Construction of hierarchical structured dual-shell hollow polyhedra NiCoO based on TiCT for advanced lithium-ion and sodium-ion capacitors.

The development of lithium/sodium ion hybrid capacitors has been constrained by the dynamic disparity between the anode and cathode, in conjunction with the volume expansion of the anode material during the cycling phase. In this study, a dual-shell dodecahedral structure NiCoO composite was fabricated by combining it with hydrofluoric acid-etched TiCT lamellar material. The NiCoO dual-shell dodecahedron structure manifests a substantial specific surface area and more active sites.

Single-cell transcriptomic landscape of sciatic nerve after transection injury.

Peripheral nerve injuries, particularly those affecting the sciatic nerve, often result in incomplete functional recovery due to the limited regenerative capacity of adult peripheral nerves. To elucidate the cellular and molecular mechanisms underlying nerve regeneration, we performed single-cell RNA sequencing (scRNA-seq) on rat sciatic nerve tissues at seven time points (Days 0, 1, 3, 5, 7, 10, and 14) following transection injury. Through unsupervised clustering, we identified four major cellular compartments-neurofibroblasts (NFs), glial cells (Glis), immune cells, and vascular cells-and delineated their dynamic trajectories during regeneration.

Aggregation-induced emission in synthetic macrocycle-based supramolecular systems.

Aggregation-induced emission (AIE) has emerged as an effective strategy to overcome the traditional aggregation-caused quenching (ACQ) effect, offering great promise for developing advanced luminescent materials. Synthetic macrocycles, owing to their preorganized cavities and well-defined geometries, provide unique platforms for constructing supramolecular assemblies with tunable photophysical properties. This review summarises recent advances in the construction of AIE-active supramolecular architectures through macrocycle-directed assembly, with a particular focus on systems based on tetraphenylethylene (TPE) and triphenylamine (TPA).

Design and Synthesis of Box[6]arenes for 3D Charge-Transfer Co-Crystal Engineering via Macrocyclic Self-Complementary and Exo-Wall Interactions.

The construction of well-defined 3D charge-transfer (CT) co-crystals using new macrocyclic hosts to enable programmable functionality remains challenging due to the dimensional constraints imposed by conventional assembly strategies. Herein, we address this limitation using a new synthetic macrocycle named box[6]arene (B[6]A) with a flexible skeleton, which adopts two distinct conformations (B[6]Aα and B[6]Aβ). Crucially, the self-complementary and exo-wall CT co-assembly of B[6]A facilitates the construction of 3D macrocycle-based co-crystals (MCCs) with planar electron-deficient guests, including 1,2,4,5-tetracyanobenzene (TCNB), tetrafluoroterephthalonitrile (TFTN), and tetrachloroterephthalonitrile (TClTN).

A practical photocatalytic strategy for radical (deuterio)difluoromethylation using imidazolium reagents.

The difluoromethyl group (CFH) has garnered significant interest in medicinal chemistry owing to its unique biochemical and physicochemical properties. Its deuterated counterpart (CFD), building on the established utility of CFH, exhibits multifaceted potential for advancing biomedical research and therapeutic development. While the incorporation of the difluoromethyl group (CFH) into drug molecules has matured, efficient installation of its deuterated counterpart (CFD) remains a formidable challenge in medicinal chemistry.

Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site.

Objective: This study investigated the biomechanical properties of the dura mater from 29 Chinese adult donors (20 -86 years), focused on the influence of age, anatomical region, sex and loading direction, to establish Chinese population - specific material parameters for cranial finite element (FE) models and enhance forensic traumatic brain injury analysis.

Methods: In this study, a total of 275 dural specimens were prepared and categorized into young adult (20-44 years), middle aged (45-64 years), and elderly (≥65 years) cohorts. Samples were excised from frontal, temporal, parietal and occipital regions and tested uniaxially in sagittal and coronal directions, with strain measured via digital image correlation (DIC) techniques.

Assessment of drug-related migraine in a real-world large-scale database.

Background: Drug-induced migraine represents a clinically significant yet under-investigated subtype of migraine. This study aims to evaluate the risk of drug-related migraine based on real-world data from the FDA Adverse Event Reporting System (FAERS).

Methods: A retrospective pharmacovigilance analysis was conducted using FAERS data from Q1 2004 to Q4 2024.

DNA damage response pathway regulates Nrf2 in response to oxidative stress.

Nrf2 acts as a transcriptional master regulator to orchestrate antioxidant responses and maintain redox balance. However, the cellular pathway for translating oxidative stress signals into Nrf2-dependent antioxidant responses remain incompletely understood. Here, we show that reactive oxygen species (ROS) function as signaling molecules in modulating Nrf2's stability and transcriptional activity by activating the DNA damage response (DDR) signaling pathway.

Circ_0007429 promotes hepatocellular carcinoma resistance to sorafenib through the miR-377-3p/THBS1 axis.

Objective: To elucidate the function of circ_0007429 in hepatocellular carcinoma (HCC) chemoresistance, with a focus on its regulatory mechanisms via the miR-377-3p/THBS1 (Thrombospondin 1) axis.

Methods: The expression levels of circ_0007429, miR-377-3p, and THBS1 mRNA were quantified using quantitative Reverse Transcription Polymerase Chain Reaction (qRT-PCR). Cell viability was assessed with the CCK-8 assay, and THBS1 protein expression was evaluated by western blotting.

Optical Trapping of Aggregation-Induced Emission Molecules for Crystallization at the Air/Solution Surface.

This study investigates the optical trapping-induced crystallization (OTIC) of aggregation-induced emission (AIE) molecules 4,4'-((1E,1'E)-anthracene-9,10-diylbis(ethene-2,1-diyl))bis(1-methylpyridin-1-ium) iodide (AEMPI) at the air-solution interface through luminescence. We synthesized the AIE molecule AEMPI, which exhibits an emission wavelength of 640 nm in powder form at room temperature. At the beginning of focusing a 1064 nm continuous-wave (CW) laser at the interface of an unsaturated AEMPI DO solution, its luminescence is hardly detectable.

Two transcription factor cascades regulate odorant-binding protein NlOBP8 affecting the recognition of linalool in the brown planthopper Nilaparvata lugens.

The insect olfactory system is pivotal in mediating chemical-driven behaviors, including host plant selection, mate identification, oviposition site localization, and ecological niche recognition. Although odorant-binding proteins (OBPs) are known to facilitate olfactory signal transduction in insects, the transcriptional regulatory mechanisms governing their expression remain elusive. Here, we identified 2 transcriptional cascades involving the transcription factors (TFs) distal-less (Dll) and aristaless (al) that converge to regulate NlObp8 expression in the brown planthopper (Nilaparvata lugens, BPH) through bioinformatics and transcriptomic analysis.

Expanding point cloud statistical shape model applications: Generalized vascular modeling for population-level hemodynamic simulations.

Background And Objective: Population-scale hemodynamic research faces limitations due to the trade-off between computationally expensive patient-specific Computational Fluid Dynamics (CFD) and overly idealized cylindrical models. To overcome this, we propose a novel Tier-2 workflow that integrates point-cloud statistical shape modeling (Pcd-SSM) with HDBSCAN clustering. This approach aims to efficiently characterize the C1 geometries of the internal carotid artery (ICA) and analyze their corresponding flow patterns.

Orchestration of Gut-Liver-Associated Transcription Factors in MAFLD: From Cross-Organ Interactions to Therapeutic Innovation.

Metabolic dysfunction-associated fatty liver disease (MAFLD) represents a global health burden, however, therapeutic advancements remain hindered by incomplete insights on mechanisms and suboptimal clinical interventions. This review focused on the transcription factors (TFs) associated with the gut-liver axis, emphasizing their roles as molecular interpreters of systemic crosstalk in MAFLD. We delineate how TF networks integrate metabolic, immune, and gut microbial signals to manage hepatic steatosis, inflammation, and fibrosis.

TRANS: a prediction model for EGFR mutation status in NSCLC based on radiomics and clinical features.

Background: Early detection of epidermal growth factor receptor (EGFR) is critical for guiding therapeutic decisions in non-small-cell lung cancer (NSCLC). The study aims to develop a predictive model for EGFR mutations with multicohort data.

Methods: The study enrolled 254 NSCLC patients of four cohorts: the Affiliated Hospital of Qingdao University (AHQU, n = 54), the Second Affiliated Hospital of Soochow University (SAHSU, n = 78), TCGA-NSCLC (n = 91), and CPTAC-NSCLC (n = 31).

Symmetric n/p Schottky Barrier Modulation for Precision-Configurable Neural Network.

Achieving both high precision and efficiency in edge devices presents a notable challenge in neuromorphic computing. Conventional neuristors typically operate with fixed computational precision, forcing a trade-off between accuracy and efficiency when addressing tasks of varying complexity. To overcome this limitation, we propose a Schottky barrier neuristor that combines high-efficiency nonlinear logic with high-precision linear operations within a single device.

Activated Immune and Complement C3 Are Potential Contributors in MASH via Stimulating Neutrophil Extracellular Traps.

The number of metabolic dysfunction-associated steatotic liver disease (MASLD) patients is increasing rapidly. More attention has been paid to the relationship between immunity and MASLD. This study explored the roles of serum autoantibodies, immunoglobulins, and complements in MASLD.

Comparison of initial empirical antibiotic regimens in severe community-acquired pneumonia: a network meta-analysis.

Background: Severe community-acquired pneumonia (SCAP) remains a leading cause of morbidity and mortality worldwide. Identifying the optimal antibiotic regimen for treating SCAP is crucial for improving patient outcomes.

Methods: We searched the PubMed, Embase, and Cochrane Central Register of Controlled Clinical Trials databases to identify studies reporting initial empirical antibiotic regimens in patients with SCAP.

Odd-Even Effects of Linear Alkyl-Based Organic Spacers for Efficient Charge Transport in Two-Dimensional Dion-Jacobson Tin Perovskites.

Two-dimensional (2D) tin (Sn)-based perovskites have emerged as promising p-type semiconducting materials for (opto)electronic devices due to their favorable balance of electrical performance and structural stability. While previous studies on 2D perovskites predominantly investigated Ruddlesden-Popper (RP) perovskites with monoammonium spacers, Dion-Jacobson (DJ) perovskites with diammonium spacers have recently sparked attention in the research community. The strong hydrogen bonds at both ends of the diammonium spacer, connecting neighboring inorganic octahedral layers, promote structural stability and efficient charge transport in DJ perovskites.

SLAMF7 Restrains Pro-Inflammatory Macrophage Activation to Counteract Doxorubicin-Induced Cardiotoxicity.

Doxorubicin-induced cardiotoxicity (DIC) poses a significant challenge in cancer treatment. This study investigated the role of SLAMF7 in DIC, particularly in macrophage-mediated inflammation. Using SLAMF7 knockout mice, we found that SLAMF7 deficiency exacerbates DIC and amplifies inflammatory responses.

A High-Temperature-Resistant and Conductive Flexible Silicone Rubber with High Phenyl Content Based on Silver-Coated Glass Fibers.

To enhance the high-temperature resistance of silicone rubber and meet the application requirements of flexible conductive silicone rubber under elevated temperature conditions, this study adopts a chemical modification strategy by introducing phenyl groups into the molecular chains of silicone rubber to improve its thermal resistance. High-phenyl-content hydroxyl-terminated silicone oil (MPPS) was used as the polymer backbone, and vinylmethyldimethoxysilane (VDMS) served as the chain extender. Through a silanol condensation reaction, vinylmethylphenyl polysiloxane (VMPPS) with a crosslinkable structure was synthesized, providing reactive sites for subsequent vulcanization and molding.

A Mendelian randomization study investigating the causal associations of 35 blood and urinary metabolite biomarkers with breast cancer development.

Breast cancer is the most common cancer among women worldwide. The present study utilized a bidirectional Mendelian randomization methodology to explore the causal associations between 35 blood and urinary metabolic markers and distinct subtypes of breast cancer. The MR-PRESSO method was employed to detect and correct for pleiotropic effects, with statistical significance adjusted using the false discovery rate (FDR).

Nonlinear Association Between the Visceral-to-Subcutaneous Fat Area Ratio and the Risk of Hypertension in Prediabetic Individuals: Evidence From a Large-Scale Health Screening Dataset in China.

Abdominal fat distribution, particularly the visceral-to-subcutaneous fat area ratio (V/S ratio), offers a promising avenue for exploring the development of hypertension. However, there is a paucity of quantitative studies examining the relationship between the V/S ratio and the risk of hypertension in individuals with prediabetes, especially within the Chinese population. This cross-sectional study was conducted at the Health Management Center of Henan Provincial People's Hospital, involving 4071 participants with prediabetes.

CXCL1 and CXCL8: Reliable and feasible biomarkers differentiating intrapulmonary metastasis from multiple primary neoplasms in non-small cell lung cancers.

ObjectiveIn NSCLC, the main approach to differentiate between intrapulmonary metastases (IPM) and multiple primary lung cancer (MPLC) is to integrate histopathological and genomic information. Here, we identified viable biomarkers that can distinguish IPM from MPLC by integrating comprehensive genomic profiling (CGP) and targeted RNA sequencing.MethodsWe retrospectively collected tissues from at least two lesions in 34 patients.

Optical Tweezer-Driven Mechanotransduction: Probing pN-Scale Forces and Calcium-Mediated Redox Signaling in Single Endothelial Cells.

Endothelial cells (ECs) regulate vascular function by converting mechanical forces into biochemical signals; however, the molecular mechanisms of pN-scale mechanotransduction remain elusive. Here, we develop an optical tweezer-integrated confocal microscopy system that allows precise, noninvasive manipulation of the cell membrane localization with mechanical stimuli within the 0-100 pN range while monitoring Ca-mediated NO/ROS redox signaling in situ in single ECs under varying force parameters. We show that pN-scale mechanical stimulation regulates extracellular Ca influx, triggering downstream production of NO and ROS, which subsequently affects intracellular redox homeostasis.