Dynamic Macropore Formation via Dual-Degrading Injectable Microgels Enhances Host-Mediated Angiogenesis and Regeneration.

Hydrogels are widely employed in tissue engineering for their biomimetic microenvironments. However, the dense crosslink network of hydrogels with matching mechanical properties of soft tissues often restricts cell infiltration and tissue integration. While granular hydrogels enhance host integration through the formation of porous channels between particles, they self-anneal in vivo, thereby limiting porosity and interconnectivity.

-probiotic synergy alleviates chemotherapy-induced cancer-related fatigue via gut microbiota-metabolic axis regulation in mice.

Introduction: This study investigated the effects of a compound preparation combining and probiotics (LB-Pro) on chemotherapy-induced cancer-related fatigue (CRF) in a murine model. The aim was to explore potential mechanisms related to the gut microbiota-metabolic axis.

Materials And Methods: A CRF model was established in C57BL/6NCr mice using 5-fluorouracil.

Ex vivo expansion and hydrogel-mediated in vivo delivery of tissue-resident memory T cells for immunotherapy.

Tissue-resident memory T (T) cells preferentially reside in peripheral tissues, serving as key players in tumor immunity and immunotherapy. The lack of effective approaches for expanding T cells and delivering these cells in vivo hinders the exploration of T cell-mediated cancer immunotherapy. Here, we report a nanoparticle artificial antigen-presenting cell (nano-aAPC) ex vivo expansion approach and an in vivo delivery system for T cells.

Granular Nanofiber-Hydrogel Composite-Programmed Regenerative Inflammation and Adipose Tissue Formation.

The interplay between biomaterials and host immune responses critically determines outcomes in tissue restoration. Recent studies suggest that physicochemical properties of materials can dictate pro-regenerative versus pro-fibrotic responses and have begun to define the key immune cell types and signals governing these divergent effects. This emerging understanding enables the engineering of regenerative biomaterials capable of functional restoration in situ.

Anion-Doped Thickness-Insensitive Electron Transport Layer for Efficient Organic Solar Cells.

In organic solar cells, interfacial materials play essential roles in charge extraction, transportation, and collection. Currently, highly efficient and thickness-insensitive interfacial materials are urgently needed in printable large area module devices. Herein, water/alcohol-soluble conjugated polyelectrolyte PFNBT-Br, with medium bandgap based on benzothiadiazole, are doped by two alkali metal sodium salts, NaH PO , Na C O with different counter anions, to pursue high efficiency and thickness-insensitive electron-transport layers.

dbAMP 2.0: updated resource for antimicrobial peptides with an enhanced scanning method for genomic and proteomic data.

The last 18 months, or more, have seen a profound shift in our global experience, with many of us navigating a once-in-100-year pandemic. To date, COVID-19 remains a life-threatening pandemic with little to no targeted therapeutic recourse. The discovery of novel antiviral agents, such as vaccines and drugs, can provide therapeutic solutions to save human beings from severe infections; however, there is no specifically effective antiviral treatment confirmed for now.

dbPTM in 2022: an updated database for exploring regulatory networks and functional associations of protein post-translational modifications.

Protein post-translational modifications (PTMs) play an important role in different cellular processes. In view of the importance of PTMs in cellular functions and the massive data accumulated by the rapid development of mass spectrometry (MS)-based proteomics, this paper presents an update of dbPTM with over 2 777 000 PTM substrate sites obtained from existing databases and manual curation of literature, of which more than 2 235 000 entries are experimentally verified. This update has manually curated over 42 new modification types that were not included in the previous version.

Dodecacyclic-Fused Electron Acceptors with Multiple Electron-Deficient Units for Efficient Organic Solar Cells.

Fused aromatic cores in non-fullerene electron acceptors (NFEAs) play a significant role in determining their optoelectronic properties and photovoltaic performance. In this work, a dodecacyclic-fused core with three electron-deficient units is synthesized through a double intramolecular Cadogan reduction cyclization. Terminal groups with different halogen substitution (F or Cl) are grafted onto the dodecacyclic-fused core to afford MS-4F and MS-4Cl, both of which showed strong and broad absorption, narrow bandgaps around 1.

Microemulsion-Assisted Self-Assembly and Synthesis of Size-Controlled Porphyrin Nanocrystals with Enhanced Photocatalytic Hydrogen Evolution.

Design and engineering of highly efficient light-harvesting nanomaterial systems to emulate natural photosynthesis for maximizing energy conversion have stimulated extensive efforts. Here we present a new class of photoactive semiconductor nanocrystals that exhibit high-efficiency energy transfer for enhanced photocatalytic hydrogen production under visible light. These nanocrystals are formed through noncovalent self-assembly of In(III) meso-tetraphenylporphine chloride (InTPP) during microemulsion assisted nucleation and growth process.