[Varicocele ligation with mobile phone microscope: Report of 5 cases and literature review].

Objective: To investigate the feasibility of varicocele ligation with mobile phone microscope.

Methods: The high-performance mobile phone and mobile phone stand were combined to act as a mobile phone microscope. And the varicocele ligation was performed under the mobile phone microscope.

A Ubiquitous Volatile in Noctuid Larval Frass Attracts a Parasitoid Species.

Natural enemies commonly probe larval bodies and frass with their antennae for prey hunting. However, the attractants to natural enemies emitted directly from hosts and host-associated tissues remained largely unknown. Here, we used two generalist noctuid species, (Hübner) and (JE Smith), along with the larval endoparasitoid (Haliday) to address the question.

Physiological pH Transition-Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles.

Protein corona alters the biological identities and interactions of nanoparticles with cells, needing to be thoroughly scrutinized before in vivo applications. Importantly, protein corona is evolving as nanoparticles cross different microenvironments, leading to unpredictable biological behaviors. Unveiling how physiological conditions change, especially pH changes associated with tumor-targeted delivery, affect protein corona composition and subsequent bio-interactions, is thus essential for understanding the bio-fate and therapeutic efficacy of nanomedicines.

Effect of mixed fermentation with and on the flavor precursor and flavor formation of Kazak cheese.

Previous research has demonstrated that notably enhances flavor stability with the cost of diminishing the inherent milk flavor in cheese, which may be rescued by the incorporation of . To investigate the effects of mixed fermentation with and on the formation of taste during the ripening period of kazak cheese, this study determined its sensory attributes, flavor precursors, volatile flavor components (VFCs), and Odorant Activity Value (OAV). The mixed fermentation increased the levels of organic acids, aromatic and umami amino acids, saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs), ultimately intensifying the concentration of aldehydes and ketones.

Protective effects of Yiqi Huoxue Huatan formula on atherosclerosis: An in vivo and in vitro study.

Atherosclerosis (AS) is a significant pathological contributor to cardiovascular disease, marked by high rates of death and illness globally. Yiqi Huoxue Huatan formula (YHH), a Chinese traditional decoction, has been clinically validated as effective for patients with AS; however, its underlying mechanisms remain partially unexplained. The goal of this research is to understand the protective effects of YHH against AS and the mechanisms involved.

Topological prethermal strong zero modes on superconducting processors.

Symmetry-protected topological phases cannot be described by any local order parameter and are beyond the conventional symmetry-breaking model. They are characterized by topological boundary modes that remain stable under symmetry respecting perturbations. In clean, gapped systems without disorder, the stability of these edge modes is restricted to the zero-temperature manifold; at finite temperatures, interactions with mobile thermal excitations lead to their decay.

JA Signaling Inhibitor JAZ Is Involved in Regulation of AM Symbiosis with Cassava, Including Symbiosis Establishment and Cassava Growth.

Mutualism between plants and arbuscular mycorrhizal fungi (AMF) is imperative for sustainable agricultural production. Jasmonic acid (JA) signal transduction has been demonstrated to play an important role in AMF symbiosis with the host. In this study, SC9 cassava was selected as the research object to investigate the effect of the jasmonic acid signaling pathway on symbiosis establishment and cassava growth in AMF and cassava symbiosis.

Bioengineered human pre-vascularized microtissues reconstruct vascular niche and regenerative microenvironment to enhance functional skeletal muscle regeneration.

Skeletal muscle regeneration mediated by muscle satellite cells (MuSCs) is supported by the specific vascular niche containing endothelial cells, pericytes, and mesenchymal stem cells. Volumetric muscle loss (VML) severely disrupts the vascular niche and impairs the ability of MuSCs to regenerate functional skeletal muscle. Until now, it remains a great challenge to reconstruct the vascular niche for muscle regeneration.

Genetic lineages analysis of black goat subpopulations in southern areas of China: Correlation of SNPs and methylation sites in their differentiated genes.

Black goats are widely distributed across southern China, exhibiting substantial phenotypic diversity across geographical regions. However, the genetic lineages distinct black goat populations across diverse geographical regions have remained critically under explored. In this study, whole-genome sequencing analysis was conducted on 66 black goats collected from 3 varieties in Hainan, Guangdong, Shandong, Guangxi, and Yunnan Provinces.

Correlation and Influencing Factor Analysis Between Gal-3 and Recurrent Patients With Nonvalvular Atrial Fibrillation After Radiofrequency Ablation.

This prospective cohort study was aimed at evaluating the association of galectin-3 (Gal-3) and other prognostic factors with atrial fibrillation (AF) recurrence in patients with nonvalvular AF undergoing radiofrequency catheter ablation (RFCA). Overall, 92 patients were included, with the AF group comprising 70 patients and the control group comprising 20 (supraventricular tachycardic) patients. Preablation parameters were recorded, including baseline Gal-3 levels.

Zn@ZIF-8 activated O for HO generation: synergistic bacteria deactivation and wound healing.

Hydrogen peroxide (HO) exhibits significant potential in antimicrobial applications due to its broad-spectrum biocidal activity. However, its widespread utilization is limited by stringent storage requirements, concentration-dependent efficacy, and transient bactericidal action. Herein, Zinc@Zeolitic Imidazolate Framework-8 (Zn@ZIF-8), synthesized via a facile stirring-physical grinding method, enabled the in-situ generation of substantial HO through the two-electron (2e) oxygen reduction reaction (ORR).

The uteroplacental circulation at high altitude: adaptation and maladaptation.

The greatest challenge of living at high altitude is hypoxia. Hypoxia imposes immense impacts on reproduction. Gestation at high altitude is associated with high incidence of fetal growth restriction (FGR) and pre-eclampsia owing to maladaptation of uteroplacental circulation/placenta insufficiency and oxygen delivery to the fetus.

Effect of hydrogen-oxygen inhalation on sleep disorders and abnormal mood: a single-blind, randomized controlled trial.

JOURNAL/mgres/04.03/01612956-202606000-00002/figure1/v/2025-08-18T154854Z/r/image-tiff Sleep disorders are associated with various chronic diseases. While hydrogen has anti-inflammatory, antioxidant, and antifibrotic effects and has potential applications in disease management, its impact on sleep disorders remains unclear.

Establishment of CRISPR/Cas9 lineage tracking technology for pig embryos.

Understanding tissue development in pigs is critical for biomedical research and genetic engineering, particularly for modeling human disease. However, tracing developmental origins and reconstructing lineage trees for pig cells remains a significant challenge. Here, we present a high-resolution lineage tracing system that combines molecular barcoding with single-cell transcriptomics in pigs.

Bacterial K-strategists playing pivotal roles in degrading alkanes, upholding system stability and regulating microbial diversity in natural attenuation of petroleum hydrocarbon polluted sediment of Laizhou Bay.

Natural attenuation represents a pivotal process in the management of oil spills within marine ecosystems, one of which is to monitor bioprocess that is inseparable from microbial action. However, the behaviors of microorganism with different survival strategies under petroleum contamination remain largely unexplored in gulf environments. Herein, ecological and evolutionary characteristics of K- and r-strategist were comprehensively investigated in diesel-polluted sediment from Laizhou Bay via molecular sequencing and physicochemical experiments.

Increased vaginal abundance and reduced D-galactose metabolism are associated with preterm birth in older mothers with columnar ectopy in South China.

Advanced maternal age is associated with adverse pregnancy outcomes. However, the impact of changes in maternal physiology, biochemistry, vaginal microbiome, and its metabolites related to reproductive age on pregnancy outcomes is uncertain. Multi-omics were used to analyze vaginal samples collected from 195 pregnant women of different age groups to characterize the factors affecting the occurrence of adverse pregnancy outcomes in older mothers.

Mechanism of Action of Resveratrol Affecting the Biological Function of Breast Cancer Through the Glycolytic Pathway.

Background: Phosphoglycerate kinase 1 (PGK1) plays a crucial role in the glycolytic pathway and its overexpression has a negative impact on tumor development and prognosis. Resveratrol, a natural polyphenolic compound, has gained significant attention in recent years due to its anti-inflammatory, antioxidant, and anti-tumor properties. However, the mechanism by which resveratrol inhibits breast cancer growth, invasion, and metastasis through the PGK1 glycolytic pathway is still not fully understood.

Adsorption of Pb and Cd from Aqueous Solutions by Porous Carbon Foam Derived from Biomass Phenolic Resin.

Due to its lightweight and superior adsorption properties, carbon foam is frequently employed for the removal of heavy metal pollutants from aqueous solutions. In this study, a novel modified carbon foam (M-CF) was successfully synthesized for the effective removal of Pb and Cd from water. The synthesis involved partially substituting phenol with the liquefaction product of bamboo powder, followed by modification with a silane coupling agent (KH560) and foaming with n-hexane-loaded activated carbon (H/AC).

Genomic Insights into Genes: Key Role in Cotton Leaf Abscission Formation.

The cytokinin response regulator () gene is essential for cytokinin signal transduction, which plays a crucial role in plant growth and development. However, the functional mechanism of genes in cotton leaf abscission remains incompletely understood. In this study, a total of 86 genes were identified within the genome of .

EXPRESS: Targeting sphingosine-1-phosphate receptor 1 alleviates neuropathic pain associated with pancreatic ductal adenocarcinoma in mice and inhibits tumor progression.

Background: Pancreatic neuropathy occurs during the development of pancreatic ductal adenocarcinoma (PDAC), with changes correlating to pancreatic neuropathic pain and increased expression of nociceptive genes in sensory ganglia. Emerging evidence suggests that sphingosine-1-phosphate receptor 1 (S1PR1) plays critical roles in the onset and maintenance of pain. However, whether S1PR1 in sensory ganglia contributes to PDAC-associated neuropathic pain remains unclear.

Rational design, synthesis, and evaluating primary biological activities of novel HIV-1 protease inhibitors containing heteraryl acetamides as the P2 ligands.

A series of novel potent HIV-1 protease inhibitors featuring diverse hydroxyaromatic acetanilide derivatives as P2 ligands and 4-substituted phenyl sulfonamides as P2' ligands were designed, synthesized, and biologically evaluated. The majority of the target compounds demonstrated potent enzyme inhibitory activity with IC values below100 nM. Notably, compound 18h, incorporating a 2-(4-hydroxypyrimidin-5-yl) acetamide P2 ligand and a 4-methoxybenzenesulfonamide as the P2' ligand, exhibited exceptional potency with an enzyme IC of 0.

Combination immunotherapy targeting LAG-3, PD-1 and STING suppresses hepatocellular carcinoma as monitored by LAG-3 targeted PET imaging.

Background: The low response rate of anti-PD-1 monoclonal antibodies (mAbs) in hepatocellular carcinoma (HCC) requires the development of combination immunotherapy strategies to improve their efficacy. This study aimed to use LAG-3-targeted PET imaging to monitor the efficacy of anti-PD-1 mAb, a stimulator of interferon genes (STING) agonist, and anti-LAG-3 mAb, both individually and in combination. Furthermore, we evaluated the potential of a triple immunotherapy regimen (anti-PD-1 mAb, STING agonist, and anti-LAG-3 mAb) to improve HCC treatment.