Targeted soluble epoxide hydrolase inhibits M1 macrophage polarization to improve cartilage injury in temporomandibular joint osteoarthritis.

Background: Macrophage immunomodulation has emerged as a novel intervention and therapeutic strategy for temporomandibular joint osteoarthritis (TMJOA), potentially serving as a key approach for reducing synovial inflammation and promoting cartilage repair. The soluble epoxide hydrolase inhibitor (sEHi), TPPU, has shown potential therapeutic effects against inflammatory diseases and osteogenesis by elevating endogenous Epoxyeicosatrienoic acids (EETs). However, it remains largely unknown whether TPPU can reduce inflammation and cartilage degradation in the TMJOA.

Electron Transfer-Tailored D-Band Center to Boost Nanozyme Catalysis for Interpretable Machine Learning-Empowered Intelligent Biosensing.

The escalating global burden of infectious diseases demands biosensing technologies that transcend the complexity-sensitivity-accuracy trade-off in real-world applications. Herein, an interpretable machine learning-empowered multimodal biosensor synergizing electron transfer-enhanced nanozymes and aggregation-induced emission luminogens (AIEgens) for ultrasensitive pathogen detection is presented. By engineering aminophenol formaldehyde resin nanobowls anchored with monodisperse Pt nanoparticles, interfacial electron transfer (N→Pt→O) induces an upshift of Pt d-band center relative to the Fermi level, as validated by density functional theory.

Molecular-Device Co-Engineering of Ultra-Low Dark Current SWIR Organic Photodetectors for High-Quality Blood-Pressure Monitoring and Optical Communication.

The limited noise-responsivity balance in Short-wave infrared (SWIR) organic photodetectors (OPDs) restricts their biomedical and optoelectronic applications. In this study, this challenge is addressed through molecular-device co-engineering by designing two fluorinated narrow-bandgap non-fullerene acceptors (BTT-DTPn and BTT-DTPn-2F) coupled with solvent vapor annealing (SVA), achieving low noise and high detectivity in SWIR OPDs. The optimized devices based on BTT-DTPn-2F, which features enhance π-π stacking due to terminal fluorination, extend its absorption capability to 1300 nm.

A novel 3DOM Pt/MeO-SiO catalyst for the catalytic oxidation of VOCs.

In this work, we utilized three-dimensional ordered macroporous (3DOM) SiO and non-noble metal oxides (CeO, CoO and MnO) to confine highly dispersed Pt species. The 3DOM Pt/MeO-SiO catalyst was used for the catalytic oxidation of benzene to evaluate its catalytic activity, long-term thermal stability, sulfur resistance, and water resistance. The results verified that the 3DOM Pt/CeO-SiO catalyst had superior activity ( = 210 °C) and strong sulfur resistance (10 ppm).

Development of a highly selective near-infrared fluorescent probe for sensitive detection of Hg in environmental and biological samples.

Mercury ions (Hg), as highly toxic heavy metals, severely threatened environmental and biological health. Herein, we reported a near-infrared fluorescent probe (DHC) for selective Hg sensing. This probe, after reacting with Hg, featured an emission wavelength of 650 nm and enabled detection with a limit of 0.

Unexplained cardiac hypertrophy as a clue to plasma cell tumour: a case study.

Initial diagnosis: A 60-year-old male presented with initial diagnosis chest tightness, fatigue, and arrhythmia. Indications for plasma cell tumour: Initial imaging suggested amyloidosis due to myocardial thickening. Left ventricular hypertrophy and delayed enhancement on Magnetic Resonance Imaging (MRI), along with an elevated κ:λ ratio, raising suspicion for a plasma cell tumour.

Metabolomic insights into late-life depression: a systematic review.

Late-life depression (LLD) is a prevalent mental health issue that significantly impacts the quality of life in the elderly population. In recent years, metabolomics has emerged as a novel research tool, offering fresh insights into the molecular mechanisms underlying LLD. This systematic review synthesizes metabolomic studies from January 2004 to March 2024, aiming to identify differential metabolites, explore diagnostic and predictive potential, and investigate aberrant metabolic pathways in LLD.

Correlation between tidal breathing pulmonary function, exhaled nitric oxide and airway hyperresponsiveness in children aged 0-3 years with suspected asthma.

Objective: To investigate the correlation between tidal breathing pulmonary function parameters combined with mixed exhaled gas nitric oxide values and the degree of airway hyperresponsiveness (AHR) in children aged 0-3 years with suspected asthma.

Methods: In this retrospective study, we collected baseline clinical data, tidal breathing pulmonary function parameters (measured before methacholine inhalation), fractional exhaled nitric oxide (FeNO) levels, and methacholine challenge test (MCT) results from 818 pediatric asthma patients treated at the Children's Hospital of Chongqing Medical University between January 2021 and June 2023. Baseline data, tidal respiratory pulmonary function parameters, and FeNO values were used to analyze their correlation with AHR.

Mobile App-Based Self-Management of Urinary Incontinence in Pregnant Women: Multicenter Pragmatic Randomized Controlled Trial.

Background: Urinary incontinence (UI) is a common condition during pregnancy, significantly impacting the physical and mental well-being as well as quality of life. With advancements in mobile health technology, mobile apps provide innovative approaches for managing UI. Although small-scale studies have demonstrated their efficacy in alleviating maternal UI symptoms, there is a notable lack of large-scale, multicenter trials to validate these findings.

Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD.

Magnetic stimulation has made significant strides in the treatment of psychiatric disorders. Nonetheless, current magnetic stimulation techniques lack the precision to accurately modulate specific nuclei and cannot realize deep brain magnetic stimulation. To address this, we utilized superparamagnetic iron oxide nanoparticles as mediators to achieve precise targeting and penetration.

Identification of palmitoylated biomarkers in non-alcoholic fatty liver disease via integrated bioinformatics analysis and machine learning.

Unlabelled: Non-alcoholic fatty liver disease (NAFLD) is a global health challenge with complex pathogenesis and limited diagnostic biomarkers. Palmitoylation, a post-translational modification, has emerged as a critical regulator in metabolic disorders, yet its role in NAFLD remains underexplored. This study integrated bioinformatics analysis and machine learning to identify palmitoylation-related biomarkers for NAFLD.

Integrated bioinformatics and experimental validation identify lysosome and immune infiltration-related genes as therapeutic targets in late-onset major depressive disorder.

This study leverages bioinformatics to identify differential genes linked to lysosomal alterations in late-onset major depressivedisorder (LOD) patients and explores potential therapeutic drugs. We analyzed differential genes in the GSE76826 dataset usingWGCNA to identify modules associated with LOD. After intersecting with lysosomal genes, we utilized ROC and Lasso regression toassess diagnostic significance.

Risk-Stratified Pretransplant Immunosuppressive Strategy Improves Outcomes of Unrelated Cord Blood Transplantation in Pediatric β-Thalassemia Major.

Unrelated umbilical cord blood transplantation (UD-UCBT) is a curative option for children with β-thalassemia major (β-TM) who lack HLA-matched sibling donors. However, challenges such as low CD34+ cell dose, pre-existing immune activation, and iron overload contribute to poor engraftment and high transplant-related mortality (TRM) in high-risk patients. To evaluate the safety and efficacy of a novel 5-factor risk-stratified pretransplant immunosuppressive strategy, combined with a myeloablative conditioning regimen featuring "early" reduced-dose anti-thymocyte globulin (ATG), in improving transplant outcomes and immune reconstitution in pediatric patients undergoing UD-UCBT for β-TM.

Influence of Polymorphisms in Gene SATB2 on Antipsychotics Response in Chinese Han Population.

Background: Responses to antipsychotic drugs vary significantly among patients with schizophrenia. This study explored the correlation between rs1900327, rs7557687, rs733156, and rs6745135 in gene SATB2 and antipsychotics response in the Chinese Han population.

Methods: This study included 228 patients with schizophrenia.

Analysis of the Longitudinal Association Between Parental Feeding Practices and Body Composition Among Children in Shenzhen.

: A national study from China in 2023 predicted that the prevalence of overweight and obesity among children aged 7-18 will increase from 23.4% in 2019 to 32.7% by 2030.

Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia.

Background: High rates of misdiagnosis and missed diagnosis of schizophrenia highlight the urgent need for objective diagnostic indicators. Previous studies showed that microRNAs and circular RNAs are potential candidates. This study aimed to investigate the regulatory patterns and brain validation of circular RNAs-microRNAs-messenger RNAs in early-onset schizophrenia.

Transcriptomic combined physiological analysis illuminated the gastrointestinal stress mechanism of .

Gastrointestinal stress significantly influences the functionality and survival of food-derived probiotics after ingestion. is widely recognized for its remarkable resilience to gastrointestinal challenges, yet the molecular mechanisms underlying this tolerance remain incompletely understood. In this study, an integrated physiological and transcriptomic approach was employed to elucidate the adaptive responses of to gastrointestinal stress.

The diagnostic potential of unconjugated bilirubin in schizophrenia and bipolar disorder.

Background: Schizophrenia is not well differentiated from bipolar disorder when acute psychiatric symptoms are present. Recently, several studies have suggested a potential link between unconjugated bilirubin and schizophrenia and bipolar disorder, but the exact relationship has not been elucidated.

Methods: To compare the levels of unconjugated bilirubin in the blood of patients with schizophrenia and bipolar disorder and to analyze whether there is a potential causal relationship between unconjugated bilirubin and schizophrenia and bipolar disorder using mendelian randomization, and finally to validate the relationship between them by the clinical symptoms and the levels of unconjugated bilirubin before and after MECT.

Association of Parental Feeding Styles with Body Composition Among Children in Two Regions in China.

This study aimed to investigate the correlation between parental feeding practices and children's body composition in two Chinese regions with distinct socioeconomic characteristics. A cross-sectional study was conducted in Shenzhen (economically developed) and Yulin (economically underdeveloped) regions. Data were collected in 2023 from 1298 (age 8-10 years) children and their parents in two regions.

CircRNA-miRNA-mRNA networks in plasma extracellular vesicles as biomarkers for first-onset schizophrenia.

Background: The circRNA-miRNA-mRNA networks of extracellular vesicles (EVs) in first-onset schizophrenia (FOS) have not been reported yet. Here, we constructed circRNA-miRNA-mRNA networks of EVs, and examined their diagnostic efficiency in FOS.

Methods: The expression levels of circRNAs, miRNAs and mRNAs in EVs derived from 10 FOS patients and 10 healthy controls (HC) were determined by high-throughput sequencing.

PIEZO2 is the underlying mediator for precise magnetic stimulation of PVN to improve autism-like behavior in mice.

The precision magnetic stimulation system (pMSS), mediated by superparamagnetic iron oxide nanoparticles (SPIONs), can modulate endogenous oxytocin secretion by targeting the paraventricular nucleus (PVN) and improve autistic-like behavior in mice. In this study, the underlying mechanisms of this system were explored. Our findings demonstrate that pMSS bi-directionally regulates oxytocin secretion, inhibiting secretion at a low frequency (1 Hz) and promoting secretion at a high frequency (10 Hz).

Campus risk detection using the S-YOLOv10-SIC network and a self-calibrated illumination algorithm.

In order to realize intelligent and accurate campus risk detection, this paper proposes an improved YOLOv10 algorithm that integrates self-calibrated illumination algorithm. The algorithm optimizes the loss function by introducing an auxiliary bounding box, and accelerates model convergence. StarNet is employed to enhance the original network structure, feature extraction capability, and decrease parameter count and calculations.

The unique characteristics of extraversion: A systematic review and coordinate-based meta-analysis of resting state functional magnetic resonance imaging studies.

Extraversion, a core personality trait with significant implications for various life and work domains, has been extensively studied for its neural underpinnings, yet yielding inconsistent results. To resolve this, we employed the AES-SDM meta-analytic method and conducted a systematic review and meta-analysis of resting-state functional magnetic resonance imaging (rs-fMRI) studies to elucidate the relationship between extraversion and spontaneous brain activities at rest. Our analysis included 9 datasets from 11 studies, encompassing a total of 1242 participants, both adults and minors.

Reference equations for pulmonary function testing in healthy Chinese children aged 4-18 years.

Background: Accurate spirometry reference equations are essential for diagnosing and managing respiratory conditions in children. Although the GLI Global Equations have been proposed for general use, there were few Asian populations available for inclusion. This study aims to develop and validate spirometric reference equations for healthy Chinese children.

[Role of in regulating the Wnt/β-catenin signaling pathway in a bronchopulmonary dysplasia model].

Objectives: To investigate the role and mechanism of Brahma-related gene 1 () in regulating the Wnt/β-catenin signaling pathway in a bronchopulmonary dysplasia (BPD) model.

Methods: Wild-type C57BL/6 and mice were randomly divided into four groups: wild-type control, wild-type BPD, control, and BPD (=5 each). Immortalized mouse pulmonary alveolar type 2 cells (imPAC2) were cultured, and gene was knocked down using lentivirus transfection technology.