Efficacy and safety of induction immunotherapy plus chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a meta-analysis.

Background: Locally advanced nasopharyngeal carcinoma (LA-NPC) has a heterogeneous prognosis, with approximately one-fourth of patients experiencing poor outcomes. Studies have explored the application of induction chemoimmunotherapy followed by chemoradiotherapy, but its efficacy was controversial.

Methods: The protocol was registered in the Prospective Register of Systematic Reviews (PROSPERO, CRD42024619387).

An Efficient Lasso Framework for Admixture-Aware Polygenic Scores.

Polygenic scores (PGS) have promising clinical applications for risk stratification, disease screening, and personalized medicine. However, most PGS are trained on predominantly European ancestry cohorts and have limited portability to external populations. While cross-population PGS methods have demonstrated greater generalizability than single-ancestry PGS, they fail to properly account for individuals with recent admixture between continental ancestry groups.

Analysis of Blood Pressure Status and Influencing Factors Among 7218 Emergency Department Nurses: An Observational Cross-Sectional Study.

As frontline healthcare workers, emergency department nurses face high levels of urgency in their work and are exposed to a high risk of contingencies. Their blood pressure status and influencing factors require close attention. This study employed a census method and conducted a cross-sectional survey in 11 cities in Hebei Province from November 2016 to July 2018, measuring blood pressure and collecting questionnaires on influencing factors.

Biomimetic semiconducting polymer dots for dual targeted NIR-II phototheranostic and multimodal coordinated immunostimulatory therapy.

Breast cancer is a global health challenge necessitating more precise and effective treatment strategies. In this study, we developed a novel drug-loaded therapeutic nanoplatform, OCPdots@CTe, which integrated near-infrared-II (NIR-II) window phototheranostic for targeted treatment of orthotopic breast tumors. The outer membrane vesicles (OMVs) can stimulate more immune responses based on precise targeting, while chelerythrine (CTe) can induce apoptosis by generating reactive oxygen species (ROS), thereby enhancing the therapeutic effect.

A non-specific lipid transfer protein gene HcnsLTP111 positively regulates drought and salt stress tolerance in kenaf (Hibiscus cannabinus L.).

Kenaf (Hibiscus cannabinus L.), an important bast fiber crop with strong abiotic stress tolerance, holds significant significance in the utilization of saline-alkali land and other marginal lands. Non-specific lipid transfer protein (nsLTPs) are key regulators of plant stress responses, yet their roles in kenaf and the underlying molecular mechanisms remain uncharacterized.

Advanced Magnetic Imprinted Polymers Integrated with In Situ Ionization Mass Spectrometry for High-Throughput Pesticide Screening and Detection in Food Matrices.

This research introduces magnetic molecularly imprinted polymers (MMIPs) as a novel tool for the efficient extraction and detection of pesticide residues in food products. The MMIPs exhibit a notable adsorption capacity ranging from 15.70 to 23.

SLC39A14 Is a Potential Therapy Target and Prognostic Biomarker for Acute Myeloid Leukemia.

: Programmed cell death-related genes (PCDRGs) have been reported to play an important role in diagnosis, treatment and immunity regarding cancer, but their prognostic value and therapeutic potential in acute myeloid leukemia (AML) patients still need to be fully explored. : Cox regression analysis and Least Absolute Shrinkage and Selection Operator (LASSO) analysis were used to identify PCDRGs significantly associated with the prognosis of AML patients. Furthermore, a prognostic risk model for AML patients was constructed based on the selected PCDRGs, and their immune microenvironment and biological pathways were analyzed.

Risk of cervical squamous cell carcinoma associated with a single nucleotide polymorphism in the RAD18 gene in the Chinese population and its significance as a predictive biomarker.

RAD18 is a crucial mismatch repair gene associated with the post-replication repair, and genetic variations in RAD18 gene are closely related to tumorigenesis. We selected 6 RAD18 SNP and performed mismatch amplification PCR on 650 cases of CIN III, 580 cervical squamous cell carcinoma (CSCC), and 1320 healthy controls. The RAD18 rs250403 GG and G allele (AG + GG) genotype risk in CIN III and CSCC were significantly increased.

Chloride-induced electron enrichment strategy: Stabilization mechanism and efficacy of calcium/magnesium modified biochar against chromium contamination in soil.

The chromium (Cr) pollution in the soil poses serious ecological risks because hexavalent chromium (Cr) has high mobility and carcinogenicity, and its main source is the oxidation of the unstable form of trivalent chromium (Cr) in the soil. Traditional metal oxide-modified biochar has limited ability to passivate trivalent chromium (Cr) due to its low surface electron density. To address this issue, we propose a chlorine ion-induced electron enrichment strategy, taking advantage of the strong electrophilicity of chlorine ions (Cl).

Increased reflux secondary bile acids are associated with changes to the microbiome and transcriptome in Barrett's esophagus.

Bile acids are a major component of gastro-esophageal refluxate, thought to contribute to the development of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). As the microbiome shifts with EAC progression and bile acids influence bacterial composition, we examined these connections in a multi-center, cross-sectional study. We analyzed biospecimens from patients undergoing endoscopy using LC-MS to quantify bile acids in gastric aspirates, 16S rRNA sequencing for tissue microbiome profiling, and RNA sequencing on BE or cardia tissue.

Association between Chinese visceral adiposity index and heart failure in diabetic patients.

Aims: This study aimed to investigate the association between Chinese visceral adiposity index (CVAI) and heart failure (HF) risk in diabetic individuals and to evaluate the predictive capability of CVAI compared to other obesity metrics.

Materials And Methods: A prospective cohort study (Kailuan Study) spanning 2006 to 2022 involved 12 243 diabetic patients. Participants were stratified into CVAI quartiles (Q1: <96.

MiR-181d-5p affects skin wound healing processes via the Ikbkg/NF-κB axis.

The skin, a vital barrier against environmental damage, plays a crucial role in maintaining organismal homeostasis. However, the molecular mechanisms underlying skin wound repair remain incompletely understood, with microRNA regulation potentially serving as a key regulatory component. Utilizing the amphibian-derived cyclic peptide Cy as a molecular probe, we identified the miR-181d-5p/Ikbkg/NF-κB axis as significantly associated with wound healing through small RNA sequencing of early-stage skin injury.

MPEP ameliorates sepsis-associated delirium by modulating hippocampal mGluR5 signaling and pyramidal neuron excitability in mice.

Background: Delirium is a cerebral manifestation commonly seen in sepsis, known as sepsis-associated delirium (SAD), and is thought to be closely related to excitatory nervous system disorders. Metabotropic glutamate receptor 5 (mGluR5) is one of the important receptors in the central glutamatergic nervous system, which is widely involved in the regulation of synaptic transmission, synaptic plasticity and excitatory/inhibitory balance. The inhibition of mGluR5 is considered as a potential drug target for reversing excitatory nervous system disorders.

Cryobiopsy as a Salvage Technique Following Negative Flexible Forceps Biopsy of the Pleura Under Rapid On-Site Evaluation Guidance: A Prospective Study.

A diffusely thickened or hard pleura is a special type of macroscopic appearance associated with benign or malignant conditions. Medical thoracoscopy (MT) is the gold standard for pleural pathology, but its diagnostic yield is imperfect. Although cryobiopsy may provide greater and deeper tissue, its impact on the diagnostic yield remains uncertain, and safety concerns persist.

Tirzepatide, a dual GIP/GLP-1 receptor agonist, alleviates metabolic dysfunction-associated steatotic liver disease by reducing the expression of CD36 and OBP2A.

Metabolic dysfunction-associated steatotic liver disease (MASLD) is defined by excessive hepatic lipid accumulation. This study evaluated the therapeutic effects and molecular mechanisms of tirzepatide, a dual GIP and GLP-1 receptor agonist, in treating hepatic steatosis. Eight-week-old C57BL/6J mice were fed either a high-fat diet or a high-fat, high-fructose, and high-cholesterol diet for 12 weeks to induce MASLD.

Clinical pharmacist-led costs optimization in ischaemic stroke care: A diagnosis-related groups-based intervention study.

Aims: This study aimed to evaluate the impact of clinical pharmacists' intervention on drug cost optimization for ischaemic stroke inpatients under the diagnosis-related groups (DRGs) payment model.

Methods: This study collected hospitalization data of patients with ischaemic stroke in the BR23 disease group from the neurology department between June 2023 and July 2024. The dataset was divided into a control group (no pharmacist intervention) and an experimental group (pharmacist intervention).

Biological Functions of Growth Differentiation Factor 9 in Early Ovarian Development of Japanese Eel (Anguilla japonica).

Growth differentiation factor 9 (GDF9) is a member of the transforming growth factor-β (TGF-β) superfamily and is expressed in an oocyte-specific manner. It plays a crucial role in the early stage of ovarian development. Japanese eel (Anguilla Japonica), a spawning migration teleost, has artificial reproduction still under investigation.

Translational control of innate barrier defense by the gut microbiota.

The intestinal epithelium is protected by a mucus barrier, infused with antimicrobial proteins, that restricts microbial access to host tissue. Because assembling this barrier is energetically costly, its production must be tightly regulated. Here, we show that the microbiota regulates the translation of key mucus barrier components, including the structural glycoprotein mucin 2 and the antimicrobial enzyme lysozyme.

Nanofibrous Hyper-Cross-Linked Polymer Based on Veratraldehyde-Derived Triarylimidazole for Cationic Organic Pollutant Adsorption.

Lignin, a byproduct of the pulp and paper industry and the second-most abundant biomacromolecule, exhibits distinctive characteristics including an aromatic skeleton, complex structure, and challenges related to its utilization. In this study, a triarylimidazole was synthesized from veratraldehyde, a potential lignin derivative, and employed as a monomer for the preparation of ionic hyper-cross-linked polymers characterized by a fibrous and porous microstructure. The presence of methoxy groups endows the resulting ionic hyper-cross-linked polymers with a chemical structure comprising electron-rich aromatic rings and adjacent imidazolium groups, which facilitate synergistic noncovalent interactions with cationic organic pollutants, thereby promoting effective adsorption.

Efficacy analysis of fiberoptic bronchoscopy combined with thoracoscopy in the treatment of mediastinal bronchogenic cysts in children.

This study explores the clinical efficacy of perioperative application of fiberoptic bronchoscopy (FB) combined with thoracoscopic minimally invasive surgery for mediastinal bronchogenic cysts in children. A retrospective analysis was conducted on 48 pediatric patients with mediastinal tumors who were admitted to our hospital from January 2015 to December 2023. Postoperative pathological results confirmed the diagnosis of bronchogenic cysts.

[6-Shogaol alleviates cerebral injury after cardiac arrest-cardiopulmonary resuscitation in rats by inhibiting death-associated protein kinase 1-mediated autophagy].

Objective: To observe the neuroprotective effect of 6-shogaol (6-SH) in global cerebral ischemia/reperfusion injury (CIRI) following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR) in rats.

Methods: Computer-aided molecular docking was used to determine whether 6-SH could spontaneously bind to death-associated protein kinase 1 (DAPK1). SPF-grade male SD rats were randomly divided into a sham group (n = 5), a CPR group (n = 7), and a CPR+6-SH group (n = 7).

Association between sarcopenia and hypercoagulability in elderly patients with chronic obstructive pulmonary disease.

Purpose: Blood hypercoagulability is associated with poor prognosis in elderly patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to explore whether sarcopenia, a common disease among the elderly, could promote the hypercoagulable state in such patients.

Methods: Elderly patients with stable-phase COPD were divided into the sarcopenia group (n = 192) and the non-sarcopenia group (n = 264).