Role of LPC 18:1 in the Lipid Metabolic Response to Combined Vitamin D and Resistance Exercise for Protecting Diabetic Skeletal Muscle Function.

Purpose: We have previously found that vitamin D and resistance exercise synergistically improve type 2 diabetes mellitus (T2DM)-related skeletal muscle atrophy. This study aims to investigate the impact of varying exercise intensity on synergistic effects of vitamin D and resistance exercise on their efficacy in improving type 2 diabetes mellitus (T2DM)-induced myopathy, and further elucidate the underlying mechanism.

Methods: We compared the effects of vitamin D combined with low-, moderate- and high-intensity resistance exercise on metabolic status and skeletal muscle function.

Targeting E3 ubiquitin ligases: a new frontier in idiopathic pulmonary fibrosis treatment.

Ubiquitination is a modification prevalent in eukaryotic cells. Disruptions in ubiquitination processes can have detrimental effects, potentially leading to diseases that endanger life. E3 ubiquitin ligases specifically recognize substrate proteins during ubiquitin modification, regulating intracellular protein levels and functions through the ubiquitin-proteasome pathway or TGF-β signal transduction.

Novel compound bacterial agent effects on pig farm wastewater denitrification and nitrogen transformation.

This research involved the screening and combination of Escherichia coli, Acinetobacter radioresistens, and Klebsiella michiganensis to create a novel compound bacterial agent known as SSF-1. The efficacy of SSF-1 in treating real pig farm wastewater was assessed, focusing on its impact on nitrogen transformation, the structure of bacterial communities, and functional genes. SSF-1 demonstrated stable ammonia nitrogen conversion under both weakly acidic and weakly alkaline conditions, exhibiting superior environmental adaptability compared to individual strains.

High-fat diet-induced obesity-related hypertension via altered gut microbiota-mediated histone butyrylation.

Hypertension is a chronic cardiovascular disease that significantly impacts human quality of life. Gut microbiota and its metabolites have been reported to be involved in lipid metabolism and blood pressure regulation, but the specific alterations and pathogenic mechanisms of gut microbiota in obesity-related hypertension (OrHTN) remain unclear. In this study, we observed a significant proliferation of Desulfobacterota and Proteobacteria, while a decrease in the abundance of several butyrate-producing bacterial genera, accompanied by decreased fecal and plasma butyrate levels in high-fat diet (HFD)-induced OrHTN rats.

DistilCLIP-EEG: Enhancing Epileptic Seizure Detection Through Multi-modal Learning and Knowledge Distillation.

Epilepsy is a prevalent neurological disorder marked by sudden, brief episodes of excessive neuronal activity caused by abnormal electrical discharges, which may lead to some mental disorders. Most existing deep learning methods for epilepsy detection rely solely on unimodal EEG signals, neglecting the potential benefits of multimodal information. To address this, we propose a novel multimodal model, DistilCLIP-EEG, based on the CLIP framework, which integrates both EEG signals and text descriptions to capture comprehensive features of epileptic seizures.

Unraveling morphological brain network disparities Parkinsonian tremor from essential tremor: an artificial intelligence approach for clinical differentiation.

Tremor-dominant Parkinson's disease (TD) and Essential Tremor (ET) are the two most common types of tremors, posing huge challenges in diagnosis. This study was to investigate the pathogenesis of tremors using brain morphology and employ artificial intelligence techniques for distinguishing them. The cortical thickness differences in TD were primarily centered on the right precuneus, while in ET were mainly observed in the right medial orbitofrontal cortex.

Postbiotic Limosilactobacillus reuteri cultured with Polygonatum kingianum polysaccharides ameliorates high-fat-high-sugar-deteriorated colitis and associated hepatobiliary disorders.

Unhealthy diet exacerbates inflammatory bowel disease and its associated hepatic disruptions. The present study demonstrated the superior efficacy of the heat-inactivated Limosilactobacillus reuteri WX-94 (L. reuteri), cultured with Polygonatum kingianum polysaccharides (PKP postbiotic) in ameliorating a high-fat-high-sugar (HFHS)- deteriorated colitis in rats, which outperforming PKP alone, its symbiotic form, and inactivated L.

Association between oxidative balance score with cardiovascular - kidney - metabolic syndrome and all-cause mortality among US population.

Background: Cardiovascular-Kidney-Metabolic (CKM) syndrome is a multi-stage condition with significant public health implications. The oxidative balance score (OBS), which integrates dietary and lifestyle pro-oxidants and antioxidants, offers a novel approach for evaluating oxidative stress in relation to CKM stages and outcomes. This study aimed to investigate the association between OBS and advanced CKM stages, as well as its relationship with all-cause mortality in a US population.

Comparative analysis and optimization of tumor regression grade assessment systems in neoadjuvant therapy for esophageal squamous cell carcinoma.

Objective: This study aims to compare and analyze the effectiveness of different tumor regression grade (TRG) assessment systems in evaluating neoadjuvant therapy for esophageal cancer, with the goal of identifying an optimal assessment method to guide clinical practice.

Methods: A total of 467 patients with esophageal squamous cell carcinoma who underwent neoadjuvant therapy followed by surgical resection were included in this study. We comprehensively evaluated the effectiveness of five TRG assessment systems-Mandard, CAP, Becker, JSED, and Ryan-in predicting the prognosis of the primary tumor (PT) and lymph nodes (LN).

Computer aided diagnostic model for knee osteoarthritis: A multi-modal feature regression approach.

Background: X-ray imaging is crucial for diagnosing knee osteoarthritis (KOA) in clinical treatment. Computer-assisted diagnostic models reduce the impact of physicians' subjective factors on the accuracy of X-ray diagnoses. Therefore, continuous improvement of these models is necessary.

Subthalamic nucleus deep brain stimulation for cranial-cervical dystonia: optimal stimulation sites and networks.

Background And Objectives: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an effective treatment for medically refractory cranial-cervical dystonia (CCD or Meige syndrome). However, clinical responses vary substantially across individuals, likely due to differences in electrode placement and modulation of target neural circuits.

Methods: We retrospectively analyzed 51 patients with CCD treated with STN-DBS at a single center.

Highly efficient antibacterial hydrogel-based multifunctional coatings for ureteral stent to inhibit severe infectious encrustation.

Ureteral stents are prone to encrustation due to urinary crystallization and bacterial infection, leading to severe complications and restricting long-term use. In this study, a multifunctional hydrogel-based coating was developed, which integrates the crosslinking of polyacrylic acid coupled with zinc ions (PAA(Zn)) possessing antibacterial properties and polyvinylpyrrolidone (PVP) with hydrophilic lubrication properties on the PU stent (PPAZ/PU). This novel PPAZ/PU coating was devised to mitigate the challenges of bacterial infectious encrustation associated with stent placement in clinical settings.

Whole-Genome Resequencing Analysis of Athletic Traits in Grassland-Thoroughbred.

Speed is not only the primary objective of racehorse breeding but also a crucial indicator for evaluating racehorse performance. This study investigates a newly developed racehorse breed in China. Through whole-genome resequencing, we selected 60 offspring obtained from the crossbreeding of Thoroughbred horses and Xilingol horses for this study.

Association Between Time in Targeted Blood Glucose Range With All-Cause Mortality in Critically Ill Patients With Heart Failure.

Objectives: Heart failure (HF) patients in ICU experience high mortality rates, often complicated by glycemic dysregulation. Time in targeted blood glucose range (TTBR) provides a comprehensive assessment of glycemic control, but its association with outcomes in critically ill HF patients remains unclear.

Methods: This retrospective cohort study analyzed 5396 critically ill HF patients from the MIMIC-IV database.

Significantly improved antibiotics removal and material utilization in novel electrodialysis integrated with nanostructured carbon microspheres.

Due to the limited effectiveness of electrodialysis (ED) in removing organic micro-contaminants, various carbon-based adsorption materials can be utilized to enhance the overall removal performance. Integrating adsorption materials into the ED process may improve removal efficiency and material utilization under the influence of electric field. In this study, uniformly sized activated carbon microspheres (ACMs) with bimodal pore structures were packed into the dilute compartment of an ED system to remove antibiotics while desalting brackish water.

Minimally Invasive Multimodal Flexible Sensors to Monitor Stem Growth Rate, Soil Water Content, and Soil pH.

Smart agriculture, which integrates sensing, robotics, and AI technologies, offers a promising paradigm to optimize plant growth and resource efficiency. However, current biological monitoring systems are often bulky, invasive, or require multiple discrete devices, which limits their applicability during early stage plant growth. This study proposes a fully integrated, multimodal flexible sensor system capable of minimally invasive and continuous monitoring of key physiological and environmental parameters, i.

Development and validation of a prediction model for lymph node metastasis in thyroid cancer: integrating deep learning and radiomics features from intra- and peri-tumoral regions.

Background: Current preoperative imaging methods, such as ultrasound, are limited by operator dependency and suboptimal sensitivity for detecting central lymph node metastasis (CLNM). This study aimed to propose a method that integrates deep learning and radiomics to accurately predict lymph node metastasis in thyroid cancer by analyzing intra- and peri-tumoral imaging features, thereby improving the preoperative prediction accuracy.

Methods: From July 2020 to June 2022, 405 patients diagnosed with PTC were enrolled from two centers: Center 1 (Shanghai Sixth People's Hospital) with 294 patients divided into a training set (n=294) and an internal validation set, and Center 2 (Tongji Hospital Affiliated to Tongji University) with 111 patients as the external test set.

Establishing a Predictive Model for the Occurrence of CI-AKI After PCI in Patients With Coronary Heart Disease Based on Serum-Derived Biomarkers.

To identify risk factors for contrast-induced acute kidney injury (CI-AKI) post-PCI in coronary heart disease (CHD) patients, analyze novel inflammatory markers, and develop a predictive model. CHD patients admitted to Northern Jiangsu People's Hospital in Yangzhou, Jiangsu Province, China, from January 1, 2019, to December 31, 2022, were selected, and a total of 628 patients were included in this study by collecting the general information, past history, and relevant laboratory test results of all patients and excluding those with imperfect relevant medical records, including 142 cases in the CI-AKI group and 486 cases in the non-CI-AKI group. According to the ratio of 7:3, they were randomly divided into a training group ( = 439) and a validation group ( = 189).

Preliminary investigation of the effect of ferulic acid on miRNAs and LncRNAs in Mongolian horse skeletal muscle satellite cells.

Introduction: Ferulic acid (FA), a natural antioxidant, has attracted considerable attention for its regulatory potential in skeletal muscle development, energy metabolism, and muscle fiber type transformation.

Methods: This study established a research system based on Mongolian horse skeletal muscle satellite cells to elucidate the molecular basis by which ferulic acid regulates muscle fiber type transformation through a non-coding RNA interaction network.

Results: A total of 18 differentially expressed miRNAs (DEMIRs) and 128 differentially expressed lncRNAs (DELs) were identified through transcriptome sequencing of the ferulic acid-treated (FA) group and the control group (NC).

Deep brain stimulation surgical timing, outcomes, and prognostic factors in patients with Parkinson's disease: A Chinese retrospective multicenter cohort study.

Background: Deep brain stimulation (DBS) has been increasingly introduced for patients with Parkinson's disease (PD). However, there has been extensive controversy regarding its surgical timing. This study aimed to evaluate surgical outcomes of DBS across different PD durations and identify key prognostic factors.

Analysis of ROH Characteristics Across Generations in Grassland-Thoroughbred Horses and Identification of Loci Associated with Athletic Traits.

The core objective of racehorse breeding is to enhance the speed and endurance of the horses. The Grassland-Thoroughbred is an emerging horse breed developed in northern China in recent years, characterized by excellent speed performance, enduring stamina, and strong environmental adaptability. However, research on the genetic characteristics within this breed and the genes associated with athletic performance remains relatively limited.

Transcriptomic combined physiological analysis illuminated the gastrointestinal stress mechanism of .

Gastrointestinal stress significantly influences the functionality and survival of food-derived probiotics after ingestion. is widely recognized for its remarkable resilience to gastrointestinal challenges, yet the molecular mechanisms underlying this tolerance remain incompletely understood. In this study, an integrated physiological and transcriptomic approach was employed to elucidate the adaptive responses of to gastrointestinal stress.

Crystal Orientation Engineering for Energy Storage and Conversion Applications.

Nanoscale material design is crucial to the development of efficient renewable energy and storage technologies. While conventional research paradigms have emphasized material morphology, crystal polymorphs, and defect engineering, recent years have witnessed an emerging research interest in crystal orientation engineering since it can exploit anisotropic material properties to significantly enhance  emerging energy storage and conversion applications. Herein, a comprehensive review of engineering the crystal orientation of materials to improve various energy conversion and storage technologies is provided.

Activated TBK1 promotes ACSL1-mediated microglia lipid droplet accumulation and neuroinflammation in Parkinson's disease.

Unlabelled: Microglia-mediated neuroinflammation plays a crucial role in the progression of Parkinson’s disease (PD). Dysregulation of lipid droplet homeostasis is a significant factor affecting microglial inflammatory responses, but the mechanisms underlying lipid droplet imbalance in PD are currently unclear. Here, we report a subtype of microglia characterized by high expression of long-chain acyl-CoA synthetase 1 (ACSL1) through single-nucleus RNA sequencing analysis and machine learning algorithms, linking lipid metabolism to PD neuroinflammation.

Ferulic acid mediates Mongolian horse skeletal muscle fiber remodeling through PDK1.

Ferulic acid (FA), a natural antioxidant and major active component in Angelica sinensis, has beneficial effects on skeletal muscle health; however, its role in modulating muscle fiber type composition Mongolian horse remains unclear. In this study, we found that FA promotes the proliferation of Mongolian horse skeletal muscle satellite cell (MuSCs), upregulates the expression of fast-twitch muscle marker genes (e.g.