LASSO-based machine learning algorithm for prediction of dysphagia in patients suffering anterior cervical discectomy and fusion.

Purpose: To develop and validate a predictive model for postoperative dysphagia in patients undergoing anterior cervical discectomy and fusion (ACDF).

Methods: We retrospectively analyzed 500 patients who underwent ACDF at our institution between 2018 and 2022. A total of 53 candidate predictors-including 21 radiographic measurements, 19 preoperative blood biomarkers, 9 medical history variables, and 4 surgical characteristics-were evaluated.

Peptide Coacervates with Metal-Phenolic Membranes Modulate Glucose Metabolism and Enhance Cancer Immunotherapy.

Glucose consumption by tumors induces metabolic restriction of T cells, which results in immune evasion and tumor progression. Regulating cellular metabolism represents a promising strategy to enhance cancer immunotherapy; however, redirecting glucose utilization from tumor cells to T cells is challenging. Herein, the activation of cytotoxic T cells using engineered peptide coacervates (PCs) containing interferon alpha (IFNα) and membranized with metal-phenolic networks (MPNs) (PC-IFNα@MPNs), which promote glucose uptake and glycolysis, is reported.

The Role of Emerging Digital Technologies in Revolutionizing Dental Education: A Bibliometric Analysis.

Background: The integration of artificial intelligence (AI), virtual reality (VR), augmented reality (AR), and other digital technologies in dental education has gained significant attention, revolutionizing teaching methodologies, clinical training, and student assessment. However, despite the growing body of literature, there is no comprehensive bibliometric analysis mapping influential studies, research trends, and emerging topics in this field. This study aims to analyze the structure, hotspots, and evolution of digital technology research in dental education through bibliometric methods.

Mechanical response mechanism and parameter optimization of double-arch tunnels without middle drift during construction.

Due to the high construction efficiency and low cost, double-arch tunnels without middle drift has been gradually promoted in engineering in recent years. However, the excavation characteristics of the left and right tunnels are easy to cause structural disturbance and deformation out of control. In particular, the surrounding rock disturbance of the front tunnel caused by the construction of the secondary tunnel often leads to lining cracking and structural instability.

Treatments of depressive symptoms in cancer patients: A systematic review and network meta-analysis.

Background: Depression is are often insufficiently managed in cancer patients globally. To address this, we conducted a comprehensive systematic review and network meta-analysis to evaluate and compare the effectiveness of pharmacological and non-pharmacological interventions in alleviating depressive symptoms in adult cancer patients.

Methods: We searched PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.

Photochemical CO Reduction by a Postsynthetically Modified Zr-MOF.

Metal-organic frameworks are an excellent platform for photochemical CO reduction into valuable chemicals. Herein, we report the synthesis and photocatalytic behavior of Ru@MOF-808, a Zr-based MOF, modified with a Ru-polypyridyl complex. The postsynthetic modification was achieved using solvent-assisted incorporation of bipyridine-carboxylate ligands onto the nodes of the MOF-808, followed by the coordination of Ru(II)-terpyridine moiety.

Aquatic Microcosms in Ecotoxicology: The Community-Level Ecological Risk Assessment of Pollutants.

Microcosm technology serves as a sophisticated tool for simulating natural ecosystems, facilitating the examination of pollutants' ecological impacts across population, community, and ecosystem scales. Currently, this technology finds extensive application in ecological toxicology and ecological risk assessment research. This concise review highlights the utility of microcosm technology in ecotoxicology, detailing the establishment of aquatic microcosms and analyzing key research trends to assess the ecological impacts of pollutants.

Ultrasound-assisted fermentation and microencapsulation of corn gluten meal-rice bran mixture enhance nutritional quality, bioactive stability, and gut delivery.

Corn gluten meal and rice bran mixture (CRM) are major agricultural by-products of food processing. The nutritional quality of fermented CRM (FCRM) was enhanced through ultrasound-assisted fermentation with Aspergillus oryzae AOX and Lactobacillus helveticus LHS. Additionally, polydopamine/chitosan-gum Arabic/FCRM (P-C-FCRM) microcapsules were fabricated under ultrasonic conditions to enhance the stability of bioactive compounds.

Identification of SUMOylation modifiers involved in lung adenocarcinoma progression and Osimertinib resistance by integrated bioinformatics analysis.

This study investigates the mechanisms of Osimertinib resistance in lung adenocarcinoma (LUAD) by identifying prognostic genes associated with SUMOylation. We performed differential expression analysis to identify differentially expressed genes (DEGs) in LUAD samples, Osimertinib-tolerant cell samples and SUMOylation-related genes (SRGs). Utilizing Cox regression and LASSO regression, we developed a prognostic model that highlighted five key prognostic genes-BIRC5, AURKA, BLM, NR3C2, and NDC1.

Evaluative performance of TyG-ABSI versus traditional indices in relation to cardiovascular disease and mortality: evidence from the U.S. NHANES.

Background: Metabolic Syndrome (MetS) significantly increases the risk of cardiovascular disease (CVD), with central obesity and insulin resistance as major contributors. The TyG-ABSI index is a newly proposed composite measure that combines the TyG index and ABSI, aiming to assess both insulin resistance and central obesity simultaneously. Previous studies have shown that TyG-ABSI has potential in predicting cardiovascular mortality, but its applicability in MetS populations remains unclear.

[Corrigendum] Overexpression of SET oncoprotein is associated with tumor progression and poor prognosis in human gastric cancer.

Subsequently to the publication of the above paper, the authors contacted the Editor to explain that, concerning the cell invasion assay experiments shown in Fig. 4, and due to an error made in filing the data, the image featured for the OA group / MGC803 cellular experiment in Fig. 4C had been inadvertently duplicated from the invasion image showing the shSET group / SGC7901 cellullar experiment in Fig.

2 × 2 Charge Density Wave in FeNbSe Stabilized by Disordered Intercalation.

The complex interplay between electronic and lattice degrees of freedom underlies a rich variety of emergent phenomena in quantum materials, particularly charge density waves (CDWs). Understanding the distinct roles of electron carriers and structural order in CDW formation is crucial for elucidating the underlying mechanisms and enabling control over material properties. The intertwined effects of charge doping and structural periodicity make it challenging to isolate the individual contributions to lattice modulations.

The role of RANBP1 in regulating MiRNA expression and apoptosis in breast cancer cells.

Background: Breast cancer poses a huge health threat in China. Emerging evidence has indicated that RANBP1 is associated with poor prognosis of breast cancer and has been shown to influence miRNA expression in colorectal cancer. But its role in breast cancer remains unclear.

Cold-Inducible RNA-Binding Protein Causes Prolonged Immersion-Induced Hypothermic Acute Lung Injury in a Rat Model Through TREM-1 and NF-κB.

Hypothermia can cause acute lung injury (ALI). The pathogenetic mechanism of hypothermic ALI involves various proteins. Cold-inducible RNA-binding protein (CIRP) is secreted by macrophages or damaged cells and enhances the inflammatory response, resulting in tissue and organ damage.

Prognostic value of the C-reactive protein-albumin-lymphocyte index in cancer patients with sarcopenia: A study on overall survival.

Objectives: The C-reactive protein-albumin-lymphocyte (CALLY) index has been widely used in previous studies to investigate its relationship with postoperative prognosis in various cancers. However, malnutrition, a common issue among cancer patients, often manifests as sarcopenia, which is closely associated with inflammation, nutrition, and immunity. This study aimed to evaluate the relationship between the CALLY index and overall survival in cancer patients with sarcopenia.

Polyethylene microplastics interfere with MICP-based cadmium remediation: A dual-system evaluation of microbial performance and environmental response.

Microbially induced calcite precipitation (MICP) is a sustainable and effective approach for immobilizing heavy metals such as cadmium (Cd) in contaminated environments. However, the influence of coexisting microplastics (MPs), particularly polyethylene microplastics (PE-MPs), on MICP performance remains unclear. This study systematically investigated the effects of 1 μm and 50 μm PE-MPs on MICP-mediated Cd remediation in both liquid cultures and soil systems.

The Predictive Power of the Cystatin C-Creatinine Score in Assessing Frailty.

Background: As the global population ages, identifying reliable biomarkers to predict frailty and mortality is critical for early intervention. This study aims to construct a valuable biomarker and evaluate its predictive performance in assessing frailty and all-cause mortality.

Methods: Data from 3613 participants in the Health and Retirement Study (HRS) were used to construct the nomogram and main analysis, whereas data from the National Health and Nutrition Examination Survey were used to validate the robustness of the model.

Postoperative adjuvant hepatic arterial infusion chemotherapy with gemcitabine-cisplatin sequential capecitabine combined with PDL1 inhibitors in resected high-risk intrahepatic cholangiocarcinom: study protocol for a prospective, multicenter, single-arm, phase 2 trial (HgcCP trial).

Background: Although capecitabine is recommended for postoperative adjuvant treatment of biliary tract cancers (BTC), no studies have specifically focused on the postoperative adjuvant treatment of intrahepatic cholangiocarcinoma (ICC). In recent years, the combination of PD-L1 inhibitors and gemcitabine-cisplatin (GC) has demonstrated promising results in advanced BTC. The combination of GC, PD-L1 inhibitors, and capecitabine may be a potential adjuvant treatment for ICC.

Synergistic Multi-Mechanism Enhancement in Chemomechanical Abrasive Polishing of Polycrystalline Diamond via a New SiO-Diamond Slurry in High-Concentration HO Solution.

The high-efficiency polishing of large-sized polycrystalline diamond (PCD) wafers continues to pose significant challenges in its practical applications. Conventional mechanical polishing suffers from a low material removal rate (MRR) and surface damage. To improve the process efficiency, this study investigates the effect of chemomechanical abrasive polishing (CMAP) with a slurry containing high-concentration HO and varying mass percentages of SiO powder and diamond particles on surface morphology, surface roughness, material removal rate (MRR), and microstrain of PCD disks.

Group-common and individual-specific effects of structure-function coupling in human brain networks with graph neural networks.

The human cerebral cortex is organized into functionally segregated but synchronized regions bridged by the structural connectivity of white matter pathways. While structure-function coupling has been implicated in cognitive development and neuropsychiatric disorders, it remains unclear to what extent the structure-function coupling reflects a group-common characteristic or varies across individuals, at both the global and regional brain levels. By leveraging two independent, high-quality datasets, we found that the graph neural network accurately predicted unseen individuals' functional connectivity from structural connectivity, reflecting a strong structure-function coupling.

Ulcerative Colitis Aggravates Periodontitis via Inducing Myelopoiesis.

Objectives: The intercorrelations between periodontitis and inflammatory bowel disease have been recognized for years. Accumulating evidence has shown that patients with ulcerative colitis (UC) have a higher prevalence and severity of periodontitis. However, the underlying mechanisms by which UC aggravates periodontal destruction are still unclear.

DNA-polyarginine probe-enabled nanopore Sensing for ultrasensitive detection of Dam methyltransferase activity and inhibition.

Aberrant DNA methyltransferase (DNA MTase) activity correlates with abnormal DNA methylation patterns observed in various cancers, establishing DNA MTase as a therapeutic target for early clinical diagnosis and anticancer/antimicrobial treatment. Current DNA MTase detection methods remain laborious and technically challenging. This study presents a label-free, single-molecule nanopore sensing strategy for sensitive Dam MTase detection utilizing a DNA-polyarginine (DNA-R5) probe.

ULBP2 CAR-T cells enhance gastric cancer immunotherapy by inhibiting CAF activation.

Gastric cancer (GC) is characterised by a dense stromal microenvironment, lack of therapeutic targets, and limited effective treatment options, collectively leading to a poor prognosis. Here, we identify UL16 binding protein 2 (ULBP2) as a potential therapeutic target in GC. Mechanistically, ULBP2 overexpression activates the TGF-β signalling pathway, promoting the activation of cancer-associated fibroblasts (CAFs) and tumor progression in GC.

Microbial manipulators: modulates the tumor immune microenvironment in colorectal cancer.

, a microorganism ordinarily detected in the oral cavity, is considered as a pathobiont related to periodontitis and a range of human diseases, including colorectal cancer (CRC). The dynamics of how encourages CRC tumorigenesis and progression has been well-investigated. Recently, mechanisms by which regulates the tumor immune microenvironment (TiME) and subsequently alters CRC oncogenesis and advancement have drawn more and more attention.

Phosphine Oxide-Induced Strong Emission and Multistimuli-Responsive Fluorochromism of -Carborane-Based Luminogens.

A series of -carborane-based triads, functionalized at the carbon vertices with diphenylphosphine groups (phosphine or phosphine oxide) as auxiliary groups and polycyclic aromatic moieties (naphthyl, phenanthryl, or pyrenyl) as donors, were successfully synthesized. The synergistic effects of phosphine and aromatic groups on the optoelectronic properties of -carborane-based luminescent molecules were studied. All of these compounds exhibit both locally excited (LE) emission and intramolecular charge transfer (ICT) emission, with the LE/ICT ratio and the occurrence of multiple emissions significantly influenced by the valence state of phosphorus and the steric hindrance of the aromatic rings.