Differences and Influencing Factors of Soil Bacterial Communities Under Different Forest Types on the Southern Slope of the Qilian Mountains.

Understanding the distribution patterns of soil bacterial community structure and diversity across different forest types is essential for elucidating the mechanisms underlying microbial community assembly and its ecological drivers, particularly under the pressures of climate change. In this study, we examined six forest types-including four monocultures and two mixed-species stands-to systematically evaluate the structural composition, diversity metrics, and functional potential of soil bacterial communities. Significant differences in microbial structure and functional composition were observed among forest types.

Heavy metals exposure and HPG-axis related hormones in women across the lifespan: An integrative epidemiological and bioinformatic perspective.

Background: Hormonal disruption evidence of metal exposure is lacking and contradictory.

Objectives: To elucidate the association of multiple metals exposure with a comprehensive panel of sex hormones in women across the lifespan.

Methods: 5492 women aged 3-80 from a national survey were included.

Enhancing photoredox catalysis by suppressing back electron transfer with the aid of a spin catalyst.

While organic dye-based photoredox catalysis provides a sustainable platform for inert bond activation, its efficiency remains limited by detrimental back electron transfer (BET) processes. Herein, we present a spin catalysis strategy that addresses this challenge by manipulating the spin kinetics of radical ion pairs (RIPs) using Gd-DOTA as a spin catalyst. In photocatalytic hydrodechlorination of methyl 4-chlorobenzoate, this approach achieved a remarkable spin catalysis effect (SCE) of 70%, accompanied by a 25-fold acceleration in reaction kinetics (65% conversion in 25 min 640 min without spin catalyst).

Association between high-density lipoprotein-related inflammation index and prevalence of sleep disorders with depression as a mediator.

Background: Sleep disorders have a significant impact on physical health, mental health, and daily functioning, exacerbated by the accelerating pace of life and rising work-related stress in contemporary society. The incidence of sleep disorders continues to rise annually, becoming a significant global public health issue. The white blood cell-to-HDL-cholesterol ratio (WHR), lymphocyte-to-HDL-cholesterol ratio (LHR), monocyte-to-HDL-cholesterol ratio (MHR), neutrophil-to-HDL-cholesterol ratio (NHR), and platelet-to-HDL-cholesterol ratio (PHR) are emerging, convenient, and cost-effective biomarkers that reflect systemic inflammation and immunometabolic status.

Abnormal brain morphology and morphological brain network in adults with acute mild traumatic brain injury.

Background: Mild traumatic brain injury (mTBI) commonly has long-term cognitive and functional consequences; however, it is not clear whether these adverse outcomes begin in the acute phase of mTBI and are associated with changes in brain morphology and function.

Methods: The current study used T1-weighted MRI to determine whether cortical thickness, gray matter volume (GMV), and morphological brain networks were altered in patients with mTBI within 7 days of injury, and to examine whether these changes were associated with postacute cognitive and emotional abnormalities. Adults aged 18-56 years with mTBI ( n  = 43) and healthy controls ( n  = 37) completed the cognitive, emotional evaluation, and MRI examination, during which patients with mTBI completed symptom reports.

Space-confined synthesis of sinter-resistant high-entropy nanoparticle library.

The tailorable confinement of high-entropy nanoparticles (HE-NPs) within molecular sieves (HE-NPs@MSs), synergizing merits of cocktail effects and geometric polymorphs, holds potential for advancing heterogeneous catalysis. However, effective and universal synthesis affording size homogeneity and production scalability remains elusive. In this contribution, we present a versatile strategy for encapsulating ultrafine HE-NPs within diverse mesoporous/microporous MSs to enable the rational construction of HE-NPs@MS library.

Impact of per- and polyfluoroalkyl substances exposure on renal dysfunction: Integrating epidemiological evidence with mechanistic insights.

Renal dysfunction poses a growing global health burden, yet the role of environmental contaminants like per- and polyfluoroalkyl substances (PFAS), particularly their underlying mechanisms, remains understudied. This cross-sectional study included 2801 adults from North China (Shijiazhuang and Baoding City). Plasma concentrations of 21 legacy and alternative PFAS were quantified via ultra-high-performance liquid chromatography-tandem mass spectrometry.

Advances in molecular pathology and therapy of non-small cell lung cancer.

Over the past two decades, non-small cell lung cancer (NSCLC) has witnessed encouraging advancements in basic and clinical research. However, substantial unmet needs remain for patients worldwide, as drug resistance persists as an inevitable reality. Meanwhile, the journey towards amplifying the breadth and depth of the therapeutic effect requires comprehending and integrating diverse and profound progress.

A multi-modal sarcasm detection model based on cue learning.

The rapid proliferation of internet data, particularly through social media, has amplified the need for effective sentiment analysis, including the complex task of sarcasm detection. This paper presents a novel multi-modal sarcasm detection model leveraging cue learning techniques to address the challenges posed by data scarcity, especially in low-resource languages. The proposed model builds upon the CLIP architecture, integrating text and image modalities to co-learn sarcasm cues.

Deep learning-aided preparation and mechanism revaluation of waste wood lignocellulose-based flame-retardant composites.

Wood and its derivatives play a decisive role in traditional Chinese architecture. Waste wood as a major source of garbage in the construction industry represents a valuable source. The efficient recycling of waste wood has become an urgent technical problem in waste recycling research.

Enhanced retention of small-sized microplastics by iron-containing sand filtration system: Effectiveness and mechanisms.

This study explores the enhanced retention of small-sized microplastics (MPs) in sand filtration systems using iron-loaded sand (IS). Conventional sand filtration has limited efficiency in removing MPs smaller than the pore size of the filter media, which presents a significant challenge for drinking water treatment plants (DWTPs). To address this issue, quartz sand was modified with iron (hydro)oxide coatings to alter the surface charge, enabling a strong electrostatic attraction with negatively charged MPs.

Microbe-assisted fabrication of circularly polarized luminescent bacterial cellulosic hybrids.

The fabrications of circularly polarized luminescent (CPL) material are mainly based on the chemical and physical strategies. Controlled biosynthesis of CPL-active materials is beset with difficulties due to the lack of bioactive luminescent precursors and bio-reactors. Enlighted by microbe-assisted asymmetric biosynthesis, herein, we show the in situ bacterial fermentation of Komagataeibacter sucrofermentants to fabricate a series of bacterial cellulosic biofilms with CPL of green, orange, red, and near-infrared colors.

Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR.

Hypoxia is a common feature of glioblastoma (GBM). Circular RNAs (circRNAs) are identified as regulators in cancers. However, the role of circRNAs in GBM remains elusive.

Monitoring of single-nucleus chromatin landscape of ischemic stroke in mouse cerebral cortex across time.

Ischemic stroke constitutes a multifaceted neurological affliction that spans various cellular types. Lack of dynamic chromatin accessibility data after stroke is one of the obstacles to understanding this process. To gain insights into the variations in transcriptional regulation among various cell types subsequent to a stroke, we employed single-nucleus ATAC-seq to curate a chromatin accessibility compendium from the cerebral cortex of mice subjected to middle cerebral artery occlusion/reperfusion (MCAO/R).

Protocol to profile snATAC-seq datasets and motif enrichment analysis during zebrafish early embryogenesis.

The scarcity of zebrafish-specific motif databases presents a challenge to the analysis of transcription factor (TF) motif within zebrafish single-cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) data, thus hindering the identification of regulatory elements throughout zebrafish embryonic development. Here, we provide a protocol to analyze single-nucleus chromatin accessibility dataset during zebrafish early embryogenesis. We describe steps for fragment file retrieval, sample integration, quality control, Latent Semantic Indexing (LSI) clustering, and peak calling via ArchR.

An innovative minimally invasive approach for hypertrophic obstructive cardiomyopathy: Transaortic septal myectomy via right infra-axillary incision.

Objective: To assess the short-term outcomes of the transaortic modified Morrow procedure when performed via a minimally invasive right infra-axillary incision.

Methods: We conducted a retrospective observational study at a single center of patients diagnosed with hypertrophic obstructive cardiomyopathy from September 2021 to July 2023.

Results: The cohort comprised 148 patients (mean age 47.

Dysregulated RBM24 phosphorylation impairs APOE translation underlying psychological stress-induced cardiovascular disease.

Psychological stress contributes to cardiovascular disease (CVD) and sudden cardiac death, yet its molecular basis remains obscure. RNA binding protein RBM24 plays a critical role in cardiac development, rhythm regulation, and cellular stress. Here, we show that psychological stress activates RBM24 S181 phosphorylation through eIF4E2-GSK3β signaling, which causally links psychological stress to CVD by promoting APOE translation (apolipoprotein E).

Minimally Invasive Video-Assisted Surgery for Concomitant Ascending Aorta and Aortic Valve Replacement via Right Infra-Axillary Thoracotomy.

Objective: This study aims to assess the safety, efficacy, and esthetic outcomes of an innovative 4 cm right infra-axillary incision approach for concomitant ascending aorta and aortic valve replacement (AAR and AVR), with a specific focus on achieving optimal surgical outcomes while ensuring minimal visible scarring.

Methods: We retrospectively examined all elective cases of concomitant AAR and AVR surgery performed at our institution from July 2021 to June 2023. Exclusions encompassed emergency surgery, acute type A aortic dissection, active aortic valve endocarditis, redo cardiac surgery, the necessity for concurrent mitral valve replacement, or left ventricular assist device implantation.

Management strategies and outcomes in pregnancy-related acute aortic dissection: a multicentre cohort study in China.

Background: Acute aortic dissection (AD) in pregnancy poses a lethal risk to both mother and fetus. However, well-established therapeutic guidelines are lacking. This study aimed to investigate clinical features, outcomes and optimal management strategies for pregnancy-related AD.

Stanniocalcin-1 promotes temozolomide resistance of glioblastoma through regulation of MGMT.

Temozolomide (TMZ) resistance is a major challenge in the treatment of glioblastoma (GBM). Tumour reproductive cells (TRCs) have been implicated in the development of chemotherapy resistance. By culturing DBTRG cells in three-dimensional soft fibrin gels to enrich GBM TRCs and performing RNA-seq analysis, the expression of stanniocalcin-1 (STC), a gene encoding a secreted glycoprotein, was found to be upregulated in TRCs.

Impact of Combined Pollution of Ciprofloxacin and Copper on the Diversity of Archaeal Communities and Antibiotic-Resistance Genes.

This study aimed to explore the response of archaeal communities and antibiotic-resistance genes (ARGs) to ciprofloxacin (CIP, 0.05-40 mg/L) and copper (Cu, 3 mg/L) combined pollution during stress- and post-effect periods in an activated sludge system. With the increase in the CIP concentration, the diversity of archaea decreased, but the richness increased under the stress of 10 mg/L CIP.