Dynamic Macropore Formation via Dual-Degrading Injectable Microgels Enhances Host-Mediated Angiogenesis and Regeneration.

Hydrogels are widely employed in tissue engineering for their biomimetic microenvironments. However, the dense crosslink network of hydrogels with matching mechanical properties of soft tissues often restricts cell infiltration and tissue integration. While granular hydrogels enhance host integration through the formation of porous channels between particles, they self-anneal in vivo, thereby limiting porosity and interconnectivity.

Changes in dynamic and static functional connectivity in amygdala subregions in major depressive disorder treated with esketamine in and sertraline: A pilot study.

Introduction: Dysfunction in amygdala networks has been implicated in major depressive disorder (MDD). Pharmacological treatments, such as esketamine and sertraline, are believed to exert their antidepressant effects by modulating amygdalar activity. This study aimed to investigate the relationship between changes in dynamic functional connectivity (dFC) within amygdala subregions and treatment outcomes, with a focus on identifying potential neuroimaging markers.

Enhanced meningeal lymphatic drainage alleviates cognitive dysfunction induced by anesthesia and surgery in aged mice.

Postoperative cognitive dysfunction (POCD) occurs in elderly surgical patients as a common complication and manifests as cognitive decline. It is associated with neuroinflammation, microglial activation, and impaired metabolic waste clearance-key mechanisms underlying POCD. Meningeal lymphatic vessels (MLVs) facilitate the drainage of cerebrospinal fluid (CSF) and interstitial fluid (IF), regulating brain immune responses and clearing metabolic waste, immune cells, and antigens, thus modulating neuroinflammation.

The treatment of amphotericin B-resistant C neoformans meningitis: A case report and literature review.

Rationale: Cryptococcal meningitis is caused by Cryptococcus neoformans and Cryptococcus gattii, predominantly affects immunocompromised host. Resistance to amphotericin B poses therapeutic challenges, especially in immunocompetent individuals, where evidence is scarce.

Patient Concerns: This study reports a case of an old immunocompetent male diagnosed with amphotericin B-resistant C neoformans meningitis.

Harnessing non-equilibrium hot electrons in a quantum-engineered ternary heterostructure for sub-ppb C9 biomarker detection.

Photoactivated sensors offer a safe, low-power alternative to thermal sensors, yet their performance against trace concentrations of weakly reactive biomarkers is fundamentally crippled by the rapid energy loss of photogenerated carriers electron relaxation into the band-edge. This process limits the number of electrons available for sensing. Here, we overcome this limitation by introducing a new principle: non-equilibrium hot-electron-mediated chemoresistance.

Case Report: Syndrome of inappropriate antidiuretic hormone secretion induced by pramipexole: a case report and literature review.

Pramipexole, a novel dopamine receptor agonist, is widely used in the treatment of Parkinson's disease and related syndromes. While studies have demonstrated that pramipexole can cause various adverse reactions, primarily involving the central nervous system or gastrointestinal symptoms, there remains limited reporting on pramipexole-induced syndrome of inappropriate antidiuretic hormone secretion (SIADH). This article analyzes and discusses a case of pramipexole-induced SIADH that occurred in our hospital.

Research advances in methane emission from agricultural drainage ditch in coastal reclamation area.

Coastal reclamation area is an agricultural region formed by artificial transformation of coastal tidal flats. Changes in land use types would reshape regional carbon cycling patterns. Methane (CH) is a short-lived greenhouse gas with a high global warming potential, the emission of which is a key contributor to the accelerated global climate change.

Association Between PNPLA3 Inhibition and Gout: A Drug Target Mendelian Randomization Study.

Patatin-like phospholipase domain-containing protein 3 (PNPLA3) plays a crucial role in metabolic dysfunction-related steatotic liver disease. ARO-PNPLA3 is a therapeutic agent designed to target PNPLA3, but its long-term effects remain uncertain. The objective of this study was to ascertain the impact of PNPLA3 inhibition on the risk of gout through Mendelian randomization.

Modulating supramolecular Pt⋯Pt interactions and π-π stacking for high-contrast mechanochromic and vapochromic materials.

A platinum(II) complex (Pt-PF) with bis(imidazolyl)pyridine ligands was synthesized, and its photophysical properties were comprehensively characterized. Two distinct forms of Pt-PF (Y-Pt-PF and R-Pt-PF) exhibiting different colors and structural arrangements were identified. Modulated supramolecular Pt⋯Pt interactions and π-π stacking patterns make the yellow Y-Pt-PF to red R-Pt-PF transformation occur under mechanical grinding or exposure to CHCN or MeOH vapors demonstrating high-contrast mechanochromic and vapochromic properties.

Electrocardiogram abnormalities and cardiovascular risk prediction in older Chinese: the Guangzhou Biobank Cohort Study.

Background: Evidence on the associations of multiple minor ECG abnormalities (EA) with cardiovascular disease (CVD) and mortality in older populations is limited, particularly whether a weighted EA score better predicts CVD risk than a single EA severity.

Methods: We analysed 26 846 Chinese aged 50+ years from Guangzhou Biobank Cohort Study (GBCS), without CVD at baseline. Minor and major EAs were classified based on the Minnesota Code Manual.

Local Delivery of Molecular Hydrogen by Fluorinated Zeolitic Imidazole Framework Nanosheets Boosts Cancer Immunotherapy.

Identifying strategies to improve the efficacy of the immune checkpoint blockade (ICB) remains a major clinical need. Based on the high tissue penetration capability of hydrogen molecules (H) and their immunomodulatory effects, this work proposes a local gas delivery strategy targeting the tumor microenvironment for high-efficacy hydrogen immunotherapy. We synthesized hepta-fluorinated zeolitic imidazolate frameworks nanosheet (F-ZIF) with high H payload, sustained acid-responsive gas release property, and biodegradation.

SpaIM: single-cell spatial transcriptomics imputation via style transfer.

Spatial transcriptomics (ST) technologies have transformed our understanding of cellular organization but are limited by sparse signals and restricted gene coverage. To address these challenges, we introduce SpaIM, a style transfer learning model that leverages single-cell RNA sequencing (scRNA-seq) data to predict unmeasured gene expressions in ST profiles. By disentangling shared content and modality-specific styles, SpaIM effectively integrates scRNA-seq's rich gene expression with the spatial context of ST.

Machine Learning-Guided Construction of Cobalt Hexacyanoferrate Space-Confined in Hollow Carbon with Yolk-Shell Structure for Advanced Aqueous Zinc-Ion Batteries.

Carbon-modified materials have shown great promise as cathode candidates for aqueous zinc-ion batteries (AZIBs). However, the indistinctness of screening standards along with the time-consuming experimental procedures inevitably restricts their practical uses. With the increasing prevalence of artificial intelligence, machine learning (ML) offers an avenue to enhance the performance of energy storage devices.

Facet-selective synthesis of cadmium sulfide photocatalysts for high-efficiency CO conversion.

The surface of photocatalysts plays a key role in the adsorption and activation of CO molecules. Establishing the conformational relationship between the crystalline phase of the photocatalysts and the CO reduction reaction (CORR) activity is crucial to understanding the catalytic reaction mechanism. Herein, we synthesized CdS catalysts with different exposed crystalline facets (CdS[100], CdS[001], and CdS[111]) using hydrothermal and water bath methods and evaluated their photocatalytic CORR performances.

How plants respond to salt stress: Lessons form RBOHs.

RBOH is called respiratory burst oxidase homolog is one of the key enzymes in producing reactive oxygen species (ROS). Studies have shown that ROS (such as ·O, HO) are widely involved in plant growth development and response to various biological and abiotic stresses. In recent years, with the gradual deepening of research, more and more plant NOX/RBOH members have been identified, and their biological functions and participating signal regulatory pathways have been revealed.

Aquatic fungal intrusion increases microbial risk in premise plumbing system: Novel insights into water quality, bacterial community and function of pathogens.

Fungi in drinking water pose a potential biohazard because treatment plants only partially remove them. The potential ecological impacts of viable fungi and fungal-derived organic matter entering premise plumbing systems remain uncertain. In this study, we established pipeline systems to examine the impact of fungi and fungal dissolved organic matter (DOM) on water quality, microbial stability, and function of pathogens.

Gaussian primitives for deformable image registration.

Background And Purpose: Deformable image registration (DIR) plays a critical role in radiotherapy by compensating for anatomical deformations. However, existing iterative and data-driven methods are often hindered by computational inefficiency or limited generalization. In response, our objective was to develop a novel optimization-based DIR method that reduces computational overhead and preserves the robust generalization of iterative methods while enhancing interpretability.

S TU-Net: Structured convolution and superpixel transformer for lung nodule segmentation.

Accurate segmentation of lung adenocarcinoma nodules in computed tomography (CT) images is critical for clinical staging and diagnosis. However, irregular nodule shapes and ambiguous boundaries pose significant challenges for existing methods. This study introduces STU-Net, a hybrid CNN-Transformer architecture designed to enhance feature extraction, fusion, and global context modeling.

Analyzing relationship between ureter and lumbar vertebrae: insights from digital radiography.

Background: In order to mitigate the risk of iatrogenic ureteral injury during surgical procedures, previous research has explored the anatomical relationship between the ureter and the lumbar spine. The primary aim of this study was to elucidate the anatomical relationship between the ureter and the lumbar vertebrae utilizing digital radiography (DR) images.

Methods: We retrospectively analyzed anteroposterior DR images of the abdomen from 39 male and 40 female patients with double J ureteral stents.

Optimizing co-combustion of sewage sludge and bamboo scraps: Analysis of NO emissions and ash slagging behavior.

This paper investigates the co-combustion of sewage sludge (SS) and bamboo scraps (BS) in a tubular furnace at 700 °C, 800 °C, and 900 °C, focusing on NO emission characteristics and ash slagging behavior. NO emissions from SS combustion occur in two distinct stages, corresponding to the release and reaction of volatile-N and char-N, respectively. Increasing the BS content decreases total NO emissions but raises NO formation from char-N.

Efficacy and safety of CT-guided 125I particle implantation for the treatment of elderly lung cancer: a system evaluation and meta-analysis.

Background: To systematically evaluate the efficacy and safety of 125I particle implantation in the treatment of elderly lung cancer.

Methods: Both randomized and non-randomized controlled studies on CT-guided 125I particle implantation therapy for the treatment of elderly lung cancer patients were retrieved from databases including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data, VIP, and SinoMed from inception to October 31, 2022. Two researchers screened the retrieved studies, extracted data, and evaluated the study quality independently.

Association between dietary fatty acid intake and preserved ratio impaired spirometry in U.S. adults: a population-based cross-sectional study.

Background: Preserved ratio impaired spirometry (PRISm) is increasingly recognized as a clinically relevant but underdiagnosed lung function abnormality. This pulmonary phenotype is clinically significant yet remains insufficiently studied. Although dietary fatty acids are known to have anti-inflammatory and immune-regulating properties, their relationship with PRISm has not been previously explored.

Multiomics reveals changes in lipid metabolism in the livers of landes geese before and after overfeeding.

Objective: : The aim of this experiment was to integrated production indices with omics sequencing to elucidate the systemic perturbations between hepatic metabolism and the gut microbiota during overfeeding.

Methods: : A total of 120 seven-week-old male Landes geese were floor reared in a pen environment. Overfeeding commenced at week 8 using a corn-based diet containing 5% soybean oil.

Evaluation of Immunoprotective Activities of White Button Mushroom () Water Extract Against Major Pathogenic Bacteria ( or ) in Goldfish ().

The white button mushroom () is a widely cultivated edible and medicinal mushroom, which contains various active substances, and has application value against pathogenic bacteria in aquaculture. Firstly, water extract (AB-WE) was prepared. Through the detection kits, it was found that the polysaccharide, protein, and polyphenol components of AB-WE were 9.