Enhancement mechanism of low-frequency magnetic field on the gelation and structures of potato protein emulsion gel.

The objective of this study was to investigate the enhancement mechanism of low-frequency magnetic field (LF-MF) on the gelation and structures of potato protein-linseed oil emulsion gel. Results indicated that the gel strength and water holding capacity of the gel induced by 6 mT LF-MF intensity were significantly increased from 0.33 N‧mm and 42.

Preliminary Functional Outcome Following Robotic Intracorporeal Orthotopic Ileal Neobladder with Integrated Pelvic Fascial Structure-Sparing in Males with Bladder Cancer.

Purpose: To describe our integrated pelvic fascial structure-sparing (IPFSS) technique for robotic-assisted radical cystectomy (RARC) with intracorporeal orthotopic neobladder (ONB) reconstruction and to evaluate its impact on urinary continence and sexual function in male patients.

Methods: This retrospective observational study was conducted at a single high-volume center. Male bladder cancer patients who underwent IPFSS RARC with ONB were included.

Alterations in EEG functional connectivity in preterm infants: A systematic review.

Objective: To synthesise current evidence on electroencephalography-based functional connectivity in preterm infants and clarify how prematurity alters early brain-network maturation.

Methods: A PRISMA-guided search (PubMed and Web of Science, inception-Mar 2025) identified 24 studies that quantified resting-state functional connectivity or graph-theory metrics in infants born <37 weeks' gestation. Study quality was rated with a six-item electroencephalography-functional connectivity checklist (reference montage, epoch length/number, artefact rejection, volume-conduction control, multiple-comparison correction).

Structure-Based Discovery of Active Pan-KRas Inhibitors Targeting G12D Mutants by Enhanced Sampling Simulations.

Ras is a node protein in the classic tumor signaling pathway known as RAS-RAF-MEK. Mutations in Ras are reported to occur in approximately 19% of human cancers. Among them, the G12D mutation is one of the most prevalent mutations found in Ras.

Development and validation of a new yearning induction task: a cross-cultural study of Chinese and Swiss bereaved.

Yearning is a core symptom of prolonged grief disorder (PGD), typically manifesting as vivid counterfactual thoughts and bittersweet emotions. However, current self-report measures fail to capture the dynamic nature of yearning and are often compromised by social desirability bias. This highlights the critical need for accurate and objective tools to assess this complex emotional experience.

Evaluation efficacy and accuracy of a real-time computer-aided polyp detection system during colonoscopy: a prospective, multicentric, randomized, parallel-controlled study trial.

Introduction: Colorectal cancer (CRC) ranks as the second deadliest cancer globally, impacting patients' quality of life. Colonoscopy is the primary screening method for detecting adenomas and polyps, crucial for reducing long-term CRC risk, but it misses about 30% of cases. Efforts to improve detection rates include using AI to enhance colonoscopy.

Salt-templated transformation of waste plastics into single-atom catalysts for environmental and energy applications.

Upcycling plastic waste into single-atom catalysts (SACs) not only offers a sustainable solution for plastic waste management but also yields valuable functional materials for catalytic applications. Here, we report a simple and scalable method to transform various types of plastics, including polyethylene, polypropylene, polystyrene, polyethylene terephthalate, polyvinyl chloride, and their mixtures, into a diversity of porous SACs with different coordination chemistry and their excellent applications in a variety of catalytic reactions. Lamellar transition metal chloride salts (Ni, Fe, Co, Mn, and Cu) are employed as a template and catalyst for confined carbonization of plastics into layered SACs.

Metabolite Fusion between Breath and Blood Enables More In-Depth Understanding of the Endogenous Metabolome.

Blood is a widely used sample type in metabolomics but often loses volatile compounds during analysis. In contrast, exhaled breath offers a noninvasive and complementary matrix that retains these volatiles. However, the accuracy of metabolite identification in breath remains a key challenge.

SAMHD1 deficiency disrupts macrophage autophagy-lysosomal homeostasis and promotes inflammation via the mTOR-MITF-CTSD axis in ulcerative colitis.

Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by dysregulated immune responses and macrophage-driven inflammation. In this study, we identify SAMHD1 (SAM domain and HD domain-containing protein 1) as a critical regulator of macrophage homeostasis in UC. Single-cell RNA sequencing (scRNA-seq) of colonic tissues revealed reduced SAMHD1 expression in UC-associated macrophages.

Structural characteristics of Brassica rapa L. Polysaccharide and its bioactivity on alcoholic liver injury.

The global prevalence of alcoholic liver disease (ALD) has shown a concerning upward trend, with an increasing incidence among younger demographics. In this study, ultrasound-assisted extraction was employed to isolate polysaccharides from Brassica rapa L (BRL). The purified polysaccharide (BRLPP) was structurally characterized, and its protective effects against alcoholic liver disease (ALD) were investigated.

Plumbagin inhibits CYP2J/EETs metabolic pathway and leads to heart injury in cardiac organoids and rats.

Cytochrome P450 2J (CYP2J) enzymes are critical in synthesizing cardioprotective epoxyeicosatrienoic acids (EETs), which help reduce oxidative stress, inflammation, and apoptosis. Plumbagin, a natural antitumor agent, induces cardiac injury, although its mechanism remains uncharacterized. This study systematically evaluated the mechanism behind plumbagin-induced heart injury.

Pulmonary arterial blowout syndrome as a serious adverse event in patients with advanced lung cancer: a 12-year retrospective study.

Objective: Massive haemoptysis due to central pulmonary artery (CPA) rupture in patients with advanced lung cancer is a fatal complication with limited early diagnostic tools. This study aimed to identify risk factors associated with pulmonary artery rupture and to propose a grading model to facilitate early diagnosis and timely endovascular intervention.

Materials And Methods: This retrospective study included patients with advanced lung cancer who experienced in-hospital sudden haemoptysis-related death and received endovascular treatment for CPA abnormalities.

MoC Ceramic Electrode Embedded with PtMo Nanograins for Hydrogen Evolution Reaction at High Current Density.

The scarcity and high price seriously hinder the large-scale industrial application of Pt as the preferred catalyst for the hydrogen evolution reaction (HER). A PtMo@MoC catalytic electrode was designed based on a porous MoC ceramic membrane with finger-like holes, where PtMo nanograins were uniformly embedded in the surface of the MoC grains by electrodeposition and thermal reduction. The loading of Pt is as small as 7.

Sintilimab plus anlotinib in patients with pre-treated locally advanced or metastatic sarcoma: a prospective, single-arm, phase II clinical trial.

Advanced sarcomas have limited treatment options after standard therapy, and therefore we investigated the efficacy and safety of sintilimab plus anlotinib in this setting. Patients aged 18-75 years with advanced sarcomas and prior systemic therapy were enrolled. Patients with untreated, primary chemotherapy-resistant tumor types, such as alveolar soft part sarcoma, clear cell sarcoma, etc.

Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study.

Background: Iron, an essential micronutrient, plays a critical role in fetal neurodevelopment. Animal studies have demonstrated that maternal iron-deficient diets during pregnancy induce permanent structural and functional alterations in offspring brains. Dietary iron exists in two forms: heme iron (found in animal-derived foods), which exhibits high bioavailability (15-35%), and non-heme iron (predominantly from plant-based sources), with lower bioavailability (1-20%).

Lightweight deep neural network for contour detection and extraction of wheat spikes in complex field environments.

Background: Spikelet number, a core phenotypic parameter for wheat yield composition, requires precise estimation through accurate spike contour extraction and differentiation between grain surfaces and spikelet surfaces. However, technical challenges persist in precise spike segmentation under complex field backgrounds and morphological differentiation between grain/spikelet surfaces.

Method: Building on two-year multi-angle wheat spike imagery, we propose an enhanced YOLOv9-LDS multi-scale object detection framework.

Downhill running regulates cardiac immune response through GCN2.

Downhill running (DR) has recently emerged as a promising exercise modality for cardiac rehabilitation, but the effect and mechanism of DR on myocardium remains unclear. General control nonderepressible 2 (GCN2), an eukaryotic initiation factor 2α (eIF2α) kinase, is beneficial to the heart when it is deficiency. The current study aimed to explore whether the GCN2 is associated with cardioprotective effects in downhill running.

A Mn-O-Ce interface-engineered nanozyme platform for visual stratified exosome screening of lung cancer: Toward primary care application.

The development of portable exosome detection platforms is crucial for noninvasive early diagnosis of lung cancer, particularly in resource-limited settings. Herein, we engineered a paper-based colorimetric biosensor utilizing a MnO/CeO heterojunction nanozyme for visual quantification of plasma exosomes. The heterojunction synergistically integrates the high surface area of CeO (45.

Integrating biological mechanisms and identifying key climate refugia to enhance biodiversity climate change adaptation.

As global climate change accelerates, it is imperative to obtain a more accurate understanding of the impacts of climate change on biodiversity and identify climate refugia to guide effective protection. This study utilized the endangered Tragopan caboti as a model organism. A species distribution model was constructed via a holistic approach that incorporated various biological mechanisms, including local adaptation, dispersal, responses to environmental variation, and species interactions.

: explore its carcinogenic potential and understand its role, prognostic value and biological significance in pan-cancer.

Background: The protein belongs to the family and is primarily localized to early endosomes. It regulates the endocytic pathway through its GTPase activity, thereby affecting various aspects such as cell signaling and metabolic regulation. Dysfunction of is closely associated with the progression and deterioration of multiple types of tumors.

Tegoprazan and low- or high-dose amoxicillin dual therapy versus bismuth-containing quadruple therapy for eradication (TREAT): protocol for a multicenter, open-label, non-inferiority, randomized controlled trial.

Background: Recently, tegoprazan was widely used for the treatment of acid-related diseases, including () infection. However, the optimized parameters of tegoprazan and amoxicillin used in dual therapy for eradicating remained unresolved.

Objectives: We mainly aim to compare the efficacy and safety of 14-day tegoprazan and low-dose amoxicillin dual therapy (LTA) or high-dose amoxicillin dual therapy (HTA) with 14-day bismuth-containing quadruple therapy (BQT) as first-line treatment of infection.

Ni Carboxylate Metal-Organic Frameworks.

Octanuclear nickel cube (Ni) is considered as a highly attractive inorganic building block in the field of metal-organic frameworks (MOFs) due to its high symmetry (), 12 connection sites, and excellent chemical stability of the constructed MOFs. In this study, we report the synthesis of Ni-based MOFs constructed exclusively from carboxylic acid ligands, breaking from the conventional use of pyrazolate in Ni-containing MOFs. Two carboxylate-based MOFs featuring fcu topology (NNM-2 and NNM-3) were successfully synthesized.