Unveiling the social and environmental benefits of electric vehicles: A case study of Shanghai.

The economic viability of battery electric vehicles (BEVs) relies on effectively balancing carbon mitigation benefits with development costs. This study addresses this issue by establishing a comprehensive social and environmental benefit (SEB) assessment model integrating life cycle assessment and life cycle cost methodologies. The aim is to quantify and analyze the economic costs and carbon reduction potential of BEVs throughout their life cycle, focusing on the case study of Shanghai.

Metformin and berberine synergistically improve NAFLD via the AMPK-SREBP1-FASN signaling pathway.

Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic condition linked to dyslipidemia, insulin resistance, and persistent inflammation. Due to its complex pathogenesis, no approved pharmacological treatments currently exist. The research sought to explore the combined impact of metformin (Met) and berberine (BBR) on NAFLD, focusing on the AMPK-SREBP1-FASN pathway implicated in liver lipid regulation.

A Innovative Strategy for Identifying Subtypes Through the Analysis of Multi-Omics Data with Adversarial Autoencoders.

Cancer is a disease that is both complex and diverse, and effective diagnosis and treatment require an accurate depiction of tumor subtypes. Traditional methods of cancer identification, which rely on clinical and histopathological criteria, have limitations in identifying key molecular subtypes. With the advancement of high-throughput genomics technologies, the field of cancer research has undergone a transformation, enabling detailed analysis of tumor molecular characteristics on a large scale.

Carbon emission assessment of lithium iron phosphate batteries throughout lifecycle under communication base station in China.

The demand for lithium-ion batteries has been rapidly increasing with the development of new energy vehicles. The cascaded utilization of lithium iron phosphate (LFP) batteries in communication base stations can help avoid the severe safety and environmental risks associated with battery retirement. This study conducts a comparative assessment of the environmental impact of new and cascaded LFP batteries applied in communication base stations using a life cycle assessment method.

Chemical-Free Recycling of Cathode Material and Aluminum Foil from Waste Lithium-Ion Batteries by Combining Plasma and Ultrasonic Technology.

With the rapid demand for lithium-ion batteries due to the widespread application of electric vehicles, a significant amount of battery electrode pieces requiring urgent treatment are generated during battery production and disposal. The strong bonding caused by the presence of binders makes it challenging to achieve thorough separation between the cathode active materials and Al foil, posing difficulties in efficient battery material recycling. To address this issue, a plasma-ultrasonically combined physical separation method is proposed in this study.

Design and synthesis of highly TRAIL expression HDAC inhibitors based on ONC201 to promote apoptosis of colorectal cancer.

Activation of the TRAIL proapoptotic pathway can promote cancer cell apoptosis. Histone deacetylases (HDACs) also are promising drug targets for cancers, and their synergistic effect with TRAIL can improve the inhibitory effect on cancer cells. Therefore, the development of highly TRAIL-sensitive HDAC inhibitors might be a promising strategy for the treatment of cancers.

Design and synthesis of dual inhibitors targeting snail and histone deacetylase for the treatment of solid tumour cancer.

Snail and histone deacetylases (HDACs) have an important impact on cancer treatment, especially for their synergy. Therefore, the development of inhibitors targeting both Snail and HDAC might be a promising strategy for the treatment of cancers. In this work, we synthesized a series of Snail/HDAC dual inhibitors.

Design, synthesis and biological evaluation of 1H-indazole derivatives as novel ASK1 inhibitors.

Apoptosis signal-regulating kinase 1 (ASK1, MAP3K5), a member of the mitogen-activated protein kinase (MAPK) signaling pathway, is involved in cell survival, differentiation, stress response, and apoptosis. ASK1 kinase inhibition has emerged as a promising therapeutic strategy for inflammatory disease. A series of novel ASK1 inhibitors with 1H-indazole scaffold were designed, synthesized and evaluated for their ASK1 kinase activity and AP1-HEK293 cell inhibitory effect.

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis.

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Here, we describe the structural optimization of hit compound 7 and conduct further structure-activity relationship (SAR) studies that result in the development of compound 19 with a novel indole-2-carboxamide hinge scaffold. Compound 19 displays potent anti-ASK1 kinase activity and stronger inhibitory effect on ASK1 in AP1-HEK293 cells than previously described ASK1 inhibitor GS-4997.

[Chemical constituents of Cudrania cochinchinensis].

Objective: To study the chemical constituents of Cudrania cochinchinensis.

Methods: Compounds were isolated and purified by silica gel column, sephadex LH-20 chromatography and recrystallization. Their structures were elucidated by physicochemical properties and spectral data.