N-Doping/KOH Synergy in Waste Moss Biochar for Geosmin Removal in Aquaculture Water: Elucidating Surface Functionalization and Activation Mechanisms.

Taste and odor (T&O) has always been a critical issue in drinking water treatment and quality improvement of aquatic products [...

CYP2C19 genotype-guided antiplatelet therapy to prevent thromboembolic events after stent-assisted coil embolization of unruptured intracranial aneurysms: a retrospective cohort study.

Background: CYP2C19 genotyping has been widely studied to guide antiplatelet therapy in cardiovascular disease; however, its role in neurointerventional procedures, particularly for unruptured intracranial aneurysms (UIA), remains underexplored. This study aimed to evaluate the clinical utility of CYP2C19-guided antiplatelet therapy following stent-assisted coil embolization (SAC) in patients with UIA.

Methods: A total of 403 patients who underwent SAC were included.

Engineering for Efficient Terpenoid Production.

Terpenoids are structurally complex natural products with broad agricultural and therapeutic value, yet their low natural abundance and oxidative tailoring requirements complicate scalable production. Conventional microbial hosts often fail to support cytochrome P450-mediated oxidative tailoring, limiting access to complex derivatives. Here, we developed two hosts as alternative chassis, leveraging their extensive biosynthetic capabilities and native oxidative enzyme repertoires.

Genome mining reveals a highly oxidized bacterial perhydrophenanthrene meroterpenoid smelanic acid.

Bacterial perhydrophenanthrene meroterpenoids are rare natural products featuring highly oxidized 6/6/6 fused tricyclic scaffolds. Using our previously characterized non-canonical terpene cyclase AtoE as a guide, we conducted targeted genome mining and identified a cryptic biosynthetic gene cluster in containing SmeD, an AtoE homolog with 46.15% sequence identity.

Supramolecular nanomedicines derived from phase-change materials coated with hyaluronic acid for multi-modality cancer therapy.

The treatment of malignant tumors such as melanoma has always been a world-class problem. Single-modality therapy for melanoma is often faced with a balance of therapeutic outcomes and side effects. Combination of multi-modality could greatly improve therapeutic effect without introducing side effects.

Encapsulation of nanoparticles with Xe adsorption sites into MOFs for enhanced Xe/Kr separation.

Xenon (Xe) and krypton (Kr) are important gases with significant industrial and medical applications. Metal-organic frameworks (MOFs) are a promising class of sorbent materials for Xe/Kr separation. To enhance the Xe/Kr separation performance of MOFs, we develop a strategy to encapsulate Pt nanoparticles into MOFs to introduce strong Xe adsorption sites.

Imaging of non-ideal leakage from electromagnetic shielding components using quantum magnetometry.

In this work, nitrogen-vacancy (NV) center ensembles in diamond were employed to map leakage magnetic fields from electromagnetic shielding components. A phase accumulation method enabled self-traceable magnetic field calibration without external references. With synchronous current excitation, the leakage field of an RG316 coaxial cable was characterized, revealing T-level field strength for the first time.

Effect of endovascular management and anticoagulation alone on acute deep venous thrombosis in patients with inferior vena cava thrombosis.

This retrospective analysis assesses the effectiveness and safety of pharmacomechanical thrombectomy (PMT) and join CDT (catheter-directed thrombolysis) compared to CDT and with standard anticoagulation therapy for LEDVT (acute lower extremity deep vein thrombosis) with concomitant IVCT (inferior vena cava thrombosis). From January 2014 to January 2020, a total of 114 patients were diagnosed with acute LEDVT and IVCT at Shanxi Bethune Hospital. Patients were separated into three groups: PMT ± CDT (n = 77; 25 in this group also received CDT), CDT ± catheter thrombectomy (CDT ± CT) (n = 21), and conservative management (n = 16).

Ultrafast Coherent Electron Transfer through Intermolecular Quantum Well States.

Molecular materials offer a boundless design palette for light absorption and charge transport in both natural photosynthesis and engineered photovoltaics. They function in combination as chromophores, donors, conductors, and acceptors, enabling the excitation and charge carrier transport through space and wire-like intramolecular pathways. Although quantum coherence is believed to enhance photoexcitation and photoinduced charge transfer, fluctuating and inhomogeneous environments accelerate decoherence.

Association Between the Amount of Carotid Perivascular Adipose Tissue and Prior Ischemic Stroke: An MR Imaging Study.

Background: This study aimed to explore the association between the amount of carotid artery perivascular adipose tissue (PVAT) quantified by magnetic resonance imaging and prior cerebral infarction.

Methods: A total of 139 patients (mean age, 64.4±8.

RNA methylated long non-coding RNAs as potential biomarkers for prognosis prediction in patients with lung adenocarcinoma: development of a risk assessment model.

Introduction: Lung adenocarcinoma (LUAD) is the most prevalent form of lung cancer worldwide. Long non-coding RNA (lncRNAs) are non-protein coding RNAs that are involved in lung cancer. This study aimed to develop a lncRNA-based risk assessment model based on RNA methylation to evaluate the prognosis of patients with LUAD.

Chemical and optical distinctions between elemental carbon subcategories Char-EC and Soot-EC: Insights from a haze event in North China.

Elemental carbon (EC), an important pollutant component in the atmosphere, is composed of two subcategories: Char-EC and Soot-EC. Their differences in chemical structure and light absorption capacity need further investigation. This study focused on an hourly time-resolved haze event in Wangdu, Hebei Province, eliminating potential interference from organic carbon, to compare the differences in aromatic condensation degree and mass absorption cross-section (MAC) between Soot-EC and Char-EC.

Crystal Structure and Catalytic Mechanism of the cis-Eunicellane Cyclase AriE.

Eunicellane diterpenoids, with over 360 known examples characterized by a cis- or trans-6/10-bicyclic carbon skeleton, exhibit diverse biological activities. To date, five eunicellane cyclases (ECs) have been reported: cis-ECs (Bnd4, CpDTS2 and EcTPS1) and trans-ECs (AlbS and MicA), yet the structural basis and molecular mechanisms governing their distinct cis- or trans-cyclization modes remain unsolved. Here, we present the crystal structure of a cis-EC AriE from Amycolatopsis arida, which catalyzes geranylgeranyl diphosphate to form cis-6/10-fused bicyclic benditerpe-2,6,15-triene (1) in aridacin biosynthesis.

Accelerating Nitrite Reduction to Ammonia: The Synergistic Effect of Dual Active Site Pt-Ir Catalysts.

Ir-based catalysts have been demonstrated as promising catalysts for the reduction of NO to ammonia (NRA). However, the strong competitive adsorption of NO over H on Ir sites, leading to H* deficiency at high NO concentrations, would hinder its real application. Here, we proposed an effective strategy to solve this problem by constructing dual active site Ir-Pt/TiO composite catalysts with physical mixing (Ir+Pt/TiO) and co-impregnation (IrPt/TiO) methods.

Knowledge, attitude, and practice of orthopedic, vascular surgery, and anesthesiology doctors regarding postoperative deep vein thrombosis prevention in surgical patients.

Orthopedic and vascular surgeries carry a high risk of postoperative deep vein thrombosis (DVT). This cross-sectional study assessed the knowledge, attitude, and practice (KAP) of orthopedists, vascular surgeons, and anesthesiologists regarding postoperative DVT prevention in surgical patients. The study was performed at two hospitals in China from November 22 to December 13, 2023.

The electronic, stability and mechanical properties of the kagome lattice CsTiBiunder pressure: a first-principles study.

The kagome lattices of theTiBifamily have recently garnered significant attention due to their superconducting and topological properties. Here, we conducted an in-depth analysis of the band structure of the prototypical titanium-based kagome lattice material, CsTiBi, using Density Functional Theory. We revealed its topological properties and demonstrated that the Van Hove singularities can be effectively tuned to the Fermi level under 18 GPa.

Integration Analysis of Circle-Sequencing and Transcriptome Reveals Extrachromosomal Circular DNA Is Involved in the Regulation of Vascular Cambium Annual Cycle in Chinese Pine.

Extrachromosomal circular DNA (eccDNA) has been reported to play important roles in regulating genome replication, immune response and cellular communications in humans and animals. Recently, the presence of eccDNA has also recently been discovered in Arabidopsis, Amaranthus palmeri and Oryza sativa. Nevertheless, whether eccDNA exists and has roles in woody plants remains enigmatic.

RNF112 Facilitates Ubiquitin-Mediated Degradation of c-Myc, Suppressing Proliferation, Migration and Lipid Synthesis in Bladder Cancer.

The E3 ubiquitin ligase RNF112 is significantly downregulated in bladder cancer (BLCA) and is correlated with disease progression. In vitro and in vivo studies indicated that RNF112 suppresses BLCA cell proliferation, migration, and lipid synthesis. Mechanistically, RNF112 directly interacts with the MB II domain of MYC through its N-terminal zinc finger motif, and its catalytic site C97 facilitates K48-linked polyubiquitination of the K389 residue on the c-Myc protein, accelerating its degradation.

FeP/ZnS Heterostructures Supported on N-Doped Porous Carbon as Efficient Oxygen Reduction Electrocatalysts for High-Performance Zinc-Air Batteries.

The development of oxygen reduction reaction (ORR) catalysts with high catalytic activity, high stability, and low cost is of great significance for the development of rechargeable zinc-air batteries (ZABs). Designing heterostructures within the catalyst can regulate the charge distribution to enhance the electron transfer rate during the catalytic process, and optimize the adsorption of oxygen-containing intermediates, resulting in high-performance ORR catalysts. In this study, FeP/ZnS heterostructures supported on N-doped porous carbon (FeP/ZnS@NC) are designed and fabricated through one-step synthesis via high-temperature pyrolysis.

EC-IC Bypass for Skull Base Necrosis and ICA Rupture Hemorrhage After Radiotherapy for Nasopharyngeal Carcinoma.

Background: Skull base necrosis can cause life-threatening massive bleeding in patients following radiotherapy and chemotherapy for nasopharyngeal carcinoma. Patients with bilateral internal carotid artery rupture and hemorrhage are especially susceptible, which is a major challenge for clinicians.

Methods: A team at the Eye and ENT Hospital affiliated with Fudan University recently successfully treated a patient with skull base necrosis after radiotherapy and chemotherapy for nasopharyngeal carcinoma.

[Moxibustion Inhibits Postmenopausal Bone Loss by Regulating the Metabolism of Gut Microbiota-Related Serotonin].

Objective: To investigate the regulatory effect of moxibustion, a traditional Chinese medicine therapy, on bone metabolism in ovariectomized (estrogen-deficient) mice and to explore its underlying mechanisms.

Methods: Female C57BL/6J mice of 12 weeks old were randomly assigned to five groups, including a sham operation control group (SHAM), an ovariectomy group (OVX), a group given ovariectomy and broad-spectrum antibiotics (OVX-A), a group given ovariectomy and moxibustion (OVX-M), and a group given ovariectomy, broad-spectrum antibiotics, and moxibustion (OVX-A-M), with 5 mice in each group. Then, 4 weeks post-surgery, the mice in each group received broad-spectrum antibiotics and/or moxibustion intervention for an additional 4 weeks.

Sterically chained amino acid-rich water-soluble carbon quantum dots as a robust tumor-targeted drug delivery platform.

Effective antitumor nanomedicines maximize therapeutic efficacy by prolonging drug circulation time and transporting drugs to target sites. Although numerous nanocarriers have been developed for accurate tumor targeting, their limited water solubility makes their stable storage challenging, and poses biosafety risks in clinical translation. Herein, we choose reduced glutathione (GSH) to quick synthesize gram-scale water-soluble large amino acids mimicking carbon quantum dots (LAAM GSH-CQDs) enriched in steric chain amino acid groups with solubility of up to 2.

Recent Progress in the Design and Application of Strong Metal-Support Interactions in Electrocatalysis.

The strong metal-support interaction (SMSI) in supported metal catalysts represents a crucial factor in the design of highly efficient heterogeneous catalysts. This interaction can modify the surface adsorption state, electronic structure, and coordination environment of the supported metal, altering the interface structure of the catalyst. These changes serve to enhance the catalyst's activity, stability, and reaction selectivity.

Characteristics, Incidence, and Management of Immune Checkpoint Inhibitors Related Cardiovascular Adverse Events in Real-World Practice-A Retrospective Study in Chinese Han Population.

Purpose: This study aimed to elaborate on the incidence, clinical features, and management of immune checkpoint inhibitors (ICIs) related cardiovascular adverse events (CVAEs) in real-world practice.

Patients And Methods: We performed a retrospective chart review study on patients receiving at least one dose of ICI therapy at a Chinese tertiary hospital from March 2020 to March 2021. CVAEs were identified through clinical assessment and the Naranjo algorithm.

5-hydroxymethylcytosine features of portal venous blood predict metachronous liver metastases of colorectal cancer and reveal phosphodiesterase 4 as a therapeutic target.

Metachronous liver metastases (MLM) are characterised by high incidence and high mortality in clinical colorectal cancer treatment. Currently traditional clinical methods cannot effectively predict and prevent the occurrence of metachronous liver metastasis in colorectal cancer. Based on 5hmC-Seal analysis of blood and tissue samples, this study found that portal venous blood was more relevant to tumour gDNA than peripheral blood.