98%
921
2 minutes
20
The early diagnosis of brain tumors is crucial for patient prognosis, and medical imaging techniques such as MRI and CT scans are essential tools for diagnosing brain tumors. However, high-quality medical image data for brain tumors is often scarce and difficult to obtain, which hinders the development and application of medical image analysis models. With the advancement of artificial intelligence, particularly deep learning technologies in the field of medical imaging, new concepts and tools have been introduced for the early diagnosis, treatment planning, and prognosis evaluation of brain tumors. To address the challenge of imbalanced brain tumor datasets, we propose a novel data augmentation technique based on a diffusion model, referred to as the Multi-Channel Fusion Diffusion Model(MCFDiffusion). This method tackles the issue of data imbalance by converting healthy brain MRI images into images containing tumors, thereby enabling deep learning models to achieve better performance and assisting physicians in making more accurate diagnoses and treatment plans. In our experiments, we used a publicly available brain tumor dataset and compared the performance of image classification and segmentation tasks between the original data and the data enhanced by our method. The results show that the enhanced data improved the classification accuracy by approximately 3% and the Dice coefficient for segmentation tasks by 1.5%-2.5%. Our research builds upon previous work involving Denoising Diffusion Implicit Models (DDIMs) for image generation and further enhances the applicability of this model in medical imaging by introducing a multi-channel approach and fusing defective areas with healthy images. Future work will explore the application of this model to various types of medical images and further optimize the model to improve its generalization capabilities. We release our code at https://github.com/feiyueaaa/MCFDiffusion.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12215855 | PMC |
http://dx.doi.org/10.1038/s41598-025-06529-1 | DOI Listing |
Curr Med Imaging
September 2025
Department of Pharmacy, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325035, China.
Unlabelled: Leptomeningeal metastasis (LM) is a severe complication of solid malignancies, including lung adenocarcinoma, characterized by poor prognosis and diagnostic challenges. This study assesses whether curvilinear peri-brainstem hyperintense signals on MRI are a characteristic feature of LM in lung adenocarcinoma patients.
Methods: This retrospective study analyzed data from multiple centers, encompassing lung adenocarcinoma patients with peri-brainstem curvilinear hyperintense signals on MRI between January 2016 and March 2022.
Front Immunol
September 2025
Precision Pharmacy and Drug Development Center, Department of Pharmacy, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China.
Gliomas are the most common primary malignant tumors of the central nervous system (CNS), and despite progress in molecular diagnostics and targeted therapies, their prognosis remains poor. In recent years, immunotherapy has emerged as a promising treatment modality in cancer therapy. However, the inevitable immune evasion by tumor cells is a key barrier affecting therapeutic efficacy.
View Article and Find Full Text PDFiScience
September 2025
Department of Molecular Pathology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences, QingDao, Shandong 266300, China.
Gliomas are common primary brain tumors in the central nervous system, characterized by invasiveness, heterogeneity, and drug resistance, posing a threat to patients' lives. Glioblastoma (IDH wild-type) exhibits the highest invasiveness and mortality rate, making it a challenging therapeutic target. This review first outlines the characteristics of gliomas and their impact on the nervous system, then explores the pathological mechanisms and unique behaviors of glioblastoma (IDH wild-type), as well as the influence of the nervous system on its occurrence and progression.
View Article and Find Full Text PDFBiochem Biophys Rep
December 2025
Department of Neurosurgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany.
Brillouin microscopy allows mechanical investigations of biological materials at the subcellular level and can be integrated with Raman spectroscopy for simultaneous chemical mapping, thus enabling a more comprehensive interpretation of biomechanics. The present study investigates different in vitro glioblastoma models using a combination of Brillouin and Raman microspectroscopy. Spheroids of the U87-MG cell line and two patient-derived cell lines as well as patient-derived organoids were used.
View Article and Find Full Text PDFFront Endocrinol (Lausanne)
September 2025
Neurosurgery Department, 10th Military Research Hospital and PolyClinic SPZOZ, Bydgoszcz, Poland.
Background: Pheochromocytoma (PCC) is a rare neuroendocrine tumor, with 10-15% of cases showing malignant behavior defined by metastatic spread, including exceptionally rare central nervous system (CNS) involvement. Brain metastases present unique diagnostic and therapeutic challenges due to their potential to impair neurological function. This study reports a case of malignant PCC (mPCC) with CNS metastases and a systematic review to clarify the clinical patterns, management strategies, and prognostic factors.
View Article and Find Full Text PDF