Phenotypic and transcriptomic analysis reveals the antibiofilm mechanism of essential oil against and its application in pork preservation.

is a common foodborne pathogen that can result in diarrhea and vomiting. It can easily exist in food production environments and form biofilms that are difficult to remove. This study investigated the inhibitory effect and mechanism of essential oil (LC-EO) against biofilm based on phenotype and transcriptomics, as well as the application in pork preservation.

Effect of Gene Polymorphism on the Pharmacokinetics and Clinical Outcomes of Rivaroxaban: State-of-the-Art Review.

Rivaroxaban is a direct oral anticoagulant (DOAC) that directly inhibits coagulation factor Xa and exerts its anticoagulant effects. Although rivaroxaban generally exhibits predictable pharmacokinetic (PK) and pharmacodynamic (PD) profiles, significant interindividual variability in therapeutic responses exists. Research on the role of genetic factors in the clinical variability of rivaroxaban is relatively new and extensive.

Autophagy-dependent sensitization effects of PARP inhibitors on recurrent nasopharyngeal carcinoma treated with carbon ion and photon irradiation.

Tumor radioresistance and severe toxicity make reirradiation for recurrent nasopharyngeal carcinoma (NPC) a significant clinical challenge. This study aims to investigate the ability of the poly(ADP-ribose) polymerase (PARP) inhibitor olaparib to sensitize recurrent NPC cells irradiated with photon or carbon ion (C-ion), and to explore the underlying mechanism of the synergistic promotion of cell death by olaparib and ionizing radiation. The results show that olaparib has significant X-ray and C-ion radiosensitization effects on recurrent NPC cells and the associated HK-RR photon-resistant model.

Inequality in mortality risk of older adults between rural and urban areas exposure to temperature variations in China.

Background: Non-optimal ambient temperatures have been demonstrated to negatively affect a variety of health outcomes, particularly population mortality. However, the mortality risk of older adults between rural and urban areas exposure to temperature variations remain unclear.

Methods: Here, leveraging the panel data for 27,193 older adults from the largest and most complete Chinese Longitudinal Healthy Longevity Survey during 2005-2018, we explored the impacts of temperature variations like low/high and extreme temperatures on mortality risk of older adults in China.

New role of obscure acylation modifications in cardiovascular diseases: what's beyond?

Cardiovascular diseases remain the leading cause of global mortality, yet their molecular mechanisms are incompletely understood. Recent advances highlight the critical role of obscure acylation modifications in regulating cardiac homeostasis and disease pathogenesis, such as succinylation, crotonylation, malonylation, β-hydroxybutyrylation, and lactylation. These post-translational modifications serve as metabolic sensors, dynamically linking cellular metabolism to epigenetic and functional changes in proteins.

The development and validation of a self-reinforcement scale for repeated blood donation.

The current study aimed to develop and validate a self-reinforcement scale for repeated blood donation (SRS-RBD). In Study 1, six items were created, and the factor structure of SRS-RBD was explored among 155 Chinese student blood donors. In Study 2, SRS-RBD was validated among 164 donors.

Revealing the photocatalytic dissociation of water molecules on rutile TiO surface hybrid functional based linear response time-dependent density functional theory.

Rutile TiO shows great potential for photocatalytic water (HO) splitting into oxygen (O) and hydrogen peroxide (HO). However, the mechanism of surface water oxidation on rutile TiO remains unclear, involving complex ground-state thermal catalysis and excited-state photocatalysis processes. Here, by using linear response time-dependent density functional theory (LR-TDDFT), we investigate HO oxidation at both the ground-state and excited-state levels.

Reshaping the Ability-Strategy Link in Emotion Regulation: The Role of a Structured Picture-Book Intervention for Preschoolers.

Emotion-regulation ability and strategy (i.e., the specific behaviors used to manage feelings) are crucial for preschoolers' socioemotional development.

Low-Rank Approximations for Accurate and Efficient Plane-Wave Second-Order Møller-Plesset Perturbation Theory.

The second-order Møller-Plesset perturbation (MP2) theory is a post-Hartree-Fock method widely used to describe weak correlation energies in solids and molecules, but its high computational cost scales as (). Herein, we present an accurate and efficient implementation of MP2 within the plane-wave (PW) basis set for both periodic and molecular systems, which incorporates the interpolative separable density fitting (ISDF) decomposition and the Laplace transformation (LT) of the energy denominator. These innovations avoid the direct construction of electron repulsion integrals (ERIs) and reduce the computational complexity of MP2 from () to ().

Superconductivity in Electrochemically Intercalated /‑CTA-SnSe by Using Chiral Piezoelectric Precursors.

Molecule intercalation has shown distinct advantages in modulating the superconducting properties of 2D materials. Chiral molecule intercalation provides a strategy for tuning electronic properties, while this approach has been limited to a few 2D materials such as TaS and TiS. Although extensive research on 2D SnSe exists, chiral molecule intercalation in SnSe remains unexplored.

Integration of Carbonyl Groups with 1,3,4-Oxadiazoles: A Heat-Resistant Energetic Compound with Well-Balanced Performance via Heterocycle Transformation.

The exceptional combination of high density and superior thermal stability renders ketone-based energetic compounds particularly attractive for heat-resistant explosives. While extensive research has demonstrated successful carbonyl functionalization of azoles, such as pyrazoles, triazoles, 1,2,4-oxadiazoles, and imidazoles, the potential of carbonyl-substituted 1,3,4-oxadiazole systems has surprisingly never been explored in energetic materials. In this study, the tetrazole-based energetic material 2,2'-bis(dinitromethyl)-2,2'-5,5'-bitetrazole () reacted with nitrosulfur mixed acid, successfully yielding the ketone-based energetic compound [2,2'-bi(1,3,4-oxadiazole)]-5,5'(4,4')-dione () featuring a bis(1,3,4-oxadiazole) skeleton.

Detachable coils and glue embolization for hemoptysis secondary to anomalous systemic arterial supply to the left lower lobe: a case report and literature review.

Anomalous systemic arterial supply to the left lower lobe (ASALLL) is a rare congenital vascular malformation. It predominantly occurs in young and middle-aged adults, often presenting with recurrent hemoptysis of unknown etiology. The condition has a high clinical misdiagnosis rate, and its optimal treatment remains controversial.

Constructing NIR-II Fluorophores with Enhanced Fluorescence Quantum Efficiency via Asymmetric D-A-D' Molecular Architectures.

Organic donor-acceptor-donor (D-A-D) fluorophores with emission in the second near-infrared (NIR-II) window have attracted growing attention for bioimaging applications. While incorporating strong electron donor and acceptor units into the molecular framework enables long-wavelength emission, it inevitably leads to a decrease in the fluorescence quantum efficiency (FQE). Herein, we investigated the microscopic mechanism underlying luminescent efficiency enhancement in NIR-II chromophores featuring asymmetric D-A-D' molecular architectures.

Schistosoma japonicum leishmanolysin SjLLPi1 facilitates the invasion of cercariae into the host skin.

Background: Schistosomiasis is an important neglected tropical disease necessitating focus. Cercarial proteases are essential for schistosome invasion. Leishmanolysin has been identified as the most predominant protease in Schistosoma japonicum (S.

Effect of acid modification of Biochar derived from spent mushroom substrate on the production of oyster mushroom (Pleurotus ostreatus).

Spent mushroom substrate (SMS) disposal presents significant environmental challenges in the edible fungi industry. Converting SMS into biochar offers a promising resource utilization approach; however, the original biochar properties limit its effectiveness in mushroom cultivation applications. In this study, SMS biochar was modified by phosphoric acid treatment to form acid-modified mushroom substrates (AMMS), and the influence of acid-modified mushroom substrates on the production of oyster mushroom was evaluated.

Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression.

Background: Osteosarcoma (OS) is one of the most common malignancies arising in bone. Hypoxia and immune regulation are pivotal in tumor biology. However, their combined effects and mechanisms in OS remain understudied.

CYP2C19 genotype-guided antiplatelet therapy to prevent thromboembolic events after stent-assisted coil embolization of unruptured intracranial aneurysms: a retrospective cohort study.

Background: CYP2C19 genotyping has been widely studied to guide antiplatelet therapy in cardiovascular disease; however, its role in neurointerventional procedures, particularly for unruptured intracranial aneurysms (UIA), remains underexplored. This study aimed to evaluate the clinical utility of CYP2C19-guided antiplatelet therapy following stent-assisted coil embolization (SAC) in patients with UIA.

Methods: A total of 403 patients who underwent SAC were included.

Machine Learning-Assisted Real-Time Inflammation Monitoring and Optimal Treatment of Diabetic Wounds Based on a Ratiometric Fluorescent Sensing Peptide Hydrogel.

Managing inflammation in diabetic chronic wounds remains a major clinical challenge, primarily due to the lack of real-time monitoring techniques. To address this issue, we developed a peptide hydrogel capable of simultaneously monitoring the inflammation status and promoting healing. The hydrogel was formed by coassembling polyglutamic acid with polylysine that was premodified with coumarin 7 (an ACQ fluorophore) and tetraphenylethene (an AIE fluorophore).

Structural stability and thermal transport properties of CaSiOmonolayer.

Thermoelectric materials exhibit significant potential for efficiently converting temperature differentials into electrical energy. Recent advancements in material science and nanotechnology continue to drive improvements in thermoelectric performance and broaden their range of applications. Here, we carry out extensive structure searches of two dimensional (2D) CaSiOmonolayer by CALYPSO structural prediction method and first-principles calculations.

LocPro: A deep learning-based prediction of protein subcellular localization for promoting multi-directional pharmaceutical research.

Drug development encompasses multiple processes, wherein protein subcellular localization is essential. It promotes target identification, treatment development, and the design of drug delivery systems. In this research, a deep learning framework called LocPro is presented for predicting protein subcellular localization.

CRISPR/Cas9-mediated editing of ptprfb (protein tyrosine phosphatase receptor type fb) reveals its regulatory role in zebrafish spermatogenesis.

Gonadal development and gamete maturation are essential for fish reproduction. The protein tyrosine phosphatase receptor type Fb (Ptprfb) is a member of the tyrosine phosphatase family. In the present study, we used CRISPR/Cas9 to mutate ptprfb in zebrafish.

Study on the Mechanism of Bone Marrow Stem Cell-Derived Exosome miR-30a/DLL4 Acting on Traumatic Brain Injury Angiogenesis.

Objective: To explore the effects of bone marrow stem cell (BMSC)-derived exosome miR-30a/DLL4 expression on angiogenesis following traumatic brain injury (TBI), which may provide a novel therapeutic strategy for postoperative TBI recovery.

Methods: A rat TBI model was established using the free-fall method, and exosomes from different sources were injected into the brain. Rats were divided into sham-operated, TBI model, TBI+inhibitor NC-Exo, TBI+miR-30a-inhibitor-Exo, TBI+OE NC-Exo, and TBI+DLL4-OE-Exo groups.

Migrasome-Related Prognostic Genes in Gastric Cancer: A Transcriptomic and Immunotherapeutic Analysis.

Introduction: Gastric cancer (GC) remains one of the leading causes of cancer-related deaths worldwide, characterized by complex pathogenesis and poor prognosis. Migrasomes, as newly discovered organelles, play crucial roles in tumor microenvironment modulation and immune regulation. However, their specific mechanisms in GC remain largely unknown.

A Survey of Attacks on Large Vision-Language Models: Resources, Advances, and Future Trends.

With the significant development of large models in recent years, large vision-language models (LVLMs) have demonstrated remarkable capabilities across a wide range of multimodal understanding and reasoning tasks. Compared with traditional large language models (LLMs), LVLMs present great potential and challenges due to their closer proximity to the multiresource real-world applications and the complexity of multimodal processing. However, the vulnerability of LVLMs is relatively underexplored, posing potential security risks in the daily use of LVLM applications.

RAC2 drives hypoxia-mediated radiation resistance in nasopharyngeal carcinoma.

Nasopharyngeal carcinoma (NPC) exhibits unique radiosensitivity, yet radioresistance remains a major therapeutic challenge. This study investigates the role of RAC2 in hypoxia-induced radioresistance through reactive oxygen species (ROS) regulation. Radiation effectiveness was demonstrated through dose-dependent DNA damage, proliferation inhibition, and ROS elevation in NPC cells, while hypoxic conditions attenuated these effects.