HWANet: A Haar Wavelet-based Attention Network for remote sensing object detection.

Remote sensing object detection (RSOD) is highly challenging due to large variations in object scales. Existing deep learning-based methods still face limitations in addressing this challenge. Specifically, reliance on stride convolutions during downsampling leads to the loss of object information, and insufficient context-aware modeling capability hampers full utilization of object information at different scales.

A modified QuEChERS method for simultaneous determination of 73 pesticides, 23 PCBs and 16 PAHs in wheat by GC-MS/MS.

In this study, a modified QuEChERS method for the simultaneous determination of 73 pesticides, 23 PCBs and 16 PAHs in wheat was developed by gas chromatography-triple quadrupole tandem mass spectrometry (GC-MS/MS). The sample was first hydrated with 4 mL of ultrapure water, extracted with 10 mL of acetone-hexane (1 : 1, V:V), and then cleaned up with a mixture of 50 mg of PSA, 150 mg of C18, and 400 mg of anhydrous MgSO. Under the optimized conditions, the samples were analyzed by GC-MS/MS for quantitative analysis using the matrix-matched external standard method.

Metabolomics Investigation of a Multi-Ingredient Supplements-Modulated Changes in Metabolism in Mice After Endurance Exercise.

Energy metabolism manipulation strategy, enhancing fat metabolism while reducing the dependence on glucose, is beneficial to improve exercise performance. The multi-ingredient supplements (MIS) mixed with valine, isoleucine, leucine, β-alanine, creatine, L-carnitine, quercetin, and betaine were found to be able to improve the endurance performance of mice, which was associated with a shift of energy substrates from glucose to fatty acids. Thus, we hypothesized that the MIS regulating lipid metabolism contributes to enhancing exercise endurance in mice.

Antithrombotic strategies in adult COVID-19 patients: a systematic review and Bayesian network meta-analysis.

Objectives: To systematically compare the effects of various antithrombotic strategies on prespecified outcomes including 28-day all-cause mortality (primary outcome), major thrombotic events and major bleeding events (secondary outcomes) in adult COVID-19 patients.

Design: Systematic review and Bayesian network meta-analysis (NMA).

Data Sources: PubMed, Web of Science, Embase, Cochrane Library and ClinicalTrials.

Screening of essential oils with acaricidal activity against the poultry red mite (Dermanyssus gallinae) and analysis of active components.

Dermanyssus gallinae is a common ectoparasite in the laying hen industry, damaging chicken health by sucking blood. With mites developing acaricide resistance, there's an urgent need for alternatives. In this study, we evaluated the efficacy of 34 essential oils (EOs) on D.

Clinical characteristics, pregnancy outcomes, and neonatal effects of cytomegalovirus infection in pregnant women in Liuzhou city, North central Guangxi of Southern China: a retrospective study from 2018 to 2024.

Objective: To evaluate the clinical characteristics, pregnancy and neonatal outcomes of cytomegalovirus (CMV) infection in pregnant women.

Methods: This retrospective study included 22,673 pregnant women from Liuzhou, Guangxi, China, between 2018 and 2024. Amniotic fluid samples collected during mid-to-late pregnancy were tested for CMV DNA.

Support-tuned iridium reconstruction with crystalline phase dominating acidic oxygen evolution.

The dynamic reconstruction of oxygen evolution electrocatalysts dictates their performance, yet conventional Ir-based materials face an inherent activity-stability trade-off due to surface amorphization into hydrous IrO phases accompanied by lattice oxygen mechanisms. Here, we uncover a distinct reconstruction pathway for supported Ir nanoparticles, where a TiO@Ti substrate drives a bulk phase transition from metallic Ir to crystalline rutile IrO during electrocatalysis. Unlike surface-limited amorphization, this support-guided crystallization shifts the reaction mechanism from involving lattice oxygen mechanism to the complete adsorbate evolution mechanism, as confirmed by mechanistic and structural analyses.

One-Pot Isothermal Nucleic Acid Amplification Assisted CRISPR/Cas Detection Technology: Challenges, Strategies, and Perspectives.

The cutting-edge CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)/Cas (CRISPR-associated proteins) system, as an emerging molecular diagnostic technique, is driving revolutionary developments in the detection field due to its high specificity and efficiency. However, the CRISPR-based assays typically require the combination with an additional pre-amplification step based on isothermal nucleic acid amplification to meet the requirements of clinical diagnosis, which brings issues including complicated operation and the risk of aerosol contamination. To address these challenges, one-pot CRISPR platforms are emerging as an attractive solution to streamline workflows, enabling rapid, cost-effective, and high-sensitivity diagnostics.

Nickel-Catalyzed Cyanation of Aryl Halides.

Nickel-catalyzed cyanation of aryl halides has emerged as a powerful and sustainable method for the synthesis of aryl nitriles-valuable motifs widely found in pharmaceuticals, agrochemicals, and functional materials. Compared to traditional cyanation methods that involve harsh conditions and toxic reagents, nickel catalysis enables mild, efficient, and versatile transformations. This review systematically summarizes recent advances in this field, categorized by different cyanide sources, including metal cyanides (NaCN, KCN, Zn(CN), K[Fe(CN)]) and non-metal or organic cyanide sources (e.

Modeling the Historical and Future Potential Global Distribution of the Pepper Weevil Using the Ensemble Approach.

The pepper weevil is a devastating pest native to Central America that can cause severe damage to over 35 pepper varieties. Global trade in peppers has significantly increased the risk of its spread and expansion. Moreover, future climate change may add more uncertainty to its distribution, resulting in considerable ecological and economic damage globally.

Amidinium versus Ammonium Ligands for Thermal Stability and Efficiency Boost in CsPbI Perovskite Solar Cells.

Inorganic CsPbI perovskite solar cells (PSCs) hold notable promise but suffer from instability in maintaining the photoactive black phase under ambient and thermal conditions; this work systematically investigates the impacts of phenylenediamine dihydrochloride (PPD·2HCl, containing ammonium groups) and terephthalimidamide dihydrochloride (TPID·2HCl, featuring amidinium groups) ligands on device performance and stability, with a focus on dissecting TPID's thermal stabilization mechanisms. While both ligands enhance room-temperature phase stability via surface defect passivation, TPID·2HCl-treated devices exhibit superior thermal resilience: its amidinium group features delocalized electron density across the N-C-N skeleton, strengthening coordination with undercoordinated sites and mitigating lattice distortion under heat; thermogravimetric analysis (TGA) shows TPID·2HCl decomposes at ∼350 °C with gradual mass loss, surpassing PPD·2HCl's rapid degradation at ∼300 °C; density functional theory (DFT) calculations reveal TPID binds more strongly to the CsPbI surface (adsorption energy: -1.51 eV vs -1.

Solid pseudopapillary neoplasm of the pancreas with elevated β-HCG levels: A case report.

Rationale: Solid pseudopapillary neoplasm of the pancreas, first classified as a malignant epithelial tumor of the pancreas in 2019, is rare and usually occurs in young women, with a high incidence at approximately 30 years of age. Herein, we present a case of solid pseudopapillary neoplasm of the pancreas with elevated β-human chorionic gonadotropin (HCG) levels, which, to our knowledge, has not been reported in the literature.

Patient Concerns: A 35-year-old woman of childbearing age presented with a chief complaint of vaginal bleeding and was admitted to our hospital.

Evolution, dissemination, and genetic dynamics of the carbapenem resistance gene in China.

Background: , which encodes a metallo-β-lactamase that can hydrolyze most β-lactam antibiotics, has become a serious public health concern in China. It is crucial to investigate the evolution, dissemination, and genetic dynamics of to develop potential strategies to control the proliferation of .

Methods: In this study, we collected 1021 -positive isolates, which features 67 new genomes from our laboratory and 954 genomes from NCBI.

Optimal endoscopic resection method based on vertical margin distance for small rectal neuroendocrine tumors: Propensity score-matched study.

Background And Study Aims: Advanced endoscopic resection methods are recommended for removing rectal neuroendocrine tumors (NETs) < 10 mm, but there is no consensus on optimal endoscopic technique. This study aimed to determine whether endoscopic mucosal resection with ligation (EMR-L) is superior to endoscopic submucosal dissection (ESD) in terms of efficacy and safety, focusing on achieving adequate vertical margin distance.

Patients And Methods: This dual-center cohort study included consecutive patients with rectal NETs ≤ 10 mm.

Successful live birth of a healthy infant by preimplantation genetic testing for aneuploidy in a couple with recurrent spontaneous abortion: a case report.

Recurrent spontaneous abortion (RSA), characterized by the occurrence of three or more pregnancy losses prior to the 28th week of gestation, stands as a formidable challenge in the realm of assisted reproductive medicine, presenting significant difficulties in both clinical diagnosis and treatment. In recent years, there has been a discernible upward trend in the incidence of RSA, and its etiology is multifaceted and intricate. Pinpointing the root causes of RSA remains an arduous task that urgently demands resolution within the field of reproductive medicine.

SERS mapping combined with explainable deep learning for exosome analysis to enhance lung cancer detection.

Exosomes are critical biomarkers for early cancer diagnosis and prognosis due to their rich biological information. Nevertheless, analyzing exosomal biomarkers comprehensively remains challenging. Surface-enhanced Raman scattering (SERS) has been employed to detect exosomes due to its high sensitivity and reliable fingerprint.

Proof of concept for voice based MRI scanner control using large language models in real time guided interventions.

In clinical MRI-guided interventions, the lack of high-quality peripheral equipment and specialized interventional MRI systems often necessitates delegating real-time control of MRI scanners to an assistant. We proposed a voice-based interaction system powered by large language models that enabled hands-free natural language control of MRI scanners. The system leveraged multi-agent collaboration driven by large language models to execute scanner functionalities, including sequence execution, parameter adjustment, and scanner table positioning.

A multicenter single-arm clinical study of Chinese children's cancer group-acute promyelocytic leukemia-2017 (CCCG-APL-2017) protocol.

The Realgar-Indigo Naturalis formula (RIF) is a proprietary Chinese medicine, which is one of the important drugs in the treatment of pediatric acute promyelocytic leukemia (APL). However, the dose of RIF in clinical application is not uniform and the long-term effectiveness and safety of combining RIF with all-trans retinoic acid (ATRA) in a larger population of pediatric APL patients remains undocumented. We conducted a multicenter single-arm clinical trial (ChiCTR-OIC-16010014) in China.

Assessing the stability of suitable reference genes for real-time qPCR analyses in Perina nuda Fabricius (Lepidoptera, Lymantriidae).

Perina nuda Fabricius (Lepidoptera, Lymantriidae) is a significant pest affecting banyan trees, with a widely spread across Japan, Southern China, and Southeast Asia. Real-time quantitative polymerase chain reaction is a cornerstone method in molecular biological science to evaluating gene expression; however, the accuracy critically depends on the selection of stable reference genes for standardization. Here, we systematically assessed 12 candidate reference genes' expression stability- actin (ACT), β-actin (BACT), arginine kinase (AK), ribosomal protein S3 (RPS3), ribosomal protein L13 (RPL13), ribosomal protein L28 (RPL28), 18S ribosomal RNA (18S rRNA), 25S ribosomal RNA (25S rRNA), glyceraldehyde-3-phosphate dehydrogenase (GAPDH), tubulin (TUB), TATA-box protein (TBP), and elongation factor 1A in eukaryotic (EEF1A)-under 6 distinct experimental conditions relevant to P.

Angiopoietin-like 4 exacerbates renal tubular epithelial cell pyroptosis in acute kidney injury via integrin β5/FAK signaling pathway.

Introduction: Angiopoietin-like 4 (Angptl4) is a secreted protein that participates in multiple biological processes. Our previous study on the effect of Angptl4 in minimal change disease (MCD) unexpectedly indicated a close correlation between Angptl4 and kidney function, especially in MCD patients combined with AKI, implying a possible function of Angptl4 in AKI. However, the role and molecular mechanism of Angptl4 in AKI are undetermined.

The Impact of Nurse-Led Intervention on Breast Cancer Screening and Early Detection in China: Randomized Control Trial.

Objective: To evaluate whether nurse-led intervention with the assistance of community health workers (CHWs) increases breast cancer awareness and uptake of breast cancer screening among Chinese women.

Background: Breast cancer is the leading cause of cancer death among women, with breast cancer incidences being on the rise in China. Early detection through cancer screening and awareness of cancer prevention is imperative.

Cyclocarya paliurus polysaccharides alleviate hyperuricemia in mice by regulating gut microbiota to enhance uric acid excretion.

Hyperuricemia, characterized by increased serum uric acid (SUA) levels, correlates with renal dysfunction and gut microbiota dysbiosis. Existing therapies often exhibit limited efficacy and adverse effects, highlighting the need for safe alternatives. This study aimed to evaluate the hypouricemic effects of Cyclocarya paliurus polysaccharides (CPP), and elucidate the gut microbiota-driven mechanisms by which CPP ameliorate hyperuricemia and renal inflammation.