Engineering of an Exosome-Based mRNA Delivery System for Efficient Therapy of Familial Hypertriglyceridemia.

Familial hypertriglyceridemia (FHTG), a severe subtype of primary hypertriglyceridemia caused by mutations in and other related genes, is linked to life-threatening cardiovascular complications. Current therapies inadequately address the underlying genetic pathology. Here, we developed a novel exosome-based mRNA delivery platform to restore functional glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 () expression, providing a targeted therapeutic strategy for FHTG.

Overcoming tetracycline pollution in soils through the addition of a mycorrhizal fungal species Funneliformis mosseae.

The presence of residual antibiotics in the black soils of northeastern China poses a significant threat to food safety. This study investigated the potential of Funneliformis mosseae, one of the predominant biocontrol fungi in northeastern China, to mitigate the negative effects of tetracycline contamination (40 mg kg⁻¹) in soil. Advanced biotechnological methods were employed to assess plant growth, soil microbial antioxidant enzyme activity, and soil fertility.

Engineered iron oxide nanoplatforms: reprogramming immunosuppressive niches for precision cancer theranostics.

Iron oxide nanoparticles (IONPs) have transitioned from conventional magnetic resonance imaging (MRI) contrast agents into structurally programmable combined imaging/treatment tools, leveraging their superparamagnetism, catalytic activity, and surface engineering versatility to achieve spatiotemporal control over drug delivery and immune modulation. Advances in nanofabrication now yield size-optimized aggregates with enhanced tumor accumulation through the enhanced permeability and retention (EPR) effect, while clinically approved formulations like ferumoxytol demonstrate intrinsic immunomodulatory functionality, positioning IONPs as pivotal tools for precision oncology. Conversely, cancer immunotherapy remains limited by the immunosuppressive tumor microenvironment (TME), where cellular suppression via M2-polarized macrophages and regulatory T cells (Tregs) synergizes with physical exclusion from dense extracellular matrices and metabolic sabotage through lactate-driven acidosis.

Iron-Catalyzed Photochemical Defluorinative Functionalization of Polyfluorinated Aromatics.

Iron photocatalysis has emerged as a sustainable platform for C-H functionalization. This study describes a photocatalytic strategy for the selective defluorinative functionalization of polyfluorinated aromatics. The developed methodology enables selective defluorosulfonylation with sulfur dioxide and defluorinative alkylation with alkanes under visible light irradiation.

Long chain fatty acid transport via SLC27A1 enhances DAG-3-P synthesis and accelerates colorectal cancer metastasis.

Colorectal cancer (CRC) is a major global health issue. Despite advancements in treatment, CRC patients still face challenges of metastasis and variable prognosis. Circulating tumor cells (CTCs) shed from the primary tumor into the peripheral blood circulation provide new insights into the potential molecular mechanisms driving tumor progression and metastasis.

Visible light-driven activation of peroxymonosulfate by tubular O, S co-doped g-CN for efficient aflatoxin B degradation in edible oils.

Aflatoxin B (AFB) contamination in edible oils poses severe food safety threats, with traditional photocatalysis hindered by insufficient reactive oxygen species (ROS) precursors in lipid matrices. This study integrates tubular O, S co-doped g-CN (OSTCN) photocatalysis into edible oil water-washing, in the simulated dual-phase systems, OSTCN activates peroxymonosulfate (PMS) under visible light to generate ROS, achieving complete degradation of oil-phase migrated parent AFB within 120 min while maintaining oil quality within acceptable thresholds. Combined evidence reveals that the tubular structure enhances light harvesting, while O, S co-doping creates electron donor-acceptor sites that strengthen PMS adsorption and electron transfer, reducing activation barriers and conferring 6.

Wave succession in the pandemic clone of Vibrio parahaemolyticus driven by gene loss.

While spontaneous mutation and gene acquisition are well-established drivers of pathogen adaptation, the role of gene loss remains underexplored. Here we investigated the emergence and diversification of the pandemic clone of Vibrio parahaemolyticus through large-scale phylogenomic analysis of 8,684 global isolates. The pandemic clone rapidly acquired multiple marker genes and genomic islands, subsequently diverging into successive sublineages mediating independent waves of cross-country transmission, as also observed in Vibrio cholerae.

Symmetrical peripheral gangrene complicating recurrent cholangiocarcinoma: a case report.

Symmetrical peripheral gangrene (SPG) is a rare, lifethreatening complication often linked to severe illnesses. This case report describes the case of a 28-year-old male with recurrent cholangiocarcinoma who developed SPG after being admitted to the intensive care unit (ICU) for septic shock. Despite initial survival with antibiotics, vasopressors, and supportive care, he refused amputation, leading to secondary infection and death.

Molecular Insights into Active Sites of Manganese Oxide Based Water Oxidation Eletrocatalysts.

Manganese oxides (MnO) are promising candidates for water oxidation catalysts. However, the true active centers remain elusive due to the dynamic nature of MnO during electrolysis and/or activation, hindering progress in catalyst design and optimization. Herein, we aim to address such a challenge by preparing a defective cubical tri-manganese complex and a di-manganese complex to mimic the in-plane and on-edge subunits of birnessite-like heterogeneous MnO electrocatalysts.

Saline pasture improve meat quality in Qinghai Tibetan sheep through changes in the rumen microbiota.

Introduction: This study aimed to investigate the effects of natural forage from different regions (saline-alkali and non-saline-alkali areas) on the rumen microbiota, muscle metabolites, and meat quality of Tibetan sheep.

Methods: Targeted and non-targeted metabolomics were used to comprehensively analyze both pasture and meat quality, metabolites. Additionally, 16S rDNA sequencing was employed to analyze the rumen microbial community structure of Tibetan sheep.

Cardiac toxicity and intervention strategies during thoracic cancer radiotherapy.

Radiation-induced heart disease (RIHD) represents a major dose-limiting complication of thoracic radiotherapy, with a multifaceted pathogenesis involving endothelial dysfunction, chronic oxidative stress, and progressive fibrotic remodeling. Emerging evidence reveals distinct molecular mechanisms underlying RIHD's heterogeneous clinical manifestations, including pericarditis, accelerated coronary artery disease, cardiomyopathy, valvular degeneration, and conduction abnormalities-which often manifest after prolonged latency periods. Modern radiotherapy techniques have reduced but not eliminated cardiac toxicity, particularly in high-risk populations.

Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery.

Background: Migraine, a debilitating neurological disorder with distinct subtypes (migraine with aura [MA] and migraine without aura [MO]), exhibits genetic and spatial heterogeneity that remains poorly understood. While genetic correlations between subtypes are established, spatially resolved molecular mechanisms driving their divergent clinical phenotypes-particularly in tissue microenvironments-are unclear, limiting targeted therapeutic development.

Methods: We integrated genome-wide association study (GWAS) data from FinnGen R11 and international cohorts with transcriptomic, epigenomic, and spatially resolved single-cell spatial transcriptomics (sc-ST) profiles.

Temperature-dependent sign reversal of tunneling magnetoresistance in van der Waals ferromagnetic heterojunctions.

Magnetic tunnel junctions (MTJs) are the elemental devices for advanced spintronic technologies, where tunneling magnetoresistance (TMR) serves as one of the key performance metrics. Here, we used the topologically nontrivial magnetic insulator CrVI and magnetic metal FeGeTe to fabricate CrVI/FeGeTe heterojunctions and FeGeTe/CrVI/FeGeTe MTJs. In the heterojunctions, the addition of CrVI led to a 180% coercive field enhancement of FeGeTe near the Curie temperature () of CrVI, which originated from the antiferromagnetic coupling between them.

GSDME-dependent astrocyte pyroptosis promotes the progression of neuroinflammation in experimental cerebral malaria.

Cerebral malaria (CM), a life-threatening neurological complication of Plasmodium falciparum infection, is characterized by severe neuroinflammation and long-term neurological sequelae. Central nervous system inflammation, driven by brain-infiltrated CD8 T cells, represents a hallmark pathological feature of CM. In this study, we demonstrate that astrocytes, a critical component of the blood-brain barrier and neurovascular unit, exhibit a robust interferon-γ response during CM, facilitating CD8 T cell recruitment into the brain parenchyma and antigen presentation to these immune cells.

Constructing Amine-Functionalized Hierarchically Porous Porphyrin-Based Metal-Organic Frameworks for Highly Enhanced Direct Air Capture of CO.

Direct air capture (DAC) of carbon dioxide (CO) has emerged as a prominent negative carbon emission technology for mitigating the greenhouse effect. Among various adsorbents, amine-functionalized metal-organic frameworks (MOFs) have shown exciting potential as adsorbents for atmospheric CO capture. However, the intrinsic microporosity of many MOFs restricts amine loading and uniform dispersion, diminishing the CO adsorption efficiency.

Hierarchically Porous Multiphase Si-Based Ceramics with Synergistic Electromagnetic Wave Absorption Mechanisms.

The development of high-performance electromagnetic wave absorbers is critical for mitigating electromagnetic pollution in modern electronic and communication systems. Here, a scalable strategy is developed to fabricate hierarchically porous, multiphase Si-based ceramics (Si-O-C) via one-step activation of carbon-rich polycarbosilane precursors. The resulting material integrates β-SiC crystals, amorphous SiOC, and conductive carbon within a tunable porous architecture.

Survival outcomes and risk factors after lung transplantation in patients with pre-transplant malignancy: a national cohort study.

Background: Pre-transplant malignancy (PTM) is a relative contraindication for lung transplantation (LTx). The proportion of patients with PTM in LTx is increasing annually. We sought to identify modifiable risk factors affecting patient survival and evaluate the prognosis of different types of PTM.

Catheter-related right atrial thrombosis from malpositioned totally implantable venous access ports: Case series and preventive lessons.

Totally implantable venous access ports are widely used for long-term intravenous therapy in oncology patients. However, catheter malpositioning may result in catheter-related right atrial thrombosis, a rare but potentially life-threatening complication. We report three breast cancer patients who developed catheter-related right atrial thrombosis due to deeply located catheter tips within the mid-right atrium.