Metformin and berberine synergistically improve NAFLD via the AMPK-SREBP1-FASN signaling pathway.

Nonalcoholic fatty liver disease (NAFLD) is a prevalent metabolic condition linked to dyslipidemia, insulin resistance, and persistent inflammation. Due to its complex pathogenesis, no approved pharmacological treatments currently exist. The research sought to explore the combined impact of metformin (Met) and berberine (BBR) on NAFLD, focusing on the AMPK-SREBP1-FASN pathway implicated in liver lipid regulation.

[Chemical constituents of Cudrania cochinchinensis].

Objective: To study the chemical constituents of Cudrania cochinchinensis.

Methods: Compounds were isolated and purified by silica gel column, sephadex LH-20 chromatography and recrystallization. Their structures were elucidated by physicochemical properties and spectral data.