Hypoxia Triggers ALYREF-Mediated mC Methylation of KIF20A to Activate KIF20A/BUB1 for Generating Ferroptosis Resistance in Cervical Cancer Cells.

Ferroptosis resistance is a key player in cervical cancer (CC) development. Hypoxia is a negative factor affecting CC treatment by inducing ferroptosis resistance. Our study aimed to investigate the detailed mechanisms of hypoxia-induced ferroptosis resistance in CC cells.

Psychological distress in Chinese women with benign breast disease and breast cancer during diagnosis: A cross-sectional study.

Background: Research on the psychological distress experienced by women with benign breast disease (BBD) remains limited, though some evidence suggests it may resemble that of women with breast cancer (BC).

Objectives: This study aimed to use the Distress Thermometer (DT) to assess the levels of psychological distress and identify influencing factors during the diagnostic phase in patients with BC and BBD.

Material And Methods: From October 2022 to May 2023, a questionnaire survey incorporating the DT and Problem List (PL) was conducted among inpatients in the diagnostic phase for BC or BBD at the Breast Surgery Department of Shanxi Bethune Hospital (Taiyuan, China).

The association between triglyceride glucose-waist height ratio index and cardiometabolic multimorbidity among Chinese middle-aged and older adults: a national prospective cohort study.

Background: Cardiometabolic multimorbidity (CMM) imposes a progressively severe health burden worldwide. Triglyceride-glucose (TyG) index and waist-to-height ratio (WHtR), as indicators of insulin resistance and central adiposity, respectively, have been shown to be strongly associated with CMM. However, there is currently a lack of research combining the two for CMM risk assessment.

Global trends and inequalities in eye cancer burden: a comprehensive analysis based on the global burden of disease study.

Background: Eye cancer is a significant threat to vision and survival because of its location, diagnostic challenges, and aggressive nature. However, its global epidemiology, especially regarding differences across countries, age groups, and sex, is not well-studied.

Methods: This study analyzed data from the Global Burden of Disease Study 2021 to evaluate trends in eye cancer, focusing on incidence, prevalence, mortality, and disability-adjusted life years (DALYs) across 204 countries from 1990 to 2021.

Kinetics-Controlled Crystallization Unlocking Eu-Doped Barium Silicate Glass Ceramic for Efficient X-Ray Scintillation.

Developing efficient scintillators is crucial for advancing radiation detection. Glass ceramics (GCs) offer promise by combining processability with enhanced luminescence, but crystallizing phases with optimal scintillation properties remain challenging. Herein, a kinetics-controlled in situ crystallization strategy is presented to selectively precipitate high-performance BaSiO:Eu crystals within a barium silicate glass.

SPANXB1 drives brain metastasis in breast cancer via MMP1 regulation: potential therapeutic insights with metformin.

Cancer-testicular antigens (CTAs) have been considered as potential prognostic biomarkers and therapeutic targets due to their specific expression and roles in tumorigenesis and metastasis. Among these, the function and mechanism of SPANXB1 in breast cancer brain metastasis (BCBM) remain poorly understood. In this study, we investigated the role of SPANXB1 in BCBM.

Nursing care for a patient with post-penile prosthesis implantation infection: a case report.

Background: Three-piece expandable penile prosthesis implantation is the ultimate means to treat penile erectile dysfunction, and patients can achieve high levels of satisfaction. However, once postprosthetic infection occurs, clinical treatment and care become very challenging. However, the nursing experience about this disease is rare reported.

Integrating Large Language Models into Fluid Antenna Systems: A Survey.

Fluid antenna system (FAS) has emerged as a promising technology for next-generation wireless networks, offering dynamic reconfiguration capabilities to adapt to varying channel conditions. However, FAS faces critical issues from channel estimation to performance optimization. This paper provides a survey of a how large language model (LLM) can be leveraged to address these issues.

Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer.

The aberrant expression of RNAs in ovarian cancer (OC) progression highlights their potential as clinical biomarkers. However, rapid and accurate quantification of these RNAs in biosamples remains a significant challenge. In this study, we develop a modular isothermal rolling circle amplification (RCA)-activated Cas12a loop-enhanced (MIRACLE) amplification method for circRNA and miRNA quantification without the need of reverse transcription.

Prognostic Value of Late Gadolinium Enhancement Cardiac MRI-derived Entropy in Patients after Myocardial Infarction.

Purpose To investigate the prognostic value of left ventricular (LV) and scar entropy for major adverse cardiac events (MACEs) and ventricular arrhythmias (VAs) in patients who have experienced myocardial infarction (MI). Materials and Methods The medical records of patients who underwent late gadolinium enhancement (LGE) cardiac MRI following MI between October 2015 and September 2022 were retrospectively evaluated for MACEs and VAs. LV and scar entropy data were derived from the probability distributions of the pixel signal intensities of the LV myocardium and scar tissue, respectively.

AI-Enabled Parallel Assembly of Thousands of Defect-Free Neutral Atom Arrays.

Assembling increasingly larger-scale defect-free optical-tweezer-trapped atom arrays is essential for quantum computation and quantum simulations based on atoms. Here, we propose an AI-enabled, rapid, constant-time-overhead rearrangement protocol, and we experimentally assemble defect-free 2D and 3D atom arrays with up to 2024 atoms with a constant-time cost of 60 ms. The AI model calculates the holograms for real-time atom rearrangement.

Histone Methyltransferase SETD1B Maintains Cancer Stem Cell Niche by Regulating the Crosstalk between CD24 and Surface Adhesion Molecules in Hepatocellular Carcinoma.

Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with a dismal prognosis that is largely attributed to the capacity of liver cancer stem cells (LCSCs) to self-renew in response to conventional therapies. Therefore, it is crucial to develop new therapeutic strategies that target LCSCs to improve the clinical outcomes of patients with HCC. We surveyed and analyzed publicly available single-cell TCGA (the cancer genome atlas), single-cell (scRNA-seq) and spatial RNA-sequencing databases from HCC patient specimens for genes uniquely expressed in LCSCs.

Smart IoT with the hybrid evolutionary method and image processing for tumor detection.

The primary objective of modern healthcare systems is to enhance public health by providing efficient, reliable, and well-structured solutions. Improving patient satisfaction through tailored medical services has driven rapid advancements in healthcare, leading to increased competition and system complexity. However, the expansion of healthcare services introduces challenges such as high data volume, latency, response time constraints, and security vulnerabilities.

Study on effects of the train-induced airflow on the temperature field of single-track high-speed railway tunnels in cold regions.

High-speed trains bring cold air into tunnels, significantly affecting the temperature field in cold-region tunnels, leading to risks of lining freeze-thaw damage, track deformation, and safety hazards, which is detrimental to thermal insulation design. Using the Kunlunshan Tunnel as a case study and based on unsteady flow theory, this study constructed the Navier-Stokes equations and proposed a theoretical calculation method for train-induced airflow. Dynamic mesh technology was adopted to develop an "equivalent wind speed" train-induced-airflow-temperature coupling computational model.

Transform waste into profit: Extract licorice residue fiber to load Zr-MOF as a promising adsorbent.

The research on the reuse of resources is crucial for achieving high-value utilization of traditional Chinese medicine (TCM). In this study, licorice residues were selected to extract fibers by alkaline hydrogen peroxide oxidation because of their high cellulose content and widespread use. The cellulose, hemicellulose and lignin content of obtained fibers were found to be 55 %, 8.

CircZFR/YTHDF3 axis drives lymph node metastasis in cervical cancer via FASN translation.

Background: Lymph node metastasis is a key driver of poor outcomes in cervical cancer. However, the molecular mechanisms of circular RNAs (circRNAs) driving cervical cancer lymph node metastasis remain unclear.

Methods: We identified circZFR, fatty acid synthase (FASN) and YTH N6-methyladenosine RNA binding protein F3 (YTHDF3) protein expression in the cervical cancer patients with long and short disease-free survival (DFS).

Dexamethasone treatment is associated with a higher HBsAg sero-clearance rate in HBeAg-positive patients with hepatitis B flares.

Purpose: Short-term dexamethasone has been used in patients with chronic hepatitis B flares to reduce inflammation in the liver. We aim to identify the potential population that may benefit from dexamethasone treatment.

Methods: A retrospective cohort study was conducted involving 856 hospitalized hepatitis B e antigen-positive patients with chronic hepatitis B flares.

Review of Recent Advances in Porous Organic Frameworks as Additives for Lubrication.

Friction and wear control are critical challenges for the efficient operation and sustainable development of modern industries. The performance limitations of conventional lubricants under extreme conditions, coupled with their environmental impacts, necessitate innovative solutions. Recently, covalent and metal porous organic frameworks (POFs), including covalent organic frameworks (COFs) and metal organic frameworks (MOFs), have emerged as promising candidates for tribological applications, attributed to their designable nanoporous architectures, ultrahigh specific surface areas, and abundant functional active sites.

Biomass-derived carbon quantum dots as fluorescent probes for biosensing: a review.

The conversion of biomass waste into value-added carbon quantum dots (CQDs) has been recognized as a green synthetic pathway in CQD manufacturing. The distinctive nanostructure of biomass-derived carbon quantum dots (BCQDs) confers superior fluorescence properties and biocompatibility, rendering them highly promising as fluorescent probes for biosensing applications. The preparation of BCQD fluorescent probes using biomass as the primary carbon source not only realizes the high-quality recycling of waste resources but also has excellent biocompatibility and fluorescence emission stability, which has received great attention from researchers.

Enhancing photoacoustic trace gas detection via a CNN-transformer denoising framework.

We present a novel approach for gas concentration measurement using a differential resonant photoacoustic cell combined with a deep learning-based signal denoising model. This method addresses the persistent challenge of noise interference in 2  signals at low gas concentrations, where conventional processing methods struggle to maintain signal fidelity. To resolve this, we propose a deep learning model that integrates 1D Convolutional Neural Networks (1D CNNs) for local feature extraction and Transformer networks for capturing global dependencies.

The study on the function of the receptor kinase BnFERONIA of Brassica napus in regulating salt tolerance and ABA tolerance.

CrRLK1L receptor kinases, particularly FERONIA (FER), play critical roles in plant stress adaptation and hormonal signaling, yet their functional characterization in economically vital crops like Brassica napus remains limited. Here, we identified 108 CrRLK1L family members through genome wide screening in B. napus and focused on BnFERONIA, a homolog evolutionarily conserved with FERONIA orthologs in Arabidopsis and related crucifers.

Efficacy and safety of PD-1 inhibitors in combination with chemotherapy as first-line treatment for HER2-negative advanced gastric or gastroesophageal junction cancer across subgroups: A comprehensive systematic review and meta-analysis.

Background: The advent of immune checkpoint inhibitors has introduced innovative therapeutic paradigms for the management of human epidermal growth factor receptor 2 (HER2)-negative advanced gastric or gastroesophageal junction cancer (GC/GEJC). However, the efficacy and safety of programmed cell death protein 1 (PD-1) inhibitors combined with chemotherapy versus chemotherapy alone in patients with HER2-negative advanced GC/GEJC remain contentious. The comparability among different subgroups is not fully understood, necessitating the identification of optimal patient demographics and the exploration of potential biomarkers.

Prevalence, incidence, and risk factors for herpes zoster in systemic lupus erythematosus: a systematic review and meta-analysis.

Background: Patients with systemic lupus erythematosus (SLE) are particularly vulnerable to infections, with herpes zoster (HZ) being the most common opportunistic infection. This meta-analysis aimed to systematically review the available literature on the prevalence, incidence, and risk factors of HZ in SLE patients.

Methods: A comprehensive search through Embase, PubMed, Web of Science, and Cochrane Library was conducted for studies published up to November 1, 2024.

Genotypic diversity and genome-wide association study of phosphorus content, amylose content, pasting, and textural properties of potato starch.

Potato (Solanum tuberosum L.) is a globally important food crop, with starch being a key component influencing its functional, economic, and nutritional value. This study examined the genotypic diversity and genome-wide associations of phosphorus content (PC), apparent amylose content (AAC), pasting, and textural properties of starch across 102 potato accessions grown in two environments.

Psychological dilemmas and distress among Chinese primiparas during the postpartum transition underlying implicit cultural norms: a phenomenological inquiry.

Background: Previous research has overlooked the formative influence of cultural beliefs in shaping postpartum postpartum challenges and psychological symptoms. This study aims to examine the challenges faced by primiparous women within the sociocultural context of China. It will enhance understanding of the specific mechanisms through which sociocultural factors impact maternal mental health during the postpartum period.