Non-iridescent yet angle-dependent structural colors on titanium surfaces induced by laser oxidation.

Optically variable features are widely used in product design and anti-counterfeiting. However, current industrial methods rely heavily on chemical inks, which pose environmental concerns and suffer from poor wear and corrosion resistance. We experimentally demonstrate the generation of non-iridescent yet angle-dependent structural colors on titanium surfaces using a nanosecond laser-induced oxidation.

Characterization of the tumor immune microenvironment in pregnancy-associated breast cancer through multiplex immunohistochemistry and transcriptome analyses.

Background: Pregnancy-associated breast cancer (PABC) is breast cancer diagnosed during pregnancy or within 2 years postpartum. Although relatively rare, it is associated with a poor prognosis, and the underlying mechanisms contributing to this unfavorable condition remain incompletely understood. In this study, we investigated tumor microenvironmental features linked to pregnancy and lactation in an effort to elucidate these mechanisms.

Multiomics-based investigation on the mechanism of Dachengqi decoction in improving constipation through the microbiota-gut-brain axis.

Objective: Based on analyses of gut microbiota, fecal metabolomics and microbiota-gut-brain (MGB) axis, this study aimed to elucidate the potential mechanism of Dachengqi decoction (DCQ) in improving constipation.

Methods: High performance liquid chromatography was used to determine the contents of 10 active ingredients in DCQ. Next, the effects of DCQ on constipation rats was evaluated, and the contents of brain-gut peptides in rat plasma were detected.

White matter hyperintensity burden and infarct volume predict functional outcomes in anterior choroidal artery stroke: a multimodal MRI study.

Objective: To investigate the relationship between white matter hyperintensity (WMH) burden and infarct volume with functional outcomes in patients with anterior choroidal artery (AChA) territory infarction.

Methods: This retrospective cohort study included patients with AChA territory infarction admitted to two comprehensive stroke centers between September 2018 and September 2024. WMH burden was assessed using the Fazekas visual rating scale and an automated volumetric quantification method based on lesion prediction algorithms.

Recent advances of muconic acid production using microbial synthetic biology.

Muconic acid is a high-value intermediate with unique properties. Traditional methods for muconic acid production showed some disadvantages including expensive raw materials, environmentally sensitive, and high concentration of heavy metal catalysts. With the development of synthetic biology, bio-strategies for muconic acid production have been widely studied.

Orbital Cellulitis Management in Pediatric and Adult Cohorts: A 12-Year Retrospective Analysis From a Tertiary Center.

Purpose: Orbital cellulitis (OC) is a vision-threatening infection requiring prompt medical and/or surgical intervention. This study evaluates clinical features, management outcomes, and predictors of surgical necessity in pediatric and adult OC patients.

Methods: Retrospective analysis of 40 OC patients (13 pediatric, 27 adult, ages: 34.

Impact of pre-transplant body mass index on outcomes in AML patients aged ≥ 50 years after allogeneic hematopoietic cell transplantation.

Introduction: The prognostic significance of body mass index (BMI) in elderly acute myeloid leukemia (AML) patients undergoing allogeneic hematopoietic cell transplantation (allo-HCT) remains controversial.

Methods: This retrospective study analyzed 142 AML patients aged ≥50 years receiving allo-HCT (2013-2022), stratified by Chinese BMI criteria: low BMI (<24 kg/m², n = 83) vs. high BMI (≥24 kg/m², n = 59).

Characterization of vaginal microbiota across female reproductive phases.

Background: The vaginal microbiota plays a crucial role in women's reproductive health, but its composition and function throughout different female reproductive phases remain poorly understood. This study aimed to investigate the dynamic variations in vaginal microbial communities corresponding to different hormonal states throughout the female reproductive phase.

Methods: Vaginal samples were collected from 150 healthy women across five reproductive phases: follicular phase, luteal phase, early pregnancy, lactation, and menopause (30 samples per group).

Pathogen biosensors for food safety and public healthcare based on specific biological probes biopanned by phage display: A critical review.

Pathogens are one of the primary threats to the environment, food safety and public healthcare. Rapid, selective and sensitive detection methods or biosensors are crucial in are crucial in effectively evaluating pathogen-induced emergency. Phage display is powerful in rapidly screening specific biological probes with high affinity.

Three-dimensional surface deformation field monitoring and influencing factors analysis in mountainous areas based on SBAS-INSAR technology (Tianjin, China).

Synthetic aperture radar interferometry (InSAR) technology has emerged as a critical methodology for disaster reduction and prevention, offering unprecedented all-weather operational capabilities and extensive spatial coverage that effectively address the limitations of traditional detection methods. Despite the inherent challenges of temporal and spatial coherence in conventional time-series InSAR approaches, the small baseline subset InSAR (SBAS-InSAR) technique presents a sophisticated solution by significantly mitigating coherence-related uncertainties and enhancing measurement precision. While existing research predominantly focuses on urban environments, this study uniquely addresses the research gap in mountainous terrain deformation monitoring by utilizing Sentinel-1A and 1B single-look complex (SLC) data from ascending and descending orbits between January 2018 and May 2022.

Evaluating Large Language Models in Ptosis-Related inquiries: A Cross-Lingual Study.

Purpose: The purpose of this study was to evaluate the performance of large language models (LLMs)-GPT-4, GPT-4o, Qwen2, and Qwen2.5-in addressing patient- and clinician-focused questions on ptosis-related inquiries, emphasizing cross-lingual applicability and patient-centric assessment.

Methods: We collected 11 patient-centric and 50 doctor-centric questions covering ptosis symptoms, treatment, and postoperative care.

Relationship between antibiotic resistance genes and microbiome in the Arctic marine sediments.

The global dissemination of antibiotic resistance genes (ARGs) presents a significant threat to public health and ecosystems. The Arctic has been contaminated with ARGs due to the global spread of ARGs. However, the remote nature of the Arctic need a comprehensive characterization of the diversity and distribution of ARGs.

Per- and polyfluoroalkyl substances in tissues of intermediate egrets (Ardea intermedia) from the South China Sea.

Despite decades of extensive production and applications of per- and polyfluoroalkyl substances (PFASs), their contamination in marine biota from the South China Sea (SCS) has received limited investigations. Aquatic birds are ideal biomonitoring indicators for environmental contaminants and associated ecological risks. In this study, we explored PFAS contamination in the tissues of intermediate egrets (Ardea intermedia), a representative aquatic bird with large population, inhabiting the islets of the SCS.

AI assistance enhances histopathologic distinction between sebaceous and squamous cell carcinoma of the eyelid.

Sebaceous gland carcinoma (SGC) and some poorly differentiated squamous cell carcinomas (SC) of the eyelid may have overlapping clinical and histopathologic features, leading to potential misdiagnosis and delayed treatment. The authors developed a deep learning (DL)-based pathological analysis framework to classify SGC and SC automatically. In total, 282 whole slide images (WSIs) were used for training, validating and inner testing the DL framework and 36 WSIs were obtained from another hospital as an external testing dataset.

Comparison of Clinical and Angiographic Outcomes of Ranibizumab and Aflibercept in Type 1 and Aggressive Retinopathy of Prematurity.

Background: To compare the clinical and angiographic outcomes of aggressive retinopathy of prematurity (A-ROP) and type 1 retinopathy of prematurity (ROP) treated with intravitreal injection of ranibizumab (IVR) or aflibercept (IVA).

Methods: This retrospective, non-randomised study included a consecutive series of patients with type 1 ROP or A-ROP who initially treated with ranibizumab (0.25 mg/0.

Development and multicenter validation of on-site breast cancer diagnosis using paper spray ionization miniature mass spectrometry.

Background: Conventional histopathological examination for breast core needle biopsy diagnosis is time-consuming and labor-intensive, leading to delayed medical treatments and increased psychological burden for patients. A rapid and reliable diagnostic method is needed to assist routine pathological diagnosis.

Methods: We developed a miniature mass spectrometry platform coupled with paper spray ionization (MiniMaP) for rapid breast cancer diagnosis.

Diagnostic and prognostic values of serum insulin-like growth factor binding protein 4 expression in cervical cancer.

Objective: Insulin-like growth factor binding protein 4 (IGFBP4) is lowly expressed in cervical cancer (CC) cells. However, it remains unclear about its expression and diagnostic and prognostic values in CC. Therefore, this research probed the serum expression of IGFBP4 in CC patients and its diagnostic and prognostic values.

Genetic and transcriptional profiles of ammonia oxidizing communities in Bohai sediments: abundance, activity, and environmental correlations.

Ammonia oxidation, a crucial part in nitrogen cycle, is thought to be jointly driven by ammonia-oxidizing archaea (AOA), ammonia-oxidizing bacteria (AOB), and complete ammonia oxidation (comammox) in the ocean. However, the spatial distribution of these three ammonia-oxidizing microorganisms in the marine sediments, especially at the transcriptional level, remains underexplored. This study utilizes quantitative PCR and activity experiments to quantify the gene of three ammonia oxidizers at both DNA and RNA levels, measure their potential nitrification rate, and assess their relative contribution to ammonia oxidation in the marine sediments in Bohai region in China.

Association of white matter hyperintensity burden and infarct volume in the anterior choroidal artery territory with early neurological progression: a dual-center retrospective study.

Objective: To investigate the associations of white matter hyperintensity (WMH) burden and infarct volume with early neurological progression in anterior choroidal artery (AChA) territory infarction, and to identify potential imaging-based predictive thresholds.

Methods: This retrospective cohort study consecutively enrolled AChA infarct patients admitted to two comprehensive stroke centers between September 2018 and September 2024. WMH burden and infarct volume were assessed using the Fazekas visual rating scale and an automated volumetric quantification method based on lesion prediction algorithm, respectively.

Symmetric n/p Schottky Barrier Modulation for Precision-Configurable Neural Network.

Achieving both high precision and efficiency in edge devices presents a notable challenge in neuromorphic computing. Conventional neuristors typically operate with fixed computational precision, forcing a trade-off between accuracy and efficiency when addressing tasks of varying complexity. To overcome this limitation, we propose a Schottky barrier neuristor that combines high-efficiency nonlinear logic with high-precision linear operations within a single device.

Methylation testing versus cervical cytology for triage of HPV-positive women: A comparative study.

Background: In many countries, HPV testing has replaced cervical cytology as the primary screening method for cervical cancer. While HPV testing has high sensitivity, its limited specificity necessitates triage to reduce unnecessary colposcopy referrals. This study evaluates the performance of cervical cytology (TCT) and the GynTect® six-gene methylation test as triage methods for HPV-positive women.

Feline Panleukopenia Virus ZZ202303 Strain: Molecular Characterization and Structural Implications of the Gene Phylogenetic Divergence.

Feline panleukopenia virus (FPV), the etiological agent of a highly contagious multispecies disease, demonstrates concerning phylogenetic divergence that compromises vaccine cross-protection. This study aimed to characterize a novel FPV strain through integrated virological and molecular analyses to assess epidemiological implications. From seven clinical specimens obtained from feline hosts with panleukopenia in Henan Province, China, we isolated FPV ZZ202303 using an F81 cell culture coupled with PCR verification, demonstrating potent cytopathic effects (TCID: 10/0.

Toward high-current-density and high-frequency graphene resonant tunneling transistors.

Negative differential resistance (NDR), a peculiar electrical property in which current decreases with increasing voltage, is highly desirable for multivalued logic gates, memory devices, and oscillators. Recently, 2D quantum-tunneling NDR devices have attracted considerable attention because of the inherent atomically flat and dangling-bond-free surfaces of 2D materials. However, the low current density of 2D NDR devices limits their operating frequency to less than 2 MHz.

Integrated analysis of microbiome and metabolome reveals insights into cervical neoplasia aggravation in a Chinese cohort.

Introduction: Cervical carcinoma (CC) remains one of the significant cancers threatening women's health globally. Increasing evidence suggests that alterations in the microbiota are closely associated with cancer development. However, the understanding of reliable biomarkers and underlying mechanisms during the aggravation of cervical neoplasia such as cervical intraepithelial neoplasia (CIN) and CC is still relatively limited.

Neoadjuvant arterial infusion chemotherapy combined with immunotherapy in treating locally advanced lower esophageal and esophagogastric junction cancer.

Background: The treatment of locally advanced lower esophageal cancer/esophagogastric junction cancers still has certain limitations. This study shares a new therapeutic strategy, namely neoadjuvant arterial infusion chemotherapy combined with immunotherapy (neo-AICIT).

Methods: The data of patients who received neoadjuvant arterial infusion chemotherapy (docetaxel + cisplatin) combined with immunotherapy (tislelizumab) for locally advanced lower esophageal cancer or esophagogastric junction cancers from October 2021 to May 2023 were collected.