Unveiling the social and environmental benefits of electric vehicles: A case study of Shanghai.

The economic viability of battery electric vehicles (BEVs) relies on effectively balancing carbon mitigation benefits with development costs. This study addresses this issue by establishing a comprehensive social and environmental benefit (SEB) assessment model integrating life cycle assessment and life cycle cost methodologies. The aim is to quantify and analyze the economic costs and carbon reduction potential of BEVs throughout their life cycle, focusing on the case study of Shanghai.

Environmental noise exposure and cardiovascular diseases in a Shanghai cohort.

Background: Little is known about the impact of environmental noise on cardiovascular diseases (CVDs) in low- and middle-income countries, where high population density and complex sources of noise are prevalent. This study aimed to explore associations of environmental noise with CVDs and cardiovascular risk factors.

Methods: 27,444 participants aged 18-74 years were included in this study.

Status of COVID-19 vaccination in patients undergoing dialysis in China: a national cross-sectional study (2022).

Introduction: Due to their comorbidities and frequent exposure to healthcare settings, patients undergoing dialysis are at a high risk of developing severe COVID - 19. However, there are no customized vaccination guidelines for this group in China. This study had two aims: to systematically evaluate the current status of COVID - 19 vaccination among Chinese dialysis patients and to offer a basis for policy - making and further research.

Relationship between dietary acid-base load and non-insulin-based resistance measures in patients with chronic kidney disease.

Unlabelled: This study explored the associations between triglyceride glucose (TyG), TyG with body mass index (TyG-BMI), triglyceride-to-high-density lipoprotein cholesterol (TG/HDL-C) ratio, and metabolic score for insulin resistance (METS-IR) and the effects of dietary acid-base load in patients with chronic kidney disease (CKD).

Methods: A total of 288 patients with CKD were included in this study. Four non-insulin-based insulin resistance (IR) markers were used to assess IR levels in patients with CKD; dietary intake - 24-h dietary recall; and diet-based acidity - potential renal acid load (PRAL), net endogenous acid production (NEAP), and dietary acid load (DAL).

Performance comparison of dual-layer detector CT parameters from different blood vessels in the detection of anemia.

Background: Anemia negatively affects an individual's overall prognosis and quality of life, and thus represents a significant health burden. Dual-layer computed tomography (DLCT) detector imaging enables substance differentiation. This study aimed to compare the performance of DLCT parameters for different blood vessels in detecting anemia.

Associations of serum total light chain kappa and lambda levels with all-cause mortality in Chinese centenarians.

The purpose of this study was to determine the relationship between the serum levels of kappa (κ) and lambda (λ) total light chain (TLC), the κ/λ ratio, and the combined serum TLCκ and TLCλ (ΣTLC) levels in Chinese centenarians and all-cause mortality. The association between serum TLC and all-cause mortality was investigated using restricted cubic spline (RCS) analysis, Cox proportional hazards models, and Kaplan‒Meier curves. The study included 906 centenarians (18.

Development Of the VAMPCT Score for Predicting Mortality in CKD Patients with COVID-19.

Chronic kidney disease (CKD) patients with coronavirus disease 2019 (COVID-19) are at significant risk of death. However, clinical identification of high-risk individuals remains suboptimal despite the recognition of many pathophysiological and comorbidity-related risk factors. We aim to develop a clinically simple machine learning (ML)-based score to predict acute COVID-19 mortality among CKD patients.

High-Sensitivity, Low-Hysteresis, Flexible Humidity Sensors Based on Carboxyl-Functionalized Reduced-Graphene Oxide/Ag Nanoclusters.

The measurement of humidity is of great significance for precision instruments, semiconductor integrated circuits, and element manufacturing factories. The oxygen-containing groups and noble metals in graphene-based sensing materials can significantly influence their humidity-sensing performance. Herein, 1,3,5-benzenetricarboxylic acid-functionalized reduced graphene oxide (H3BTC-rGO) loaded with Ag nanocluster nanocomposites (H3BTC-rGO/Ag) was synthesized via a facile one-step reduction method.

Correlation between dietary acid-base load and chronic kidney disease patients with type 2 diabetes mellitus.

Objective: This study aimed to investigate the effect of dietary acid-base load on patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM).

Design: A total of 300 patients with CKD were enrolled and divided into three groups according to DAL tertiles. Dietary intake was assessed using a 24-h dietary recall, and diet-based acidity was assessed using net endogenous acid production (NEAP), potential renal acid load (PRAL), and dietary acid load (DAL).

Point-of-Care Monitoring for Lung Cancer from Exhaled Breath Formaldehyde via Luminescent Metal-Organic Frameworks.

The identification of specific markers in exhaled gas from individuals with lung cancer has significantly enhanced the feasibility of early lung cancer screening. This paper presents the synthesis of a 2D Cu-BDC-NH nanosheet at room temperature, which has been applied for the noninvasive diagnosis and point-of-care test (POCT) of lung cancer. During this approach, the hydrazine group in the ligand molecule was employed to enhance the intrinsic fluorescence of Cu-BDC-NH through a Schiff base reaction with formaldehyde (HCHO), thereby reducing the detection limits of HCHO gas and aqueous solution (25 ppb and 0.

Effects of the carcinogen TCDD on δ-catenin stability and tumorigenic potential in prostate cancer cells.

δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins and is known to be upregulated in prostate cancer, promoting tumorigenesis. Unfortunately, the molecular mechanism underlying this effect remains unclear. The carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been linked to an increased risk of prostate cancer.

Mechanistic insights into the cardiovascular effects of acute heat exposure: A multi-omics analysis based on a randomized crossover trial.

Heat exposure has been identified as a significant contributory factor in the development of cardiovascular diseases, but the biological mechanisms are not yet fully elucidated. We conducted a randomized crossover trial in healthy adults in Shanghai, China. Each subject was alternatively exposed to moderate temperature (22 °C) and elevated temperature (32 °C) in a chamber for 2 h in random order.

Associations of the triglyceride-glucose index and triglyceride-glucose/body mass index with all-cause mortality in Chinese centenarians.

Background: The triglyceride-glucose (TyG) index and triglyceride-glucose/body mass index (TyG-BMI) have been shown to be associated with cardiovascular and cerebrovascular disorders and the risk of death. The aim of this study was to explore the relationships of the TyG index and TyG-BMI with all-cause mortality among Chinese centenarians.

Methods: Data from the China Hainan Centenarian Cohort Study (CHCCS) were analyzed.

Heat-stable protein PGSL1 enhances pollen germination and tube growth at high temperature.

Global warming intensifies extreme heat events, threatening crop reproduction by impairing pollen development, germination, and tube growth. However, the mechanisms underlying pollen heat responses remain elusive. The actin cytoskeleton and actin-binding proteins (ABPs) are crucial in these processes, yet their roles under heat stress are poorly understood.

Oxidation mechanism and interrelationship of lipid and protein oxidation in duck leg muscles during sous vide cooking.

The laws and interrelationships of lipid and protein oxidation in duck meat during sous vide cooking (SVC) are still unclear. In this study, the oxidation mechanisms of the muscle of duck legs during SVC were investigated from the aspects of fatty acid (FA) profile, antioxidant system activity, enzyme activity, and iron element. Lipid oxidation predominantly occurred within the initial 0-2 h of the SVC process, during which the Thiobarbituric acid reactive substances (TBARS) value escalated to 10-fold of its initial level.

Effect of different combinations of serum antimüllerian hormone levels and body mass index on pregnancy outcomes in women with polycystic ovary syndrome.

Background: Both antimüllerian hormone and body mass index are associated with the pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization.

Objective: This study aimed to explore the effect of different combinations of antimüllerian hormone and body mass index on pregnancy outcomes in women with polycystic ovary syndrome undergoing in vitro fertilization.

Study Design: This was a post hoc secondary analysis of a multicenter randomized trial.

Associations of ambient fine particulate matter with lung function and nasal microbiota: A panel study in asthmatic children.

Fine particulate matter (PM) has been associated with an increased risk of asthma. However, the underlying mechanisms through which PM affects respiratory health in children with asthma remain poorly understood. To address this gap, we performed a panel study to investigate the associations of short-term PM exposure with lung function and nasal microbiota in asthmatic children.

Interictal paroxysmal fast activity and functional connectivity in steroid responsive and non-responsive Lennox-Gastaut syndrome.

Objective: The aim of this study was to investigate the changes in interictal paroxysmal fast activity and functional connectivity before and after steroid pulse therapy in patients with Lennox-Gastaut syndrome (LGS).

Methods: The medical records of patients who visited the pediatric neurology clinics with LGS as their primary complaint and completed intravenous methylprednisolone therapy were reviewed. Effects of steroid therapy on clinical seizures and scalp EEG were analyzed.

Sexual reproduction in plants under high temperature and drought stress.

Climate-change-induced extreme heat and drought increasingly threaten plant growth and development, with a particularly significant impact on sexual reproduction. Heat and drought stress can disrupt key stages of plant sexual reproduction, including flowering time, gametophyte development, pollination, and seed formation, leading to infertility and substantial yield reductions in crops. This review systematically summarizes the latest research on the effects of heat and drought stress on various stages of plant sexual reproduction and proposes specific strategies to mitigate the agricultural hazards posed by these stresses.

A family of α/β hydrolases removes phytol from chlorophyll metabolites for tocopherol biosynthesis in Arabidopsis.

Tocopherol synthesis requires phytyl diphosphate derived from phytol esterified to chlorophyll metabolites. The >600-member Arabidopsis thaliana α/β hydrolase (ABH) gene family contains 4 members that can release phytol from chlorophyll metabolites in vitro; however, only pheophytinase (PPH) affects tocopherol synthesis when mutated, reducing seed tocopherols by 5%. We report the biochemical analysis of 2 previously uncharacterized ABHs, chlorophyll dephytylase 2 (CLD2) and CLD3, and their respective mutants singly and in combinations with pph and cld1 alleles.

Acute Impact of Nonoptimal Ambient Temperatures on Plasma Levels of 3000 Proteins in Chinese Adults.

Nonoptimal ambient temperatures (i.e., cold and heat) are leading environmental determinants of major diseases worldwide, but the underlying pathological mechanisms are still poorly understood.

Association between embryo transfer season and the risks of hypertensive disorders of pregnancy and gestational diabetes mellitus.

Purpose: To explore the impact of seasonal variations on the risks of hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM) in women who undergo in vitro fertilization (IVF) treatment.

Methods: We retrospectively included a total of 21,469 women who achieved singleton delivery during their first cycles of IVF, the risks of HDP and GDM were compared in different seasonal groups according to the time of embryo transfer and the time of oocyte retrieval.

Results: After adjustment via multivariable logistic regression, women who underwent embryo transfer in spring with the expected date of confinement in winter had a higher risk of HDP (4.

Synergistic enhancement of the Ag/ZIF-67 cage@MXene 3D heterogeneous structure for ultrahigh SERS sensitivity and stability.

There is an urgent need in the field for rapid extraction and analysis of target molecules from irregular surfaces. The application of SERS technology is often limited by low adhesion between precious metal nanoparticles and the substrate and complex fabrication processes. In order to solve this problem, a carbon fiber cloth (CFC) loaded Ag/ZIF-67 cage@MXene 3D detection platform (AZMC) was constructed in this study.

Flexible Ag nanoparticle-decorated SU-8 micron-column array films as sensitive SERS substrates for in situ detection of pesticide residues.

In this study, we prepared large-area polydimethylsiloxane (PDMS) 3D flexible films deposited with silver nanoparticles (Ag NPs) by assembling Ag NPs on ordered micron-column (MC) arrays fabricated using SU-8 colloidal lithography (Ag NP@SU-8-MC). The large-scale, highly ordered 3D MC array flexible film offers numerous adsorption sites for densely packed Ag NPs. High-density sub-nanometer gaps between Ag NPs create spatial hot spots, enhancing the electromagnetic field.

Predicting Health Utilities Using Health Administrative Data: Leveraging Survey-linked Health Administrative Data from Ontario, Canada.

Background: The quality-adjusted life year (QALY) is widely used to measure health outcome that combines the length of life and health-related quality of life (HRQoL). To be a reliable QALY measure, HRQoL measurements with a preference-based scoring algorithm need to be converted into health utilities on a scale from zero (dead) to one (perfect health). However, preference-based health utility data are often not available.