Drought tolerance evaluation of Fraxinus mandshurica in a semi-arid area.

Background: Rupr. is a key forest species in Northeast Asia, primarily distributed in semi-humid regions. Given its wide range of provenances, exhibits substantial genetic and phenotypic variations.

Reduction-responsive RNAi nanoplatform for enhanced cancer sonoimmunotherapy via dual inhibition of mitophagy and Nrf2 pathways.

Sonodynamic therapy (SDT) has emerged as a promising non-invasive modality with deeper tissue penetration than photodynamic or chemodynamic therapies. However, its therapeutic efficacy remains limited due to inadequate reactive oxygen species (ROS) generation, largely attributed to tumor-intrinsic antioxidant systems and mitophagy. Existing combinations of SDT with immunotherapy are primarily additive and fail to address the mechanistic interplay between ROS suppression and immune evasion.

Long-Term Effect of Cognitive Behavioral Therapy in Managing Subclinical Depression: A Systematic Review and Meta-Analysis.

Recent research has emphasized the continuum of depression, highlighting the significance of early intervention for subclinical depression. However, previous studies often focused on specific populations or lacked comparisons across participants and intervention characteristics in the effectiveness of cognitive behavioral therapy (CBT). This systematic review and meta-analysis (CRD42024498284) aimed to address these gaps by examining the effectiveness of CBT in managing subclinical depression and its potential for preventing the transition to major depression.

Comparison of proximal femoral universal nail and proximal femoral nail anti-rotation internal fixation for older patients with intertrochanteric femoral fracture: a retrospective cohort study.

Introduction: Intertrochanteric femoral fractures (IFF) are among the most common lower limb fractures in the older population. Our team has developed a new cephalomedullary nail design called the proximal femoral universal nail (PFUN). This study aimed to compare the clinical outcomes of PFUN and proximal femoral nail anti-rotation (PFNA) internal fixation for the treatment of IFF in older patients.

Risk and protective factors for bereavement adaptation: a protocol for a systematic review and meta-analysis.

Introduction: Many people experience lifelong impacts after losing a loved one. Bereavement adaptation, which refers to how people adapt to changes after a death, is crucial for their subsequent life stages. Bereavement experienced during one's childhood or teenage years can be even more challenging, considering the dual burden of bereavement adaptation and developmental tasks.

Nanoparticle-induced excessive mitophagy combined with immune checkpoint blockade for enhanced cancer immunotherapy.

Tumor microenvironment (TME) is the major obstacle in cancer immunotherapy due to its adverse effects on tumor-infiltrating immune cells. Emerging evidences have revealed that mitophagy plays an important role in regulating cell fate and immune microenvironment. Targeted regulation of mitophagy could be a promising strategy for enhanced cancer immunotherapy, which however remains unexploited due to the absence of robust therapeutic platform.

Popliteal sciatic nerve block versus intrathecal anesthesia for Achilles tendon rupture repair surgery: a mono-centric retrospective comparative study.

Background: To compare the anesthetic and analgesic effects of popliteal sciatic nerve block and intrathecal anesthesia in acute Achilles tendon rupture patients undergoing surgery.

Methods: This retrospective cohort study analyzed 115 patients with acute Achilles tendon rupture who underwent surgery at Peking University Third Hospital between May and November 2023. After excluding cases lost to follow-up or declining participation, 96 patients were ultimately enrolled.

Case Report: A case of severe pulmonary hypertension combined with FBN1 mutation associated geleophysic dysplasia.

Background: FBN1 gene mutation-associated geleophysic dysplasia (GD) leads to the formation of complex and refractory pulmonary hypertension (PH) through a multifactorial combination of precapillary factors, postcapillary factors, and respiratory pathology. However, clinical experience regarding the diagnosis and management of these patients remains limited.

Case Report: The patient was admitted to the hospital with severe PH symptom.

Association of serum lysophosphatidylcholine acyltransferase 3 levels with metabolic variables and risk of type 2 diabetes mellitus: A cross-sectional study.

Aims: This study aimed to explore the role of serum lysophosphatidylcholine acyltransferase 3 (LPCAT3) in glucose and lipid metabolism and its association with type 2 diabetes mellitus (T2DM).

Methods: Between July and December 2024, we recruited 256 newly diagnosed T2DM patients and 252 gender- and age-matched individuals with normal glucose tolerance (NGT). Serum LPCAT3 levels were measured using ELISA.

SAM2-DFBCNet: A Camouflaged Object Detection Network Based on the Heira Architecture of SAM2.

Camouflaged Object Detection (COD) aims to segment objects that are highly integrated with their background, presenting significant challenges such as low contrast, complex textures, and blurred boundaries. Existing deep learning methods often struggle to achieve robust segmentation under these conditions. To address these limitations, this paper proposes a novel COD network, SAM2-DFBCNet, built upon the SAM2 Hiera architecture.

Clinical study of 3D-printed personalized prostheses for the treatment of traumatic metacarpophalangeal joint defects.

Background: Complex trauma results in a variety of nonstandard bone defects in the metacarpophalangeal (MCP) joints of patients, limiting the choice of commercial prostheses. This study aims to investigate the early clinical efficacy of 3D-printed personalized prostheses in the reconstruction of traumatic MCP joints.

Methods: A retrospective analysis was conducted on 7 cases of 3D printed MCP joint prostheses replacement surgeries performed by the same surgeon.

Single-cell transcriptomics identifies PDGFRA progenitors orchestrating angiogenesis and periodontal tissue regeneration.

Periodontal bone defects, primarily caused by periodontitis, are highly prevalent in clinical settings and manifest as bone fenestration, dehiscence, or attachment loss, presenting a significant challenge to oral health. In regenerative medicine, harnessing developmental principles for tissue repair offers promising therapeutic potential. Of particular interest is the condensation of progenitor cells, an essential event in organogenesis that has inspired clinically effective cell aggregation approaches in dental regeneration.

Delivery of an ERK inhibitor using bioactive lipid nanoparticles reduces angiogenesis and prevents oral squamous cell carcinoma development.

Extracellular regulated protein kinases (ERK) signaling is aberrantly activated in oral squamous cell carcinoma (OSCC), and targeting ERK signaling with ERK1/2 inhibitors is a potential strategy for OSCC treatment. However, methods for the more efficient delivery of ERK inhibitors to improve drug utilization remains a pressing challenge. Notably, the application of antiangiogenic therapies to treat OSCC has received increasing attention, yet single therapies often have very limited efficacy.

Chatbot-delivered structured psychological intervention (SPI-Bot) for teenagers with adolescent idiopathic scoliosis in Hong Kong: protocol for a pilot randomised controlled trial.

Introduction: Adolescent idiopathic scoliosis (AIS) often imposes a significant psychological burden on teenagers. Cognitive and behavioural strategies have demonstrated the potential to alleviate these challenges. Chatbots, with their real-time interaction capabilities, provide a promising and accessible approach to delivering psychological interventions for young people.

Open surgery and minimally invasive repair of acute Achilles tendon rupture: stratified outcomes based on immobilization duration in a prospective cohort study.

Background: Acute Achilles tendon rupture (AATR) surgical repair debates center on the clinical efficacy of minimally invasive surgery (MIS) versus open surgery (OS), with immobilization duration poorly stratified. This prospective cohort study aimed to compare clinical outcomes of OS and MIS for AATR repair and evaluate the impact of immobilization duration (0, 2, or 4 weeks) on postoperative rehabilitation.

Methods: A total of 474 patients undergoing surgical repair for acute AATR were stratified into six groups based on surgical approach (OS: 265 cases; MIS: 209 cases) and immobilization duration (0, 2, or 4 weeks).

Knowledge attitude and practice of pregnant women on postnatal depression in Henan Province China.

Postnatal depression is a common maternal mental health problem with substantial public health implications, yet limited attention has been given to pregnant women's perceptions and responses to it. There are few studies explore pregnant women's Knowledge, Attitude, and Practice (KAP) towards postnatal depression. This study aimed to investigate the knowledge, attitude, and practice (KAP) of pregnant women regarding postnatal depression in Henan Province, China, between June and November 2023.

A novel immunocompetent transgenic mouse model of DHF reveals Syk-mediated Th2-polarized cytokine storm as a key driver of vascular leakage.

Dengue virus (DENV) infection remains a critical global health threat, with DENV-2 being the most virulent serotype capable of causing lethal dengue hemorrhagic fever (DHF), a severe complication characterized by plasma leakage and hemorrhagic manifestations. While the search for viral receptors and immunocompetent animal models has persisted since the first recorded outbreak in 1779, significant gaps remain. Here, we establish the first immunocompetent murine model of DHF with intact innate/adaptive immunity by generating hTim4-transgenic C57BL/6J mice.

E-Cigarette Use Behavior and Influencing Factors Among People Aged 15 Years and Above - Beijing Municipality, China, 2016-2023.

What Is Already Known About This Topic?: The electronic cigarette (e-cigarette) market in China has been gradually expanding. Substantial evidence indicates that e-cigarettes pose considerable health risks to the human body.

What Is Added By This Report?: The prevalence of e-cigarette ever use among Beijing residents aged ≥15 years ranged from 5.

Scenario-based simulation of ecosystem service supply and demand in China's Yangtze River Economic Belt.

Balancing the supply and demand of ecosystem services is essential for achieving regional sustainable development. A key scientific challenge lies in identifying and improving areas with ecosystem service supply-demand ratio (ESR) imbalances across different spatial scales. Aiming to promote the coordinated development of the economy and ecology in China's Yangtze River Economic Belt (YREB), this study employed a simulated annealing algorithm coupled with the FLUS model to simulate five future land use scenarios for the year 2030.

STAT5/VCAN/PI3K signaling pathway promotes fibroblast activation and lung fibrosis.

Rationale: Pulmonary fibrosis (PF) is a progressive and debilitating disease characterized by the excessive deposition of extracellular matrix (ECM) components. The activation of fibroblasts and the production of large amounts of ECM are important factors in the development of PF. This study aimed to elucidate the role and mechanism of versican (VCAN) in promoting PF and to identify therapeutic targets for PF.

The effects of anterior spaces on the intrusion of mandibular incisors with clear aligners in extraction cases: a finite-element analysis.

Background: The intrusion of mandibular incisors presents significant challenges for orthodontists utilizing clear aligner therapy, primarily due to issues such as reduced accuracy in achieving intrusion and unexpected tipping movements. This study aims to investigate the biomechanical effects of varying anterior tooth spaces on the intrusion of mandibular incisors in extraction cases, offering insights that may enhance treatment outcomes.

Methods: A finite element model was created, encompassing the mandibular dentition (excluding first premolars), mandible, periodontal ligaments, and clear aligners.

Necroptosis in sepsis: Mechanisms and therapeutic potential.

Sepsis, a life-threatening condition characterized by systemic inflammatory responses, remains a significant challenge in clinical settings due to its complex pathogenesis and limited therapeutic strategies. Central to this conundrum is the role of cell death mechanisms, particularly necroptosis, in the progression and resolution of sepsis. Necroptosis, a regulated form of necrotic cell death, not only exacerbates inflammation through the release of intracellular contents but also compromises barrier functions, facilitating microbial translocation and systemic spread.

Multi channel fusion diffusion models for brain tumor MRI data augmentation.

The early diagnosis of brain tumors is crucial for patient prognosis, and medical imaging techniques such as MRI and CT scans are essential tools for diagnosing brain tumors. However, high-quality medical image data for brain tumors is often scarce and difficult to obtain, which hinders the development and application of medical image analysis models. With the advancement of artificial intelligence, particularly deep learning technologies in the field of medical imaging, new concepts and tools have been introduced for the early diagnosis, treatment planning, and prognosis evaluation of brain tumors.

Ultrabright Entanglement Based Quantum Key Distribution over a 404 km Optical Fiber.

Entangled photons are crucial resources for quantum information processing. Here, we present an ultrabright polarization-entangled photon source based on a periodically poled lithium niobate waveguide designed for practical quantum communication networks. Using a 780 nm pump laser, the source achieves a pair generation rate of 2.

Assessment of pressure discomfort for over-ear wearables and the relationships with objective metrics.

The objective of this study is to develop an enhanced methodology for analysing individuals' perceptions of discomfort due to the pressure exerted by over-ear headphones. Using principal component analysis and K-means clustering, we categorise 602 samples into six clusters and create representative Chinese head-and-ear models. A pressure tester was then developed to quantify the pressure exerted on head and ear regions by the headphone cushions.