Nursing care for a patient with post-penile prosthesis implantation infection: a case report.

Background: Three-piece expandable penile prosthesis implantation is the ultimate means to treat penile erectile dysfunction, and patients can achieve high levels of satisfaction. However, once postprosthetic infection occurs, clinical treatment and care become very challenging. However, the nursing experience about this disease is rare reported.

Novel biomarkers of the Framingham risk score in patients with depression: A cross-sectional study.

Background: The prevalence of coronary heart disease (CHD) is higher in patients with depression than in the general population. Recently, multiple novel biomarkers have been proposed to predict CHD risk, and these factors have been reported to be altered in patients with depression.

Aim: To explore whether these new biomarkers are associated with an increased risk of CHD in patients with depression.

Intrauterine fetal death due to Brucella melitensis infection: a case report and literature review.

Brucellosis is a zoonotic disease caused by Brucella species In pregnant women, this disease may lead to adverse obstetric outcomes, such as abortion, preterm delivery, intrauterine fetal death (IUFD), and congenital brucellosis. However, only a few studies have reported IUFD due to Brucella. In our case, one woman residing in Guangxi Province, China-a non-endemic region-developed symptoms 11 months after exposure.

Exploration of potential biomarkers and immune cell infiltration characteristics for peripheral atherosclerosis in sjögren's syndrome based on comprehensive bioinformatics analysis and machine learning.

Background: Sjögren's syndrome (SS) is an autoimmune disorder impacting exocrine glands, while peripheral atherosclerosis (PA) demonstrates a close link to inflammation. Despite a notable rise in atherosclerosis risk among SS patients in prior investigations, the precise mechanisms remain elusive.

Methods: A comprehensive analysis was conducted on seven microarray datasets (GSE7451, GSE23117, GSE143153, GSE28829, GSE100927, GSE159677, and GSE40611).

Novel compound heterozygous MRTFA gene variants cause multiple dysfunctions of neutrophils and autoinflammation.

Background: Compound heterozygous mutations in the MRTFA gene have not been reported; the complete clinical phenotypic spectrum associated with MRTFA deficiency remains undefined. Whether such mutations can result in autoinflammatory manifestations is also yet to be determined.

Methods: Comprehensive analyses were conducted on a patient with novel compound heterozygous MRTFA variants, encompassing clinical data collection, genetic validation, and functional studies.

Case Report: Heterozygous out-of-frame frameshift variant in without evidence of neutropenia.

Mutations in the gene, which encodes neutrophil elastase, are known to cause cyclic neutropenia (CyN) and severe congenital neutropenia (SCN). Currently, targeting for insertion-deletion to trigger nonsense-mediated mRNA decay (NMD) may be a simple and universal method to treat SCN caused by mutations. Here, we present a patient with a heterozygous out-of-frame frameshift variant (-2 frame indel) in exon 4 of the gene.

Honeycomb-inspired chitosan-based beads with pore structure and multifunctional groups: Improvement of fluoride ion adsorption efficiency and DFT calculations.

Selective removal of F from industrial wastewater containing multiple anions is a major challenge. Here, we propose a biomimetic chitosan/FeOOH/AlOOH bead (CFeAlB) with a unique honeycomb porous structure and amino and hydroxyl multifunctional groups and AlOOH/FeOOH bimetallic active components for enhanced selective adsorption capacity and enrichment of F. The adsorption of F by CFeAlB (29.

Loss of MALT1 Function in a Patient With Combined Immunodeficiency: a Novel Pathogenic Variant and Immunological Insights.

Background And Objectives: Germline pathogenic variants in the mucosa-associated lymphoid tissue lymphoma translocation gene 1 (MALT1) encodes a caspase-like protease that plays a crucial role in the caspase recruitment domain (CARD)-B-cell lymphoma 10 (BCL10)-MALT1 (CBM) complex. This complex mediates the activation of nuclear factor-kB (NF-kB) pathway and are associated with diverse human diseases including combine immunodeficiency (CID), lymphoproliferation and others. This study aimed to determine the underlying cause of immune deficiency and immune dysregulation in a patient presented with recurrent respiratory infections, aphthous ulcers, dermatitis, chronic diarrhea, failure to thrive and early death.

GSAformer: Group sparse attention transformer for functional brain network analysis.

Functional brain network (FBN) analysis based on fMRI has proven effective for neurological/mental disorder classification. Traditional methods usually separate the FBN construction from the subsequent classification tasks, resulting in a suboptimal solution. Recently, transformers, known for their attention mechanisms, have shown strong performance in various tasks, including brain disorder classification.

LINC00634 is a novel prognostic biomarker for colon cancer associated with immune infiltration.

Background: Colon cancer is a highly heterogeneous and most common malignant tumor of the gastrointestinal tract, which is prone to metastasis in advanced stages, leading to a poor prognosis for patients.

Methods: To gain a comprehensive understanding of genes associated with the prognosis of colon cancer, we identified a gene set (DPP7, TRPM5, ASB6, LINC00634 and GABRD) with potential prognostic value via genome-wide overall survival (OS) analysis. Further, LINC00634 was silenced by constructing small interfering RNAs (siRNAs) in Colo-320 cells.

Organic‒Inorganic Multiscale Crosslinking Assembly for Ultrahigh-Toughness Nanocomposites.

Strength and toughness have traditionally been regarded as mutually exclusive, but simultaneously achieving both high strength and high toughness in organic‒inorganic nanocomposites remains a significant challenge. Inspired by natural nacre and bone, inorganic ionic oligomers and organic molecular chains are employed to achieve multiscale crosslinking assembly, advancing from the ionic-molecular level to nanolines, nanorods, nanofibers, microfibers, and ultimately to nanocomposite films and bulk nanocomposite materials. This process results in a highly integrated organic‒inorganic hierarchical ordered structure, imparting exceptional record-breaking ultrahigh toughness (558.

Clinical value of free ubiquitin in the identification of diabetic nephropathy in patients with type 2 diabetes mellitus and preliminary exploration of its protective effect.

Objective: Free ubiquitin (Ub) is crucial in various cellular processes. Recent studies suggest that alterations in free Ub levels may be closely associated with the development of diabetes. However, its levels and functional role in diabetic nephropathy (DN) remain unclear.

The Prognostic Value of Combined Systemic Immune-Inflammatory Index (SII) and Prognostic Nutritional Index (PNI) in Solid Tumor.

Background: Inflammation and nutrition status were the essential factors for cancer initiation and progression. Previous studies have confirmed systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) could predict the prognosis of cancer patients. The aim of this study was to evaluate the pre-treatment SII and PNI in predicting outcomes in different cancers.

Self-Assembly MXene/PDA@Cotton Fabric Pressure Sensor Integrated with Deep Learning for Sign Language Recognition.

In recent years, smart textiles and flexible wearable products have garnered significant attention in fields such as human-computer interaction, medical rehabilitation training, and motion monitoring. Flexible pressure sensors have attracted significant attention due to their excellent flexibility, stability, and multifunctional integration. Herein, a multifunctional wearable MXene/polydopamine (PDA)@cotton fabric pressure sensor was developed by modifying weft-knitted cotton fabric based on a dual hydrogen bond self-assembly strategy.

Modeling the vertebrate regulatory sequence landscape by UUATAC-seq and deep learning.

The regulatory sequences of vertebrate genomes remain incompletely understood. To address this, we developed an ultra-throughput, ultra-sensitive single-nucleus assay for transposase-accessible chromatin using sequencing (UUATAC-seq) protocol that enables the construction of chromatin accessibility landscapes for one species in a 1-day experiment. Using UUATAC-seq, we mapped candidate cis-regulatory elements (cCREs) across five representative vertebrate species.

Clinical relevance of loss-of-function mutations of /.

Dysfunctional inhibitor of nuclear factor-κB (NF-κB) kinase regulatory subunit gamma () is known to trigger incontinentia pigmenti (IP), anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID), immunodeficiency (ID), and deleted exon 5 autoinflammatory syndrome (NDAS). The correlation between genotype and phenotype remains elusive because of the considerable variability in genes. This study aimed to systematically describe gene mutations and clinical characteristics.

An iPSC-derived CD19/BCMA CAR-NK therapy in a patient with systemic sclerosis.

This study reports the first-in-human application of iPSC-derived CD19/BCMA dual-targeting chimeric antigen receptor-natural killer (CAR-NK) cells (QN-139b) in a patient with severe, diffuse cutaneous systemic sclerosis. The allogeneic product was genetically edited for reduced alloreactivity and improved in vivo performance, with no structural chromosomal abnormalities detected. The treatment led to significant B cell depletion with minimal toxicity, similar to CAR T cell therapy.

Global Burden of Maternal Disorders and Mortality Among Female Individuals Aged 15-49 Years, 1990-2021.

Objective: To quantify mortality trends among female individuals of childbearing age (15-49 years) across global regions from 1990 to 2021, systematically evaluating persistent geographic inequities in preventable deaths.

Methods: We analyzed data from the GBD (Global Burden of Diseases, Injuries, and Risk Factors Study) 2021, focusing on five leading causes of maternal mortality: hemorrhage, hypertensive disorders, sepsis and infections, obstructed labor and uterine rupture, and abortion and miscarriage. We calculated estimated annual percent change (APC) in age-standardized incidence rate (ASIR) and age-standardized mortality rate (ASMR) for these conditions, stratified by age group and sociodemographic index, to examine temporal trends.

TRANS: a prediction model for EGFR mutation status in NSCLC based on radiomics and clinical features.

Background: Early detection of epidermal growth factor receptor (EGFR) is critical for guiding therapeutic decisions in non-small-cell lung cancer (NSCLC). The study aims to develop a predictive model for EGFR mutations with multicohort data.

Methods: The study enrolled 254 NSCLC patients of four cohorts: the Affiliated Hospital of Qingdao University (AHQU, n = 54), the Second Affiliated Hospital of Soochow University (SAHSU, n = 78), TCGA-NSCLC (n = 91), and CPTAC-NSCLC (n = 31).

Perovskite as a Promising Candidate for Treating Typical Contaminants in Medical Wastewater: Synthesis, Progress, and Mechanism.

With the fast development of global medical and health undertakings, medical wastewater has increasingly posed a great threat to human survival and ecosystems. This type of wastewater might contain many components, such as drugs, radioactive substances, heavy metals, etc., making it difficult to meet discharge standards.

Dextrose prolotherapy at varying concentrations ameliorates tendon injury via IGF-2R: an integrated study of Mendelian randomization and an animal model.

Background: This study integrates Mendelian randomization (MR) analysis with animal experiments to systematically evaluate the therapeutic efficacy of varying concentrations of hypertonic dextrose on tendon injury and elucidate the underlying mechanisms in the context of tendon repair.

Methods: The SwissTargetPrediction database was utilized to identify potential molecular targets of dextrose. Two-sample MR analysis was performed to investigate the causal relationships between the identified targets and Achilles tendinopathy.

Study on the Photosynthetic Physiological Responses of Greenhouse Young Chinese Cabbage ( L. ) Affected by Particulate Matter Based on Hyperspectral Analysis.

Particulate matter affects both the light environment and air quality in greenhouses, obstructing normal gas exchange and hindering efficient physiological activities such as photosynthesis. This study focused on young Chinese cabbage ( L. ) in a greenhouse at harvest time, monitoring and comparing hyperspectral information, net photosynthetic rate, and microscopic leaf structure under two conditions: a quantitative artificial particulate matter environment and a healthy environment.

Synthesis and Anticancer Activity Evaluation of Novel Carborane-Containing Isoflavonoid Analogues.

Isoflavonoids represent a privileged structure derived from natural products with diverse bioactivities. Carborane has been utilized as a three-dimensional mimetic of phenyl rings in medicinal chemistry. Herein, we replaced the phenyl group of isoflavonoids with carborane and prepared a series of carborane-containing isoflavonoid analogues.

PLGA-Encapsulated Elvitegravir and Curcumin Modulates ART Penetration, Oxidative Stress, and Inflammation.

HIV persists in central nervous system (CNS) reservoirs, where infected microglia and macrophages drive neuroinflammation, oxidative stress, and neuronal damage, contributing to HIV-associated neurocognitive disorder (HAND). Nanoparticle-based drug delivery systems, particularly poly(lactic-co-glycolic acid) (PLGA) nanoparticles, offer a promising strategy to improve CNS antiretroviral therapy (ART) delivery. This study aimed to evaluate the efficacy of co-administration of PLGA nanoparticles (NPs) encapsulating elvitegravir (EVG) and curcumin (CUR) in targeting CNS reservoirs, reducing neuroinflammation, and mitigating oxidative stress.