Self-supported DNA hydrogel facilitates microenvironment remodeling and cartilage repair to prevent osteoarthritis progression via an ambidextrous strategy.

Osteoarthritis (OA), a prevalent degenerative joint disease, currently lacks effective therapeutic options beyond symptomatic relief. Persistent inflammation and impaired cartilage repair accelerate the disease progression. The enzyme inducible nitric oxide synthase (iNOS) contributes to OA by producing nitric oxide (NO), which intensifies inflammation and inhibits cartilage regeneration.

-probiotic synergy alleviates chemotherapy-induced cancer-related fatigue via gut microbiota-metabolic axis regulation in mice.

Introduction: This study investigated the effects of a compound preparation combining and probiotics (LB-Pro) on chemotherapy-induced cancer-related fatigue (CRF) in a murine model. The aim was to explore potential mechanisms related to the gut microbiota-metabolic axis.

Materials And Methods: A CRF model was established in C57BL/6NCr mice using 5-fluorouracil.

Machine Learning-Assisted Prediction of Persistent Incomplete Occlusion in Intracranial Aneurysms From Angiographic Parametric Imaging-Derived Features.

Rationale And Objectives: To develop machine-learning (ML) models incorporating angiographic parametric imaging (API)-derived parameters in predicting persistent incomplete occlusion of intracranial aneurysms (IAs) after flow diverter (FD) treatment.

Materials And Methods: We analyzed 763 patients with 834 FD-treated IAs, split into training (n=583) and test (n=251) sets. The training set was further subdivided into incomplete (n=96) and complete occlusion (n=487) groups according to O'Kelly-Marotta grading.

Efficacy and safety of a new mechanical balloon-based flow diverter in the treatment of intracranial aneurysms.

Background: Flow diverters (FDs) are the first-line treatment of intracranial aneurysms (IAs). A groundbreaking mechanical balloon-based FD device was developed to enhance the precise landing and deployment efficiency for FDs.

Objective: To investigates the efficacy and safety of this innovative device in a prospective cohort.

Biodegradable Double-Layer Hydrogels with Sequential Drug Release for Multi-Phase Collaborative Regulation in Scar-Free Wound Healing.

Scarring is a prevalent and often undesirable outcome of the wound healing process, impacting millions worldwide. The complex and dynamic nature of wound healing, including hemostasis, inflammation, proliferation, and remodeling, necessitates precise, making it hard for stage-specific interventions to prevent pathological scarring. This study introduces a double-layer hydrogel system designed for sequential drug release, aligning with the stage-specific need for wound healing.

Risk Factors and Predictive Model for Ischemic Complications in Endovascular Treatment of Intracranial Aneurysms: Insights From a Large Patient Cohort.

Objectives: There remains a conspicuous absence of systematic analysis concerning the risk factors for the development of ischemic complications in the interventional treatment of IAs. Our study aimed to identify the risk factors for ischemic complications after the interventional treatment of IAs and to make an individualized prediction of the occurrence of ischemic complications, providing important reference guidance for clinicians.

Methods: This study encompassed a sample of 473 patients diagnosed with intracranial aneurysms (IA) and treated at our center between February 2022 and April 2024.

Delayed ischemic stroke after PED placement for aneurysms: optimal duration of dual antiplatelet therapy and risk factors.

Background: Delayed ischemic stroke (DIS) is a rare complication that may occur in patients with cerebral aneurysms treated with the Pipeline Embolization device (PED). This study aims to evaluate the characteristics of DIS following PED placement and to investigate the optimal duration of dual antiplatelet therapy (DAPT) in relation to the incidence of DIS.

Methods: We conducted a multicenter retrospective cohort study on consecutive cases of intracranial aneurysms treated with PED.

Synthesis of ternary heterostructured rice-stick-like Ag/polyoxometalates/nitrogen-doped carbon nanotube hybrids for the sensitive detection of adrenaline.

This study presents the innovative design and synthesis of rice-stick-like Ag/polyoxometalates/nitrogen-doped carbon nanotubes (Ag/POM/N-CNTs) using an efficient and mild reduction method. N-CNTs are first synthesized through a self-degrading template method followed by the carbonization of polypyrrole nanotubes (PPy-NTs). The N-CNTs exhibit excellent characteristics, including a high length-to-diameter ratio and an interconnected nanotube structure, which shorten the electron transport distance and enhance electrochemical properties.

Normal Values of Echocardiographic Left Atrioventricular Coupling Index and Left Atrial Stiffness Index Reflecting Left Ventricular Diastolic Function: A Multicenter Study.

Background: The left atrioventricular coupling index (LACI) and left atrial stiffness index (LASI) have recently demonstrated significant correlations with left ventricular (LV) diastolic function. However, the absence of reference values limits their widespread use. This study aimed to establish normal reference ranges for LACI and LASI.

Selenium nanozyme-crosslinked composite hydrogel for promoting cartilage regeneration in osteoarthritis via an integrated 'outside-in' and 'inside-out' strategy.

Osteoarthritis (OA), a degenerative joint disease, is characterized by chondrocyte senescence, extracellular matrix (ECM) degradation, and chronic inflammation, with limited regenerative capacity. Current therapies primarily provide symptom relief, therefore highlighting the need for more effective strategies to address OA's multifactorial pathology. This study introduces an innovative selenium nanozyme-crosslinked injectable composite hydrogel (Se/PRP-OGel), which combines selenium nanoparticles (SeNPs) with platelet-rich plasma (PRP) in a biocompatible oxidized chondroitin sulfate-gelatin scaffold (OGel), to address OA through an integrated "outside-in" and "inside-out" strategy.

Multifunctional Gold Super-Nanoparticle-Based Nanosystem for SERS-Guided Oxygen-Independent Phototherapy.

Cancer treatment remains a formidable challenge due to the complex and hypoxic microenvironment of tumors, which often compromises therapeutic efficacy. To address this issue, a multifunctional gold super-nanoparticle-based nanosystem (GSPs@PDA-AIPH-cRGD) was developed for surface-enhanced Raman scattering (SERS)-guided oxygen-independent phototherapy. This nanosystem integrates diagnostic and therapeutic functionalities through a gold superlattice-nanoparticle (GSP) core self-assembled from 5.

Trans-arterial approach for neural recording and stimulation: Present and future.

Neural recording and stimulation are fundamental techniques used for brain computer interfaces (BCIs). BCIs have significant potential for use in a range of brain disorders. However, for most BCIs, electrode implantation requires invasive craniotomy procedures, which have a risk of infection, hematoma, and immune responses.

Guided Antiplatelet Therapy for Stent-Treated Intracranial Aneurysms: A Cluster-Randomized Trial.

Background During neurointerventional treatment of intracranial aneurysms (IAs), poor antiplatelet drug response increases the risk of a cerebral ischemic event (IE). Replacing clopidogrel with ticagrelor may reduce this risk. Purpose To determine whether platelet function test (PFT)-guided antiplatelet therapy reduces incidence of IEs compared with standard dual antiplatelet therapy (SDAT; daily oral aspirin and clopidogrel, 100 mg and 75 mg, respectively) in patients undergoing endovascular intervention for IAs.

Development of a Clinical and Laboratory-Based Predictive Nomogram Model for Unfavorable Functional Outcomes Among Patients Who Undergo Interventions for Aneurysmal Subarachnoid Hemorrhage.

This study elucidates the prognostic significance of perioperative changes in laboratory indicators for aneurysmal SAH and develops a nomogram model for outcome prediction. Aneurysmal SAH patients who received clipping or coiling at our institution between January 2016 and December 2022 were included. All patients were randomly assigned to derivation and validation cohorts.

Ultra-Sparse-View Cone-Beam CT Reconstruction-Based Strictly Structure-Preserved Deep Neural Network in Image-Guided Radiation Therapy.

Radiation therapy is regarded as the mainstay treatment for cancer in clinic. Kilovoltage cone-beam CT (CBCT) images have been acquired for most treatment sites as the clinical routine for image-guided radiation therapy (IGRT). However, repeated CBCT scanning brings extra irradiation dose to the patients and decreases clinical efficiency.

A mitochondria-targeted nanozyme with enhanced antioxidant activity to prevent acute liver injury by remodeling mitochondria respiratory chain.

Developing nanomedicines with enhanced activity to scavenge reactive oxygen species (ROS) has emerged as a promising strategy for addressing ROS-associated diseases, such as drug-induced liver injury. However, designing nanozymes that not only remove ROS but also accelerate the repair of damaged liver cells remains challenging. Here, a two-pronged black phosphorus/Ceria nanozyme with mitochondria-targeting ability (TBP@CeO) is designed.

Pathway plaques and diffusion-weighted lesion analysis after endovascular treatment of unruptured intracranial aneurysms: a prospective study.

Objectives: To evaluate the prevalence and predictors of ischemic lesions on thin-slice DWI (2 mm) in endovascular treatments for unruptured intracranial aneurysms (UIA), particularly explore the potential relationship with pathway plaques.

Methods: Participants eligible for endovascular treatments with UIA at a national stroke center between March 2023 and August 2023 were prospectively enrolled. All participants performed thin-slice DWI (slice thickness of 2 mm) before and after procedures.

DNA-templated nanosheets for enhanced chemodynamic therapy and gene therapy to inhibit tumor recurrence and metastasis.

Recurrence and metastasis stand as the primary contributors to mortality among patients with triple-negative breast cancer post-surgery, presenting a formidable clinical obstacle. Chemodynamic therapy (CDT), leveraging metal-ion-mediated Fenton-like reactions within the tumor microenvironment (TME), emerges as a promising avenue for addressing cancer metastasis. Despite recent progress, challenges such as tumor cell antioxidant defenses and epithelial-mesenchymal transition (EMT) impede the efficacy of CDT.

Preparation of unique corn-stalk-like MnO₂/CoNi nanowires via in situ epitaxial attachment growth for monitoring environmental pollutant hydrazine.

This paper presents the synthesis of a novel corn-stalk-like MnO₂/CoNi oxide composite using an in situ epitaxial attachment growth strategy, in which CoNi oxide nanosheets are anchored onto MnO₂ nanowires. The one-dimensional MnO₂ nanowires, with their large specific surface area, serve as a support to enhance the electronic conductivity of the CoNi oxides. Hexamethylenetetramine (HMTA) is employed as an alkaline linking agent, playing a key role in shaping the CoNi oxide nanosheets and ensuring their successful growth on the MnO₂ nanowires.

Near-Infrared Light-Activatable DNA Tentacles for Efficient Inhibition of Tumor Metastasis by Bio-Orthogonal Cell Assembly.

Tumor metastasis remains a major challenge in cancer management. Among various treatment strategies, immune cell-based cancer therapy holds a great potential for inhibiting metastasis. However, its wide application in cancer therapy is restricted by complex preparations, as well as inadequate homing and controllability.

A model with multiple intracranial aneurysms: possible hemodynamic mechanisms of aneurysmal initiation, rupture and recurrence.

Background: Hemodynamic factors play an important role in aneurysm initiation, growth, rupture, and recurrence, while the mechanism of the hemodynamic characteristics is still controversial. A unique model of multiple aneurysms (initiation, growth, rupture, and recurrence) is helpful to avoids the confounders and further explore the possible hemodynamic mechanisms of aneurysm in different states.

Methods: We present a model with multiple aneurysms, and including the states of initiation, growth, rupture, and recurrence, discuss the proposed mechanisms, and describe computational fluid dynamic model that was used to evaluate the likely hemodynamic effect of different states of the aneurysms.

Evaluation of the EMBOPIPE flow diverter device: in vivo and in vitro experiments.

Background: Although flow diverter device (FDD) has brought revolutionized advances in endovascular treatment of intracranial aneurysms, it also presents considerable drawbacks as well, as the innovation for novel device has never stopped. This preclinical research aims to evaluate the safety and efficacy of a newly developed FDD, the EMBOPIPE, through in vivo and in vitro experiments.

Methods: Aneurysms were induced in 20 New Zealand white rabbits which were randomized to three follow-up groups according to the time elapsed after EMBOPIPE implantation (28, 90, and 180 days).