Higher chlorine dosage does not consistently enhance antibiotic resistance mitigation in the Cl-UV process.

Health problems arising from antibiotic resistance are a global concern. The Cl-UV disinfection process has shown potential for controlling antibiotic resistance in water; however, the influence of disinfectant dosage on its effectiveness remains insufficiently understood. Can antibiotic resistance be controlled by simply increasing the disinfectant dosage? This study demonstrated that higher disinfectant levels improved antibiotic resistance gene (ARG) removal, with certain ARGs reaching 1.

Size-Dependent Restructuring of Supported Platinum Cluster Catalysts.

Supported metal clusters have reactivities that depend on their nuclearity and structure. Herein, we present a strategy for precisely controlling the nuclearity of platinum clusters and demonstrate their size-dependent restructuring behavior and catalytic properties. The clusters are located on isolated CeO nanoislands on high-area SiO, and the isolation facilitates control of the migration of the platinum.

Integrated acupuncture-pharmacotherapy for perimenopausal insomnia: a systematic review and meta-analysis.

Objective: Insomnia is a prevalent symptom among perimenopausal women, mainly attributed to estrogen-progesterone imbalance and neuropsychiatric factors, significantly impacting their quality of life. This article seeks to systematically evaluate the efficacy of integrated acupuncture-pharmacotherapy (AP) in treating perimenopausal insomnia (PMI), offering new insights for the management of insomnia in women.

Methods: Searches were conducted in 8 databases: PubMed, Web of Science (WOS), Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), China Biology Medicine Disc (CBM), Wanfang Academic Journal Full-text Database (Wanfang), and Chongqing VIP Database (CQVIP).

Practice of data sharing plans in clinical trial registrations and concordance between registered and published data sharing plans: a cross-sectional study.

Background: The International Committee of Medical Journal Editors (ICMJE) recommends that trial authors must specify data sharing plans when trials are registered and published, yet this uptake remains unclear. We aimed to assess the practice of data sharing plans in trial registration platforms and the concordance between registered and published data sharing plans.

Methods: We included clinical trials published between 2021 and 2023 in six high-profile journals (The Lancet, The New England Journal of Medicine, JAMA, BMJ, JAMA Internal Medicine, and Annals of Internal Medicine) that enrolled participants no earlier than 2019 and registered on clinical trial platforms.

Site-specific engineering of S-Te-S bridged nano-prodrug: A dual equilibrium strategy for enhanced antitumor efficacy and safety of paclitaxel.

Homodimeric prodrug nanoassemblies (HPNs) have emerged as an effective strategy to enhance the therapeutic efficacy and safety of chemotherapeutic drugs. However, achieving both stable assembly and rapid drug release in tumor remains a critical challenge. Herein, we designed S-Te-S linkages with varying linkage lengths (α-, β-, and γ-) to develop three paclitaxel (PTX) homodimeric prodrug nanoassemblies (PHPNs).

Hydration behaviors, knowledge, and attitudes among Chinese recreational marathon runners: a cross-sectional study.

Objectives: This cross-sectional study aimed to assess fluid replenishment behaviors, knowledge, and attitudes among Chinese recreational marathon runners and to inform future health education strategies regarding optimal hydration.

Design: The survey was conducted between January and December 2024. Based on previously validated questionnaires, the instrument was adapted and administered to assess hydration behaviors, knowledge, and attitudes among marathon participants in major road races across China.

Nickel-Catalyzed Cyanation of Aryl Halides.

Nickel-catalyzed cyanation of aryl halides has emerged as a powerful and sustainable method for the synthesis of aryl nitriles-valuable motifs widely found in pharmaceuticals, agrochemicals, and functional materials. Compared to traditional cyanation methods that involve harsh conditions and toxic reagents, nickel catalysis enables mild, efficient, and versatile transformations. This review systematically summarizes recent advances in this field, categorized by different cyanide sources, including metal cyanides (NaCN, KCN, Zn(CN), K[Fe(CN)]) and non-metal or organic cyanide sources (e.

Nutrient-Enriched Germinated Brown Rice Alters the Intestinal Ecological Network by Regulating Lipid Metabolism in Rats.

Metabolic diseases such as high blood lipids, high blood sugar, and disrupted gut microbiota pose a serious threat to people's physical health. The occurrence of these diseases is closely related to the lack of nutrients in daily rice staple foods, but there is a lack of comprehensive analysis of the underlying mechanisms. This study used fully nutritious brown rice as raw material, and after germination under various stress conditions, it significantly increased the levels of gamma aminobutyric acid (GABA, four carbon non protein amino acid), resistant starch, flavonoids, and other components that regulate metabolic diseases.

N6-Methyladenosine RNA Methylation: A Key Regulator in Male Reproductive Disorders and Urological Cancers.

In the field of male health, disorders of the reproductive and urological systems present significant challenges. The global increase in male infertility, primarily attributed to environmental and lifestyle factors, along with the high incidence of urological cancers, not only places a significant socio-economic burden but also emphasizes the urgent need for in-depth research. Epigenetic modifications, especially N6-methyladenosine (m6A) methylation, are of great importance in these conditions.

The longitudinal relationship between family socioeconomic status and students' academic achievement: The mediating roles of learning anxiety-learning engagement profiles and the moderating role of negative parenting styles.

This study examined the longitudinal relationship between family socioeconomic status (family SES) and students' academic achievement through learning anxiety-learning engagement profiles and the moderating role of negative parenting styles. Using longitudinal data from 425 Chinese primary students (200 boys, M = 9.73 ± 0.

Bioengineered human pre-vascularized microtissues reconstruct vascular niche and regenerative microenvironment to enhance functional skeletal muscle regeneration.

Skeletal muscle regeneration mediated by muscle satellite cells (MuSCs) is supported by the specific vascular niche containing endothelial cells, pericytes, and mesenchymal stem cells. Volumetric muscle loss (VML) severely disrupts the vascular niche and impairs the ability of MuSCs to regenerate functional skeletal muscle. Until now, it remains a great challenge to reconstruct the vascular niche for muscle regeneration.

EXPRESS: Peripheral eosinophilia and preserved ratio impaired spirometry (PRISm).

Preserved ratio impaired spirometry (PRISm) may be in the pre-stage of chronic obstructive pulmonary disease. However, little is known about peripheral eosinophils in PRISm. This study ultimately enrolled 7,301 community-dwelling participants aged 20 to 79 years without airflow obstruction.

The current situation and factors influencing the use of traditional Chinese medicine therapies among patients with chronic disease in china: a cross-sectional study.

Chronic noncommunicable diseases, which can be referred to as chronic diseases, have become a significant challenge to global public health. Various studies have shown that traditional Chinese medicine (TCM) therapies are effective means of preventing and treating chronic diseases. The purpose of our study was to analyze the present circumstances of the use of TCM therapies among Chinese patients who have chronic diseases and explore the related influencing factors.

Interfacial Charge Separation Engineering Enables Dual Small-Molecule Probe-Based Photoelectrochemical Multi-Enzyme Sensing.

Photoelectrochemical (PEC) biosensors remain constrained in multianalyte detection due to inefficient charge separation and signal crosstalk. To address these challenges, we developed a dual small-molecule probe-modulated charge separation system by integrating coumarin 6 (C6) and a silane probe (SP) into a titanium-based metal organic framework (Ti MOF). The porous crystalline structure and favorable electron transport properties of the Ti MOF enable efficient interfacial electron redistribution between the molecular probes and the MOF scaffold.

Preclinical evaluation of STSA-1002, a novel human and rhesus monkeys cross-reactive monoclonal antibody targeting C5a, in acute respiratory distress syndrome models.

Background: The complement-activated product (C5a) is a key mediator in the pathogenesis of acute respiratory distress syndrome (ARDS). While blocking C5a represents a promising therapeutic strategy, novel anti-C5a therapies require further development.

Purpose: This study aimed to develop a novel, human anti-C5a monoclonal antibody (STSA-1002) and evaluate its efficacy in treating ARDS through in vitro and vivo studies.

Plant negative-strand RNA virus phosphoprotein condensates exploit host trafficking and lipid synthesis for viral factory assembly.

RNA viruses often remodel host intracellular membranes to establish specialized replication compartments through viral protein-induced phase separation. However, the mechanisms underlying membrane remodeling and the characteristics that render these sites conducive to replication remain poorly understood, particularly in plant negative-strand RNA viruses. Here, we demonstrate that the phosphoprotein (P) of rice stripe mosaic virus (RSMV) forms biomolecular condensates via liquid-liquid phase separation (LLPS) to recruit essential components for viral replication factories (VFs).

Bioartificial liver: Where lies the path ahead-A review.

Despite its proven effectiveness in treating liver failure, liver transplantation is often impractical due to its high surgical risks involved and the limited availability of donor organs. Blood purification technologies used in non-bioartificial liver (NBAL) systems have improved clinical cure rates, but they do not substitute for the complex biosynthesis, detoxification, metabolism, and biological transformation roles of the liver. To overcome these challenges brought by NBAL systems, bioartificial liver (BAL) systems have been developed with repeated optimization of both hepatocyte sources and bioreactors to emulate a "fully functional liver".

Dual Bioconversion Strategy: Synergistic Germination and Fermentation Engineering for a γ-Aminobutyric Acid-Enriched Beverage from Brown Rice.

Growing demand for plant-based nutraceuticals drives the need for innovative bioprocessing strategies. This study developed an integrated approach combining germination and Lactobacillus-mediated fermentation to produce a γ-aminobutyric acid (GABA)-enriched functional beverage from brown rice. Systematic screening identified an optimal rice cultivar for germination.

Factors influencing awareness of beverage grading policies and their association with beverage consumption patterns.

Background: Given the current lack of government-led front-of-package nutrition labeling policies in China, research on Chinese consumers' genuine perceptions of nutrition labels and their association with healthy behaviors remains scarce. Notably, Shanghai's beverage grading policy stands out as one of the rare existing initiatives, providing a valuable opportunity to explore public awareness of the policy, its potential determinants, and its associations with consumer choices.

Design: To gain a clearer understanding of public perceptions of the beverage grading policy, a survey was conducted across seven hospitals in Shanghai, yielding 931 valid responses for analysis.

Unsedated cerebrovascular reactivity imaging is well-tolerated in children.

Background: Unsedated MRI use in pediatric clinical and research settings is often feasible, but advanced imaging techniques like cerebrovascular reactivity (CVR) may affect tolerability of unsedated MRIs. Exogenous carbon dioxide (CO) provides a CVR vasodilatory challenge, but its impact on unsedated children's MRI tolerability is unknown.

Objective: We hypothesized that children would tolerate MRI with exogenous CO as well as children undergoing only MRI.

NRT1.1B acts as an abscisic acid receptor in integrating compound environmental cues for plants.

Abscisic acid (ABA) is the most crucial phytohormone for plants in adapting to environmental conditions. While the ABA signaling network in plants has been extensively explored, our understanding of the diverse ABA sensing systems remains limited. Here, we found that the transcriptional response to ABA is suppressed under high-nitrate conditions but substantially increases under low-nitrate conditions, suggesting a tight integration of ABA signaling with nutrient conditions.

Overcoming venetoclax resistance through heme-mediated NOXA/cyclin D1/Mcl-1 axis with a novel artemisinin conjugate.

The Bcl-2 inhibitor venetoclax remains the sole apoptosis-inducing agent approved for combination therapy in elderly patients with acute myeloid leukemia (AML). However, its clinical efficacy is frequently constrained by the emergence of drug resistance, which involves the overexpression or induction of Mcl-1 and Bcl-xL proteins. To address this challenge, we developed a novel strategy to enhance venetoclax activity and overcome resistance by producing NOXA through the conjugation of dihydroartemisinin (DHA) to venetoclax using a chemical synthesis approach.

Hydrogel technologies in andrology: advances in research and prospective applications.

Hydrogels, owing to their outstanding physicochemical properties and excellent biocompatibility, have emerged as a focal point of research and clinical application in andrological diseases. This review systematically summarizes cutting-edge progress in hydrogel applications for Prostate Cancer (PC), Bladder Cancer (BC), Erectile Dysfunction (ED), Male Reproductive Medicine (MRM), and urinary tract tissue engineering. Current studies indicate that hydrogels can serve as protective spacers in PC radiotherapy to mitigate radiation-induced rectal toxicity and as precise drug-delivery vehicles to enhance antitumor efficacy.

Inhibition of Ferroptosis by Adipose Stem Cell-Derived Apoptotic Vesicles Enhances Angiogenesis and Accelerates Diabetic Wound Healing.

Purpose: Impaired angiogenesis is a critical challenge in diabetic wound healing. While apoptotic derivatives of stem cells hold promise for regenerative therapy, their role in modulating angiogenesis within the diabetic wound microenvironment remains underexplored. This study aims to investigate whether adipose stem cell-derived apoptotic vesicles (ASCs-apoVs) promote angiogenesis and accelerate diabetic wound healing by inhibiting endothelial cell ferroptosis.

Rational combination of homoharringtonine to selectively target FLT3-ITD acute myeloid leukemia through synthetic lethality.

Background: Homoharringtonine (HHT), a natural product used clinically to treat acute myeloid leukemia (AML) in combination with chemotherapy, induced transient remission in 25 % of unclassified AML patients when administered alone. Recent studies showed that HHT could be combined with targeting agents for AML treatment. However, the rationales of these combinations require further exploration to optimize therapeutic efficacy.