Hepatotoxicity induced by polylactic acid microplastics: The mediating role of gut microbiota and uric acid metabolism.

Introduction: The increasing use of biodegradable plastics has led to the inevitable human consumption of biodegradable microplastics (MPs). These MPs can be degraded and absorbed into various organs and tissues via the gastrointestinal tract, with the liver being the primary target for digestion and absorption.

Objectives: This study aimed to investigate the toxic effects and mechanisms of biodegradable MPs on the liver following gastrointestinal degradation.

Efficacy and safety of tazemetostat, an EZH2 inhibitor, in Chinese patients with relapsed/refractory follicular lymphoma: a multicentre, single-arm, phase 2 study.

Background: Tazemetostat, the first enhancer of zeste homolog 2 (EZH2) inhibitor approved by the U.S. Food and Drug Administration, has shown efficacy in a global population with relapsed or refractory (R/R) follicular lymphoma (FL).

Dual-scale chemical ordering for cryogenic properties in CoNiV-based alloys.

The mechanical properties of metallic materials often degrade under harsh cryogenic conditions, posing challenges for low-temperature infrastructures. Here we introduce a dual-scale atomic-ordering nanostructure, characterized by an exceptionally high number density of co-existing subnanoscale short-range ordering (approximately 2.4 × 10 m) and nanoscale long-range ordering (approximately 4.

In Situ Selenization Engineered Dual Schottky Heterojunctions: A Novel Architecture for High-Speed Broadband Photonic Communication Detector Arrays.

2D transition metal dichalcogenide WSe exhibits unique band structure tunability, and its van der Waals heterostructures with 3D semiconductors demonstrate significant potential for high-performance photodetection. However, inherent limitations (interface defects) in conventional thin-film transfer hinder their development. This study addresses interfacial defects and integration challenges in WSe-based 2D-3D heterojunction devices by proposing a GeSi diffusion barrier-mediated interfacial engineering strategy combined with dual-temperature-zone furnace-based in situ selenization, achieving controllable growth of high-quality WSe films on GeSi/Ge substrates.

Inhibition of eEF2 kinase ameliorates hepatic injury induced by ACR through regulation of the MAPK pathway.

Background And Aims: Acrylamide (ACR) induces hepatotoxicity, yet its underlying mechanisms remain incompletely understood. Our prior proteomic analysis of serum from occupationally ACR-exposed individuals identified significantly elevated levels of eukaryotic elongation factor 2 (eEF2). Given that eEF2 activity is regulated by its phosphorylation status, which is solely mediated by eukaryotic elongation factor 2 kinase (eEF2K), we investigated the role of eEF2K in ACR-induced hepatic injury.

Safety and efficacy of HH2853, a novel EZH1/2 dual inhibitor, in patients with refractory solid tumours or non-Hodgkin lymphomas: a phase I study.

Background: HH2853 is a novel dual EZH1/2 inhibitor that exhibits superior antitumour activity compared to tazemetostat across various preclinical models. Here, we evaluated the safety, pharmacokinetic (PK), pharmacodynamic (PD), and preliminary efficacy of HH2853 in patients with refractory advanced solid tumours and non-Hodgkin lymphomas (NHLs).

Methods: This open-label, global multicentre, phase I study was conducted at 12 centres in China and the USA, enrolling patients (aged ≥18 years) with relapsed or refractory solid tumours or NHLs.

Quantum-Confined 0D/2D/3D Heterostructure Photodetectors with an Ultrafast Self-Powered Broadband Response for Short-Wave Infrared Imaging.

The integration of quantum-confined nanostructures with two-dimensional (2D) and three-dimensional (3D) materials presents a promising avenue for advancing optoelectronic devices, yet achieving synergistic enhancement in broadband detection, self-powered operation, and ultrafast response remains challenging. Here, a novel 0D/2D/3D heterostructure photodetector is demonstrated by integrating PdTe quantum islands (QIs) with PtTe and n-Ge, leveraging quantum confinement, van der Waals interfacial coupling, and light-trapping mechanisms. The unique architecture enables broadband photodetection spanning 532-2200 nm, overcoming the intrinsic absorption limit of Ge above 1850 nm.

A systematic review and meta-analysis of randomized controlled trials on the efficacy and safety of tanshinone IIA sodium sulfonate injection as adjunctive therapy for stroke.

Ethnopharmacological Relevance: Tanshinone IIA is the core ingredient of Salvia miltiorrhiza Bge, with the effect of blood circulation promotion and blood stasis removement, widely used in cardiovascular and cerebrovascular diseases treatment as adjunctive therapy.

Aim Of The Study: Stroke, remains a leading cause of disability and death, posing a serious public health threat. Tanshinone IIA sodium sulfonate injection (STS), derived from Salvia miltiorrhiza Bge (Danshen), is widely used in China as adjunctive therapy for ischemic stroke.

Experimental validation of cuproptosis-associated molecular signatures and their immunological implications in pulmonary tuberculosis.

Background: The pathogenic mechanism underlying (MTB) remains elusive, posing challenges to its diagnosis and treatment. Cuproptosis is a newly identified mechanism of cell death. This study explores the role of cuproptosis-related genes (CRGs) in pulmonary tuberculosis (PTB) to uncover potential diagnostic biomarkers and therapeutic targets.

[NSD1 regulates H3K36me2 in the pathogenesis of non-obstructive azoospermia].

Objective: To explore the role of nuclear receptor-binding SET-domain protein 1 (NSD1) in the pathogenesis of nonobstructive azoospermia (NOA) by regulating the expressions of relevant genes.

Methods: We detected the expression of NSD1 in the testis tissue of 7 male patients with obstructive azoospermia (OA) and 18 with NOA by qPCR and immunofluorescence assay, and determined the modification level of H3K36me2 in the testes of two groups of patients by immunofluorescence staining, Western blot and immunoprecipitation (IP). We examined the difference in the enrichment of H3K36me2 in the testis tissue by chromatin IP-based sequencing (ChIP-Seq), analyzed the genomic distribution and target genes using bioinformatics, and verified the expression levels of the target genes in the testes of the two groups of patients by qPCR.

Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes.

Follicular lymphoma (FL) is characterized by clinical, phenotypic, and genetic heterogeneity. Here, we conduct whole-genome sequencing on 131 Chinese FL samples and identify three clinically relevant genetic subtypes. These include C1, associated with favorable prognoses and enriched for BCL6-related translocations and mutations in the NOTCH/nuclear factor κB (NF-κB)/immune evasion pathways; C2, characterized by BCL2-IGH translocations and mutations in chromatin modifiers; and C3, associated with poorer prognosis, lacking BCL2-IGH/BCL6-related translocations but exhibiting more copy number variations.

An Enhanced CT-Based Radiomics Model for Predicting the Anaplastic Lymphoma Kinase Mutation Status in Lung Adenocarcinoma.

Introduction: This study aimed to explore the relationship between radiomics features and anaplastic lymphoma kinase (ALK) gene mutation status in lung adenocarcinoma and to develop a radiomics nomogram for preoperative prediction of ALK mutations.

Methods: A retrospective analysis was conducted on 210 patients with histologically confirmed lung adenocarcinoma (50 ALK mutation-positive, 160 mutation-negative), divided into training (n=147) and validation (n=63) cohorts (7:3 ratio). Preoperative enhanced CT images were analyzed using ITK-SNAP for region-of-interest delineation, and radiomics features were extracted via A.

Association between alcoholic beverage consumption and cerebral small vessel disease burden.

Background: The relationship between alcohol consumption and cerebral small vessel disease (CSVD) remains uncertain, particularly regarding drinking patterns and beverage types. We investigated how total alcohol intake, drinking frequency, and beverage-specific consumption are associated with CSVD burden using cross-sectional data.

Methods: We included 27,326 UK Biobank (UKB) participants with MRI data, among whom 21,130 were current drinkers with full alcohol intake data.

Immunofocusing design of a fusion glycoprotein monomer vaccine for respiratory syncytial virus.

Respiratory syncytial virus (RSV) can cause severe lower respiratory tract infections in infants and the elderly. Previously, most RSV vaccine antigen design strategies have focused on the stability of the prefusion (PreF) protein trimer conformation. We hypothesized that the RSV monomer might serve as a vaccine candidate immunogen.

An Aliasing Measure of Factor Effects in Three-Level Regular Designs.

For three-level regular designs, the confounding from the perspectives of both factor and component effects leads to different results. The aliasing properties of factor effects are more significant than the latter in the experimental model. In this paper, a new three-level aliasing pattern is proposed to evaluate the degree of aliasing among different factors.

Enantioselective Propargylic Substitution of Ketone Enolates with Propargylic Alcohol Derivatives through Cooperative B/Cu Catalysis.

We present an asymmetric propargylic substitution reaction of -hydroxy aryl ketones with propargylic acetates catalyzed by a B/Cu system. The reaction initiates with the activation of -hydroxy aryl ketones via achiral borinic acid to form a tetracoordinated enol boronate complex, which then reacts with propargylic acetates catalyzed by copper salts with chiral P,N,N-ligand. This method is amenable to a broad range of substrates and delivers a series of chiral β-ethynyl ketones with high yields and remarkable enantioselectivity under mild conditions.

Cadonilimab (a PD-1/CTLA-4 bispecific antibody) Plus Neoadjuvant Chemotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma: A Phase Ⅱ Clinical Trial.

Purpose: Preclinical and clinical findings suggest that programmed cell death protein 1 (PD-1) /cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) bispecific antibodies may offer synergistic anti-tumor activity. This study aimed to explore the efficacy and safety of cadonilimab combined with neoadjuvant chemotherapy in locally advanced, resectable head and neck squamous cell carcinoma (HNSCC).

Patients And Methods: Eligible patients were consecutively enrolled and received cadonilimab (10 mg/kg) and chemotherapy (docetaxel, 75 mg/m2 plus cisplatin, 60 mg/m2) every 3 weeks for three cycles.

Ordered Copper Triangular Atomic Sites for Industrial-Grade Electromethanation of CO via Self-Regulated Adsorption of Reactants.

Copper single-atom catalysts have shown considerable potential for electrocatalytic CO reduction reaction (CORR) to methane but face constraints of low selectivity at industrial-grade current densities (>400 mA cm) and limited economic viability. Herein, we report an ion exchange strategy to precisely construct ordered Cu triangular atomic sites loaded on poly(heptazine imide) (Cu TAS/PHI), achieving a methane Faradaic efficiency (FE) of 80.5% at 400 mA cm and >60% across 100-800 mA cm.

Two cases of Amyloid-Related Imaging Abnormalities (ARIA) following lecanemab treatment for alzheimer's disease and a literature review.

Objective: To investigate the imaging characteristics and management strategies of amyloid-related imaging abnormalities (ARIA) in Alzheimer's disease (AD) patients treated with lecanemab.

Methods: We report two clinical cases of ARIA following lecanemab treatment and analyze the imaging features, risk factors, and management strategies of ARIA based on the latest literature.

Results: The occurrence of ARIA is associated with risk factors such as advanced age, ApoE ε4 carrier status, cerebral amyloid angiopathy (CAA), and a history of cerebrovascular disease.

Enhanced immunotherapy response in lung adenocarcinoma patients with COPD: insights into tumor cells and immune microenvironment characteristics.

Background: Lung cancer and chronic obstructive pulmonary disease (COPD) are major global health challenges, and their coexistence in patients presents unique clinical complexities. Interestingly, patients with both lung adenocarcinoma (LUAD) and COPD show reduced responses to conventional chemotherapy and targeted therapies but demonstrate enhanced sensitivity to immunotherapy.

Methods: We investigated this phenomenon using a cohort of 248 LUAD patients undergoing immunotherapy.

Identification of Bioactive Ingredients and Mechanistic Pathways of Xuefu Zhuyu Decoction in Ventricular Remodeling: A Network Pharmacology, Molecular Docking and Molecular Dynamics Simulations.

Background: Xuefu Zhuyu Decoction (XFZYD) is clinically used in China to promote blood circulation, resolve blood stasis, and alleviate ventricular remodeling (VR). However, its molecular mechanisms remain unclear.

Objective: This study investigates the active components and underlying molecular mechanisms of XFZYD in treating VR.

Early assessment of therapeutic efficacy in lymphoma patients via a blood-based multi-omics response monitoring test.

Background: Periodic fluorodeoxyglucose (FDG) positron emission tomography (PET)-computed tomography (CT)/CT-based response examinations are the current standard for clinical assessment of lymphoma treatment response. In this prospective study, we applied a blood-based multi-omics test, SeekInClarity, to assess treatment response and to predict therapeutic outcomes in the major lymphoma subtypes.

Methods: We prospectively recruited 116 lymphoma patients from two clinical centers, and collected blood samples at pre-treatment (baseline) and after two treatment cycles (landmark) to calculate molecular tumor burden (MTB) score using SeekInClarity.

Evaluation of day 5 versus day 6 blastocyst biopsy in preimplantation genetic testing: clinical and neonatal outcomes.

Background: Preimplantation genetic testing (PGT) has emerged as a pivotal technique in assisted reproductive technology for enhancing success rates by identifying euploid embryos prior to transfer. The optimal timing for blastocyst biopsy during PGT remains controversial, with conflicting evidence regarding the clinical outcomes of day 5 (D5) versus day 6 (D6) biopsies, as well as neonatal and perinatal outcomes.

Methods: This study involved a retrospective analysis of 3,647 biopsied blastocysts and 673 PGT-frozen embryo transfer (FET) cycles conducted at Zhongshan Boai Hospital between May 2019 and September 2024.

A case report and review of the literature on hereditary diffuse leukoencephalopathy with spheroids presenting with stroke-like symptoms.

Hereditary diffuse leukoencephalopathy with spheroids (HDLS), a rare autosomal dominant disorder caused by CSF1R (Colony Stimulating Factor 1 Receptor) variants, manifests clinically as adult-onset cognitive-motor decline with progressive white matter degeneration. Notably, its phenotypic variability remains undercharacterized, with only limited case reports available globally. We systematically investigated a 47-year-old male presenting with acute stroke-like hemiparesis that progressed to fronto-subcortical dementia (MMSE=14) and extrapyramidal symptoms within six months.

Infrared Spectra of UF ( = 1-4) in Solid Ne and Ar Matrices: Symmetry-Breaking Structure of UF.

This study addresses two persistent challenges in uranium fluoride chemistry: resolving decades-long spectral assignment conflicts across UF, UF, and UF species, and conclusively settling the symmetry controversy of UF. By the cryogenic matrix isolation IR spectroscopy technique in combination with relativistic quantum chemical calculations, we experimentally tracked the stepwise formation of UF to UF in neon and argon matrices. Theoretical validation has led to a reassignment of the infrared absorption bands for UF, UF, and UF, defining their molecular geometries.