succinate dehydrogenase inhibitors (SDHIs) for agricultural applications, 30 pyrazole-4-carboxamide derivatives bearing a thioether group were designed and synthesized via bioisosteric replacement and scaffold-hopping based on the structure of two SDHIs lead compounds in our previous work. The antifungal efficacy of these target compounds was evaluated against five major plant pathogenic fungi, and the results indicated that the majority of the synthesized compounds exhibited strong antifungal activities, particularly against and . Among these, compound emerged as the most promising candidate, displaying exceptional antifungal potency against (EC = 0.

Effect of finerenone on urinary protein and inflammatory factor levels in type 2 diabetes mellitus patients with diabetic kidney disease.

Aims: This study aimed to investigate the efficacy and safety of finerenone in the treatment of diabetic kidney disease (DKD) in the real-world medical setting and explore the underlying mechanism of its kidney-protecting effects from the perspective of the inflammatory response.

Materials And Methods: Forty-eight DKD patients were selected and completed a 6-month finerenone treatment. Renal parameters, inflammatory cytokines, other related indicators and adverse effects were collected at every visit.

SHERO: A Community-Driven, Technology-Enabled, and Human-Led Initiative to Advance Black Perinatal Health Equity in the U.S.

Shaping Healthy Equitable Reproductive Outcomes (SHERO) is a community-driven, technology-enabled, and human-led initiative designed to address Black maternal and infant health disparities. It integrates culturally concordant care teams, digital health education, and hybrid social support into a technology-enhanced, coordinated perinatal care model. Evaluated by mixed methods, this initiative seeks to enhance maternal and infant health equity nationwide.

Application of Array Imaging Algorithms for Water Holdup Measurement in Gas-Water Two-Phase Flow Within Horizontal Wells.

Gas-water two-phase flow in horizontal and inclined wells is significantly influenced by gravitational forces and spatial asymmetry around the wellbore, resulting in complex and variable flow patterns. Accurate measurement of water holdup is essential for analyzing phase distribution and understanding multiphase flow behavior. Water holdup imaging provides a valuable means for visualizing the spatial distribution and proportion of gas and water phases within the wellbore.

Racial Minority Doulas' Perceptions of Hospital Team-Based Care.

Introduction: Doulas are skilled paraprofessionals who provide supportive care to pregnant women and birthing people resulting in improved outcomes. However, conflicts persist between health care providers and doulas in hospital-based maternity care teams. Few studies have addressed this phenomenon from the doulas' perspective, particularly doulas from racial and ethnic minority backgrounds.

Characterization and formation process analysis of peach fruit woolliness under low-temperature storage.

Woolliness in peach fruit during low-temperature storage considerably reduces quality, primarily owing to the formation of pectin gel. This study systematically analysed texture, water distribution, cell wall microstructure, and pectin gel formation during peach storage. Peaches stored at 5 °C exhibited increased firmness, membrane permeability, and water binding capacity than those at 10 °C.

[Progress in autophagy effect on the progression of SLE pathogenesis by regulating the immune system].

Autophagy is a fundamental biological metabolic process involved in immune defense, material metabolism, and homeostasis and closely linked to immune regulation. Systemic lupus erythematosus (SLE) is a widespread connective tissue disorder primarily resulting from immune system imbalance. Due to the immune system's failure to recognize its own substances, it generates autoantibodies that can affect various tissues and organs, leading to diverse clinical manifestations.

The role of Chinese medical teams in bridging healthcare gaps in Africa: a scoping review.

Background: Sub-Saharan Africa has faced profound healthcare challenges, including severe shortages of professionals and infrastructural deficits. Despite significant international aid, the full impact of Chinese Medical Teams (CMTs) in addressing these issues had remained underexplored. This scoping review aimed to synthesise existing literature on the role of CMTs in Africa, identifying key drivers, barriers, and gaps in research that could enhance the effectiveness of these programmes.

Lifestyle interventions addressing cardiometabolic health among Black American women of reproductive age in the U.S. : an integrative review.

Background: Cardiometabolic disorders among childbearing women, particularly Black American women, contribute to adverse perinatal outcomes and long-term health consequences. Lifestyle interventions are critical approaches to improve cardiometabolic health.

Objective: This integrative review synthesized evidence on lifestyle interventions promoting cardiometabolic health among Black women of childbearing age in the U.

Heterogeneous effects of physical activity on physiological stress during pregnancy.

Pregnancy is a critical period characterized by profound physiological and psychological adaptations that can significantly impact both maternal and fetal health outcomes. Thus, it is imperative to implement targeted and evidence-based interventions to enhance maternal well-being during the prenatal period. Mobile health (mHealth) technologies enable continuous, real-time monitoring of both physiological and psychological states, providing detailed insights into health behaviors and individual responses in natural settings.

Natural Brominated Fatty Acid-containing Flavonoids Bromaliphflas A-B From Marine-derived Streptomyces qinglanensis 1678.

Two new brominated fatty acid-containing flavonoids (1 and 2), together with the known compound 5-hydroxy-3',4',7-trimethoxyflavone (HTMF) (3), were obtained from marine-derived Streptomyces qinglanensis 1678. The structures of the new isolates were established on the basis of their electrospray ionization high-resolution mass spectrometry, one-, and two-dimensional nuclear magnetic resonance datasets. Bioactivity results show that compounds 2 and 3 exhibited moderate anti-inflammatory bioactivities.

Chromatin accessibility landscape of mouse early embryos revealed by single-cell NanoATAC-seq2.

In mammals, fertilized eggs undergo genome-wide epigenetic reprogramming to generate the organism. However, our understanding of epigenetic dynamics during preimplantation development at single-cell resolution remains incomplete. Here, we developed scNanoATAC-seq2, a single-cell assay for transposase-accessible chromatin using long-read sequencing for scarce samples.

Sleep Quality of Persons with Dementia and Family Caregivers in Korean Americans: Wearable Technology to Study the Dyadic Association.

Background: Sleep disturbances, such as difficulty in falling asleep and multiple awakenings at night, are prevalent among persons with Alzheimer's disease and related dementias (hereafter dementia), resulting in advanced cognitive impairment and increased behavioral problems. Additionally, family caregivers (eg, spouses or offspring) suffer from reduced sleep quality as a result of sleep disturbances in the persons with dementia (PWDs) they care for. Relatively little is known about the interaction of sleep parameters in dyads (PWD-caregiver) as paired units among understudied immigrant minorities, particularly Korean Americans.

The effects of clinical crown length on the sagittal movement of maxillary central incisor in clear aligner treatment: a finite element exploration.

Background: The mechanism of force application in clear aligner treatment involves wrapping the clinical crowns, suggesting that the size of the clinical crowns may impact tooth movement. The present finite element study aimed to explore the impact of clinical crown length on the sagittal movement of maxillary central incisor in clear aligner treatment.

Methods: The standard maxillary dentition model was developed using computer tomography scanning.

Paeoniflorin modulates AGEs/RAGE/P38MAPK/ERK/mTOR autophagy pathway to improve cognitive dysfunction in MRL/lpr mice.

Objective: The objective of this study was to investigate the therapeutic effects of paeoniflorin (PA) on cognitive impairment and to elucidate its potential mechanisms in MRL/lpr mice, a model of systemic lupus erythematosus-associated cognitive dysfunction.

Method: Cognitive performance and behavioral responses were assessed using a comprehensive battery of tests, including the Morris water maze, the Novel object recognition test, and the Y maze. Neuropathological changes in the hippocampal regions were visualized through Nissl, HE and Immunohistochemistry staining.

Individualized Time-Varying Nonparametric Model With an Application in Mobile Health.

Individualized modeling has become increasingly popular in recent years with its growing application in fields such as personalized medicine and mobile health studies. With rich longitudinal measurements, it is of great interest to model certain subject-specific time-varying covariate effects. In this paper, we propose an individualized time-varying nonparametric model by leveraging the subgroup information from the population.

Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.

Background: Pulmonary hypertension (PH) is a devastating disease marked by elevated pulmonary artery pressure, resulting in right ventricular (RV) failure and mortality. Despite the identification of several dysregulated genes in PH, the involvement of circular RNAs (circRNAs), a subset of long noncoding RNAs, remains largely unknown.

Methods: In this study, high-throughput RNA sequencing was performed to analyze the genome-wide expression patterns of circRNAs in pulmonary arteries from three models of PH rats induced by hypoxia (Hyp), hypoxia/Sugen5416 (HySu), and monocrotaline (MCT).

Mindfulness and Cardiometabolic Health During Pregnancy: An Integrative Review.

Objectives: Cardiometabolic health during pregnancy has potential to influence long-term chronic disease risk for both mother and offspring. Mindfulness practices have been associated with improved cardiometabolic health in non-pregnant populations. The objective was to evaluate diverse studies that explored relationships between prenatal mindfulness and maternal cardiometabolic health.

Steam explosion treatment for improving the quality of Xuehua pear soup: Components profile, antioxidant and anti-inflammatory activity in vitro, its flavor and metabolomics study.

In this study, steam explosion (SE) was applied to produce Xuehua pear soup (XPS) at different steam explosion pressure. The results showed that 0.3-0.

Ameliorating macrophage pyroptosis via ANXA1/NLRP3/Caspase-1/GSDMD pathway: Ac2-26/OGP-loaded intelligent hydrogel enhances bone healing in diabetic periodontitis.

Craniofacial bone defect healing in periodontitis patients with diabetes background has long been difficult due to increased blood glucose levels which cause overproduction of reactive oxygen species (ROS) and a low pH environment. These conditions negatively affect the function of macrophages, worsen inflammation and oxidative stress, and ultimately, hinder osteoblasts' bone repair potential. In this study, we for the first time found that annexin A1 (ANXA1) expression in macrophages was reduced in a diabetic periodontitis (DP) environment, with the activation of the NLRP3/Caspase-1/GSDMD signaling pathway, and, eventually, increased macrophage pyroptosis.

Comparing ceftazidime/avibactam and polymyxin B for treating carbapenem-resistant organisms infections: A propensity score-matched retrospective cohort study.

Background And Aim: There are limited comparative studies of ceftazidime/avibactam (CAZ/AVI) vs. polymyxin B (PMB) for carbapenem-resistant organisms (CRO) infections. The aim of this study was to compare the efficacy and safety of CAZ/AVI and PMB in treating CRO infections.

Role of sleep and neurochemical biomarkers in synaptic plasticity related to neurological and psychiatric disorders: A scoping review.

Sleep is vital for maintaining physical and mental well-being, impacting cognitive functions like memory and learning through neuroplasticity. Sleep disturbances prevalent in neurological and psychiatric disorders exacerbate cognitive decline, imposing societal burdens. Exploring the relationship between sleep and neuroplasticity elucidates the mechanisms influencing cognition, particularly amidst the prevalent sleep disturbances in these clinical populations.

Medicinal potential of adventitious root cultures of Hypericum perforatum: study on antioxidant stress and anti-melanogenic properties.

Background: Adventitious root (AR) culture is an effective method for the production of Hypericum perforatum raw materials. However, the ARs are seldom utilized in practical applications. Therefore, this study investigated the effects of H.

Application of Imaging Algorithms for Gas-Water Two-Phase Array Fiber Holdup Meters in Horizontal Wells.

The flow dynamics of low-yield horizontal wells demonstrate considerable complexity and unpredictability, chiefly attributable to the structural attributes of the wellbore and the interplay of gas-water two-phase flow. In horizontal wellbores, precisely predicting flow patterns using conventional approaches is often problematic. Consequently, accurate monitoring and analysis of water holdup in gas-water two-phase flows are essential.

Lhx6 deficiency causes human embryonic palatal mesenchymal cell mitophagy dysfunction in cleft palate.

Background: Overconsumption of retinoic acid (RA) or its analogues/derivatives has been linked to severe craniomaxillofacial malformations, such as cleft palate and midface hypoplasia. It has been noted that RA disturbed the proliferation and migration of embryonic palatal mesenchymal (EPM) cells in these malformations, yet the exact mechanisms underlying these disruptions remained unclear.

Methods: A model of retinoic acid (RA)-induced cleft palate in fetal mice was successfully established.