Global research trends in gut microbiota and cellular senescence: a bibliometric and visual analysis from 2015 to 2025.

Background: The human body's intestinal microbiota is a vital "organ" that coexists with it and is intimately linked to both human health and illness. Human intestinal microbiota and its metabolites are a crucial component in the development of several diseases, according to an increasing number of studies that have started to examine the function of intestinal microbiota in various illnesses. Numerous recent studies have also shown a direct relationship between cellular senescence and the gut flora.

Improper use of spinetoram on tea plants can inhibit the predation ability of Arma chinensis.

The application of pesticides is indispensable in agricultural production and mitigate the negative impact is crucial nowadays. The Agriophara rhombata is a major pest on tea trees and the Arma chinensis is a beneficial insect and its natural enemy in field production. Application of the Spinetoram to control A.

Linperlisib Plus Chidamide in Relapsed or Refractory Cutaneous T-Cell Lymphoma: A Nonrandomized Clinical Trial.

Importance: Patients with relapsed or refractory (r/r) cutaneous T-cell lymphoma (CTCL) have limited treatment options. Combining agents that target complementary oncogenic pathways may enhance efficacy while maintaining tolerability.

Objective: To evaluate the safety and efficacy of linperlisib, a PI3Kδ inhibitor, combined with chidamide, a histone deacetylase inhibitor, in patients with r/r CTCL.

Design and Simulation of a Bio-Inspired Deployable Mechanism Achieved by Mimicking the Folding Pattern of Beetles' Hind Wings.

In this paper, a beetle with excellent flight ability and a large folding ratio of its hind wings is selected as the biomimetic design. We mimicked the geometric patterns formed during the folding process of the hind wings to construct a deployable mechanism while calculating the sector angles and dihedral angles of the origami mechanism. In the expandable structure of thick plates, hinge-like steps are added on the thick plate to effectively avoid interference motion caused by the folding of the thick plate.

Relapses and outcomes of systemic chemo-free therapies combined with intravitreous methotrexate in isolated primary vitreoretinal lymphoma: an analysis based on two prospective cohort studies.

The definitive therapeutic paradigm for primary vitreoretinal lymphoma (PVRL) remains controversial, with ongoing debates surrounding the comparative efficacy of localized ocular therapy, high-dose systemic chemotherapy, and combined-modality approaches. The benefit of systemic administration of methotrexate is unambiguous and severe adverse events related to intense chemotherapy are reported. Immunomodulators such as lenalidomide and Bruton's tyrosine kinase (BTK) inhibitors, like zanubrutinib, have not been explored for their safety and efficacy as first-line treatments for PVRL.

Quality of life of family caregivers of stroke patients: A systematic review of qualitative research.

Objectives: Stroke imposes a substantial burden on individuals and families. The caregiving role for stroke survivors is often assumed by family members. This systematic review aimed to synthesize qualitative studies that explored the lived experiences of family caregivers of stroke patients, thereby determining the breadth and depth of qualitative evidence on their experiences.

Preparation and characterization of thermosensitive phase-transition hydrogel based on decanoic acid-modified chitosan and methyl cellulose for wound healing.

Hydrogels with good biocompatibility, suitable physicochemical properties, and effective wound healing promotion are currently recognized as ideal candidates for wound dressings. This study introduced an innovative thermosensitive phase-transition hydrogel (CSDA-MC-HG) for skin wound repair, prepared using decanoic acid-modified chitosan (CSDA) and methyl cellulose (MC). The enhanced hydrophobic interaction with increasing temperature was the primary mechanism behind the thermosensitive phase-transition property of CSDA-MC-HG.

Dissecting the genetic architecture of key agronomic traits in lettuce using a MAGIC population.

Background: Lettuce is a globally important leafy vegetable that exhibits diverse horticultural types and strong population structure, which complicates genetic analyses. To address this challenge, we develop the first multi-parent, advanced generation inter-cross (MAGIC) population for lettuce using 16 diverse founder lines.

Results: Whole-genome sequencing of the 16 founder lines and 381 inbred progeny reveal minimal population structure, enabling informative genome-wide association studies (GWAS).

Vitamin E ameliorates blood cholesterol level and alters gut microbiota composition: A randomized controlled trial.

Background And Aims: Antioxidants, including vitamin E (VE) and grape seed extract (GSE), as anti-aging supplementation have been widely used to improve human health. The gut microbiota plays a crucial role in health and affects the treatment effect of various interventions. However, the role of gut microbiota in VE remains unclear.

Deep learning-aided preparation and mechanism revaluation of waste wood lignocellulose-based flame-retardant composites.

Wood and its derivatives play a decisive role in traditional Chinese architecture. Waste wood as a major source of garbage in the construction industry represents a valuable source. The efficient recycling of waste wood has become an urgent technical problem in waste recycling research.

Correlations of mucin 5B gene polymorphisms and expression levels with the risk of onset of coal workers' pneumoconiosis.

This study investigates the correlations of mucin 5B (MUC5B) rs2672794, rs2075854, and rs868903 polymorphisms and MUC5B expression level with the risk of the onset of coal workers' pneumoconiosis (CWP). Overall, 506 Han Chinese men were included in this study. Among them, 143 were healthy individuals, 132 were dust-exposed workers who underwent health monitoring periodically, and 231 were patients with CWP.

Hotspots evolution and frontiers of immunotherapy for the treatment of acute myeloid leukemia: A bibliometric analysis.

Given the growing significance of immunotherapy in addressing the limitations of conventional acute myeloid leukemia (AML) treatments, this study aimed to elucidate the hotspot evolution and frontiers of immunotherapy in AML using bibliometric analysis. With a strict retrieval strategy applied in the Web of Science Core Collection, 2411 publications were obtained and exported. The temporal and geographical distributions of these publications and the countries, institutions, journals, and authors who contributed to the field were investigated.

Metabolomic profiling identifies metabolites in the pheromone glands of associated with the synthesis and release of female pheromone signals.

The tea moth pest, is an economically important and highly damaging pest that drastically affects tea plant leaves. The chemical composition of its pheromone glands metabolites before and during calling period has not been reported yet. Therefore, the present study aimed at the metabolomic profiling of female moths' sex pheromones glands before and during calling period using gas chromatography time-of-flight mass spectrometry.

Milliwatt-level single-mode laser from an erbium-doped silica microcavity using a fiber Brillouin amplifier.

Microlasers based on ultrahigh-quality-factor erbium-doped silica microcavities are renowned for their exceptionally low thresholds and remarkably narrow linewidths. However, these microlasers struggle to achieve single-mode operation while delivering high output power, which presents a significant barrier to their widespread practical application. Here, we fabricate an erbium-doped silica microsphere cavity with the ultrahigh-Q factor (exceeding 10).

Clinical and genetic profile of Chinese patients with indolent natural killer-cell lymphoproliferative disorder of the gastrointestinal tract.

Indolent natural killer cell lymphoproliferative disorder of the gastrointestinal tract (iNKLPD-GI) is an uncommon, recently recognized lymphoid proliferation of mature NK cells primarily manifesting in the GI tract. Unlike NK/T lymphoma, iNKLPD-GI exhibits a rather indolent clinical course, underscoring the need for cautious management to prevent unnecessary interventions. However, clinical and molecular features of this entity have not been thoroughly understood.

[Comprehensive intervention combined with cognitive psychological care based on quality chain for patients with benign prostatic hyperplasia].

Objective: To investigate the application effect of comprehensive intervention combined with cognitive psychological care based on the quality chain in patients with BPH.

Methods: We prospectively selected 110 cases of BPH treated in our hospital from January 2022 to March 2023 and equally randomized them into groups A and B, the former given routine intervention, while the latter comprehensive intervention combined with cognitive psychological care based on the quality chain in addition. We analyzed the results of intervention, the patients' scores on Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS), improvement of clinical indicators, self-efficacy, disease awareness and treatment compliance, and compared the data obtained between the two groups of patients.

Vaginal involvement as a rare extranodal manifestation in advanced-stage follicular lymphoma: a case report and literature review.

Apart from bone marrow involvement, extranodal involvement of follicular lymphoma (FL) is rare. Gynecologic FL is seldom reported, among which the vagina is the rarest involved site. No vaginal involvement in advanced-staged FL was reported before.

Anti-contact protein-associated protein 2 antibody encephalitis in children: A case report.

Background: Anti-contactin-associated protein-like 2 (CASPR2) antibody encephalitis is an autoimmune disorder characterized by the presence of antibodies against the voltage-gated potassium channel. This leads to neurological symptoms, such as seizures, cognitive decline, and neuropathic pain, primarily affecting the limbic system. The prognosis of this disorder varies among individuals.

A retrospective study of prognostic factors and treatment outcome in advanced-stage Mycosis Fungoides and Sezary Syndrome.

: Mycosis fungoides (MF) and Sezary Syndrome (SS) comprise over half of all Cutaneous T-cell lymphoma diagnoses. Current risk stratification is largely based on TNMB staging, few research investigated the prognostic value of clinical exams. Current systemic therapy for advanced disease includes immunomodulatory drugs, chemotherapy, and HADC inhibitors.

Lymphoma relapse 1 year or later after immunochemotherapy in DLBCL patients: clinical features and outcome.

Despite great advances in treatment, 30-40% of patients with DLBCL undergo relapses. Patients with a relapse within 1 year or beyond have a distinct outcome. Few clinical characteristics and survival data in the Chinese population have been published.

Synthesis and photophysical properties of dinuclear N-heterocyclic carbene (NHC) copper(I) complexes and their application to photoluminescent light-emitting diodes and anti-counterfeiting.

Here, a series of dinuclear N-heterocyclic carbene (NHC) copper(I) complexes having 3,3'-(1,4-phenylenebis(methylene))bis(1-(pyridin-2-yl)-1H-imidazolylidene as bis-NHC ligand and bis[(2-diphenylphosphino)phenyl]ether (POP) as auxiliary ligand have been successfully prepared, and their photophysical properites were investigaged experimentally and theocitcally. The resulting complexes all exhibited intense green to yellow emission that originated from the thermally activated delayed fluorescence (TADF) with a high photoluminescence quantum yield of up to 0.67 and longer excited-state lifetimes on the microsecond time scale in the solid state.

Effectiveness of Chinese Herbal Medicine in Postoperative Fatigue Syndrome Following Total Joint Arthroplasty or Hip Fracture Surgery: Evidence from Randomized Controlled Trials.

Background: There is no high-quality, evidence-based protocol for the treatment of postoperative fatigue syndrome (POFS) after total joint arthroplasty (TJA) or fracture surgery with Chinese herbal medicine (CHM).

Purpose: The purpose of this study was to explore the efficacy of CHM in the treatment of POFS after TJA or hip fracture surgery (HFS).

Methods: We searched six databases to obtain randomized controlled trials (RCTs) of CHM for the treatment of POFS after TJA or HFS.