Palmatine mitigates ischemic brain injury by regulating microglial polarization and sphingolipid metabolism.

Background: To elucidate the therapeutic effects and underlying mechanisms of palmatine, a principal alkaloid derived from Coptis chinensis, on neuroinflammation in ischemic stroke rat models induced by middle cerebral artery occlusion (MCAO).

Methods: Initially, qPCR was employed to assess the impact of neurotrophic factors secreted by SH-SY5Y neuroblastoma cells on the phenotypes of BV2 cells. Alterations in sphingolipid profiles within neuronal supernatants were characterized using liquid chromatography-tandem mass spectrometry, and molecular docking studies were conducted to investigate the interaction of palmatine with key enzymes involved in sphingolipid metabolism.

Heavy metals exposure and HPG-axis related hormones in women across the lifespan: An integrative epidemiological and bioinformatic perspective.

Background: Hormonal disruption evidence of metal exposure is lacking and contradictory.

Objectives: To elucidate the association of multiple metals exposure with a comprehensive panel of sex hormones in women across the lifespan.

Methods: 5492 women aged 3-80 from a national survey were included.

Correction: Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024.

[This corrects the article DOI: 10.3389/fonc.2025.

Decoy Receptor 2 as a Cell Cycle Arrest Biomarker for Predicting Renal Recovery Following Acute Kidney Injury.

Renal recovery following acute kidney injury (AKI) is a key determinant of long-term prognosis, while non-recovery significantly increases the risk of chronic kidney disease and progression to end-stage renal disease. Although cell cycle arrest is implicated in renal non-recovery and fibrosis, its association with decoy receptor 2 (DcR2) remains unclear. In this study, we evaluated 139 patients with biopsy-confirmed AKI, defining renal non-recovery as a ≥ 50% increase in baseline serum creatinine (Cr) or the initiation of dialysis.

Ni Carboxylate Metal-Organic Frameworks.

Octanuclear nickel cube (Ni) is considered as a highly attractive inorganic building block in the field of metal-organic frameworks (MOFs) due to its high symmetry (), 12 connection sites, and excellent chemical stability of the constructed MOFs. In this study, we report the synthesis of Ni-based MOFs constructed exclusively from carboxylic acid ligands, breaking from the conventional use of pyrazolate in Ni-containing MOFs. Two carboxylate-based MOFs featuring fcu topology (NNM-2 and NNM-3) were successfully synthesized.

Temperature-dependent sign reversal of tunneling magnetoresistance in van der Waals ferromagnetic heterojunctions.

Magnetic tunnel junctions (MTJs) are the elemental devices for advanced spintronic technologies, where tunneling magnetoresistance (TMR) serves as one of the key performance metrics. Here, we used the topologically nontrivial magnetic insulator CrVI and magnetic metal FeGeTe to fabricate CrVI/FeGeTe heterojunctions and FeGeTe/CrVI/FeGeTe MTJs. In the heterojunctions, the addition of CrVI led to a 180% coercive field enhancement of FeGeTe near the Curie temperature () of CrVI, which originated from the antiferromagnetic coupling between them.

Water mass mixing controls methane cycling and emission in highly hydrodynamic regions of the open ocean.

Ocean circulations and water mass exchange can exert significant influences on seawater biogeochemistry, microbial communities, and carbon cycling in marine systems. However, the detailed mechanisms of the impacts of physical processes in the open ocean on the cycle of greenhouse gases, particularly methane, remain poorly understood. In this study, we integrated high-resolution underway observations, experimental incubations, radioisotope labelling, and molecular analysis to constrain the controls of methanogenic pathways, methanotrophic activity, and emission fluxes in the highly hydrodynamic Kuroshio and Oyashio Extension (KOE) region of the Northwest Pacific.

Unraveling the multifaceted landscape of hepatocellular carcinoma evolution: From pivotal genetic drivers to therapeutic horizons.

Hepatocellular carcinoma (HCC) represents a malignant tumor that poses a significant threat to human health, and its occurrence and development are a complex multi-stage process. This review delineates the critical factors implicated in the transition from normal hepatocytes to malignant liver cells, encompassing dysregulated signalling pathways, key oncogenes, associated non-coding RNAs (ncRNAs), molecular alterations within the cellular microenvironment, spatial transcriptomic profiling, and advancements in anticancer therapies, thereby offering a comprehensive reference for elucidating HCC pathogenesis and formulating more targeted therapeutic approaches. Additionally, diagnostic and therapeutic aspects of liver diseases are examined, including the identification of diagnostic biomarkers, the development of therapeutic modalities, and recent innovations in pharmacological interventions, thereby providing novel insights into liver disease progression and insights into the development of novel therapeutic strategies.

Preparation of water-soluble flame retardant by cottonseed meal degradation for durable homologous flame retardant of cotton fiber.

The concept of homologous flame retardant of cottonseed meal to cotton fiber is reported. According to the chemical bond characteristics of the amide bond, ester bond, and glycosidic bond in crude protein, crude fiber, and crude fat of cottonseed meal, we developed a new system of HO-HPO degradation of dissolved cottonseed meal to prepare flame retardant. The study focuses on preparing water-soluble flame retardant (HO-HPO degradation Cottonseed meal, HPCm) by one-pot degradation of cottonseed meal and achieving durable flame retardancy for cotton fiber.

Consumer willingness to pay for green express packaging in e-commerce: an eye-tracking experiment analysis.

With the rapid development of e-commerce, packaging waste has surged, making green express packaging (GEP) a key component of sustainable logistics promotion. This study investigates the influence of product types (search goods vs. experienced goods), price sensitivity, and environmental awareness on consumers' willingness to pay for GEP.

Formation and centromere inactivation of fusion chromosomes in two allotetraploid species from the Saccharum complex.

Chromosome fusion can cause a change in the basic chromosome number of a species, thus imposing a major impact on speciation. However, there are few studies on the structure and evolution of fusion chromosomes in plants. Erianthus rockii and Narenga porphyrocoma are allotetraploid species within the Saccharum complex.

Exosome- transported FER inhibitor suppresses progression of diffuse large B-cell lymphoma via regulating AJUBA/Hippo axis.

FER, an intracellular tyrosine kinase, is ubiquitously expressed in malignancies. However, the regulatory mechanisms of FER in diffuse large B-cell lymphoma (DLBCL) remain elusive. Here, we found that FER was upregulated in DLBCL, leading to unfavorable outcomes and increased tumorigenesis, as well as resistance to chemotherapy.

Anomalous ionic conduction in ferroelectric semiconductor junctions comprising multistate CuInPS.

Van der Waals ferroelectric CuInPS (CIPS) has emerged as a compelling candidate for multifunctional electronic devices, attributed to its intrinsic multiple polarization states and the coupling of these states with highly active Cu ions migration. Such a "ferroionic" feature of CIPS opens a new paradigm for the next-generation multifunctional ferroelectric devices. Here, we present a comprehensive investigation of n-Si/CIPS/MoS ferroelectric semiconductor junction (FSJ) devices, focusing on the interplay between ferroelectric polarization and ionic migration.

The association between exposure to brominated flame retardants (BFRs) and arthritis, osteoarthritis, and rheumatoid arthritis: a cross-sectional study.

Background: The relationship between brominated flame retardants (BFRs) exposure and arthritis and its subtypes remains unclear. This study aimed to investigate the potential association between BFRs exposure and arthritis, osteoarthritis, and rheumatoid arthritis (RA) in American adults.

Methods: A cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey (NHANES) 2005-2016.

Clumped isotopes of methane trace bioenergetics in the environment.

Methane is a major greenhouse gas and a key component of global biogeochemical cycles. Microbial methane often deviates from isotope and isotopolog equilibrium in surface environments but approaches equilibrium in deep subsurface sediments. The origin of this near-equilibrium isotopic signature in methane, whether directly produced by methanogens or achieved through anaerobic oxidation of methane (AOM), remains uncertain.

Pluripotent stem cell-derived cardiomyocyte transplantation: marching from bench to bedside.

Cardiovascular diseases such as myocardial infarction, heart failure, and cardiomyopathy, persist as a leading global cause of death. Current treatment options have inherent limitations, particularly in terms of cardiac regeneration due to the limited regenerative capacity of adult human hearts. The transplantation of pluripotent stem cell-derived cardiomyocytes (PSC-CMs) has emerged as a promising and potential solution to address this challenge.

Disparities in lifestyle among community-dwelling older adults with or without mild cognitive impairment: a population-based study in north-western China.

Background: Evidences indicate that patients with unhealthy lifestyles are at a higher risk of cognitive impairment and dementia. However, uncertainty remains about the association of lifestyles with mild cognitive impairment (MCI) in less-developed areas.

Methods: We used multi-stage stratified sampling method to obtain study population aged ≥65 years, and subsequently a cross-sectional survey was produced including 509 individuals (109 MCI and 400 healthy controls) between March and June 2023.

The Role of Fatty Acid Binding Protein 7 in Neurological Diseases.

Fatty acid binding protein 7 (FABP7) is a pivotal cytoplasmic protein involved in the transport and metabolism of fatty acids, with critical functions in the nervous system. This review highlights recent advances in understanding the role and mechanisms of FABP7 in neurological diseases. It begins with an overview of FABP7's distribution and expression in the nervous system, emphasizing its involvement in essential biological processes such as lipid metabolism, energy regulation, synaptic transmission, cell growth, and neuroinflammation.

Acquired ROS1 fusion and iruplinalkib response in advanced NSCLC after multiple lines of systematic therapy: a case report.

This is the first report of a patient with lung cancer whose primary focus was the upper lobe of the left lung combined with multiple metastases in both lungs, initially diagnosed as a non-driver gene mutation, who subsequently developed SDC4-ROS1 fusion after multiple lines of systemic therapy. When diagnosis, a needle biopsy of the primary focus revealed no driver gene mutation and low PD-L1 expression (TPS < 1%, CPS 3). From November 2022 to December 2023, the patient received sequential chemotherapy-based systemic therapy including anti-angiogenesis treatment, concurrent chemoradiation and combined immunotherapy as determined by the clinician based on the initial evaluation.

The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson's Disease.

A century ago, a mystery between a virus and Parkinson's disease (PD) was described. Owing to the limitation of human brain biopsy and the challenge of electron microscopy in observing virions in human brain tissue, it has been difficult to study the viral etiology of PD. Recent discovery of virobiota reveals that viruses coexist with humans as symbionts.

Sequential comparison of single-stage laparoscopic common bile duct exploration combined with cholecystectomy.

Laparoscopic cholecystectomy (LC) combined with laparoscopic common bile duct exploration (LCBDE) is used to treat gallbladder (GB) stones combined with common bile duct (CBD) stones. Patients with GB stones combined with CBD stones who underwent single-stage LC + LCBDE surgery in our center from January 2020 to November 2023 were retrospectively analyzed and divided into LC-BDE and BDE-LC groups. LC-BDE was performed in patients with cystic duct diameter ≥ 0.

Three-dimensional KV(PO)@Carbon core-shell coaxial nanowire networks for High-rate sodium-ion batteries.

Potassium vanadium phosphate is an emerging sodium superionic conductor (NASICON) material with great potential as a cathode for sodium-ion batteries, owing to its high operating voltage, structural stability, and low cost. However, its poor electronic conductivity, along with significant volume expansion and stress effects during Na insertion and extraction, severely limits its electrochemical performance, hindering its practical application. In this study, a three-dimensional (3D) carbon-coated KV(PO) core-shell coaxial nanowire network (KVP@C) was synthesized using a simple electrospinning method combined with high-temperature annealing.

Homologous flame retardant - cottonseed meal modified as a flame retardant for cotton fiber durable flame retardancy.

Cotton fibers are widely used in various applications due to their biodegradability, low cost, and extensive availability. The cottonseed is associated with cotton, which has a large yield. After oil extraction, the remaining cottonseed meal has a high protein content, making it a potential flame retardant for cotton fibers.

A NiCo oxide/NiCo sulfate hollow nanowire-coated separator: a versatile strategy for polysulfide trapping and catalytic conversion in high-performance lithium-sulfur batteries.

Lithium-sulfur batteries (LSBs) are highly anticipated due to their remarkable theoretical specific energy and energy density. Nevertheless, the polysulfide shuttle effect severely curtails their cycle life, posing a significant obstacle to commercialization. Herein, we introduce nickel-cobalt oxide/nickel-cobalt sulfate hollow nanowires (NCO/NCSO-HNWs) as a separator modification material.

Risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery.

Background: The surgical management of rectal cancer is continuously advancing, with a current emphasis on minimising the need for a permanent stoma. Understanding the risk factors influencing sphincter preservation is crucial for guiding clinical decision-making and optimising preoperative patient evaluation.

Aim: To examine the risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery.