Genetic lineages analysis of black goat subpopulations in southern areas of China: Correlation of SNPs and methylation sites in their differentiated genes.

Black goats are widely distributed across southern China, exhibiting substantial phenotypic diversity across geographical regions. However, the genetic lineages distinct black goat populations across diverse geographical regions have remained critically under explored. In this study, whole-genome sequencing analysis was conducted on 66 black goats collected from 3 varieties in Hainan, Guangdong, Shandong, Guangxi, and Yunnan Provinces.

The U shape relationship between glucose and potassium ratio and mortality in patients with subarachnoid hemorrhage in the US population.

The prognostic value of the glucose-potassium ratio (GPR) in non-traumatic subarachnoid hemorrhage (SAH) remains undetermined. We investigated the association between the GPR at admission and all-cause mortality (ACM) in critically ill patients with SAH. We identified critically ill patients with SAH from the Medical Information Mart for Intensive Care database and stratified them into quartiles based on the GPR levels at admission.

MSA-Net: multiple self-attention mechanism for 3D lung nodule classification in CT images.

Purpose: Lung cancer is a life-threatening disease that poses a significant risk to human health. Accurate differentiation between benign and malignant lung nodules, based on computed tomography (CT), is crucial to assess lung health. Developing an automated computer-aided diagnostic method for this differentiation is essential.

Fatal Acute Necrotizing Encephalopathy in a 17-Year-Old Girl with COVID-19: A Case Report.

BACKGROUND Acute necrotizing encephalopathy (ANE) is a severe and rapidly progressive form of encephalopathy predominantly observed in children following various systemic infections. Although rare, cases of ANE have been increasingly associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. This report details a fatal case of ANE in a 17-year-old girl diagnosed with coronavirus disease 2019 (COVID-19), emphasizing the critical need for early diagnosis and prompt intervention to improve clinical outcomes.

Identification and Validation of an Explainable Prediction Model of Sepsis in Patients With Intracerebral Hemorrhage: Multicenter Retrospective Study.

Background: Sepsis is a life-threatening condition frequently observed in patients with intracerebral hemorrhage (ICH) who are critically ill. Early and accurate identification and prediction of sepsis are crucial. Machine learning (ML)-based predictive models exhibit promising sepsis prediction capabilities in emergency settings.

Case Report: Congenital hepatic hemangioma with arteriovenous fistula: 2-year multidisciplinary management and outcomes.

Background: Congenital hepatic hemangioma with arteriovenous fistula (HHAVF) is a rare condition in newborns that may manifest as respiratory distress, pulmonary hypertension, and heart failure shortly after birth. This report describes a case of HHAVF complicated by encephalomalacia identified after transcatheter arterial embolization (TAE). However, the condition improved with multidisciplinary management and long-term follow-up.

Lunar primitive mantle olivine returned by Chang'e-6.

The lunar mantle is important for unraveling the Moon's formation and early differentiation processes. Here, we identify primitive lunar olivines in soils returned by the Chang'e-6 mission. These olivines have oxygen isotopic compositions plotting along the terrestrial fractionation line, and are characterized by high forsterite contents up to 95.

Recent advances in green deep eutectic solvents for lithium-ion battery recycling: A perspective on bibliometric analysis.

The rapid growth of electric vehicles worldwide has resulted in a significant increase in the demand for lithium-ion batteries (LIBs), thereby accelerating the development of the LIBs recycling industry. Currently, the predominant methods for recycling spent LIBs include pyrometallurgical, hydrometallurgical, and direct recycling techniques, each with its own advantages and disadvantages. To enhance the recycling efficiency of cathode metals from spent LIBs while promoting environmental sustainability, green deep eutectic solvents (DESs) have attracted scholarly interest.

Effect of metformin on the clinical outcomes of stroke in patients with diabetes: a systematic review and meta-analysis.

Objectives: Stroke is a major cause of death and disability globally, especially among diabetic patients. In this study, we aim to scrutinise the effects of metformin on the clinical outcomes of stroke in diabetic patients.

Design: This study followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.

Advancements in iron-based photocatalytic degradation for antibiotics and dyes.

The accelerated growth of the economy and advancements in medical technology have led to the discharge of a diverse range of organic pollutants into water sources. Recent investigations into water treatment have demonstrated the potential for integrating photocatalysis with techniques such as photocatalytic persulfate activation and the Photo-Fenton process for more efficient wastewater management. Iron-based photocatalysts responsive to visible light offer several advantages, including non-toxicity, safety, affordability, and excellent chemical and optical properties.

Vincristine exerts antiglioma effects by inhibiting the PI3K/AKT signaling pathway: A mechanistic study based on network pharmacology, bioinformatics analysis, and experimental validation.

In clinical settings, glioma patients often develop secondary resistance to first-line chemotherapy drugs. Vincristine has been reported for its application in cancer chemotherapy, but its molecular mechanism of action remains unclear. This study aimed to identify potential targets of vincristine in glioma using network pharmacology and to experimentally validate the possible molecular mechanisms against glioma.

Robust modelling of arterial blood pressure reconstruction from photoplethysmography.

Blood pressure is a crucial indicator of cardiovascular disease, and arterial blood pressure (ABP) waveforms contain information that reflects the cardiovascular status. We propose a novel deep-learning method that converts photoplethysmogram (PPG) signals into ABP waveforms. We used [Formula: see text]-Net as a feature extractor and designed a Bi-block to capture individualised time information in encoder feature extraction.

Correction Strategies for Isotopic Ratios in Overspiked Samples Using the Double Spike Technique.

The double spike (DS) technique is a highly effective approach for measuring the isotope ratios of many elements. However, it is common for some fraction of the prepared samples to be "overspiked." The usual solution for this problem involves repurifying and reanalyzing the samples to ensure data accuracy.

Association between serum glucose potassium ratio and mortality in critically ill patients with intracerebral hemorrhage.

The effect of serum glucose-to-potassium ratio (GPR) on cerebrovascular diseases has been previously validated. However, the value of the GPR in patients with severe intracerebral hemorrhage (ICH) requiring ICU admission remains unclear. This study aimed to investigate the association between the GPR and the clinical prognosis of critically ill patients with ICH.

Safety and efficacy of Angong Niuhuang Pills in patients with moderate-to-severe acute ischemic stroke (ANGONG TRIAL): A randomized double-blind placebo-controlled pilot clinical trial.

Background: Preclinical studies have indicated that Angong Niuhuang Pills (ANP) reduce cerebral infarct and edema volumes. This study aimed to investigate whether ANP safely reduces cerebral infarct and edema volumes in patients with moderate to severe acute ischemic stroke.

Methods: This randomized, double-blind, placebo-controlled pilot trial included patients with acute ischemic stroke with National Institutes of Health Stroke Scale (NIHSS) scores ranging from 10 to 20 in 17 centers in China between April 2021 and July 2022.

Exploring the prognostic value and potential therapeutic strategies of MS4A6A in glioblastoma: A comprehensive analysis of single-cell and multi-omics data.

Glioblastoma (GBM) is a highly aggressive and treatment-resistant malignancy that poses a significant challenge in modern medicine. Despite advances in surgical resection, radiotherapy and chemotherapy, complete eradication of GBM remains elusive due to its diffuse invasion into the brain parenchyma and propensity for recurrence. The tumour microenvironment (TME), particularly macrophages, has emerged as a critical player in GBM progression, invasion and metastasis.

Improved Standard Addition Method for Measuring Stable Isotopic Compositions and Its Application to Sulfur Isotope Composition.

The standard addition method (SAM) is widely used to measure the isotopic compositions of natural samples, particularly those with a complex matrix. However, traditional SAM has limitations for isotope systems with significant variations in isotope composition due to its reliance on approximation in calculation and the requirement for estimates of analyte isotopic compositions and accurate concentrations. To overcome the issues, our work proposes an improved SAM that explicitly calculates isotope ratio (i.

Ultrasensitive and multiplexed Gastric cancer biomarkers detection with an integrated electrochemical immunosensing platform.

Developing immunosensing platforms capable of simultaneously detecting multiple cancer markers is crucial for clinical diagnosis and biomedical research. Here, we introduce a novel dual-mode electrochemical biosensing assay platform capable of detecting two gastric cancer biomarkers: pepsinogen I (PG I) and pepsinogen II (PG II). Methylene blue (MB) and Prussian blue (PB) were used as dual signal sources to label PG I and PG II, respectively.

Cd mobilization in mining-impacted soils with different bedrock lithology: Insights from stable Cd isotopes.

The environmental risk of Cd in soils strongly depends on the mobilization of Cd in soils. However, limited knowledge exists on the redistribution of exogenic Cd inputs in soils, especially across diverse lithological regions. Herein, we aimed to investigate the fate of Cd in soils from two mining areas with contrasting lithologies (siliceous and calcareous) using stable Cd isotopes.