Heavy Metals in Infant Clothing: Assessing Dermal Exposure Risks and Pathways for Sustainable Textile Policies.

Infant clothing represents a critical yet overlooked exposure pathway for heavy metals, with significant implications for child health and sustainable consumption. This study investigates cadmium (Cd) and chromium (Cr) contamination in 33 textile samples, integrating in vitro bioaccessibility assays, cytotoxicity analysis, and risk assessment models to evaluate dermal exposure risks. Results reveal that 80% of samples exceeded OEKO-TEX Class I limits for As (mean 1.

MiR-181d-5p affects skin wound healing processes via the Ikbkg/NF-κB axis.

The skin, a vital barrier against environmental damage, plays a crucial role in maintaining organismal homeostasis. However, the molecular mechanisms underlying skin wound repair remain incompletely understood, with microRNA regulation potentially serving as a key regulatory component. Utilizing the amphibian-derived cyclic peptide Cy as a molecular probe, we identified the miR-181d-5p/Ikbkg/NF-κB axis as significantly associated with wound healing through small RNA sequencing of early-stage skin injury.

Bionic Sensors for Biometric Acquisition and Monitoring: Challenges and Opportunities.

The development of materials science, artificial intelligence and wearable technology has created both opportunities and challenges for the next generation of bionic sensor technology. Bionic sensors are extensively utilized in the collection and monitoring of human biological signals. Human biological signals refer to the parameters generated inside or outside the human body to transmit information.

Recovery of complete crystalline silicon cells from waste crystalline silicon photovoltaic modules.

Firstly, the EVA adhesive film is dissolved with preheating treatment and ultrasonic-assisted toluene, and the backsheet are peeled off. The EVA film is then removed by thermal degradation. Finally, the high value but low reactivity silver (Ag) and aluminum (Al) are leached out with nitric acid (HNO).

Simulation Prediction and Experimental Research on Surface Morphology of Ball Head Milling Processing.

With the aim of improving the machined surface quality of die steel, this paper takes Cr12MoV quenched die steel as the research object and proposes a ball head milling surface morphology prediction model that comprehensively considers influencing factors, including tool vibration, eccentricity, as well as deformation. By setting key parameters, such as line spacing, feed per tooth, cutting depth, and phase difference, the system analyzed the influence of each parameter on the residual height and surface roughness of the machined surface. High-speed milling experiments were conducted, and the surface morphology of the samples was observed and measured under a microscope.

Integrative radiomics analysis of peri-tumoral and habitat zones for predicting major pathological response to neoadjuvant immunotherapy and chemotherapy in non-small cell lung cancer.

Background: It is crucial for clinical decision-making to identify non-small cell lung cancer (NSCLC) patients who are likely to achieve major pathological response (MPR) following neoadjuvant immunotherapy and chemotherapy (NICT). This study conducted a thorough analysis of the regions surrounding and within resectable NSCLC tumors, creating an integrative tumor microenvironment model that encompasses features of both the peri-tumoral areas and habitat-based subregions, aiming at enhancing accurate predictions and supporting clinical decision-making processes.

Methods: Our study involved an analysis of 243 NSCLC patients from three centers, treated with NICT and surgery and categorized into training, validation, and test cohorts.

Mass balance and metabolite profiles in humans of tegoprazan, a novel potassium-competitive acid blocker, using C-radiolabelled techniques.

Background: Tegoprazan (LXI-15028), a novel potassium-competitive acid blocker, has shown great efficacy in treating acid-related disorders. However, its metabolic and excretion characteristics are not fully understood.

Research Design And Methods: A single oral dose of 50 mg/150 μCi [C]tegoprazan was administered to six healthy subjects.

Characteristics of the positional and morphological parameters of sagittal spine alignment in a cohort of 623 healthy individuals aged >50 years in China.

Study Design: A retrospective radiologic study.

Purpose: To investigate the spinopelvic positional and morphological parameters of the sagittal spinal alignment in a healthy population from the community.

Overview Of Literature: The existing parameters for spinal alignment based on the Cobb angle are the primary reference values for evaluating spinal alignment and pelvic morphology.

Efficacy and safety of integrating consolidative thoracic radiotherapy with immunochemotherapy in extensive-stage small cell lung cancer: a real-world retrospective analysis.

Background: Extensive-stage small cell lung cancer (ES-SCLC) remains a challenging malignancy with a poor prognosis. The integration of immunochemotherapy and combined consolidative thoracic radiotherapy (cTRT) presents a potential paradigm shift in treatment. This study aims to evaluate the real-world efficacy and safety of this approach.

Innovative synergistic control of electric fields and Zn dynamics for revolutionizing zinc metal battery stability.

Aqueous zinc-ion batteries (ZIBs) are emerging as promising next-generation energy storage systems due to their inherent safety, environmental sustainability, and cost-effectiveness. However, their widespread application is hindered by challenges such as dendritic Zn growth, hydrogen evolution, and corrosion-induced passivation, which compromise performance and scalability. To overcome these obstacles, we developed a novel dual-interface modified zinc anode by integrating a zinc fluoride (ZnF)-silicon (Si) interface using fluorine-doped silicon nanoparticles encapsulated within hollow mesoporous carbon nanospheres (F-Si@HMCS).

Magnetic resonance imaging-based bone and muscle quality parameters for predicting clinical subsequent vertebral fractures after percutaneous vertebral augmentation.

Background: Clinical subsequent vertebral fracture (SVF) is a common complication following percutaneous vertebral augmentation treatment for osteoporotic vertebral compression fracture. Magnetic resonance imaging (MRI)-based vertebral bone quality (VBQ) score, cross-sectional area (CSA), and degree of fat infiltration (DFI) of paravertebral muscles are effective predictors of spinal surgery-related complications. However, the relationship between these parameters and SVF remains unclear.

Age-Related Changes and Spinal Sagittal Alignment in Asymptomatic Community Dwelling Adults Over 50.

Study Design: Monocentric, retrospective, cross-sectional study.

Objective: To investigate the age-related normative values of sagittal parameters and establish their relationships in asymptomatic community-dwelling adults aged over 50.

Background Context: Degenerative changes in the spine with aging alter the sagittal balance, causing spine pathologies.

Endoscopic obturator nerve radiofrequency ablation for femoral head necrosis: a case series.

Background: This pilot case series evaluated the feasibility and effectiveness of using endoscopic radiofrequency ablation (RFA) of the articular branch of the anterior obturator nerve under endoscopic and fluoroscopic guidance for controlling pain in patients with osteonecrosis of the femoral head (ONFH).

Methods: Data on 11 consecutive patients were collected with ONFH underwent endoscopic RFA of the anterior obturator nerve. Electromyography (EMG) examination was performed preoperatively and postoperatively.

Efficacy and safety of combining radiotherapy with immune checkpoint inhibitors in patients with advanced non-small cell lung cancer: a real-world study.

Background: The significance of local radiotherapy (RT) in advanced non-small-cell lung cancer (NSCLC) is well documented. However, the advent of immunotherapy has raised questions regarding the synergistic survival benefits or potential adverse effects.

Objective: This study aimed to explore whether a combination of RT and systematic immune checkpoint inhibitors (ICIs) can improve the survival outcomes for NSCLC patients.

Genome-Driven Discovery of Antiviral Atralabdans A-C from the Soil-Dwelling .

Heterologous expression of an terpenoid gene cluster derived from Gö66 in J1074 led to the discovery of three novel labdane diterpenoids featuring an unprecedented 6/6/5-fused tricyclic skeleton, designated as atralabdans A-C (-), along with a known compound, labdanmycin A. Compounds - were identified through extensive spectroscopic analysis, including NMR calculations with DP4+ probability analysis, and a comparative assessment of experimental and theoretical electronic circular dichroism (ECD) spectra. A plausible biosynthetic pathway for these compounds was proposed.

The preservation of cervical flexibility helps maintain cervical sagittal alignment after laminoplasty.

Background Context: Cervical spine range of motion (ROM) is a critical factor in changes in cervical sagittal alignment (CSA) and clinical outcomes after cervical laminoplasty (LMP). However, the impact of postoperative cervical ROM on CSA after cervical LMP is still unclear.

Purpose: Evaluating the imaging and symptomatic data from patients with cervical spondylotic myelopathy (CSM) to identify the influence of postoperative cervical ROM on post-LMP CSA and surgical outcomes.

Prospects for the Protective Mechanisms and Compounds of Bufei Huoxue Capsule against COVID-19 Convalescence: Evaluation of Integrating UHPLC-HRMS Analysis and Network Pharmacology Strategy.

Introduction: Most COVID-19 survivors are troubled with chronic persistent symptoms, which have currently no definitive treatments. Bufei Huoxue (BFHX) capsule exerts clinical benefit, while the material basis and molecular mechanism remain unclear.

Aim: The study aimed to elucidate the protective mechanisms of BFHX capsule against COVID-19 convalescence.

Efficacy and relative safety of caplacizumab in immune-mediated thrombotic thrombocytopenic purpura: a systematic review and meta-analysis.

Unlabelled: Immune-mediated thrombotic thrombocytopenia purpura (iTTP) is a rare microvascular disease characterized by severe disseminated microvascular thrombose-bleeding syndrome. Caplacizumab has been approved for the treatment of iTTP in combination with Plasma Exchange (PE) and immunosuppressive therapy, but its role in iTTP therapy remains uncertain. Therefore, we conducted a meta-analysis to investigate the safety and efficacy of caplacizumab for the treatment of patients with iTTP.